FB2020_06, released Dec 22, 2020

Gene: Dmel\CG10019

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General Information
Symbol
Dmel\CG10019
Species
D. melanogaster
Name
Annotation Symbol
CG10019
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031568
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
24C2-24C3
Sequence location
2L:3,730,466..3,754,617 [+]
Recombination map

2-11

RefSeq locus
NT_033779 REGION:3730466..3754617
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables monocarboxylic acid transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000888455
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in monocarboxylic acid transport
inferred from biological aspect of ancestor with PANTHER:PTN000144718
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in transmembrane transport
inferred from electronic annotation with InterPro:IPR011701
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of membrane
inferred from biological aspect of ancestor with PANTHER:PTN000145408
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC16 FAMILY OF MONOCARBOXYLATE TRANSPORTERS -
Solute carrier family 16 (SLC16) members mediate the transmembrane transport of monocarboxylates. (Adapted from FBrf0229477).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\CG10019 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.43

Gene model reviewed during 5.47

Stop-codon suppression (UGA) postulated; FBrf0243886.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 6.32

May encode a selenoprotein.

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(FlyBase Genome Annotators, 2019-)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CG10019-RD
FBtr0479853
NM_001382004
6205
1159
CG10019-RE
FBtr0479854
NM_001382005
5287
1159
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CG10019-PD
FBpp0428189
128.9
1159
9.41
AGB92538
CG10019-PE
FBpp0428190
128.9
1159
9.41
AAF51067
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1159 aa isoforms: CG10019-PD, CG10019-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG10019 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG10019 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CG10019
Transgenic constructs containing regulatory region of CG10019
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4repo.PU
Other Phenotypes
Allele
visible, with Scer\GAL4nSyb.PS
Phenotype manifest in
Allele
wing, with Scer\GAL4nSyb.PS
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC16A14
4 of 15
Yes
No
Hsap\SLC16A1
3 of 15
No
No
1  
Hsap\SLC16A2
3 of 15
No
No
1  
Hsap\SLC16A3
3 of 15
No
No
Hsap\SLC16A5
3 of 15
No
No
Hsap\SLC16A7
3 of 15
No
No
Hsap\SLC16A8
3 of 15
No
No
Hsap\SLC16A9
3 of 15
No
No
Hsap\SLC16A10
3 of 15
No
No
Hsap\SLC16A12
3 of 15
No
No
Hsap\SLC16A13
3 of 15
No
No
Hsap\SLC16A4
2 of 15
No
No
1  
Hsap\SLC16A6
2 of 15
No
No
Hsap\SLC16A11
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc16a1
3 of 15
Yes
No
Mmus\Slc16a2
3 of 15
Yes
No
Mmus\Slc16a3
3 of 15
Yes
No
Mmus\Slc16a5
3 of 15
Yes
No
Mmus\Slc16a6
3 of 15
Yes
No
Mmus\Slc16a7
3 of 15
Yes
No
Mmus\Slc16a8
3 of 15
Yes
No
Mmus\Slc16a9
3 of 15
Yes
No
Mmus\Slc16a10
3 of 15
Yes
No
Mmus\Slc16a12
3 of 15
Yes
No
Mmus\Slc16a13
3 of 15
Yes
No
Mmus\Slc16a14
3 of 15
Yes
No
Mmus\Slc16a4
2 of 15
No
No
Mmus\Slc16a11
2 of 15
No
No
Rattus norvegicus (Norway rat) (14)
Rnor\Slc16a1
3 of 13
Yes
No
Rnor\Slc16a2
3 of 13
Yes
No
Rnor\Slc16a3
3 of 13
Yes
No
Rnor\Slc16a5
3 of 13
Yes
No
Rnor\Slc16a6
3 of 13
Yes
No
Rnor\Slc16a8
3 of 13
Yes
No
Rnor\Slc16a10
3 of 13
Yes
No
Rnor\Slc16a12
3 of 13
Yes
No
Rnor\Slc16a13
3 of 13
Yes
No
Rnor\Slc16a14
3 of 13
Yes
No
Rnor\Slc16a4
2 of 13
No
No
Rnor\Slc16a7
2 of 13
No
No
Rnor\Slc16a11
2 of 13
No
No
Rnor\Slc16a9
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (14)
Xtro\slc16a1
3 of 12
Yes
No
Xtro\slc16a2
3 of 12
Yes
No
Xtro\slc16a3
3 of 12
Yes
No
Xtro\slc16a5
3 of 12
Yes
No
Xtro\slc16a6
3 of 12
Yes
No
Xtro\slc16a7
3 of 12
Yes
No
Xtro\slc16a9
3 of 12
Yes
No
Xtro\slc16a10
3 of 12
Yes
No
Xtro\slc16a12
3 of 12
Yes
No
Xtro\slc16a13
3 of 12
Yes
No
Xtro\LOC100491288
2 of 12
No
No
Xtro\LOC101733336
2 of 12
No
Yes
Xtro\slc16a14
2 of 12
No
No
Xtro\LOC733714
1 of 12
No
No
Danio rerio (Zebrafish) (23)
Drer\si:ch211-234h8.7
3 of 15
Yes
No
Drer\si:dkey-246g23.4
3 of 15
Yes
No
Drer\slc16a1a
3 of 15
Yes
No
Drer\slc16a1b
3 of 15
Yes
No
Drer\slc16a5a
3 of 15
Yes
No
Drer\slc16a6a
3 of 15
Yes
No
Drer\slc16a6b
3 of 15
Yes
No
Drer\slc16a7
3 of 15
Yes
No
Drer\slc16a8
3 of 15
Yes
No
Drer\slc16a9a
3 of 15
Yes
No
Drer\slc16a9b
3 of 15
Yes
No
Drer\slc16a10
3 of 15
Yes
No
Drer\slc16a12a
3 of 15
Yes
No
Drer\slc16a12b
3 of 15
Yes
No
Drer\slc16a13
3 of 15
Yes
No
Drer\zgc:114041
3 of 15
Yes
No
Drer\LOC103911912
2 of 15
No
No
Drer\slc16a2
2 of 15
No
No
Drer\slc16a3
2 of 15
No
No
Drer\slc16a4
2 of 15
No
No
Drer\slc16a5b
2 of 15
No
No
Drer\zgc:165507
2 of 15
No
No
Drer\tep1
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\gem-1
4 of 15
Yes
Yes
Cele\mct-2
3 of 15
No
No
Cele\mct-3
3 of 15
No
No
Cele\mct-4
3 of 15
No
No
Cele\mct-5
3 of 15
No
No
Cele\mct-6
3 of 15
No
No
Cele\F10G7.5
2 of 15
No
No
Cele\mct-1
2 of 15
No
No
Cele\slcf-1
2 of 15
No
No
Cele\Y59A8B.21
2 of 15
No
No
Cele\cat-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\ESBP6
4 of 15
Yes
No
Scer\MCH2
3 of 15
No
No
Scer\MCH4
3 of 15
No
No
Scer\MCH5
3 of 15
No
No
Scer\ATG22
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\atg22
1 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903AK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000137
Drosophila simulans
Dsim\GD23251
Drosophila sechellia
Dsec\GM18432
Drosophila erecta
Dere\GG24964
Drosophila yakuba
Dyak\GE18254
Drosophila ananassae
Dana\GF15251
Drosophila pseudoobscura pseudoobscura
Dpse\GA10013
Drosophila persimilis
Dper\GL18673
Drosophila willistoni
Dwil\GK14647
Drosophila virilis
Dvir\GJ21180
Drosophila mojavensis
Dmoj\GI23919
Drosophila grimshawi
Dgri\GH13704
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502S4 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014630
Glossina morsitans
Tsetse fly
Gmor\GMOY007547
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07564
Mayetiola destructor
Hessian fly
Mdes\Mdes014978
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL018228
Anopheles darlingi
American malaria mosquito
Adar\ADAC002448
Anopheles gambiae
Malaria mosquito
Agam\AGAP009123
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000765
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02GV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58724.1
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG8028
4 of 10
CG8034
4 of 10
CG8389
4 of 10
CG8468
4 of 10
CG12866
4 of 10
CG13907
4 of 10
hrm
4 of 10
Mct1
4 of 10
out
4 of 10
Sln
4 of 10
CG8051
3 of 10
CG14196
3 of 10
chk
3 of 10
kar
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC16A14; solute carrier family 16 member 14
    4 of 15
        SLC16A1; solute carrier family 16 member 1
        3 of 15
        600682
         
        SLC16A2; solute carrier family 16 member 2
        3 of 15
        300095
         
        SLC16A3; solute carrier family 16 member 3
        3 of 15
        603877
            SLC16A5; solute carrier family 16 member 5
            3 of 15
            603879
                SLC16A7; solute carrier family 16 member 7
                3 of 15
                603654
                    SLC16A8; solute carrier family 16 member 8
                    3 of 15
                    610409
                        SLC16A9; solute carrier family 16 member 9
                        3 of 15
                        614242
                            SLC16A10; solute carrier family 16 member 10
                            3 of 15
                            607550
                                SLC16A12; solute carrier family 16 member 12
                                3 of 15
                                611910
                                SLC16A13; solute carrier family 16 member 13
                                3 of 15
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Interactions Browser
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    BioGRID - A database of protein and genetic interactions.
                                    DroID - A comprehensive database of gene and protein interactions.
                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    External Data
                                    Linkouts
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    2L
                                    Recombination map

                                    2-11

                                    Cytogenetic map
                                    24C2-24C3
                                    Sequence location
                                    2L:3,730,466..3,754,617 [+]
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    24C2-24C3
                                    Limits computationally determined from genome sequence between P{EP}EP2595EP2595 and P{lacW}edk01102
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    Experimentally Determined Recombination Data
                                    Location

                                    2-11

                                    (FlyBase, 2016)

                                    2-9.3

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (5)
                                    Genomic Clones (11)
                                     

                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                    cDNA Clones (2)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                      Other clones
                                        Drosophila Genomics Resource Center cDNA clones

                                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                        cDNA Clones, End Sequenced (ESTs)
                                        BDGP DGC clones
                                          Other clones
                                            RNAi and Array Information
                                            Linkouts
                                            DRSC - Results frm RNAi screens
                                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                            Antibody Information
                                            Laboratory Generated Antibodies
                                             
                                            Commercially Available Antibodies
                                             
                                            Other Information
                                            Relationship to Other Genes
                                            Source for database identify of
                                            Source for database merge of
                                            Additional comments
                                            Other Comments

                                            Identified with: GH25970 <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

                                            (Zou et al., 2000)

                                            EST GH25970 is chimeric; the 5' portion (AI405831) matches part of AE003779 on 3R, the 3' portion (BG633387) corresponds to part of CG10019 on 2L.

                                            (FlyBase, 1996-)
                                            Origin and Etymology
                                            Discoverer
                                            Etymology
                                            Identification
                                            External Crossreferences and Linkouts ( 27 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                            Other crossreferences
                                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            modMine - A data warehouse for the modENCODE project
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            Synonyms and Secondary IDs (3)
                                            Reported As
                                            Symbol Synonym
                                            BEST:GH25970
                                            CG10019
                                            (FlyBase Genome Annotators, 2019-, Clandinin and Owens, 2016-, Dobson et al., 2015, Ober et al., 2015, Volkenhoff et al., 2015)
                                            GH25970
                                            (Zou et al., 2000)
                                            Name Synonyms
                                            Secondary FlyBase IDs
                                            • FBgn0043805
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            References (26)