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Gene Dmel\Spindly

General Information
Symbol	Dmel\Spindly	Species	D. melanogaster
Name	Spindly	Annotation symbol	CG15415
Feature type	protein_coding_gene	FlyBase ID	FBgn0031549
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24A1-24A1	Sequence location	2L:3,527,387..3,530,317 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Spindly is referred to in FlyBase by the symbol Dmel\Spindly (CG15415, FBgn0031549). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein phosphatase 1 binding. There is experimental evidence that it is involved in the biological process: regulation of mitotic metaphase/anaphase transition. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Spectrin repeat. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623179_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Spindly. Gene sequence location is 2L:3527387..3530317.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Bennett et al., 2006, J. molec. Biol. 364(2): 196--212 Controlled Vocabulary Terms protein phosphatase 1 binding Sequence features BKN26214 HFA00430
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24A1-24A1   Limits computationally determined from genome sequence between P{EP}ThorEP818&P{lacW}Thork07736 and P{PZ}oddrF111&P{PZ}for06860
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Spindly for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Spindly-RB FBtr0301590  NM_134947   2543   781
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Spindly-PB   FBpp0290805   88.6   781   6.13     NP_608791   AAF51090
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spectrin repeat (IPR002017)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51090   BP540233   BP540234   BT022829   CO307479   CO319030   CO319551   EC066990   EC089886   EC249455   EL883544   EL883749   EL883750   EL883864   EL883865
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQS4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031549    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031549 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031549 expression level Developmental Stage   Expression Level embryo 00-02hr    1658 embryo 02-04hr    843 embryo 04-06hr    2656 embryo 06-08hr    2431 embryo 08-10hr    1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1658) embryo 02-04hr  (843) embryo 04-06hr  (2656) embryo 06-08hr  (2431) embryo 08-10hr  (1502) embryo 10-12hr  (473) embryo 12-14hr  (358) embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2  (298) larva L3 puffstage 3-6  (438) larva L3 puffstage 7-9  (548) white prepupae new  (566) white prepupae 12hr  (787) white prepupae 24hr  (673) pupae 2d postWPP  (253) pupae 3d postWPP  (135) pupae 4d postWPP    92 adult male 01day  (205) adult male 05day  (256) adult male 30day  (187) adult female 01day  (268) adult female 05day  (971) adult female 30day  (1067) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1658) embryo 02-04hr    843 embryo 04-06hr  (2656) embryo 06-08hr  (2431) embryo 08-10hr  1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1658 embryo 02-04hr    843 embryo 04-06hr    2656 embryo 06-08hr    2431 embryo 08-10hr    1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1658 embryo 02-04hr    843 embryo 04-06hr    2656 embryo 06-08hr    2431 embryo 08-10hr    1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031549 expression level Developmental Stage   Expression Level embryo 00-02hr    1658 embryo 02-04hr    843 embryo 04-06hr    2656 embryo 06-08hr    2431 embryo 08-10hr    1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1658) embryo 02-04hr  (843) embryo 04-06hr  (2656) embryo 06-08hr  (2431) embryo 08-10hr  (1502) embryo 10-12hr  (473) embryo 12-14hr  (358) embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2  (298) larva L3 puffstage 3-6  (438) larva L3 puffstage 7-9  (548) white prepupae new  (566) white prepupae 12hr  (787) white prepupae 24hr  (673) pupae 2d postWPP  (253) pupae 3d postWPP  135 pupae 4d postWPP    92 adult male 01day  (205) adult male 05day  (256) adult male 30day  (187) adult female 01day  (268) adult female 05day  (971) adult female 30day  (1067) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1658 embryo 02-04hr    843 embryo 04-06hr  (2656) embryo 06-08hr  2431 embryo 08-10hr  1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1658 embryo 02-04hr    843 embryo 04-06hr    2656 embryo 06-08hr    2431 embryo 08-10hr    1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1658 embryo 02-04hr    843 embryo 04-06hr    2656 embryo 06-08hr    2431 embryo 08-10hr    1502 embryo 10-12hr    473 embryo 12-14hr    358 embryo 14-16hr    88 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    25 embryo 22-24hr    48 larva L1    31 larva L2    65 larva L3 12hr old    90 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    438 larva L3 puffstage 7-9    548 white prepupae new    566 white prepupae 12hr    787 white prepupae 24hr    673 pupae 2d postWPP    253 pupae 3d postWPP    135 pupae 4d postWPP    92 adult male 01day    205 adult male 05day    256 adult male 30day    187 adult female 01day    268 adult female 05day    971 adult female 30day    1067 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031549    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031549 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031549 expression level Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031549 expression level Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    77.825 Larval Midgut    2.5 Larval Hindgut    9.2 Larval Malpighian Tubules    8.7 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    23.3 Larval Carcass no informative data Adult Head    7.5 Adult Eye    4.025 Adult Brain    9.7 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut    5.9 Adult Hindgut    9.4 Adult Malpighian Tubules    7.2 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca    6.7 Adult InseminatedFemale Spermatheca    7 Adult Ovary    75.5 Adult Testis    26.9 Adult Male Accessory Gland    7.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    7.5   NA  Eye    4.025   NA  Brain    9.7   77.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   2.5  Midgut    5.9   9.2  Hindgut    9.4   8.7  Malpighian Tubules    7.2   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   23.3  Trachea    NA   NA  VirginFemale Spermatheca    6.7   NA  InseminatedFemale Spermatheca    7   NA  Ovary    75.5   NA  Testis    26.9   NA  Male Accessory Gland    7.8   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031549 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15415-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Spindly Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Spindly Class Mutagen Stocks Known lesion SpindlyHMS01283 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SpindlyKK106214 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SpindlyGD9011 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes SpindlyMtnA.C.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes SpindlyMtnA.N.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7017 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9011} NA P{KK106214} NA P{TRiP.HMS01283} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
protein phosphatase 1 binding inferred from physical interaction with flw (Bennett et al., 2006) inferred from physical interaction with Pp1-13C (Bennett et al., 2006) inferred from physical interaction with Pp1-87B (Bennett et al., 2006) inferred from physical interaction with Pp1α-96A (Bennett et al., 2006)
Biological Process
CV term Evidence References
regulation of mitotic metaphase/anaphase transition inferred from mutant phenotype (Griffis et al., 2007)
Cellular Component
CV term Evidence References
kinetochore inferred from direct assay (Griffis et al., 2007) microtubule inferred from direct assay (Griffis et al., 2007)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Spindly allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59788 DroID - A comprehensive database of gene and protein interactions. • FBgn0031549 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33578
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14665 Dere\GG24428 Dgri\GH13193 Dmoj\GI17772 Dper\GL19471 Dpse\GA13712 Dsec\GM18139 Dsim\GD22747 Dvir\GJ17596 Dwil\GK14670 Dyak\GE14842
Curated drosophilid orthologs	Dpse\GA13712
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12848 LH21472 FBgn0232434 FBgn0216676 FBgn0204766 FBgn0194143 FBgn0173046 JGI_V11_227314 FBgn0073748 FBgn0157070 FBgn0140513 FBgn0120670 FBgn0116560 FBgn0091692 CPIJ003891 BGIBMGA010912 ACYPI001034 GB12889 AGAP013500 AAEL002921 GLEAN_14593 GLEAN_14594
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	34933 y1 sc* v1; P{TRiP.HMS01283}attP2
VDRC	v107432 P{KK106214}VIE-260B
Genomic Clones ( 1 )
	BACR03G07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP13307
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EK254645 EK276030 EK279024 FGA001C09 IP13207 IP13407 IP13507
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031549 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33578
Antibody Information
Other Information
Discoverer
Etymology
	Named "Spindly" due to the spindle-shaped interphase cell morphology and metaphase spindle phenotypes observed when this gene product is depleted. (Griffis et al., 2007)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Spindly CG15415 (Griffis et al., 2007)
Source for database merge of
Additional comments
Other Comments
	The Spindly product recruits dynein to kinetochores. (Griffis et al., 2007) dsRNA has been synthesised for this gene and transfected into S2 cells. Spindly dsRNA causes interphase S2 cells to adopt an abnormal morphology with spiky and elongated microtubule-rich projections. The majority of dsRNA-treated cells become arrested in metaphase, an effect which can be rescued with a Spindly transgene. Spindly-depleted cells require 50% more time to form a metaphase plate compared with untreated cells. (Griffis et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134947 RefSeq (Proteins) • NP_608791 DDBJ / EMBL / GenBank • AAF51090 Entrez Gene - A searchable database of RefSeq genes. • 33578 UniProtKB/TrEMBL • Q9VQS4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spectrin repeat (IPR002017)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59788 DroID - A comprehensive database of gene and protein interactions. • FBgn0031549 DRSC - Results from RNAi screens. • FBgn0031549 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031549 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15415-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031549 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33578 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/spindly.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33578 modMine - Data generated by the modENCODE project. • FBgn0031549 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12848 LH21472 FBgn0232434 FBgn0216676 FBgn0204766 FBgn0194143 FBgn0173046 JGI_V11_227314 FBgn0073748 FBgn0157070 FBgn0140513 FBgn0120670 FBgn0116560 FBgn0091692 CPIJ003891 BGIBMGA010912 ACYPI001034 GB12889 AGAP013500 AAEL002921 GLEAN_14593 GLEAN_14594
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG15415 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Bennett et al., 2006) Spindly (Griffis et al., 2007)
Name Synonym	CG15415   Spindly (Griffis et al., 2007)
Secondary FlyBase IDs
References ( 11 )
Research paper	Griffis et al., 2007, J. Cell Biol. 177(6): 1005--1015 Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore. [FBrf0200141] Bennett et al., 2006, J. molec. Biol. 364(2): 196--212 Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. [FBrf0194330]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Boutros et al., 2004, Science 303(5659): Supporting Online Material: Figures S1 to S8; Tables S1 to S6. [FBrf0174218] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]