General Information Symbol Dmel\ CG8814Species D. melanogaster Name Annotation symbol CG8814 Feature type protein_coding_gene FlyBase ID FBgn0031478 Gene Model Status Current Stock availability 3 publicly
available Genomic Location Chromosome (arm) 2L Recombination map Cytogenetic map 23B8-23C1 Sequence location 2L:2,874,872..2,877,168 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information This gene is referred to in FlyBase by the symbol
Dmel\CG8814 (FBgn0031478). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : diazepam binding; enzyme inhibitor activity; fatty-acyl-CoA binding. Based on sequence similarity, it is predicted to be involved in the
biological process : cellular acyl-CoA homeostasis.
3 alleles are reported . No phenotypic data is available. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: Acyl-CoA-binding protein, ACBP; FERM/acyl-CoA-binding protein, 3-helical bundle. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval midgut, adult hindgut, adult heart, adult fat body, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1640698_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8814. Gene sequence location is
2L:2874872..2877168 .
User Contributed Data
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.45
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
1526.7
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
894.2
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
(692.1)
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
(1526.7)
Adult Midgut
420.3
Adult Hindgut
(667.7)
Adult Malpighian Tubules
327.9
Adult Fat Body
(894.2)
Adult Salivary Gland
239.2
Adult Heart
(642.4)
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
(575.5)
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
(1526.7)
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
894.2
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
1526.7
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
894.2
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
1526.7
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
894.2
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
(1526.7)
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
(894.2)
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
1526.7
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
894.2
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
154.875
Larval Midgut
692.1
Larval Hindgut
259.6
Larval Malpighian Tubules
269.4
Larval Fat Body
331.7
Larval Salivary Gland
271
Larval Trachea
269.025
Larval Carcass
289.825
Adult Head
297.2
Adult Eye
169.3
Adult Brain
345.6
Adult Thoracic-Abdominal Ganglion
409.6
Adult Crop
1526.7
Adult Midgut
420.3
Adult Hindgut
667.7
Adult Malpighian Tubules
327.9
Adult Fat Body
894.2
Adult Salivary Gland
239.2
Adult Heart
642.4
Adult VirginFemale Spermatheca
387.6
Adult InseminatedFemale Spermatheca
352.8
Adult Ovary
329
Adult Testis
35.4
Adult Male Accessory Gland
134.3
Adult Carcass
575.5
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
297.2
NA
Eye
169.3
NA
Brain
345.6
154.875
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
409.6
NA
Crop
1526.7
692.1
Midgut
420.3
259.6
Hindgut
667.7
269.4
Malpighian Tubules
327.9
331.7
Fat Body
894.2
271
Salivary Gland
239.2
NA
Heart
642.4
269.025
Trachea
NA
NA
VirginFemale Spermatheca
387.6
NA
InseminatedFemale Spermatheca
352.8
NA
Ovary
329
NA
Testis
35.4
NA
Male Accessory Gland
134.3
289.825
Carcass
575.5
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
33
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
37
digestive system, larvae L3 wandering
47
digestive system, 1-day adult
40
digestive system, 4-day adult
35
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
35
carcass, larvae L3 wandering
24
carcass, 1-day adult
36
carcass, 4-day adult
42
carcass, 20-day adult
43
ovary, virgin 4-day female
66
ovary, mated 4-day female
58
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
(33)
head, mated 4-day male
(27)
head, mated 20-day male
(27)
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
(37)
digestive system, larvae L3 wandering
(47)
digestive system, 1-day adult
(40)
digestive system, 4-day adult
(35)
digestive system, 20-day adult
(31)
fat body, larvae L3 wandering
(31)
fat body, white prepupae
18
fat body, pupae P8
(35)
carcass, larvae L3 wandering
24
carcass, 1-day adult
(36)
carcass, 4-day adult
(42)
carcass, 20-day adult
(43)
ovary, virgin 4-day female
(66)
ovary, mated 4-day female
(58)
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
33
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
37
digestive system, larvae L3 wandering
47
digestive system, 1-day adult
40
digestive system, 4-day adult
35
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
35
carcass, larvae L3 wandering
24
carcass, 1-day adult
36
carcass, 4-day adult
42
carcass, 20-day adult
43
ovary, virgin 4-day female
66
ovary, mated 4-day female
58
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
33
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
37
digestive system, larvae L3 wandering
47
digestive system, 1-day adult
40
digestive system, 4-day adult
35
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
35
carcass, larvae L3 wandering
24
carcass, 1-day adult
36
carcass, 4-day adult
42
carcass, 20-day adult
43
ovary, virgin 4-day female
66
ovary, mated 4-day female
58
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
33
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
37
digestive system, larvae L3 wandering
47
digestive system, 1-day adult
40
digestive system, 4-day adult
35
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
35
carcass, larvae L3 wandering
24
carcass, 1-day adult
36
carcass, 4-day adult
42
carcass, 20-day adult
43
ovary, virgin 4-day female
66
ovary, mated 4-day female
58
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
(33)
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
(37)
digestive system, larvae L3 wandering
(47)
digestive system, 1-day adult
(40)
digestive system, 4-day adult
(35)
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
(35)
carcass, larvae L3 wandering
24
carcass, 1-day adult
(36)
carcass, 4-day adult
(42)
carcass, 20-day adult
(43)
ovary, virgin 4-day female
(66)
ovary, mated 4-day female
(58)
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
33
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
37
digestive system, larvae L3 wandering
47
digestive system, 1-day adult
40
digestive system, 4-day adult
35
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
35
carcass, larvae L3 wandering
24
carcass, 1-day adult
36
carcass, 4-day adult
42
carcass, 20-day adult
43
ovary, virgin 4-day female
66
ovary, mated 4-day female
58
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
15
central nervous system, larvae L3
16
central nervous system, pupae P8
20
head, virgin 1-day female
26
head, virgin 4-day female
19
head, virgin 20-day female
18
head, mated 1-day female
21
head, mated 4-day female
20
head, mated 20-day female
18
head, mated 1-day male
33
head, mated 4-day male
27
head, mated 20-day male
27
salivary gland, larvae L3 wandering
15
salivary gland, white prepupae
37
digestive system, larvae L3 wandering
47
digestive system, 1-day adult
40
digestive system, 4-day adult
35
digestive system, 20-day adult
31
fat body, larvae L3 wandering
31
fat body, white prepupae
18
fat body, pupae P8
35
carcass, larvae L3 wandering
24
carcass, 1-day adult
36
carcass, 4-day adult
42
carcass, 20-day adult
43
ovary, virgin 4-day female
66
ovary, mated 4-day female
58
testis, mated 4-day male
9
accessory gland, mated 4-day male
14
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
61
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
37
embryo 16-18hr
39
embryo 18-20hr
33
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
36
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
35
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
49
adult male 01day
36
adult male 05day
43
adult male 30day
39
adult female 01day
43
adult female 05day
47
adult female 30day
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(61)
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
(37)
embryo 16-18hr
(39)
embryo 18-20hr
(33)
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
(36)
larva L3 puffstage 3-6
(31)
larva L3 puffstage 7-9
(27)
white prepupae new
26
white prepupae 12hr
(35)
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
(32)
pupae 4d postWPP
(49)
adult male 01day
(36)
adult male 05day
(43)
adult male 30day
(39)
adult female 01day
(43)
adult female 05day
(47)
adult female 30day
(51)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
61
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
37
embryo 16-18hr
39
embryo 18-20hr
33
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
36
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
35
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
49
adult male 01day
36
adult male 05day
43
adult male 30day
39
adult female 01day
43
adult female 05day
47
adult female 30day
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
61
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
37
embryo 16-18hr
39
embryo 18-20hr
33
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
36
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
35
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
49
adult male 01day
36
adult male 05day
43
adult male 30day
39
adult female 01day
43
adult female 05day
47
adult female 30day
51
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
61
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
37
embryo 16-18hr
39
embryo 18-20hr
33
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
36
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
35
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
49
adult male 01day
36
adult male 05day
43
adult male 30day
39
adult female 01day
43
adult female 05day
47
adult female 30day
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(61)
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
(37)
embryo 16-18hr
(39)
embryo 18-20hr
(33)
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
(36)
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
(35)
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
(49)
adult male 01day
(36)
adult male 05day
(43)
adult male 30day
(39)
adult female 01day
(43)
adult female 05day
(47)
adult female 30day
(51)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
61
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
37
embryo 16-18hr
39
embryo 18-20hr
33
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
36
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
35
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
49
adult male 01day
36
adult male 05day
43
adult male 30day
39
adult female 01day
43
adult female 05day
47
adult female 30day
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
61
embryo 02-04hr
19
embryo 04-06hr
18
embryo 06-08hr
18
embryo 08-10hr
17
embryo 10-12hr
23
embryo 12-14hr
20
embryo 14-16hr
37
embryo 16-18hr
39
embryo 18-20hr
33
embryo 20-22hr
22
embryo 22-24hr
20
larva L1
18
larva L2
22
larva L3 12hr old
20
larva L3 puffstage 1-2
36
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
27
white prepupae new
26
white prepupae 12hr
35
white prepupae 24hr
26
pupae 2d postWPP
25
pupae 3d postWPP
32
pupae 4d postWPP
49
adult male 01day
36
adult male 05day
43
adult male 30day
39
adult female 01day
43
adult female 05day
47
adult female 30day
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
25
Schneider line 2 Sg4
12
embryonic 1182-4H
23
embryonic GM2
15
embryonic Kc167
16
embryonic S1
26
embryonic S3
17
leg disc CME L1
19
wing disc CME-W2
7
wing disc ML-DmD8
11
wing disc ML-DmD9
15
wing disc ML-DmD16-c3
19
wing disc ML-DmD21
14
wing disc ML-DmD32
20
haltere disc ML-DmD17-c3
11
eye-antennal disc ML-DmD11
22
antennal disc ML-DmD20-c5
26
mixed discs ML-DmD4-c1
26
CNS ML-DmBG1-c1
19
CNS ML-DmBG2-c2
13
tumorous blood cells mbn2
16
ovary fGS/OSS
20
ovary OSC
16
ovary OSS
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
34
Cadmium 50 mM 6 hrs, larvae L3
40
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
36
Cadmium 100 mM 48 hrs, 4-day adult
42
Copper 0.5 mM 12 hrs, larvae L3
33
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
41
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
33
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
44
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
47
Paraquat 10 mM 48 hrs, 4-day adult
45
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
36
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(31)
cold shock, 4-day adult
21
heat shock, 4-day adult
(34)
Cadmium 50 mM 6 hrs, larvae L3
(40)
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
(36)
Cadmium 100 mM 48 hrs, 4-day adult
(42)
Copper 0.5 mM 12 hrs, larvae L3
(33)
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
(41)
Ethanol 5% 3 hrs, larvae L3
(32)
Ethanol 10% 3 hrs, larvae L3
(28)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(33)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(44)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(29)
Paraquat 5 mM 48 hrs, 4-day adult
(47)
Paraquat 10 mM 48 hrs, 4-day adult
(45)
Rotenone 2 μg 12 hrs, larvae L3
(32)
Rotenone 8 μg 12 hrs, larvae L3
(36)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
34
Cadmium 50 mM 6 hrs, larvae L3
40
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
36
Cadmium 100 mM 48 hrs, 4-day adult
42
Copper 0.5 mM 12 hrs, larvae L3
33
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
41
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
33
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
44
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
47
Paraquat 10 mM 48 hrs, 4-day adult
45
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
36
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
34
Cadmium 50 mM 6 hrs, larvae L3
40
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
36
Cadmium 100 mM 48 hrs, 4-day adult
42
Copper 0.5 mM 12 hrs, larvae L3
33
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
41
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
33
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
44
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
47
Paraquat 10 mM 48 hrs, 4-day adult
45
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
36
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
34
Cadmium 50 mM 6 hrs, larvae L3
40
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
36
Cadmium 100 mM 48 hrs, 4-day adult
42
Copper 0.5 mM 12 hrs, larvae L3
33
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
41
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
33
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
44
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
47
Paraquat 10 mM 48 hrs, 4-day adult
45
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
36
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
(34)
Cadmium 50 mM 6 hrs, larvae L3
(40)
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
(36)
Cadmium 100 mM 48 hrs, 4-day adult
(42)
Copper 0.5 mM 12 hrs, larvae L3
(33)
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
(41)
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(33)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(44)
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
(47)
Paraquat 10 mM 48 hrs, 4-day adult
(45)
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
(36)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
34
Cadmium 50 mM 6 hrs, larvae L3
40
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
36
Cadmium 100 mM 48 hrs, 4-day adult
42
Copper 0.5 mM 12 hrs, larvae L3
33
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
41
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
33
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
44
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
47
Paraquat 10 mM 48 hrs, 4-day adult
45
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
36
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
31
cold shock, 4-day adult
21
heat shock, 4-day adult
34
Cadmium 50 mM 6 hrs, larvae L3
40
Cadmium 50 mM 12 hrs, larvae L3
26
Cadmium 50 mM 48 hrs, 4-day adult
36
Cadmium 100 mM 48 hrs, 4-day adult
42
Copper 0.5 mM 12 hrs, larvae L3
33
Copper 15 mM 48 hrs, 4-day adult
22
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
23
Ethanol 2.5% 3 hrs, larvae L3
41
Ethanol 5% 3 hrs, larvae L3
32
Ethanol 10% 3 hrs, larvae L3
28
Caffeine 1.5 mg/ml 4 hrs, larvae L3
33
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
44
Caffeine 25 mg/ml 48 hrs, 4-day adult
29
Paraquat 5 mM 48 hrs, 4-day adult
47
Paraquat 10 mM 48 hrs, 4-day adult
45
Rotenone 2 μg 12 hrs, larvae L3
32
Rotenone 8 μg 12 hrs, larvae L3
36
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 1 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 2 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Transgenic Constructs & Insertions
Transgenic Constructs Insertions insertion of mobile activating element
insertion of enhancer trap
Gene Ontology: Function, Process
& Cellular Component ( 4 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 4 terms ) Molecular Function Biological Process Cellular Component ( 0 terms) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (32)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6Z637N )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6V43HF )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6GQP26 )
Apis mellifera
Western honey bee
Amel\GB54208
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH15738
Atta cephalotes
Leafcutter ant
Acep\ACEP22406
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO15528
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL17737
Linepithema humile
Argentine ant
Lhum\LH22851
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB19030
Solenopsis invicta
Red fire ant
Sinv\SINV15640
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG64B8JF )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6JB0ST )
Caenorhabditis elegans
Nematode
Caenorhabditis elegans
Nematode
Human Orthologs (0)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 3 )Bloomington VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 220 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 1 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 16 )Supplementary material Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097] Personal communication to FlyBase Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping projectDPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members, 2001-, (Computer file)(Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file)Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] FlyBase analysis FlyBase, 1992-, FlyBase curation.FlyBase curation. [FBrf0105495] Stock list Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.RNAi stocks available from NIG-FLY. [FBrf0218457] Website Fisher et al., 2012, BDGP insitu homepageBDGP insitu homepage [FBrf0219073] Curated genome annotation FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.][Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705] Milshina, 1999.11, [Annotations performed at the Celera Jamboreee.][Annotations performed at the Celera Jamboreee.] [FBrf0126686]