FlyBase Gene Report: Dmel\daw

General Information

Symbol

Dmel\daw

Species

D. melanogaster

Name

dawdle

Annotation Symbol

CG16987

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031461

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

dawdle (daw) encodes an Activin- like ligand of the TGF beta superfamily that is required for proper tricarboxylic acid cycle function in the fat body and also regulates insulin release from IPC neurons. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Alp23B, Activin Like Protein at 23B, Alp

Key Links

Genomic Location

Cytogenetic map

23B1-23B2

Sequence location

2L:2,805,261..2,812,376 [+]

Recombination map

2-7

RefSeq locus

NT_033779 REGION:2805261..2812376

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (20 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables hormone activity

inferred from mutant phenotype

(Chng et al., 2017, Chng et al., 2014)

enables receptor ligand activity

inferred from direct assay

(Peterson et al., 2012, Jensen et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cytokine activity

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

enables growth factor activity

inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (14 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in activin receptor signaling pathway

inferred from mutant phenotype

(Langerak et al., 2018, Chng et al., 2014, Peterson et al., 2012, Jensen et al., 2009)

inferred from direct assay

(Gesualdi and Haerry, 2007, Parker et al., 2006, Serpe and O'Connor, 2006)

inferred from genetic interaction with FLYBASE:babo; FB:FBgn0011300

(Wells et al., 2017)

involved_in axon guidance

inferred from mutant phenotype

(Parker et al., 2006, Serpe and O'Connor, 2006)

involved_in cellular response to glucose stimulus

inferred from mutant phenotype

(Chng et al., 2014)

involved_in cellular response to nutrient levels

inferred from mutant phenotype

(Chng et al., 2017)

acts_upstream_of_positive_effect determination of adult lifespan

inferred from mutant phenotype

(Langerak et al., 2018)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Bai et al., 2013)

involved_in negative regulation of autophagy

inferred from mutant phenotype

(Bai et al., 2013)

involved_in positive regulation of neuroblast proliferation

inferred from genetic interaction with FLYBASE:Actβ; FB:FBgn0024913

(Zhu et al., 2008)

involved_in R8 cell fate specification

inferred from mutant phenotype

(Wells et al., 2017)

involved_in regulation of imaginal disc-derived wing size

inferred from mutant phenotype

(Hevia and de Celis, 2013)

involved_in regulation of synapse structure or activity

inferred from mutant phenotype

(Kim and O'Connor, 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in BMP signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000932183

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in keratinocyte differentiation

inferred from electronic annotation with InterPro:IPR009733

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

involved_in positive regulation of pathway-restricted SMAD protein phosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in SMAD protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cornified envelope

inferred from electronic annotation with InterPro:IPR009733

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000218063

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in extracellular space

inferred by curator from GO:0005179

(Chng et al., 2014)

Gene Group (FlyBase)

ACTIVINS

Pathway (FlyBase)

Activin Signaling Pathway Core Components

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

Activin Signaling Pathway Core Components -: The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Gene Group (FlyBase)

ACTIVINS -: Activins form a subfamily of the Transforming Growth Factor(TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a member of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\daw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

daw-RA

FBtr0077721

NM_078737

2693

586

daw-RB

FBtr0077720

NM_164503

2819

586

daw-RC

FBtr0335151

NM_001273038

3050

586

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

daw-PA

FBpp0077405

67.2

586

6.62

NP_523461

AAF51204

daw-PB

FBpp0077404

67.2

586

6.62

NP_722840

AAN10416

daw-PC

FBpp0307150

67.2

586

6.62

NP_001259967

AGB92504

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

586 aa isoforms: daw-PA, daw-PB, daw-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VQG9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\daw using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

daw_1
daw_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

organism | ubiquitous

Comment: maternally deposited

(Gesualdi and Haerry, 2007)

embryonic stage 6 -- 8

mesoderm | dorsal

(Gesualdi and Haerry, 2007)

embryonic stage 9 -- 14

mesoderm | dorsal | segmentally repeated

(Gesualdi and Haerry, 2007)

third instar larval stage

embryonic/larval optic lobe

(Zhu et al., 2008)

glial cell of embryonic/larval optic lobe

(Zhu et al., 2008)

wandering third instar larval stage

embryonic/larval central nervous system

(Gesualdi and Haerry, 2007)

ring gland

(Gesualdi and Haerry, 2007)

eye-antennal disc

(Gesualdi and Haerry, 2007)

ventral thoracic disc

(Gesualdi and Haerry, 2007)

adult stage | male

somatic cell of testis | subset

(Gesualdi and Haerry, 2007)

adult stage | female

nurse cell

(Gesualdi and Haerry, 2007)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

(Bai et al., 2013)

(Bai et al., 2013)

(Bai et al., 2013)

(Bai et al., 2013)

(Bai et al., 2013)

Additional Descriptive Data

daw transcript is expressed in the developing larval optic lobe, and in many glial cells, including surface glia within the optic lobe.

(Zhu et al., 2008)

Maternally deposited daw transcript can be detected in embryos through syncytial blastoderm stage. daw transcript is expressed in the dorsal mesoderm, in a pattern that refines to segmental stripes during germ band extension and retraction stages. In third instar larvae, daw is strongly expressed in the central nervous system, and transiently in the ring gland. daw transcript is weakly expressed in eye-antennal and leg discs, and is not significantly expressed in wing discs. In the adult testis, daw transcipt is strongly expressed in somatic cells in the region where secondary spermatogonia are mitotically active. No expression is observed in the stem cells at the tip of the testis, or in primary spermatocytes; weak expression is observed during spermatid differentiation. daw transcript is expressed in nurse cells at all stages of oogenesis.

(Gesualdi and Haerry, 2007)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{daw-GAL4.Z}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval CNS perineurial glial cell

(Kanai et al., 2018)

Reporter: P{GawB}daw^NP4661

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

hemocyte | subset

(Clark et al., 2011)

adult pericardial cell

(Clark et al., 2011)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\daw in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\daw

View exonic expression by tissue for Dmel\daw

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031461

DRscDB

33474/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0031461

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG16987-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16987

Flygut - An atlas of the Drosophila adult midgut

FBgn0031461

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\daw

Stages(s) 4-6
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of daw

Transgenic constructs containing regulatory region of daw

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)C144

(Parker et al., 2006)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage

partially lethal - majority die

daw^aact1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

daw^GD5085

viable, with Scer\GAL4^Mef2.PR

daw^GD5085

viable, with Scer\GAL4^pnr-MD237

daw^GD5085

Other Phenotypes

Allele

abnormal circadian rhythm, with Scer\GAL4^P2.4.Pdf

daw^KK110248

abnormal circadian rhythm | heat sensitive, with Scer\GAL4^tim.PE, Scer\GAL80^Pdf.PS

daw^KK110248

abnormal flight | progressive, with Scer\GAL4^Mhc.PW

daw^HMS01110

abnormal neuroanatomy

daw^ex32

abnormal neuroanatomy | embryonic stage

abnormal neuroanatomy | embryonic stage (with daw³)

daw^Δ2

abnormal neuroanatomy | embryonic stage (with daw^Δ2)

daw³

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Gli-rL82

daw^KK110248

delayed aging, with Scer\GAL4^Mhc.PW

daw^HMS01110

hypoactive | larval stage

long lived | RU486 conditional, with Scer\GAL4^da.Switch.PT

daw^HMS01110

long lived | RU486 conditional, with Scer\GAL4^{αTub84B.Switch.PK}

daw^HMS01110

melanotic mass phenotype, with Scer\GAL4^Tub.PU

some die during larval stage

daw^aact1

some die during P-stage, with Scer\GAL4^Cg.PA

daw^UAS.cSa

some die during pupal stage

some die during pupal stage, with Scer\GAL4^Cg.PA

daw^UAS.cSa

uncoordinated | adult stage

Phenotype manifest in

Allele

adult somatic muscle | progressive, with Scer\GAL4^Mhc.PW

daw^HMS01110

autophagosome, with Scer\GAL4^Mhc.PW

daw^HMS01110

axon & eye photoreceptor cell

daw^ex32

bouton | third instar larval stage, with Scer\GAL4^Gli-rL82

daw^KK110248

embryonic/larval anal pad

daw^aact1

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Gli-rL82

daw^KK110248

embryonic/larval optic lobe

daw^ex32

larval abdominal segmental nerve

larval abdominal segmental nerve (with daw³)

daw^Δ2

larval abdominal segmental nerve (with daw^Δ2)

daw³

larval intersegmental nerve

larval intersegmental nerve (with daw³)

daw^Δ2

larval intersegmental nerve (with daw^Δ2)

daw³

larval intersegmental nerve branch ISNb of A1-7

leg | pharate adult stage

daw^Δ1

lysosome | progressive, with Scer\GAL4^Mhc.PW

daw^HMS01110

melanotic mass, with Scer\GAL4^Tub.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (33)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\INHBC

4 of 15

Yes

Hsap\INHBE

4 of 15

Yes

Hsap\TGFB1

4 of 15

Yes

Hsap\INHBA

3 of 15

Hsap\INHBB

3 of 15

Hsap\NODAL

3 of 15

Yes

Hsap\TGFB2

3 of 15

Yes

Hsap\BMP2

2 of 15

Hsap\BMP3

2 of 15

Yes

Hsap\BMP4

2 of 15

Hsap\BMP10

2 of 15

Yes

Hsap\BMP15

2 of 15

Yes

Hsap\GDF1

2 of 15

Hsap\GDF2

2 of 15

Yes

Hsap\GDF3

2 of 15

Hsap\GDF5

2 of 15

Yes

Hsap\GDF6

2 of 15

Yes

Hsap\GDF7

2 of 15

Yes

Hsap\GDF9

2 of 15

Yes

Hsap\GDF10

2 of 15

Yes

Hsap\GDF15

2 of 15

Hsap\INHA

2 of 15

Yes

Hsap\LEFTY1

2 of 15

Yes

Hsap\LEFTY2

2 of 15

Yes

Hsap\TGFB3

2 of 15

Hsap\AMH

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (34)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Inhbc

4 of 15

Yes

Mmus\Inhbe

4 of 15

Yes

Mmus\Tgfb1

4 of 15

Yes

Mmus\Inhba

3 of 15

Mmus\Nodal

3 of 15

Yes

Mmus\Tgfb2

3 of 15

Yes

Mmus\Bmp2

2 of 15

Mmus\Bmp3

2 of 15

Yes

Mmus\Bmp4

2 of 15

Mmus\Bmp10

2 of 15

Yes

Mmus\Bmp15

2 of 15

Yes

Mmus\Gdf1

2 of 15

Mmus\Gdf2

2 of 15

Yes

Mmus\Gdf3

2 of 15

Mmus\Gdf5

2 of 15

Yes

Mmus\Gdf6

2 of 15

Yes

Mmus\Gdf7

2 of 15

Yes

Mmus\Gdf9

2 of 15

Yes

Mmus\Gdf10

2 of 15

Yes

Mmus\Gdf15

2 of 15

Yes

Mmus\Inha

2 of 15

Yes

Mmus\Inhbb

2 of 15

Mmus\Lefty1

2 of 15

Yes

Mmus\Lefty2

2 of 15

Yes

Mmus\Tgfb3

2 of 15

Mmus\Amh

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (32)

Rnor\Inhbe

5 of 13

Yes

Rnor\Inhbc

4 of 13

Rnor\Tgfb1

4 of 13

Yes

Rnor\Inhba

3 of 13

Rnor\Nodal

3 of 13

Yes

Rnor\Tgfb2

3 of 13

Yes

Rnor\Bmp2

2 of 13

Rnor\Bmp3

2 of 13

Yes

Rnor\Bmp4

2 of 13

Rnor\Bmp10

2 of 13

Yes

Rnor\Bmp15

2 of 13

Yes

Rnor\Gdf1

2 of 13

Rnor\Gdf3

2 of 13

Rnor\Gdf5

2 of 13

Yes

Rnor\Gdf6

2 of 13

Yes

Rnor\Gdf7

2 of 13

Yes

Rnor\Gdf9

2 of 13

Yes

Rnor\Gdf15

2 of 13

Rnor\Inha

2 of 13

Yes

Rnor\Inhbb

2 of 13

Rnor\Lefty1

2 of 13

Yes

Rnor\Tgfb3

2 of 13

Yes

Rnor\Amh

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Gdf2

1 of 13

Yes

Rnor\Gdf10

1 of 13

Yes

Rnor\Gdf11

1 of 13

Rnor\Lefty2

1 of 13

Yes

Rnor\Mstn

1 of 13

Xenopus tropicalis (Western clawed frog) (35)

Xtro\inhbc.1

4 of 12

Yes

Xtro\inhba

3 of 12

Yes

Xtro\nodal1

3 of 12

Yes

Xtro\nodal5

3 of 12

Yes

Xtro\nodal6

3 of 12

Yes

Xtro\nodal

3 of 12

Yes

Xtro\tgfb1

3 of 12

Yes

Xtro\tgfb2

3 of 12

Yes

Xtro\bmp2

2 of 12

Xtro\bmp3

2 of 12

Yes

Xtro\bmp4

2 of 12

Xtro\bmp10

2 of 12

Yes

Xtro\bmp15

2 of 12

Yes

Xtro\gdf1

2 of 12

Xtro\gdf2

2 of 12

Yes

Xtro\gdf3

2 of 12

Xtro\gdf5

2 of 12

Yes

Xtro\gdf7

2 of 12

Xtro\gdf9

2 of 12

Yes

Xtro\gdf10

2 of 12

Yes

Xtro\inhbb

2 of 12

Yes

Xtro\inhbc.2

2 of 12

Yes

Xtro\nodal

2 of 12

Yes

Xtro\admp

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC101732995

1 of 12

Yes

Xtro\mstn.1

1 of 12

Xtro\nodal3.2

1 of 12

Yes

Danio rerio (Zebrafish) (44)

Drer\LOC100329520

5 of 15

Yes

Drer\inha

3 of 15

Yes

Drer\inhbab

3 of 15

Drer\inhbb

3 of 15

Drer\tgfb1a

3 of 15

Yes

Drer\tgfb1b

3 of 15

Yes

Drer\tgfb2

3 of 15

Yes

Drer\tgfb5

3 of 15

Yes

Drer\bmp2a

2 of 15

Drer\bmp2b

2 of 15

Drer\bmp3

2 of 15

Yes

Drer\bmp4

2 of 15

Drer\bmp10

2 of 15

Yes

Drer\bmp10l

2 of 15

Yes

Drer\gdf2

2 of 15

Yes

Drer\gdf3

2 of 15

Drer\gdf5

2 of 15

Yes

Drer\gdf6a

2 of 15

Yes

Drer\gdf6b

2 of 15

Drer\gdf7

2 of 15

Drer\gdf9

2 of 15

Yes

Drer\gdf10a

2 of 15

Yes

Drer\gdf10b

2 of 15

Yes

Drer\inhbaa

2 of 15

Drer\lft1

2 of 15

Yes

Drer\lft2

2 of 15

Yes

Drer\LOC100332902

2 of 15

Drer\LOC101887111

2 of 15

Yes

Drer\ndr1

2 of 15

Yes

Drer\ndr2

2 of 15

Drer\spaw

2 of 15

Yes

Drer\tgfb3

2 of 15

Yes

Drer\admp

1 of 15

Yes

Drer\amh

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\bmp16

1 of 15

Drer\gdf11

1 of 15

Drer\LOC101885590

1 of 15

Yes

Drer\mstna

1 of 15

Drer\mstnb

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\daf-7

5 of 15

Yes

Cele\tig-3

3 of 15

Yes

Cele\unc-129

3 of 15

Yes

Cele\dbl-1

2 of 15

Cele\tig-2

2 of 15

Cele\emb-30

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\DIA2

1 of 15

Yes

Scer\MCM3

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919099Q )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila persimilis

Dper\GL15444

Drosophila willistoni

Dwil\GK24277

Drosophila virilis

Dvir\GJ17906

Drosophila mojavensis

Dmoj\GI17297

Drosophila grimshawi

Dgri\GH13255

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915067Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17019213

Glossina morsitans

Tsetse fly

Gmor\GMOY002112

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_06864

Mayetiola destructor

Hessian fly

Mdes\Mdes005362

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0576 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004618

Danaus plexippus

Monarch butterfly

Dple\DPOGS213910-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006070

Apis florea

Little honeybee

Aflo\2216907236

Apis mellifera

Western honey bee

Amel\LOC726478

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20364

Bombus terrestris

Buff-tailed bumblebee

Bter\15214780

Linepithema humile

Argentine ant

Lhum\LH11184

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002e1e

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008446

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09294

Tribolium castaneum

Red flour beetle

Tcas\daw

Pediculus humanus

Human body louse

Phum\PHUM033950

Rhodnius prolixus

Kissing bug

Rpro\RPRC011115

Cimex lectularius

Bed bug

Clec\CLEC010050

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09337

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X053N )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW010227

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62674.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73585.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65051.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g12520

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_305466

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07SD )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Bmp11

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (6)

Gene Symbol

Score

Source

Alignment

4 of 10

dpp

3 of 10

gbb

3 of 10

mav

3 of 10

myo

3 of 10

scw

3 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

TGFB1; transforming growth factor beta 1

model of Camurati-Engelmann disease

IEA

(FlyBase, 2019-)

model of cystic fibrosis

IEA

(FlyBase, 2019-)

NODAL; nodal growth differentiation factor

model of situs inversus

IEA

(FlyBase, 2019-)

TGFB2; transforming growth factor beta 2

model of Loeys-Dietz syndrome 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

daw^KK110248

exacerbates atypical teratoid rhabdoid tumor

modeled by Snr1^KK101602

(Tegeder et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

INHBC; inhibin subunit beta C

4 of 15

601233

INHBE; inhibin subunit beta E

4 of 15

612031

TGFB1; transforming growth factor beta 1

4 of 15

190180

INHBA; inhibin subunit beta A

3 of 15

147290

INHBB; inhibin subunit beta B

3 of 15

147390

NODAL; nodal growth differentiation factor

3 of 15

601265

HETEROTAXY, VISCERAL, 5, AUTOSOMAL; HTX5

situs inversus

TGFB2; transforming growth factor beta 2

3 of 15

190220

LOEYS-DIETZ SYNDROME 4; LDS4

Loeys-Dietz syndrome 4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

daw - CG7737

experimental knowledge based

(Guruharsha et al., 2011)

daw - HIP-R

experimental knowledge based

(Guruharsha et al., 2011)

daw - tld

inferred by author, enzymatic study, western blot

(Serpe and O'Connor, 2006)

daw - tok

inferred by author, enzymatic study, western blot

(Serpe and O'Connor, 2006)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zhu et al., 2008)

suppressible

(Bai et al., 2013)

enhanceable

(Parker et al., 2006)

daw

enhanceable

put

(Parker et al., 2006)

daw

enhanceable

tok

(Serpe and O'Connor, 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

babo

enhanceable

daw

(Parker et al., 2006)

suppressible

daw

(Krupp et al., 2005)

suppressible

daw

(Pentek et al., 2009)

ph-p

enhanceable

daw

(Faucheux et al., 2001)

Smox

suppressible

daw

(Gesualdi and Haerry, 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59697

DroID - A comprehensive database of gene and protein interactions.

FBgn0031461

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33474

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Activin Signaling Pathway Core Components -: The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-7

Cytogenetic map

23B1-23B2

Sequence location

2L:2,805,261..2,812,376 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

23B1-23B2

Limits computationally determined from genome sequence between P{EP}EP832 and P{PZ}oho23B⁰³⁵⁷⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

23B-23B

(Parker et al., 2001)

Experimentally Determined Recombination Data

Location

2-7

(FlyBase, 2016)

2-6.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Bloomington

50911

y¹ v¹; P{TRiP.HMJ03135}attP40

43001

y¹ w^*; Mi{MIC}daw^MI05383

80605

y¹ w^*; TI{CRIMIC.TG4.1}daw^{CR00604-TG4.1}/SM6a

67529

y¹ sc^* v¹ sev²¹; P{TOE.GS00051}attP40

34974

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01110}attP2

81327

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS03180}attP40

Kyoto

113490

w^*; P{GawB}daw^NP4661 / CyO

105179

y^* w^*; P{GawB}daw^NP6274 / CyO, P{UAS-lacZ.UW14}UW14

VDRC

v105309

P{KK110248}VIE-260B

v13420

w¹¹¹⁸; P{GD5085}v13420

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (12)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH14433

Other clones

DPiM_GH14433

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031461

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031461

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33474

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Alp23B CG16987

(Parker, 2001.3.12)

Source for identity of: daw Alp23B

(Parker et al., 2006, Serpe and O'Connor, 2006)

Source for database merge of

Additional comments

This gene has been renamed from "Activin Like Protein at 23B" (Alp23B) to "dawdle" (daw) to avoid confusion with "Abnormal leg pattern" (Alp) and to better reflect the mutant phenotype.

(Parker et al., 2006)

Other Comments

Origin and Etymology

Discoverer

Etymology

The name "dawdle" refers to the delayed nature of the innervation defects seen in mutants of this gene.

(Serpe and O'Connor, 2006)

Identification

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33474

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VQG9

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031461

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031461

DRscDB

33474/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0031461

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

daw_1
daw_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16987

Flygut - An atlas of the Drosophila adult midgut

FBgn0031461

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33474

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004297

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG16987

MARRVEL_MODEL

33474

modMine - A data warehouse for the modENCODE project

FBgn0031461

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VQG9

Linkouts

BioGRID - A database of protein and genetic interactions.

59697

DroID - A comprehensive database of gene and protein interactions.

FBgn0031461

DRSC - Results frm RNAi screens

FBgn0031461

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG16987-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031461

FlyMine - An integrated database for Drosophila genomics

FBgn0031461

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33474

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

ALP23B

(Parker et al., 2001)

Alp

(Pistillo and Desplan, 2007, Ellis et al., 2005, Parker and Arora, 2002)

Alp23B

(Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Fujikawa et al., 2009, Dudu, 2006, Parker et al., 2006, Serpe and O'Connor, 2006, Kim et al., 2005, Winkler et al., 2005)

Alp23b

(Shim et al., 2009, Parker et al., 2005)

CG16987

(Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Parker et al., 2006, Metaxakis et al., 2005, Faucheux et al., 2001)

DAW

(Gesualdi and Haerry, 2007)

Daw

(Colombani and Andersen, 2020, Koyama et al., 2020, Texada et al., 2020, Zhou et al., 2020, Nil et al., 2019, Langerak et al., 2018, Chng et al., 2017, Chng et al., 2017, Liu and Jin, 2017, Song et al., 2017, Upadhyay et al., 2017, Droujinine and Perrimon, 2016, Vlisidou and Wood, 2015, Bhadra et al., 2014, Ting et al., 2014, Fuentes-Medel et al., 2012, Peterson et al., 2012, Jensen et al., 2009)

cg16987

(Gesualdi and Haerry, 2007)

Name Synonyms

Activin Like Protein at 23B

(Parker et al., 2006, Serpe and O'Connor, 2006, Parker et al., 2001)

Activin like protein

(Pistillo and Desplan, 2007)

Activin-Like Protein

(Parker and Arora, 2002)

Dawdle

(Havula and Hietakangas, 2018, Chng et al., 2017, Mattila and Hietakangas, 2017, Kwong et al., 2015, Ting et al., 2014, Ting et al., 2014, Fuentes-Medel et al., 2012, Peterson et al., 2012, Ellis et al., 2010, Jensen et al., 2009, Arora et al., 2008, Bickel et al., 2008, Zhu et al., 2008, Gesualdi and Haerry, 2007)

DmDawdle

(Wisotzkey and Newfeld, 2020)

dActivin2

(Funakoshi et al., 2004)

dawdle

(Destalminil-Letourneau et al., 2021, Kuleesha et al., 2016, Mulakkal et al., 2014, Clark et al., 2011, Hartmann et al., 2009, Parker et al., 2006, Serpe and O'Connor, 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (128)

Report Sections

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