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Gene Dmel\CG16712

General Information
Symbol	Dmel\CG16712	Species	D. melanogaster
Name		Annotation symbol	CG16712
Feature type	protein_coding_gene	FlyBase ID	FBgn0031561
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24B3-24B3	Sequence location	2L:3,696,240..3,696,658 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG16712 (FBgn0031561). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase inhibitor activity. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Proteinase inhibitor I2, Kunitz metazoa; Proteinase inhibitor I2, Kunitz, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very low expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult midgut, larval salivary gland, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628474_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG16712. Gene sequence location is 2L:3696240..3696658.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24B3-24B3   Limits computationally determined from genome sequence between P{PZ}oddrF111&P{PZ}for06860 and P{EP}EP2595EP2595
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG16712 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG16712-RA FBtr0077546  NM_134956   359   82
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG16712-PA   FBpp0077235   8.8   82   5.75     NP_608800   AAF51076
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteinase inhibitor I2, Kunitz metazoa (IPR002223) Proteinase inhibitor I2, Kunitz, conserved site (IPR020901)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51076   AI113357   AI404645   AY070668 AAL48139   AY070702 AAL48173   BG632146   BG632299   BI566919   BI567458   BI570574   BI570609   BI570644   BI572274   BI572544   BI573161   BI575434   BI575622   BI586785   BI588640   BI590913   BI591665   BI607092   BI608003   BI611257   BI614217   BI617471   BI617531   BI617736   BI621503   BI622889   BI624518   BI627480   BI630955   BI634172   BI634274   CA803890   CO320606   CO322946   EC074594   EC221347   EV578608   EV587121   EV587604   EV587749   EV590718   EV591280   EV591804   EV591932   EV592026   EV596550   GH942248   GH942883   GH944270   GH948627   GH949271   GH950342   GH950889   GH951021   GH951252   GH954024   GH954830   GH954907   GH955232   GH957218   GH959735   GH960120   GH960491   GH968279   GH968838   GH969090   GH973497   GH976889   GH978057   GH981887   GH983229   GH984605
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VQT8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult crop, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult midgut, larval salivary gland, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut    3917.7 Larval Malpighian Tubules    11 Larval Fat Body    2377.4 Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head    4562.8 Adult Eye    3821.425 Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop    3343.2 Adult Midgut    102.3 Adult Hindgut    5801.9 Adult Malpighian Tubules    1074 Adult Fat Body    5308.2 Adult Salivary Gland    590 Adult Heart    5297.9 Adult VirginFemale Spermatheca    5518.5 Adult InseminatedFemale Spermatheca    5699.3 Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass    5626.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut  (3917.7) Larval Malpighian Tubules    11 Larval Fat Body  (2377.4) Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head  (4562.8) Adult Eye  (3821.425) Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop  (3343.2) Adult Midgut    102.3 Adult Hindgut  (5801.9) Adult Malpighian Tubules  (1074) Adult Fat Body  (5308.2) Adult Salivary Gland  (590) Adult Heart  (5297.9) Adult VirginFemale Spermatheca  (5518.5) Adult InseminatedFemale Spermatheca  (5699.3) Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass  (5626.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut  (3917.7) Larval Malpighian Tubules    11 Larval Fat Body  (2377.4) Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head  (4562.8) Adult Eye  (3821.425) Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop  (3343.2) Adult Midgut    102.3 Adult Hindgut  (5801.9) Adult Malpighian Tubules  1074 Adult Fat Body  (5308.2) Adult Salivary Gland    590 Adult Heart  (5297.9) Adult VirginFemale Spermatheca  (5518.5) Adult InseminatedFemale Spermatheca  (5699.3) Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass  (5626.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut    3917.7 Larval Malpighian Tubules    11 Larval Fat Body    2377.4 Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head    4562.8 Adult Eye    3821.425 Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop    3343.2 Adult Midgut    102.3 Adult Hindgut    5801.9 Adult Malpighian Tubules    1074 Adult Fat Body    5308.2 Adult Salivary Gland    590 Adult Heart    5297.9 Adult VirginFemale Spermatheca    5518.5 Adult InseminatedFemale Spermatheca    5699.3 Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass    5626.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut    3917.7 Larval Malpighian Tubules    11 Larval Fat Body    2377.4 Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head    4562.8 Adult Eye    3821.425 Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop    3343.2 Adult Midgut    102.3 Adult Hindgut    5801.9 Adult Malpighian Tubules    1074 Adult Fat Body    5308.2 Adult Salivary Gland    590 Adult Heart    5297.9 Adult VirginFemale Spermatheca    5518.5 Adult InseminatedFemale Spermatheca    5699.3 Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass    5626.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut  (3917.7) Larval Malpighian Tubules    11 Larval Fat Body  (2377.4) Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head  (4562.8) Adult Eye  (3821.425) Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop  (3343.2) Adult Midgut    102.3 Adult Hindgut  (5801.9) Adult Malpighian Tubules  (1074) Adult Fat Body  (5308.2) Adult Salivary Gland  590 Adult Heart  (5297.9) Adult VirginFemale Spermatheca  (5518.5) Adult InseminatedFemale Spermatheca  (5699.3) Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass  (5626.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut  (3917.7) Larval Malpighian Tubules    11 Larval Fat Body  (2377.4) Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head  (4562.8) Adult Eye  (3821.425) Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop  (3343.2) Adult Midgut    102.3 Adult Hindgut  (5801.9) Adult Malpighian Tubules  1074 Adult Fat Body  (5308.2) Adult Salivary Gland    590 Adult Heart  (5297.9) Adult VirginFemale Spermatheca  (5518.5) Adult InseminatedFemale Spermatheca  (5699.3) Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass  (5626.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    11.75 Larval Midgut    25 Larval Hindgut    3917.7 Larval Malpighian Tubules    11 Larval Fat Body    2377.4 Larval Salivary Gland    395.7 Larval Trachea    422.95 Larval Carcass    192 Adult Head    4562.8 Adult Eye    3821.425 Adult Brain    253.5 Adult Thoracic-Abdominal Ganglion    306.4 Adult Crop    3343.2 Adult Midgut    102.3 Adult Hindgut    5801.9 Adult Malpighian Tubules    1074 Adult Fat Body    5308.2 Adult Salivary Gland    590 Adult Heart    5297.9 Adult VirginFemale Spermatheca    5518.5 Adult InseminatedFemale Spermatheca    5699.3 Adult Ovary    4.7 Adult Testis    24.9 Adult Male Accessory Gland    153.8 Adult Carcass    5626.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4562.8   NA  Eye    3821.425   NA  Brain    253.5   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    306.4   NA  Crop    3343.2   no informative data  Midgut    102.3   3917.7  Hindgut    5801.9   no informative data  Malpighian Tubules    1074   2377.4  Fat Body    5308.2   395.7  Salivary Gland    590   NA  Heart    5297.9   422.95  Trachea    NA   NA  VirginFemale Spermatheca    5518.5   NA  InseminatedFemale Spermatheca    5699.3   NA  Ovary    4.7   NA  Testis    24.9   NA  Male Accessory Gland    153.8   192  Carcass    5626.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    380 head, virgin 4-day female    524 head, virgin 20-day female    1461 head, mated 1-day female    605 head, mated 4-day female    890 head, mated 20-day female    1321 head, mated 1-day male    370 head, mated 4-day male    1020 head, mated 20-day male    1329 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    576 digestive system, 4-day adult    452 digestive system, 20-day adult    377 fat body, larvae L3 wandering    868 fat body, white prepupae    17 fat body, pupae P8    201 carcass, larvae L3 wandering    18 carcass, 1-day adult    865 carcass, 4-day adult    917 carcass, 20-day adult    1238 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    57 accessory gland, mated 4-day male    370 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female  (380) head, virgin 4-day female  (524) head, virgin 20-day female  (1461) head, mated 1-day female  (605) head, mated 4-day female  (890) head, mated 20-day female  (1321) head, mated 1-day male  (370) head, mated 4-day male  (1020) head, mated 20-day male  (1329) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (576) digestive system, 4-day adult  (452) digestive system, 20-day adult  (377) fat body, larvae L3 wandering  (868) fat body, white prepupae    17 fat body, pupae P8  (201) carcass, larvae L3 wandering    18 carcass, 1-day adult  (865) carcass, 4-day adult  (917) carcass, 20-day adult  (1238) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male  (57) accessory gland, mated 4-day male  (370) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female  (380) head, virgin 4-day female  (524) head, virgin 20-day female  (1461) head, mated 1-day female  (605) head, mated 4-day female  (890) head, mated 20-day female  (1321) head, mated 1-day male  (370) head, mated 4-day male  (1020) head, mated 20-day male  (1329) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (576) digestive system, 4-day adult  (452) digestive system, 20-day adult  (377) fat body, larvae L3 wandering  (868) fat body, white prepupae    17 fat body, pupae P8  (201) carcass, larvae L3 wandering    18 carcass, 1-day adult  (865) carcass, 4-day adult  (917) carcass, 20-day adult  (1238) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    57 accessory gland, mated 4-day male  (370) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    380 head, virgin 4-day female    524 head, virgin 20-day female    1461 head, mated 1-day female    605 head, mated 4-day female    890 head, mated 20-day female    1321 head, mated 1-day male    370 head, mated 4-day male    1020 head, mated 20-day male    1329 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    576 digestive system, 4-day adult    452 digestive system, 20-day adult    377 fat body, larvae L3 wandering    868 fat body, white prepupae    17 fat body, pupae P8    201 carcass, larvae L3 wandering    18 carcass, 1-day adult    865 carcass, 4-day adult    917 carcass, 20-day adult    1238 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    57 accessory gland, mated 4-day male    370 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    380 head, virgin 4-day female    524 head, virgin 20-day female    1461 head, mated 1-day female    605 head, mated 4-day female    890 head, mated 20-day female    1321 head, mated 1-day male    370 head, mated 4-day male    1020 head, mated 20-day male    1329 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    576 digestive system, 4-day adult    452 digestive system, 20-day adult    377 fat body, larvae L3 wandering    868 fat body, white prepupae    17 fat body, pupae P8    201 carcass, larvae L3 wandering    18 carcass, 1-day adult    865 carcass, 4-day adult    917 carcass, 20-day adult    1238 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    57 accessory gland, mated 4-day male    370 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female  (380) head, virgin 4-day female  (524) head, virgin 20-day female  (1461) head, mated 1-day female  (605) head, mated 4-day female  (890) head, mated 20-day female  (1321) head, mated 1-day male  (370) head, mated 4-day male  (1020) head, mated 20-day male  (1329) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (576) digestive system, 4-day adult  (452) digestive system, 20-day adult  (377) fat body, larvae L3 wandering  (868) fat body, white prepupae    17 fat body, pupae P8  (201) carcass, larvae L3 wandering    18 carcass, 1-day adult  (865) carcass, 4-day adult  (917) carcass, 20-day adult  (1238) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male  (57) accessory gland, mated 4-day male  (370) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female  (380) head, virgin 4-day female  (524) head, virgin 20-day female  (1461) head, mated 1-day female  (605) head, mated 4-day female  (890) head, mated 20-day female  (1321) head, mated 1-day male  (370) head, mated 4-day male  (1020) head, mated 20-day male  (1329) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult  (576) digestive system, 4-day adult  (452) digestive system, 20-day adult  (377) fat body, larvae L3 wandering  (868) fat body, white prepupae    17 fat body, pupae P8  (201) carcass, larvae L3 wandering    18 carcass, 1-day adult  (865) carcass, 4-day adult  (917) carcass, 20-day adult  (1238) ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    57 accessory gland, mated 4-day male  (370) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    17 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    380 head, virgin 4-day female    524 head, virgin 20-day female    1461 head, mated 1-day female    605 head, mated 4-day female    890 head, mated 20-day female    1321 head, mated 1-day male    370 head, mated 4-day male    1020 head, mated 20-day male    1329 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    576 digestive system, 4-day adult    452 digestive system, 20-day adult    377 fat body, larvae L3 wandering    868 fat body, white prepupae    17 fat body, pupae P8    201 carcass, larvae L3 wandering    18 carcass, 1-day adult    865 carcass, 4-day adult    917 carcass, 20-day adult    1238 ovary, virgin 4-day female    3 ovary, mated 4-day female    1 testis, mated 4-day male    57 accessory gland, mated 4-day male    370 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very low expression. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr    87 embryo 18-20hr    491 embryo 20-22hr    1213 embryo 22-24hr    1287 larva L1    586 larva L2    544 larva L3 12hr old    1661 larva L3 puffstage 1-2    381 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr    164 white prepupae 24hr    41 pupae 2d postWPP    48 pupae 3d postWPP    18 pupae 4d postWPP    664 adult male 01day    445 adult male 05day    452 adult male 30day    373 adult female 01day    273 adult female 05day    368 adult female 30day    533 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr  (87) embryo 18-20hr  (491) embryo 20-22hr  (1213) embryo 22-24hr  (1287) larva L1  (586) larva L2  (544) larva L3 12hr old  (1661) larva L3 puffstage 1-2  (381) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr  (164) white prepupae 24hr  (41) pupae 2d postWPP  (48) pupae 3d postWPP    18 pupae 4d postWPP  (664) adult male 01day  (445) adult male 05day  (452) adult male 30day  (373) adult female 01day  (273) adult female 05day  (368) adult female 30day  (533) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr    87 embryo 18-20hr  (491) embryo 20-22hr  (1213) embryo 22-24hr  (1287) larva L1  (586) larva L2  (544) larva L3 12hr old  (1661) larva L3 puffstage 1-2  (381) larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr  (164) white prepupae 24hr    41 pupae 2d postWPP    48 pupae 3d postWPP    18 pupae 4d postWPP  (664) adult male 01day  (445) adult male 05day  (452) adult male 30day  (373) adult female 01day  (273) adult female 05day  (368) adult female 30day  (533) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr    87 embryo 18-20hr    491 embryo 20-22hr    1213 embryo 22-24hr    1287 larva L1    586 larva L2    544 larva L3 12hr old    1661 larva L3 puffstage 1-2    381 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr    164 white prepupae 24hr    41 pupae 2d postWPP    48 pupae 3d postWPP    18 pupae 4d postWPP    664 adult male 01day    445 adult male 05day    452 adult male 30day    373 adult female 01day    273 adult female 05day    368 adult female 30day    533 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr    87 embryo 18-20hr    491 embryo 20-22hr    1213 embryo 22-24hr    1287 larva L1    586 larva L2    544 larva L3 12hr old    1661 larva L3 puffstage 1-2    381 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr    164 white prepupae 24hr    41 pupae 2d postWPP    48 pupae 3d postWPP    18 pupae 4d postWPP    664 adult male 01day    445 adult male 05day    452 adult male 30day    373 adult female 01day    273 adult female 05day    368 adult female 30day    533 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr  (87) embryo 18-20hr  (491) embryo 20-22hr  (1213) embryo 22-24hr  (1287) larva L1  (586) larva L2  (544) larva L3 12hr old  (1661) larva L3 puffstage 1-2  (381) larva L3 puffstage 3-6  (66) larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr  (164) white prepupae 24hr  (41) pupae 2d postWPP  (48) pupae 3d postWPP    18 pupae 4d postWPP  (664) adult male 01day  (445) adult male 05day  (452) adult male 30day  (373) adult female 01day  (273) adult female 05day  (368) adult female 30day  (533) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr    87 embryo 18-20hr  (491) embryo 20-22hr  (1213) embryo 22-24hr  (1287) larva L1  (586) larva L2  (544) larva L3 12hr old  (1661) larva L3 puffstage 1-2  (381) larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr  (164) white prepupae 24hr    41 pupae 2d postWPP    48 pupae 3d postWPP    18 pupae 4d postWPP  (664) adult male 01day  (445) adult male 05day  (452) adult male 30day  (373) adult female 01day  (273) adult female 05day  (368) adult female 30day  (533) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    4 embryo 10-12hr    10 embryo 12-14hr    9 embryo 14-16hr    16 embryo 16-18hr    87 embryo 18-20hr    491 embryo 20-22hr    1213 embryo 22-24hr    1287 larva L1    586 larva L2    544 larva L3 12hr old    1661 larva L3 puffstage 1-2    381 larva L3 puffstage 3-6    66 larva L3 puffstage 7-9    20 white prepupae new    16 white prepupae 12hr    164 white prepupae 24hr    41 pupae 2d postWPP    48 pupae 3d postWPP    18 pupae 4d postWPP    664 adult male 01day    445 adult male 05day    452 adult male 30day    373 adult female 01day    273 adult female 05day    368 adult female 30day    533 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    7 embryonic 1182-4H    0 embryonic GM2    5 embryonic Kc167    2 embryonic S1    0 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    1 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    4 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    23 heat shock, 4-day adult    366 Cadmium 50 mM 6 hrs, larvae L3    739 Cadmium 50 mM 12 hrs, larvae L3    266 Cadmium 50 mM 48 hrs, 4-day adult    510 Cadmium 100 mM 48 hrs, 4-day adult    88 Copper 0.5 mM 12 hrs, larvae L3    45 Copper 15 mM 48 hrs, 4-day adult    233 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    330 Ethanol 2.5% 3 hrs, larvae L3    133 Ethanol 5% 3 hrs, larvae L3    1298 Ethanol 10% 3 hrs, larvae L3    655 Caffeine 1.5 mg/ml 4 hrs, larvae L3    857 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    62 Paraquat 5 mM 48 hrs, 4-day adult    219 Paraquat 10 mM 48 hrs, 4-day adult    185 Rotenone 2 μg 12 hrs, larvae L3    967 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (32) cold shock, 4-day adult    23 heat shock, 4-day adult  (366) Cadmium 50 mM 6 hrs, larvae L3  (739) Cadmium 50 mM 12 hrs, larvae L3  (266) Cadmium 50 mM 48 hrs, 4-day adult  (510) Cadmium 100 mM 48 hrs, 4-day adult  (88) Copper 0.5 mM 12 hrs, larvae L3  (45) Copper 15 mM 48 hrs, 4-day adult  (233) Zinc 5 mM 12 hrs, larvae L3  (56) Zinc 4.5 mM 48 hrs, 4-day adult  (330) Ethanol 2.5% 3 hrs, larvae L3  (133) Ethanol 5% 3 hrs, larvae L3  (1298) Ethanol 10% 3 hrs, larvae L3  (655) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (857) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult  (62) Paraquat 5 mM 48 hrs, 4-day adult  (219) Paraquat 10 mM 48 hrs, 4-day adult  (185) Rotenone 2 μg 12 hrs, larvae L3  (967) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    23 heat shock, 4-day adult  (366) Cadmium 50 mM 6 hrs, larvae L3  (739) Cadmium 50 mM 12 hrs, larvae L3  (266) Cadmium 50 mM 48 hrs, 4-day adult  (510) Cadmium 100 mM 48 hrs, 4-day adult    88 Copper 0.5 mM 12 hrs, larvae L3    45 Copper 15 mM 48 hrs, 4-day adult  (233) Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult  (330) Ethanol 2.5% 3 hrs, larvae L3  (133) Ethanol 5% 3 hrs, larvae L3  (1298) Ethanol 10% 3 hrs, larvae L3  (655) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (857) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult    62 Paraquat 5 mM 48 hrs, 4-day adult  (219) Paraquat 10 mM 48 hrs, 4-day adult  (185) Rotenone 2 μg 12 hrs, larvae L3  (967) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    23 heat shock, 4-day adult    366 Cadmium 50 mM 6 hrs, larvae L3    739 Cadmium 50 mM 12 hrs, larvae L3    266 Cadmium 50 mM 48 hrs, 4-day adult    510 Cadmium 100 mM 48 hrs, 4-day adult    88 Copper 0.5 mM 12 hrs, larvae L3    45 Copper 15 mM 48 hrs, 4-day adult    233 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    330 Ethanol 2.5% 3 hrs, larvae L3    133 Ethanol 5% 3 hrs, larvae L3    1298 Ethanol 10% 3 hrs, larvae L3    655 Caffeine 1.5 mg/ml 4 hrs, larvae L3    857 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    62 Paraquat 5 mM 48 hrs, 4-day adult    219 Paraquat 10 mM 48 hrs, 4-day adult    185 Rotenone 2 μg 12 hrs, larvae L3    967 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    23 heat shock, 4-day adult    366 Cadmium 50 mM 6 hrs, larvae L3    739 Cadmium 50 mM 12 hrs, larvae L3    266 Cadmium 50 mM 48 hrs, 4-day adult    510 Cadmium 100 mM 48 hrs, 4-day adult    88 Copper 0.5 mM 12 hrs, larvae L3    45 Copper 15 mM 48 hrs, 4-day adult    233 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    330 Ethanol 2.5% 3 hrs, larvae L3    133 Ethanol 5% 3 hrs, larvae L3    1298 Ethanol 10% 3 hrs, larvae L3    655 Caffeine 1.5 mg/ml 4 hrs, larvae L3    857 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    62 Paraquat 5 mM 48 hrs, 4-day adult    219 Paraquat 10 mM 48 hrs, 4-day adult    185 Rotenone 2 μg 12 hrs, larvae L3    967 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  32 cold shock, 4-day adult    23 heat shock, 4-day adult  (366) Cadmium 50 mM 6 hrs, larvae L3  (739) Cadmium 50 mM 12 hrs, larvae L3  (266) Cadmium 50 mM 48 hrs, 4-day adult  (510) Cadmium 100 mM 48 hrs, 4-day adult  (88) Copper 0.5 mM 12 hrs, larvae L3  (45) Copper 15 mM 48 hrs, 4-day adult  (233) Zinc 5 mM 12 hrs, larvae L3  (56) Zinc 4.5 mM 48 hrs, 4-day adult  (330) Ethanol 2.5% 3 hrs, larvae L3  (133) Ethanol 5% 3 hrs, larvae L3  (1298) Ethanol 10% 3 hrs, larvae L3  (655) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (857) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult  (62) Paraquat 5 mM 48 hrs, 4-day adult  (219) Paraquat 10 mM 48 hrs, 4-day adult  (185) Rotenone 2 μg 12 hrs, larvae L3  (967) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    23 heat shock, 4-day adult  (366) Cadmium 50 mM 6 hrs, larvae L3  (739) Cadmium 50 mM 12 hrs, larvae L3  (266) Cadmium 50 mM 48 hrs, 4-day adult  (510) Cadmium 100 mM 48 hrs, 4-day adult    88 Copper 0.5 mM 12 hrs, larvae L3    45 Copper 15 mM 48 hrs, 4-day adult  (233) Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult  (330) Ethanol 2.5% 3 hrs, larvae L3  133 Ethanol 5% 3 hrs, larvae L3  (1298) Ethanol 10% 3 hrs, larvae L3  (655) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (857) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult    62 Paraquat 5 mM 48 hrs, 4-day adult  (219) Paraquat 10 mM 48 hrs, 4-day adult  (185) Rotenone 2 μg 12 hrs, larvae L3  (967) Rotenone 8 μg 12 hrs, larvae L3  (546) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    32 cold shock, 4-day adult    23 heat shock, 4-day adult    366 Cadmium 50 mM 6 hrs, larvae L3    739 Cadmium 50 mM 12 hrs, larvae L3    266 Cadmium 50 mM 48 hrs, 4-day adult    510 Cadmium 100 mM 48 hrs, 4-day adult    88 Copper 0.5 mM 12 hrs, larvae L3    45 Copper 15 mM 48 hrs, 4-day adult    233 Zinc 5 mM 12 hrs, larvae L3    56 Zinc 4.5 mM 48 hrs, 4-day adult    330 Ethanol 2.5% 3 hrs, larvae L3    133 Ethanol 5% 3 hrs, larvae L3    1298 Ethanol 10% 3 hrs, larvae L3    655 Caffeine 1.5 mg/ml 4 hrs, larvae L3    857 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    62 Paraquat 5 mM 48 hrs, 4-day adult    219 Paraquat 10 mM 48 hrs, 4-day adult    185 Rotenone 2 μg 12 hrs, larvae L3    967 Rotenone 8 μg 12 hrs, larvae L3    546 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • RH38008 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031561 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16712-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG16712 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG16712GD13590 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG16712 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG16712 Class Mutagen Stocks Known lesion CG16712GD13590 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG16712GL01213 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG16712KK116192 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7018 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13590} NA P{KK116192} NA P{TRiP.GL01213} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
serine-type endopeptidase inhibitor activity inferred from sequence or structural similarity with UniProtKB:O14895 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG16712 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031561
Orthologs
OrthoDB Orthologs (18) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GTM0Q Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search EOG6BK3MT Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6GTM0Q)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG16712     Drosophila simulans   Dsim\GD22734 Y   Drosophila sechellia   Dsec\GM18127 Y   Drosophila erecta   Dere\GG24412     Drosophila erecta   Dere\GG24409 Y   Drosophila erecta   Dere\GG24414     Drosophila erecta   Dere\GG24415     Drosophila yakuba   Dyak\GE14815 Y   Drosophila ananassae   Dana\GF15247     Drosophila ananassae   Dana\GF14654 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14098 Y   Drosophila persimilis   Dper\GL19459 Y   Drosophila virilis   Dvir\GJ17585 Y   Drosophila mojavensis   Dmoj\GI23877     Drosophila mojavensis   Dmoj\GI17757 Y   Drosophila grimshawi   Dgri\GH13180 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (EOG6BK3MT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_195288   Daphnia pulex Water flea  Dpux\Slco1a1
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22734 Drosophila sechellia Dsec\GM18127 Drosophila erecta Dere\GG24409 Drosophila yakuba Dyak\GE14815 Drosophila ananassae Dana\GF14654 Drosophila pseudoobscura pseudoobscura Dpse\GA14098 Drosophila persimilis Dper\GL19459 Drosophila virilis Dvir\GJ17585 Drosophila mojavensis Dmoj\GI17757 Drosophila grimshawi Dgri\GH13180
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	41631 y1 v1; P{TRiP.GL01213}attP40
VDRC	v23520 w1118; P{GD13590}v23520 v23521 w1118; P{GD13590}v23521
Genomic Clones ( 1 )
	BACR28B08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH05411 RH38008
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04126 GH06270 GH06305 GH24432 RH04604 RH05331 RH05368 RH06527 RH07750 RH08084 RH08879 RH12128 RH17441 RH26884 RH30027 RH31084 RH31366 RH36719 RH37392 RH37857 RH43543 RH47819 RH47895 RH48156 RH52855 RH54924 RH60307 RH64085 RH68815 RH74085
Other clones	Dmel_dig_009934_0667_1160 Dmel_neb_001470_0106_0335 Dmel_neb_003608_0426_3484 Dmel_neb_007071_0693_0372 Dmel_neb_009864_0628_3087 Dmel_neb_010749_0849_0531 Dmel_neb_011734_0136_2185 Dmel_neb_012026_0158_3471 Dmel_neb_014483_0445_1490 Dmel_neb_015452_0409_3103 EK189260 EK286509 ESG0111a.B21_E06 RP004063275 RP004100307 RP004107269 RP004108185 RP004120277 RP004158606 RP004162526 RP004167130 RP004173472 RP004191037 RP004196557 RP004196854 RP004212690 RP004226090 RP004242664 RP004255533 RP004258199 RP004264817 RP004308193 RP004380558 RP004446075 RP004449764 RP004456943 RP004545451 RP004549083 RP004554833
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031561 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33592
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG16712 BcDNA:RH05411 (FlyBase, 1996-) Source for merge of: CG16712 BcDNA:RH38008 (FlyBase, 1996-)
Additional comments	Source for merge of CG16712 BcDNA:RH05411 was TrEMBL update (date:020807). (FlyBase, 1996-) Source for merge of CG16712 BcDNA:RH38008 was TrEMBL update (date:020807). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134956 RefSeq (Proteins) • NP_608800 DDBJ / EMBL / GenBank • AAF51076 AAL48139 AAL48173 AY070668 AY070702 BI570644 BI634274 Entrez Gene - A searchable database of RefSeq genes. • 33592 UniProtKB/TrEMBL • Q9VQT8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteinase inhibitor I2, Kunitz metazoa (IPR002223) Proteinase inhibitor I2, Kunitz, conserved site (IPR020901) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH38008
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031561 DRSC - Results from RNAi screens. • FBgn0031561 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031561 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG16712-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031561 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33592 modMine - Data generated by the modENCODE project. • FBgn0031561
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:RH05411   BcDNA:RH38008   CG16712 (Pedersen et al., 2010, Findlay et al., 2008, Buchon et al., 2009, Goodliffe et al., 2007, Anholt and Williams, 2010, Wertheim et al., 2005, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Malone et al., 2012) CT37183 (Ceriani et al., 2002)
Name Synonym
Secondary FlyBase IDs
	FBgn0047018 FBgn0047049
References ( 23 )
Generate a list of	All references relating to this gene ( 23 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Malone et al., 2012, Genome Biol. 13(4): r28 Mediation of Drosophila autosomal dosage effects and compensation by network interactions. [FBrf0219684] Show all research papers ...