Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spindly using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Spindly in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Spindly CG15415
dsRNA has been synthesised for this gene and transfected into S2 cells. Spindly dsRNA causes interphase S2 cells to adopt an abnormal morphology with spiky and elongated microtubule-rich projections. The majority of dsRNA-treated cells become arrested in metaphase, an effect which can be rescued with a Spindly transgene. Spindly-depleted cells require 50% more time to form a metaphase plate compared with untreated cells.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Named "Spindly" due to the spindle-shaped interphase cell morphology and metaphase spindle phenotypes observed when this gene product is depleted.