FB2020_03, released Jun 16, 2020

Gene: Dmel\daw

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General Information
Symbol
Dmel\daw
Species
D. melanogaster
Name
dawdle
Annotation Symbol
CG16987
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031461
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
dawdle (daw) encodes an Activin- like ligand of the TGF beta superfamily that is required for proper tricarboxylic acid cycle function in the fat body and also regulates insulin release from IPC neurons. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Alp23B, Activin Like Protein at 23B, Alp

Key Links
Genomic Location
Cytogenetic map
23B1-23B2
Sequence location
2L:2,805,261..2,812,376 [+]
Recombination map

2-7

RefSeq locus
NT_033779 REGION:2805261..2812376
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
hormone activity
inferred from mutant phenotype
(Chng et al., 2017, Chng et al., 2014)
receptor ligand activity
inferred from direct assay
(Peterson et al., 2012, Jensen et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytokine activity
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
growth factor activity
inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (14 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
activin receptor signaling pathway
inferred from direct assay
(Gesualdi and Haerry, 2007, Parker et al., 2006, Serpe and O'Connor, 2006)
inferred from mutant phenotype
(Langerak et al., 2018, Chng et al., 2014, Peterson et al., 2012, Jensen et al., 2009)
inferred from genetic interaction with FLYBASE:babo; FB:FBgn0011300
(Wells et al., 2017)
axon guidance
inferred from mutant phenotype
(Parker et al., 2006, Serpe and O'Connor, 2006)
cellular response to glucose stimulus
inferred from mutant phenotype
(Chng et al., 2014)
cellular response to nutrient levels
inferred from mutant phenotype
(Chng et al., 2017)
determination of adult lifespan
inferred from mutant phenotype
(Bai et al., 2013)
negative regulation of autophagy
inferred from mutant phenotype
(Bai et al., 2013)
positive regulation of neuroblast proliferation
inferred from genetic interaction with FLYBASE:Actβ; FB:FBgn0024913
(Zhu et al., 2008)
R8 cell fate specification
inferred from mutant phenotype
(Wells et al., 2017)
regulation of imaginal disc-derived wing size
inferred from mutant phenotype
(Hevia and de Celis, 2013)
regulation of synapse structure or activity
inferred from mutant phenotype
(Kim and O'Connor, 2014)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
BMP signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000218210
(assigned by GO_Central )
(Gaudet et al., 2011)
keratinocyte differentiation
inferred from electronic annotation with InterPro:IPR009733
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
positive regulation of pathway-restricted SMAD protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
SMAD protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cornified envelope
inferred from electronic annotation with InterPro:IPR009733
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0005179
(Chng et al., 2014)
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
Activin Signaling Pathway Core Components -
The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Gene Group (FlyBase)
ACTIVINS -
Activins form a subfamily of the Transforming Growth Factor(TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a member of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\daw or the JBrowse view of Dmel\daw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
daw-RA
FBtr0077721
NM_078737
2693
586
daw-RB
FBtr0077720
NM_164503
2819
586
daw-RC
FBtr0335151
NM_001273038
3050
586
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
daw-PA
FBpp0077405
67.2
586
6.62
NP_523461
AAF51204
daw-PB
FBpp0077404
67.2
586
6.62
NP_722840
AAN10416
daw-PC
FBpp0307150
67.2
586
6.62
NP_001259967
AGB92504
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

586 aa isoforms: daw-PA, daw-PB, daw-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\daw using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic precursor of adult hindgut
(Fisher et al., 2012)
atrium
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval oenocyte
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
ventral imaginal tissue
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
embryonic/larval optic lobe
(Zhu et al., 2008)
glial cell of embryonic/larval optic lobe
(Zhu et al., 2008)
embryonic stage 1 -- 4
organism | ubiquitous

Comment: maternally deposited

(Gesualdi and Haerry, 2007)
embryonic stage 6 -- 8
mesoderm | dorsal
(Gesualdi and Haerry, 2007)
embryonic stage 9 -- 14
mesoderm | dorsal | segmentally repeated
(Gesualdi and Haerry, 2007)
wandering third instar larval stage
embryonic/larval central nervous system
(Gesualdi and Haerry, 2007)
ring gland
(Gesualdi and Haerry, 2007)
eye-antennal disc
(Gesualdi and Haerry, 2007)
ventral thoracic disc
(Gesualdi and Haerry, 2007)
adult stage | male
somatic cell of testis | subset
(Gesualdi and Haerry, 2007)
adult stage | female
nurse cell
(Gesualdi and Haerry, 2007)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult fat body
(Bai et al., 2013)
adult brain
(Bai et al., 2013)
adult gut
(Bai et al., 2013)
adult muscle system
(Bai et al., 2013)
adult stage | female
ovary
(Bai et al., 2013)
Additional Descriptive Data

daw transcript is expressed in the developing larval optic lobe, and in many glial cells, including surface glia within the optic lobe.

(Zhu et al., 2008)

Maternally deposited daw transcript can be detected in embryos through syncytial blastoderm stage. daw transcript is expressed in the dorsal mesoderm, in a pattern that refines to segmental stripes during germ band extension and retraction stages. In third instar larvae, daw is strongly expressed in the central nervous system, and transiently in the ring gland. daw transcript is weakly expressed in eye-antennal and leg discs, and is not significantly expressed in wing discs. In the adult testis, daw transcipt is strongly expressed in somatic cells in the region where secondary spermatogonia are mitotically active. No expression is observed in the stem cells at the tip of the testis, or in primary spermatocytes; weak expression is observed during spermatid differentiation. daw transcript is expressed in nurse cells at all stages of oogenesis.

(Gesualdi and Haerry, 2007)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{daw-GAL4.Z}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval CNS perineurial glial cell
(Kanai et al., 2018)
Reporter: P{GawB}dawNP4661
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
hemocyte | subset
(Clark et al., 2011)
adult pericardial cell
(Clark et al., 2011)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\daw in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of daw
Transgenic constructs containing regulatory region of daw
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of pupal stage
partially lethal - majority die
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
circadian rhythm defective, with Scer\GAL4P2.4.Pdf
circadian rhythm defective | heat sensitive, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS
delayed aging, with Scer\GAL4Mhc.PW
flight defective | progressive, with Scer\GAL4Mhc.PW
hypoactive | larval stage
long lived | RU486 conditional, with Scer\GAL4da.Switch.PT
long lived | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
melanotic mass phenotype, with Scer\GAL4Tub.PU
neuroanatomy defective
neuroanatomy defective | embryonic stage
neuroanatomy defective | embryonic stage (with daw3)
neuroanatomy defective | embryonic stage (with dawΔ2)
neuroanatomy defective | third instar larval stage, with Scer\GAL4Gli-rL82
some die during larval stage
some die during P-stage, with Scer\GAL4Cg.PA
some die during pupal stage
some die during pupal stage, with Scer\GAL4Cg.PA
uncoordinated | adult stage
Phenotype manifest in
Allele
abdominal segmental nerve
abdominal segmental nerve (with daw3)
abdominal segmental nerve (with dawΔ2)
adult somatic muscle | progressive, with Scer\GAL4Mhc.PW
autophagosome, with Scer\GAL4Mhc.PW
axon & eye photoreceptor cell
bouton | third instar larval stage, with Scer\GAL4Gli-rL82
embryonic/larval anal pad
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Gli-rL82
embryonic/larval optic lobe
intersegmental nerve
intersegmental nerve (with daw3)
intersegmental nerve (with dawΔ2)
intersegmental nerve branch ISNb of A1-7
leg | pharate adult stage
lysosome | progressive, with Scer\GAL4Mhc.PW
melanotic mass, with Scer\GAL4Tub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\INHBC
4 of 15
Yes
No
Hsap\INHBE
4 of 15
Yes
No
Hsap\TGFB1
4 of 15
Yes
Yes
Hsap\INHBA
3 of 15
No
No
1  
Hsap\INHBB
3 of 15
No
No
Hsap\NODAL
3 of 15
No
Yes
Hsap\TGFB2
3 of 15
No
Yes
Hsap\BMP2
2 of 15
No
No
1  
Hsap\BMP3
2 of 15
No
Yes
1  
Hsap\BMP4
2 of 15
No
No
1  
Hsap\BMP10
2 of 15
No
Yes
Hsap\BMP15
2 of 15
No
Yes
Hsap\GDF1
2 of 15
No
No
Hsap\GDF2
2 of 15
No
Yes
Hsap\GDF3
2 of 15
No
No
Hsap\GDF5
2 of 15
No
Yes
Hsap\GDF6
2 of 15
No
Yes
Hsap\GDF7
2 of 15
No
Yes
Hsap\GDF9
2 of 15
No
Yes
Hsap\GDF10
2 of 15
No
Yes
Hsap\GDF15
2 of 15
No
No
Hsap\INHA
2 of 15
No
Yes
Hsap\LEFTY1
2 of 15
No
Yes
Hsap\LEFTY2
2 of 15
No
Yes
Hsap\TGFB3
2 of 15
No
No
Hsap\AMH
1 of 15
No
Yes
Hsap\BMP5
1 of 15
No
No
Hsap\BMP6
1 of 15
No
No
Hsap\BMP7
1 of 15
No
No
5  
Hsap\BMP8A
1 of 15
No
No
Hsap\BMP8B
1 of 15
No
No
Hsap\GDF11
1 of 15
No
No
1  
Hsap\MSTN
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Inhbc
4 of 15
Yes
No
Mmus\Inhbe
4 of 15
Yes
No
Mmus\Tgfb1
4 of 15
Yes
Yes
Mmus\Inhba
3 of 15
No
No
Mmus\Nodal
3 of 15
No
Yes
Mmus\Tgfb2
3 of 15
No
Yes
Mmus\Bmp2
2 of 15
No
No
Mmus\Bmp3
2 of 15
No
Yes
Mmus\Bmp4
2 of 15
No
No
Mmus\Bmp10
2 of 15
No
Yes
Mmus\Bmp15
2 of 15
No
Yes
Mmus\Gdf1
2 of 15
No
No
Mmus\Gdf2
2 of 15
No
Yes
Mmus\Gdf3
2 of 15
No
No
Mmus\Gdf5
2 of 15
No
Yes
Mmus\Gdf6
2 of 15
No
Yes
Mmus\Gdf7
2 of 15
No
Yes
Mmus\Gdf9
2 of 15
No
Yes
Mmus\Gdf10
2 of 15
No
Yes
Mmus\Gdf15
2 of 15
No
Yes
Mmus\Inha
2 of 15
No
Yes
Mmus\Inhbb
2 of 15
No
No
Mmus\Lefty1
2 of 15
No
Yes
Mmus\Lefty2
2 of 15
No
Yes
Mmus\Tgfb3
2 of 15
No
No
Mmus\Amh
1 of 15
No
Yes
Mmus\Bmp5
1 of 15
No
No
Mmus\Bmp6
1 of 15
No
No
Mmus\Bmp7
1 of 15
No
No
Mmus\Bmp8a
1 of 15
No
No
Mmus\Bmp8b
1 of 15
No
No
Mmus\Gdf11
1 of 15
No
No
Mmus\Mcm3
1 of 15
No
No
Mmus\Mstn
1 of 15
No
No
Rattus norvegicus (Norway rat) (32)
Rnor\Inhbe
5 of 13
Yes
No
Rnor\Inhbc
4 of 13
No
No
Rnor\Tgfb1
4 of 13
No
Yes
Rnor\Inhba
3 of 13
No
No
Rnor\Nodal
3 of 13
No
Yes
Rnor\Tgfb2
3 of 13
No
Yes
Rnor\Bmp2
2 of 13
No
No
Rnor\Bmp3
2 of 13
No
Yes
Rnor\Bmp4
2 of 13
No
No
Rnor\Bmp10
2 of 13
No
Yes
Rnor\Bmp15
2 of 13
No
Yes
Rnor\Gdf1
2 of 13
No
No
Rnor\Gdf3
2 of 13
No
No
Rnor\Gdf5
2 of 13
No
Yes
Rnor\Gdf6
2 of 13
No
Yes
Rnor\Gdf7
2 of 13
No
Yes
Rnor\Gdf9
2 of 13
No
Yes
Rnor\Gdf15
2 of 13
No
No
Rnor\Inha
2 of 13
No
Yes
Rnor\Inhbb
2 of 13
No
No
Rnor\Lefty1
2 of 13
No
Yes
Rnor\Tgfb3
2 of 13
No
Yes
Rnor\Amh
1 of 13
No
Yes
Rnor\Bmp6
1 of 13
No
No
Rnor\Bmp8a
1 of 13
No
No
Rnor\Bmp8b
1 of 13
No
No
Rnor\Cers1
1 of 13
No
Yes
Rnor\Gdf2
1 of 13
No
Yes
Rnor\Gdf10
1 of 13
No
Yes
Rnor\Gdf11
1 of 13
No
No
Rnor\Lefty2
1 of 13
No
Yes
Rnor\Mstn
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (35)
Xtro\inhbc.1
4 of 12
Yes
No
Xtro\inhba
3 of 12
No
Yes
Xtro\nodal1
3 of 12
No
Yes
Xtro\nodal5
3 of 12
No
Yes
Xtro\nodal6
3 of 12
No
Yes
Xtro\nodal
3 of 12
No
Yes
Xtro\tgfb1
3 of 12
No
Yes
Xtro\tgfb2
3 of 12
No
Yes
Xtro\bmp2
2 of 12
No
No
Xtro\bmp3
2 of 12
No
Yes
Xtro\bmp4
2 of 12
No
No
Xtro\bmp10
2 of 12
No
Yes
Xtro\bmp15
2 of 12
No
Yes
Xtro\gdf1
2 of 12
No
No
Xtro\gdf2
2 of 12
No
Yes
Xtro\gdf3
2 of 12
No
No
Xtro\gdf5
2 of 12
No
Yes
Xtro\gdf7
2 of 12
No
No
Xtro\gdf9
2 of 12
No
Yes
Xtro\gdf10
2 of 12
No
Yes
Xtro\inhbb
2 of 12
No
Yes
Xtro\inhbc.2
2 of 12
No
Yes
Xtro\nodal
2 of 12
No
Yes
Xtro\admp
1 of 12
No
Yes
Xtro\bmp5
1 of 12
No
No
Xtro\bmp6
1 of 12
No
No
Xtro\bmp7.1
1 of 12
No
No
Xtro\bmp7.2
1 of 12
No
No
Xtro\bmp8
1 of 12
No
No
Xtro\gdf11.1
1 of 12
No
No
Xtro\inha
1 of 12
No
No
Xtro\lefty
1 of 12
No
Yes
Xtro\LOC101732995
1 of 12
No
Yes
Xtro\mstn.1
1 of 12
No
No
Xtro\nodal3.2
1 of 12
No
Yes
Danio rerio (Zebrafish) (44)
Drer\LOC100329520
5 of 15
Yes
Yes
Drer\inha
3 of 15
No
Yes
Drer\inhbab
3 of 15
No
No
Drer\inhbb
3 of 15
No
No
Drer\tgfb1a
3 of 15
No
Yes
Drer\tgfb1b
3 of 15
No
Yes
Drer\tgfb2
3 of 15
No
Yes
Drer\tgfb5
3 of 15
No
Yes
Drer\bmp2a
2 of 15
No
No
Drer\bmp2b
2 of 15
No
No
Drer\bmp3
2 of 15
No
Yes
Drer\bmp4
2 of 15
No
No
Drer\bmp10
2 of 15
No
Yes
Drer\bmp10l
2 of 15
No
Yes
Drer\gdf2
2 of 15
No
Yes
Drer\gdf3
2 of 15
No
No
Drer\gdf5
2 of 15
No
Yes
Drer\gdf6a
2 of 15
No
Yes
Drer\gdf6b
2 of 15
No
No
Drer\gdf7
2 of 15
No
No
Drer\gdf9
2 of 15
No
Yes
Drer\gdf10a
2 of 15
No
Yes
Drer\gdf10b
2 of 15
No
Yes
Drer\inhbaa
2 of 15
No
No
Drer\lft1
2 of 15
No
Yes
Drer\lft2
2 of 15
No
Yes
Drer\LOC100332902
2 of 15
No
No
Drer\LOC101887111
2 of 15
No
Yes
Drer\ndr1
2 of 15
No
Yes
Drer\ndr2
2 of 15
No
No
Drer\spaw
2 of 15
No
Yes
Drer\tgfb3
2 of 15
No
Yes
Drer\admp
1 of 15
No
Yes
Drer\amh
1 of 15
No
Yes
Drer\bmp6
1 of 15
No
No
Drer\bmp7a
1 of 15
No
No
Drer\bmp7b
1 of 15
No
No
Drer\bmp8a
1 of 15
No
No
Drer\bmp15
1 of 15
No
Yes
Drer\bmp16
1 of 15
No
No
Drer\gdf11
1 of 15
No
No
Drer\LOC101885590
1 of 15
No
Yes
Drer\mstna
1 of 15
No
No
Drer\mstnb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\daf-7
5 of 15
Yes
No
Cele\tig-3
3 of 15
No
Yes
Cele\unc-129
3 of 15
No
Yes
Cele\dbl-1
2 of 15
No
No
Cele\tig-2
2 of 15
No
No
Cele\emb-30
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\DIA2
1 of 15
Yes
Yes
Scer\MCM3
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919099Q )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000597
Drosophila simulans
Dsim\GD23183
Drosophila sechellia
Dsec\GM18367
Drosophila erecta
Dere\GG24887
Drosophila yakuba
Dyak\GE18181
Drosophila ananassae
Dana\GF14981
Drosophila persimilis
Dper\GL15444
Drosophila willistoni
Dwil\GK24277
Drosophila virilis
Dvir\GJ17906
Drosophila mojavensis
Dmoj\GI17297
Drosophila grimshawi
Dgri\GH13255
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915067Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019213
Glossina morsitans
Tsetse fly
Gmor\GMOY002112
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06864
Mayetiola destructor
Hessian fly
Mdes\Mdes005362
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0576 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004618
Danaus plexippus
Monarch butterfly
Dple\DPOGS213910-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006070
Apis florea
Little honeybee
Aflo\2216907236
Apis mellifera
Western honey bee
Amel\LOC726478
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20364
Bombus terrestris
Buff-tailed bumblebee
Bter\15214780
Linepithema humile
Argentine ant
Lhum\LH11184
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002e1e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008446
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09294
Tribolium castaneum
Red flour beetle
Tcas\daw
Pediculus humanus
Human body louse
Phum\PHUM033950
Rhodnius prolixus
Kissing bug
Rpro\RPRC011115
Cimex lectularius
Bed bug
Clec\CLEC010050
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09337
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X053N )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW010227
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62674.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73585.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65051.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g12520
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305466
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07SD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Bmp11
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Actβ
4 of 10
dpp
3 of 10
gbb
3 of 10
mav
3 of 10
myo
3 of 10
scw
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 4 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    INHBC; inhibin subunit beta C
    4 of 15
    601233
        INHBE; inhibin subunit beta E
        4 of 15
        612031
            TGFB1; transforming growth factor beta 1
            4 of 15
            190180
            INHBA; inhibin subunit beta A
            3 of 15
            147290
                 
                INHBB; inhibin subunit beta B
                3 of 15
                147390
                    NODAL; nodal growth differentiation factor
                    3 of 15
                    601265
                    TGFB2; transforming growth factor beta 2
                    3 of 15
                    190220
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    daw - CG7737
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    daw - HIP-R
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    daw - tld
                    inferred by author, enzymatic study, western blot
                    (Serpe and O'Connor, 2006)
                    daw - tok
                    inferred by author, enzymatic study, western blot
                    (Serpe and O'Connor, 2006)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    daw
                    enhanceable
                    Actβ
                    (Zhu et al., 2008)
                    daw
                    suppressible
                    Atg8a
                    (Bai et al., 2013)
                    daw
                    enhanceable
                    babo
                    (Parker et al., 2006)
                    daw
                    enhanceable
                    put
                    (Parker et al., 2006)
                    daw
                    enhanceable
                    tok
                    (Serpe and O'Connor, 2006)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    babo
                    enhanceable
                    daw
                    (Parker et al., 2006)
                    ct
                    suppressible
                    daw
                    (Krupp et al., 2005)
                    Fs
                    suppressible
                    daw
                    (Pentek et al., 2009)
                    ph-p
                    enhanceable
                    daw
                    (Faucheux et al., 2001)
                    Smox
                    suppressible
                    daw
                    (Gesualdi and Haerry, 2007)
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Activin Signaling Pathway Core Components -
                    The activin signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of an activin family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Smox, a members of the Smad family. Smox forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
                    Metabolic Pathways
                    External Data
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2L
                    Recombination map

                    2-7

                    Cytogenetic map
                    23B1-23B2
                    Sequence location
                    2L:2,805,261..2,812,376 [+]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    23B1-23B2
                    Limits computationally determined from genome sequence between P{EP}EP832 and P{PZ}oho23B03575
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    23B-23B
                    (Parker et al., 2001)
                    Experimentally Determined Recombination Data
                    Location

                    2-7

                    (FlyBase, 2016)

                    2-6.5

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (10)
                    Genomic Clones (11)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (12)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: Alp23B CG16987

                    (Parker, 2001.3.12)

                    Source for identity of: daw Alp23B

                    (Parker et al., 2006, Serpe and O'Connor, 2006)
                    Source for database merge of
                    Additional comments

                    This gene has been renamed from "Activin Like Protein at 23B" (Alp23B) to "dawdle" (daw) to avoid confusion with "Abnormal leg pattern" (Alp) and to better reflect the mutant phenotype.

                    (Parker et al., 2006)
                    Other Comments
                    Origin and Etymology
                    Discoverer
                    Etymology

                    The name "dawdle" refers to the delayed nature of the innervation defects seen in mutants of this gene.

                    (Serpe and O'Connor, 2006)
                    Identification
                    External Crossreferences and Linkouts ( 55 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DPiM - Drosophila Protein interaction map
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (15)
                    Reported As
                    Symbol Synonym
                    ALP23B
                    (Parker et al., 2001)
                    Alp
                    (Pistillo and Desplan, 2007, Ellis et al., 2005, Parker and Arora, 2002)
                    Alp23B
                    (Japanese National Institute of Genetics, 2012.5.21, Murray et al., 2012, Fujikawa et al., 2009, Dudu, 2006, Parker et al., 2006, Serpe and O'Connor, 2006, Kim et al., 2005, Winkler et al., 2005)
                    Alp23b
                    (Shim et al., 2009, Parker et al., 2005)
                    CG16987
                    (Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Fujikawa et al., 2009, Keleman et al., 2009.8.5, Parker et al., 2006, Metaxakis et al., 2005, Faucheux et al., 2001)
                    DAW
                    (Gesualdi and Haerry, 2007)
                    Daw
                    (Nil et al., 2019, Langerak et al., 2018, Chng et al., 2017, Liu and Jin, 2017, Song et al., 2017, Upadhyay et al., 2017, Droujinine and Perrimon, 2016, Vlisidou and Wood, 2015, Bhadra et al., 2014, Ting et al., 2014, Fuentes-Medel et al., 2012, Peterson et al., 2012, Jensen et al., 2009)
                    cg16987
                    (Gesualdi and Haerry, 2007)
                    daw
                    (Tegeder et al., 2019, Wang et al., 2019, Xu et al., 2019, Hoyer et al., 2018, Levis, 2018.8.30, Song et al., 2018, Makhijani et al., 2017, Mattila and Hietakangas, 2017, Transgenic RNAi Project members, 2017-, Wells et al., 2017, Wani et al., 2016, Mattila et al., 2015, Ashwal-Fluss et al., 2014, Bai et al., 2013, Beckwith et al., 2013, Khan et al., 2013, Stefanatos et al., 2013, Clark et al., 2011, Bauer et al., 2010, Ellis et al., 2010, Pentek et al., 2009, Arora et al., 2008, Bickel et al., 2008, Zhu et al., 2008, Parker et al., 2006, Serpe and O'Connor, 2006)
                    Name Synonyms
                    Activin Like Protein at 23B
                    (Parker et al., 2006, Serpe and O'Connor, 2006, Parker et al., 2001)
                    Activin like protein
                    (Pistillo and Desplan, 2007)
                    Activin-Like Protein
                    (Parker and Arora, 2002)
                    Dawdle
                    (Havula and Hietakangas, 2018, Chng et al., 2017, Mattila and Hietakangas, 2017, Kwong et al., 2015, Ting et al., 2014, Ting et al., 2014, Fuentes-Medel et al., 2012, Peterson et al., 2012, Ellis et al., 2010, Jensen et al., 2009, Arora et al., 2008, Bickel et al., 2008, Zhu et al., 2008, Gesualdi and Haerry, 2007)
                    dActivin2
                    (Funakoshi et al., 2004)
                    dawdle
                    (Kuleesha et al., 2016, Mulakkal et al., 2014, Clark et al., 2011, Hartmann et al., 2009, Parker et al., 2006, Serpe and O'Connor, 2006)
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (116)