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Gene Dmel\CG8837

General Information
Symbol	Dmel\CG8837	Species	D. melanogaster
Name		Annotation symbol	CG8837
Feature type	protein_coding_gene	FlyBase ID	FBgn0031520
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	23E3-23E4	Sequence location	2L:3,320,255..3,323,141 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8837 (FBgn0031520). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: transmembrane transporter activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: General substrate transporter; Major facilitator superfamily domain; Major facilitator superfamily domain, general substrate transporter; Sugar transporter, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1626081_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8837. Gene sequence location is 2L:3320255..3323141.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA00711 BKN26661
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 23E3-23E4   Limits computationally determined from genome sequence between P{lacW}Madk00237 and P{lacW}Pdswk10101
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8837 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8837-RA FBtr0077583  NM_134920   1825   485
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8837-PA   FBpp0077271   52.9   485   8.66     NP_608764   AAF51126
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Sugar transporter, conserved site (IPR005829) Major facilitator superfamily domain, general substrate transporter (IPR016196) General substrate transporter (IPR005828) Major facilitator superfamily domain (IPR020846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51126   BE977339   BT024293   EL882803   EL883066
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQN9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031520    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031520 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031520 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr  (129) embryo 16-18hr  (206) embryo 18-20hr  (447) embryo 20-22hr  (1280) embryo 22-24hr  (1092) larva L1  (789) larva L2  (773) larva L3 12hr old  (552) larva L3 puffstage 1-2  (177) larva L3 puffstage 3-6    95 larva L3 puffstage 7-9  102 white prepupae new    67 white prepupae 12hr  (219) white prepupae 24hr  (270) pupae 2d postWPP  (191) pupae 3d postWPP  (224) pupae 4d postWPP  (410) adult male 01day  (442) adult male 05day  (562) adult male 30day  (688) adult female 01day  (281) adult female 05day  (140) adult female 30day  (354) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031520 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr  129 embryo 16-18hr  (206) embryo 18-20hr  (447) embryo 20-22hr  (1280) embryo 22-24hr  (1092) larva L1  (789) larva L2  (773) larva L3 12hr old  (552) larva L3 puffstage 1-2  (177) larva L3 puffstage 3-6    95 larva L3 puffstage 7-9  102 white prepupae new    67 white prepupae 12hr  (219) white prepupae 24hr  (270) pupae 2d postWPP  (191) pupae 3d postWPP  (224) pupae 4d postWPP  (410) adult male 01day  (442) adult male 05day  (562) adult male 30day  (688) adult female 01day  (281) adult female 05day  140 adult female 30day  (354) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    8 embryo 10-12hr    62 embryo 12-14hr    55 embryo 14-16hr    129 embryo 16-18hr    206 embryo 18-20hr    447 embryo 20-22hr    1280 embryo 22-24hr    1092 larva L1    789 larva L2    773 larva L3 12hr old    552 larva L3 puffstage 1-2    177 larva L3 puffstage 3-6    95 larva L3 puffstage 7-9    102 white prepupae new    67 white prepupae 12hr    219 white prepupae 24hr    270 pupae 2d postWPP    191 pupae 3d postWPP    224 pupae 4d postWPP    410 adult male 01day    442 adult male 05day    562 adult male 30day    688 adult female 01day    281 adult female 05day    140 adult female 30day    354 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031520    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031520 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031520 expression level Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules    1088.9 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules  (1088.9) Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules  (1088.9) Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules    1088.9 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031520 expression level Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules    1088.9 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules  (1088.9) Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules  1088.9 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    32.625 Larval Midgut    2.6 Larval Hindgut no informative data Larval Malpighian Tubules    214.9 Larval Fat Body    7.2 Larval Salivary Gland    1.9 Larval Trachea    2.65 Larval Carcass    5.5 Adult Head    53.7 Adult Eye    41.775 Adult Brain    104.8 Adult Thoracic-Abdominal Ganglion    125.1 Adult Crop    2.7 Adult Midgut    1.8 Adult Hindgut    6.1 Adult Malpighian Tubules    1088.9 Adult Fat Body    8.6 Adult Salivary Gland no informative data Adult Heart    7.625 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    5.6 Adult Ovary    1.5 Adult Testis    36.7 Adult Male Accessory Gland    9.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    53.7   NA  Eye    41.775   NA  Brain    104.8   32.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    125.1   NA  Crop    2.7   2.6  Midgut    1.8   no informative data  Hindgut    6.1   214.9  Malpighian Tubules    1088.9   7.2  Fat Body    8.6   1.9  Salivary Gland    no informative data   NA  Heart    7.625   2.65  Trachea    NA   NA  VirginFemale Spermatheca    5.1   NA  InseminatedFemale Spermatheca    5.6   NA  Ovary    1.5   NA  Testis    36.7   NA  Male Accessory Gland    9.6   5.5  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031520 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8837-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG8837GD862 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG8837 Class Mutagen Stocks Known lesion CG8837EY02592 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8837 Class Mutagen Stocks Known lesion CG8837GD862 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG8837KK106661 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel8008 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD862} NA P{KK106661} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG8837EY02592 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transmembrane transporter activity inferred from electronic annotation with InterPro:IPR005828 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR005828, InterPro:IPR005829 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR005828 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8837 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031520 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33545
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14175 Dere\GG24930 Dgri\GH11265 Dmoj\GI16718 Dper\GL18603 Dpse\GA21358 Dsec\GM18406 Dsim\GD23219 Dvir\GJ17183 Dwil\GK18456 Dyak\GE18222
Curated drosophilid orthologs	Dpse\GA21358
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235651 FBgn0220454 FBgn0204360 FBgn0194608 FBgn0173313 FBgn0081346 FBgn0156204 FBgn0139466 FBgn0118745 FBgn0117059 FBgn0091202
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	15574 y1 w67c23; P{EPgy2}CG8837EY02592
VDRC	v100670 P{KK106661}VIE-260B v44217 w1118; P{GD862}v44217 v44218 w1118; P{GD862}v44218
Genomic Clones ( 1 )
	BACR15P13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP12678
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	bs62e11 IP12478 IP12778
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031520 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33545
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134920 RefSeq (Proteins) • NP_608764 DDBJ / EMBL / GenBank • AAF51126 Entrez Gene - A searchable database of RefSeq genes. • 33545 UniProtKB/TrEMBL • Q9VQN9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Sugar transporter, conserved site (IPR005829) Major facilitator superfamily domain, general substrate transporter (IPR016196) General substrate transporter (IPR005828) Major facilitator superfamily domain (IPR020846)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031520 DRSC - Results from RNAi screens. • FBgn0031520 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031520 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8837-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031520 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33545 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33545 modMine - Data generated by the modENCODE project. • FBgn0031520 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235651 FBgn0220454 FBgn0204360 FBgn0194608 FBgn0173313 FBgn0081346 FBgn0156204 FBgn0139466 FBgn0118745 FBgn0117059 FBgn0091202
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG8837 (Wang et al., 2004, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 12 )
Research paper	Wang et al., 2004, GenomeBiol. 5(9): R69 Function-informed transcriptome analysis of Drosophila renal tubule. [FBrf0180324]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]