General Information Symbol Dmel\ CG3702Species D. melanogaster Name Annotation symbol CG3702 Feature type protein_coding_gene FlyBase ID FBgn0031590 Gene Model Status Current Stock availability 2 publicly
available Genomic Location Chromosome (arm) 2L Recombination map Cytogenetic map 24D8-24E1 Sequence location 2L:4,224,650..4,227,097 [-]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information This gene is referred to in FlyBase by the symbol
Dmel\CG3702 (FBgn0031590). It is a protein_coding_gene from
Drosophila melanogaster . Its
molecular function is unknown. The
biological processes in which it is involved are not known.
5 alleles are reported . No phenotypic data is available. It has
2 annotated transcripts and
2 annotated polypeptides .
Protein features are: Cleft lip and palate transmembrane 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval salivary gland, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult hindgut, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623434_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG3702. Gene sequence location is
2L:4224650..4227097 .
User Contributed Data
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FB2013_03
FB2013_02
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
1240.8
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
1149.5
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
900.8
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
(624.7)
Larval Hindgut
(545.1)
Larval Malpighian Tubules
(1240.8)
Larval Fat Body
467.2
Larval Salivary Gland
(709.6)
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
(703.2)
Adult Hindgut
430.7
Adult Malpighian Tubules
(1149.5)
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
(900.8)
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
(1240.8)
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
(1149.5)
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
900.8
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
1240.8
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
1149.5
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
900.8
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
1240.8
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
1149.5
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
900.8
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
(1240.8)
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
(1149.5)
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
(900.8)
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
1240.8
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
1149.5
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
900.8
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
361.6
Larval Midgut
624.7
Larval Hindgut
545.1
Larval Malpighian Tubules
1240.8
Larval Fat Body
467.2
Larval Salivary Gland
709.6
Larval Trachea
322.125
Larval Carcass
397.975
Adult Head
304.1
Adult Eye
277.95
Adult Brain
383.3
Adult Thoracic-Abdominal Ganglion
398.8
Adult Crop
311.2
Adult Midgut
703.2
Adult Hindgut
430.7
Adult Malpighian Tubules
1149.5
Adult Fat Body
398.9
Adult Salivary Gland
385.7
Adult Heart
359.475
Adult VirginFemale Spermatheca
266.5
Adult InseminatedFemale Spermatheca
255.1
Adult Ovary
521.8
Adult Testis
900.8
Adult Male Accessory Gland
395
Adult Carcass
356.8
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
304.1
NA
Eye
277.95
NA
Brain
383.3
361.6
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
398.8
NA
Crop
311.2
624.7
Midgut
703.2
545.1
Hindgut
430.7
1240.8
Malpighian Tubules
1149.5
467.2
Fat Body
398.9
709.6
Salivary Gland
385.7
NA
Heart
359.475
322.125
Trachea
NA
NA
VirginFemale Spermatheca
266.5
NA
InseminatedFemale Spermatheca
255.1
NA
Ovary
521.8
NA
Testis
900.8
NA
Male Accessory Gland
395
397.975
Carcass
356.8
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
49
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
34
digestive system, 1-day adult
45
digestive system, 4-day adult
47
digestive system, 20-day adult
46
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
60
ovary, mated 4-day female
58
testis, mated 4-day male
147
accessory gland, mated 4-day male
27
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(49)
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
(27)
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
(34)
digestive system, 1-day adult
(45)
digestive system, 4-day adult
(47)
digestive system, 20-day adult
(46)
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
(27)
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
(60)
ovary, mated 4-day female
(58)
testis, mated 4-day male
(147)
accessory gland, mated 4-day male
(27)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
49
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
34
digestive system, 1-day adult
45
digestive system, 4-day adult
47
digestive system, 20-day adult
46
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
60
ovary, mated 4-day female
58
testis, mated 4-day male
(147)
accessory gland, mated 4-day male
27
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
49
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
34
digestive system, 1-day adult
45
digestive system, 4-day adult
47
digestive system, 20-day adult
46
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
60
ovary, mated 4-day female
58
testis, mated 4-day male
147
accessory gland, mated 4-day male
27
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
49
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
34
digestive system, 1-day adult
45
digestive system, 4-day adult
47
digestive system, 20-day adult
46
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
60
ovary, mated 4-day female
58
testis, mated 4-day male
147
accessory gland, mated 4-day male
27
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(49)
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
(34)
digestive system, 1-day adult
(45)
digestive system, 4-day adult
(47)
digestive system, 20-day adult
(46)
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
(60)
ovary, mated 4-day female
(58)
testis, mated 4-day male
(147)
accessory gland, mated 4-day male
27
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
49
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
34
digestive system, 1-day adult
45
digestive system, 4-day adult
47
digestive system, 20-day adult
46
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
60
ovary, mated 4-day female
58
testis, mated 4-day male
(147)
accessory gland, mated 4-day male
27
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
49
central nervous system, larvae L3
23
central nervous system, pupae P8
20
head, virgin 1-day female
18
head, virgin 4-day female
13
head, virgin 20-day female
17
head, mated 1-day female
13
head, mated 4-day female
15
head, mated 20-day female
16
head, mated 1-day male
23
head, mated 4-day male
20
head, mated 20-day male
27
salivary gland, larvae L3 wandering
5
salivary gland, white prepupae
15
digestive system, larvae L3 wandering
34
digestive system, 1-day adult
45
digestive system, 4-day adult
47
digestive system, 20-day adult
46
fat body, larvae L3 wandering
7
fat body, white prepupae
23
fat body, pupae P8
21
carcass, larvae L3 wandering
27
carcass, 1-day adult
12
carcass, 4-day adult
18
carcass, 20-day adult
17
ovary, virgin 4-day female
60
ovary, mated 4-day female
58
testis, mated 4-day male
147
accessory gland, mated 4-day male
27
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
96
embryo 02-04hr
41
embryo 04-06hr
100
embryo 06-08hr
108
embryo 08-10hr
91
embryo 10-12hr
89
embryo 12-14hr
76
embryo 14-16hr
70
embryo 16-18hr
57
embryo 18-20hr
43
embryo 20-22hr
32
embryo 22-24hr
34
larva L1
70
larva L2
73
larva L3 12hr old
45
larva L3 puffstage 1-2
34
larva L3 puffstage 3-6
41
larva L3 puffstage 7-9
47
white prepupae new
48
white prepupae 12hr
44
white prepupae 24hr
55
pupae 2d postWPP
55
pupae 3d postWPP
55
pupae 4d postWPP
55
adult male 01day
76
adult male 05day
87
adult male 30day
88
adult female 01day
58
adult female 05day
76
adult female 30day
79
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(96)
embryo 02-04hr
(41)
embryo 04-06hr
(100)
embryo 06-08hr
(108)
embryo 08-10hr
(91)
embryo 10-12hr
(89)
embryo 12-14hr
(76)
embryo 14-16hr
(70)
embryo 16-18hr
(57)
embryo 18-20hr
(43)
embryo 20-22hr
(32)
embryo 22-24hr
(34)
larva L1
(70)
larva L2
(73)
larva L3 12hr old
(45)
larva L3 puffstage 1-2
(34)
larva L3 puffstage 3-6
(41)
larva L3 puffstage 7-9
(47)
white prepupae new
(48)
white prepupae 12hr
(44)
white prepupae 24hr
(55)
pupae 2d postWPP
(55)
pupae 3d postWPP
(55)
pupae 4d postWPP
(55)
adult male 01day
(76)
adult male 05day
(87)
adult male 30day
(88)
adult female 01day
(58)
adult female 05day
(76)
adult female 30day
(79)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
96
embryo 02-04hr
41
embryo 04-06hr
100
embryo 06-08hr
(108)
embryo 08-10hr
91
embryo 10-12hr
89
embryo 12-14hr
76
embryo 14-16hr
70
embryo 16-18hr
57
embryo 18-20hr
43
embryo 20-22hr
32
embryo 22-24hr
34
larva L1
70
larva L2
73
larva L3 12hr old
45
larva L3 puffstage 1-2
34
larva L3 puffstage 3-6
41
larva L3 puffstage 7-9
47
white prepupae new
48
white prepupae 12hr
44
white prepupae 24hr
55
pupae 2d postWPP
55
pupae 3d postWPP
55
pupae 4d postWPP
55
adult male 01day
76
adult male 05day
87
adult male 30day
88
adult female 01day
58
adult female 05day
76
adult female 30day
79
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
96
embryo 02-04hr
41
embryo 04-06hr
100
embryo 06-08hr
108
embryo 08-10hr
91
embryo 10-12hr
89
embryo 12-14hr
76
embryo 14-16hr
70
embryo 16-18hr
57
embryo 18-20hr
43
embryo 20-22hr
32
embryo 22-24hr
34
larva L1
70
larva L2
73
larva L3 12hr old
45
larva L3 puffstage 1-2
34
larva L3 puffstage 3-6
41
larva L3 puffstage 7-9
47
white prepupae new
48
white prepupae 12hr
44
white prepupae 24hr
55
pupae 2d postWPP
55
pupae 3d postWPP
55
pupae 4d postWPP
55
adult male 01day
76
adult male 05day
87
adult male 30day
88
adult female 01day
58
adult female 05day
76
adult female 30day
79
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
96
embryo 02-04hr
41
embryo 04-06hr
100
embryo 06-08hr
108
embryo 08-10hr
91
embryo 10-12hr
89
embryo 12-14hr
76
embryo 14-16hr
70
embryo 16-18hr
57
embryo 18-20hr
43
embryo 20-22hr
32
embryo 22-24hr
34
larva L1
70
larva L2
73
larva L3 12hr old
45
larva L3 puffstage 1-2
34
larva L3 puffstage 3-6
41
larva L3 puffstage 7-9
47
white prepupae new
48
white prepupae 12hr
44
white prepupae 24hr
55
pupae 2d postWPP
55
pupae 3d postWPP
55
pupae 4d postWPP
55
adult male 01day
76
adult male 05day
87
adult male 30day
88
adult female 01day
58
adult female 05day
76
adult female 30day
79
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(96)
embryo 02-04hr
(41)
embryo 04-06hr
(100)
embryo 06-08hr
(108)
embryo 08-10hr
(91)
embryo 10-12hr
(89)
embryo 12-14hr
(76)
embryo 14-16hr
(70)
embryo 16-18hr
(57)
embryo 18-20hr
(43)
embryo 20-22hr
32
embryo 22-24hr
(34)
larva L1
(70)
larva L2
(73)
larva L3 12hr old
(45)
larva L3 puffstage 1-2
(34)
larva L3 puffstage 3-6
(41)
larva L3 puffstage 7-9
(47)
white prepupae new
(48)
white prepupae 12hr
(44)
white prepupae 24hr
(55)
pupae 2d postWPP
(55)
pupae 3d postWPP
(55)
pupae 4d postWPP
(55)
adult male 01day
(76)
adult male 05day
(87)
adult male 30day
(88)
adult female 01day
(58)
adult female 05day
(76)
adult female 30day
(79)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
96
embryo 02-04hr
41
embryo 04-06hr
100
embryo 06-08hr
108
embryo 08-10hr
91
embryo 10-12hr
89
embryo 12-14hr
76
embryo 14-16hr
70
embryo 16-18hr
57
embryo 18-20hr
43
embryo 20-22hr
32
embryo 22-24hr
34
larva L1
70
larva L2
73
larva L3 12hr old
45
larva L3 puffstage 1-2
34
larva L3 puffstage 3-6
41
larva L3 puffstage 7-9
47
white prepupae new
48
white prepupae 12hr
44
white prepupae 24hr
55
pupae 2d postWPP
55
pupae 3d postWPP
55
pupae 4d postWPP
55
adult male 01day
76
adult male 05day
87
adult male 30day
88
adult female 01day
58
adult female 05day
76
adult female 30day
79
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
96
embryo 02-04hr
41
embryo 04-06hr
100
embryo 06-08hr
108
embryo 08-10hr
91
embryo 10-12hr
89
embryo 12-14hr
76
embryo 14-16hr
70
embryo 16-18hr
57
embryo 18-20hr
43
embryo 20-22hr
32
embryo 22-24hr
34
larva L1
70
larva L2
73
larva L3 12hr old
45
larva L3 puffstage 1-2
34
larva L3 puffstage 3-6
41
larva L3 puffstage 7-9
47
white prepupae new
48
white prepupae 12hr
44
white prepupae 24hr
55
pupae 2d postWPP
55
pupae 3d postWPP
55
pupae 4d postWPP
55
adult male 01day
76
adult male 05day
87
adult male 30day
88
adult female 01day
58
adult female 05day
76
adult female 30day
79
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
85
Schneider line 2 Sg4
85
embryonic 1182-4H
55
embryonic GM2
43
embryonic Kc167
43
embryonic S1
70
embryonic S3
99
leg disc CME L1
79
wing disc CME-W2
80
wing disc ML-DmD8
41
wing disc ML-DmD9
76
wing disc ML-DmD16-c3
89
wing disc ML-DmD21
39
wing disc ML-DmD32
53
haltere disc ML-DmD17-c3
64
eye-antennal disc ML-DmD11
80
antennal disc ML-DmD20-c5
67
mixed discs ML-DmD4-c1
69
CNS ML-DmBG1-c1
70
CNS ML-DmBG2-c2
70
tumorous blood cells mbn2
69
ovary fGS/OSS
48
ovary OSC
34
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(85)
Schneider line 2 Sg4
(85)
embryonic 1182-4H
(55)
embryonic GM2
(43)
embryonic Kc167
(43)
embryonic S1
(70)
embryonic S3
(99)
leg disc CME L1
(79)
wing disc CME-W2
(80)
wing disc ML-DmD8
(41)
wing disc ML-DmD9
(76)
wing disc ML-DmD16-c3
(89)
wing disc ML-DmD21
(39)
wing disc ML-DmD32
(53)
haltere disc ML-DmD17-c3
(64)
eye-antennal disc ML-DmD11
(80)
antennal disc ML-DmD20-c5
(67)
mixed discs ML-DmD4-c1
(69)
CNS ML-DmBG1-c1
(70)
CNS ML-DmBG2-c2
(70)
tumorous blood cells mbn2
(69)
ovary fGS/OSS
(48)
ovary OSC
(34)
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
85
Schneider line 2 Sg4
85
embryonic 1182-4H
55
embryonic GM2
43
embryonic Kc167
43
embryonic S1
70
embryonic S3
99
leg disc CME L1
79
wing disc CME-W2
80
wing disc ML-DmD8
41
wing disc ML-DmD9
76
wing disc ML-DmD16-c3
89
wing disc ML-DmD21
39
wing disc ML-DmD32
53
haltere disc ML-DmD17-c3
64
eye-antennal disc ML-DmD11
80
antennal disc ML-DmD20-c5
67
mixed discs ML-DmD4-c1
69
CNS ML-DmBG1-c1
70
CNS ML-DmBG2-c2
70
tumorous blood cells mbn2
69
ovary fGS/OSS
48
ovary OSC
34
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
85
Schneider line 2 Sg4
85
embryonic 1182-4H
55
embryonic GM2
43
embryonic Kc167
43
embryonic S1
70
embryonic S3
99
leg disc CME L1
79
wing disc CME-W2
80
wing disc ML-DmD8
41
wing disc ML-DmD9
76
wing disc ML-DmD16-c3
89
wing disc ML-DmD21
39
wing disc ML-DmD32
53
haltere disc ML-DmD17-c3
64
eye-antennal disc ML-DmD11
80
antennal disc ML-DmD20-c5
67
mixed discs ML-DmD4-c1
69
CNS ML-DmBG1-c1
70
CNS ML-DmBG2-c2
70
tumorous blood cells mbn2
69
ovary fGS/OSS
48
ovary OSC
34
ovary OSS
22
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
85
Schneider line 2 Sg4
85
embryonic 1182-4H
55
embryonic GM2
43
embryonic Kc167
43
embryonic S1
70
embryonic S3
99
leg disc CME L1
79
wing disc CME-W2
80
wing disc ML-DmD8
41
wing disc ML-DmD9
76
wing disc ML-DmD16-c3
89
wing disc ML-DmD21
39
wing disc ML-DmD32
53
haltere disc ML-DmD17-c3
64
eye-antennal disc ML-DmD11
80
antennal disc ML-DmD20-c5
67
mixed discs ML-DmD4-c1
69
CNS ML-DmBG1-c1
70
CNS ML-DmBG2-c2
70
tumorous blood cells mbn2
69
ovary fGS/OSS
48
ovary OSC
34
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(85)
Schneider line 2 Sg4
(85)
embryonic 1182-4H
(55)
embryonic GM2
(43)
embryonic Kc167
(43)
embryonic S1
(70)
embryonic S3
(99)
leg disc CME L1
(79)
wing disc CME-W2
(80)
wing disc ML-DmD8
(41)
wing disc ML-DmD9
(76)
wing disc ML-DmD16-c3
(89)
wing disc ML-DmD21
(39)
wing disc ML-DmD32
(53)
haltere disc ML-DmD17-c3
(64)
eye-antennal disc ML-DmD11
(80)
antennal disc ML-DmD20-c5
(67)
mixed discs ML-DmD4-c1
(69)
CNS ML-DmBG1-c1
(70)
CNS ML-DmBG2-c2
(70)
tumorous blood cells mbn2
(69)
ovary fGS/OSS
(48)
ovary OSC
(34)
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
85
Schneider line 2 Sg4
85
embryonic 1182-4H
55
embryonic GM2
43
embryonic Kc167
43
embryonic S1
70
embryonic S3
99
leg disc CME L1
79
wing disc CME-W2
80
wing disc ML-DmD8
41
wing disc ML-DmD9
76
wing disc ML-DmD16-c3
89
wing disc ML-DmD21
39
wing disc ML-DmD32
53
haltere disc ML-DmD17-c3
64
eye-antennal disc ML-DmD11
80
antennal disc ML-DmD20-c5
67
mixed discs ML-DmD4-c1
69
CNS ML-DmBG1-c1
70
CNS ML-DmBG2-c2
70
tumorous blood cells mbn2
69
ovary fGS/OSS
48
ovary OSC
34
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
85
Schneider line 2 Sg4
85
embryonic 1182-4H
55
embryonic GM2
43
embryonic Kc167
43
embryonic S1
70
embryonic S3
99
leg disc CME L1
79
wing disc CME-W2
80
wing disc ML-DmD8
41
wing disc ML-DmD9
76
wing disc ML-DmD16-c3
89
wing disc ML-DmD21
39
wing disc ML-DmD32
53
haltere disc ML-DmD17-c3
64
eye-antennal disc ML-DmD11
80
antennal disc ML-DmD20-c5
67
mixed discs ML-DmD4-c1
69
CNS ML-DmBG1-c1
70
CNS ML-DmBG2-c2
70
tumorous blood cells mbn2
69
ovary fGS/OSS
48
ovary OSC
34
ovary OSS
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
44
Cadmium 50 mM 6 hrs, larvae L3
36
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
40
Cadmium 100 mM 48 hrs, 4-day adult
50
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
69
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
33
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
41
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
55
Paraquat 10 mM 48 hrs, 4-day adult
66
Rotenone 2 μg 12 hrs, larvae L3
36
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
(44)
Cadmium 50 mM 6 hrs, larvae L3
(36)
Cadmium 50 mM 12 hrs, larvae L3
(31)
Cadmium 50 mM 48 hrs, 4-day adult
(40)
Cadmium 100 mM 48 hrs, 4-day adult
(50)
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
(29)
Ethanol 2.5% 3 hrs, larvae L3
(69)
Ethanol 5% 3 hrs, larvae L3
(30)
Ethanol 10% 3 hrs, larvae L3
(33)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(27)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(41)
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
(55)
Paraquat 10 mM 48 hrs, 4-day adult
(66)
Rotenone 2 μg 12 hrs, larvae L3
(36)
Rotenone 8 μg 12 hrs, larvae L3
(31)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
44
Cadmium 50 mM 6 hrs, larvae L3
36
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
40
Cadmium 100 mM 48 hrs, 4-day adult
50
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
69
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
33
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
41
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
55
Paraquat 10 mM 48 hrs, 4-day adult
66
Rotenone 2 μg 12 hrs, larvae L3
36
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
44
Cadmium 50 mM 6 hrs, larvae L3
36
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
40
Cadmium 100 mM 48 hrs, 4-day adult
50
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
69
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
33
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
41
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
55
Paraquat 10 mM 48 hrs, 4-day adult
66
Rotenone 2 μg 12 hrs, larvae L3
36
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
44
Cadmium 50 mM 6 hrs, larvae L3
36
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
40
Cadmium 100 mM 48 hrs, 4-day adult
50
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
69
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
33
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
41
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
55
Paraquat 10 mM 48 hrs, 4-day adult
66
Rotenone 2 μg 12 hrs, larvae L3
36
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
(44)
Cadmium 50 mM 6 hrs, larvae L3
(36)
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
(40)
Cadmium 100 mM 48 hrs, 4-day adult
(50)
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
(69)
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
(33)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(41)
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
(55)
Paraquat 10 mM 48 hrs, 4-day adult
(66)
Rotenone 2 μg 12 hrs, larvae L3
(36)
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
44
Cadmium 50 mM 6 hrs, larvae L3
36
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
40
Cadmium 100 mM 48 hrs, 4-day adult
50
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
69
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
33
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
41
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
55
Paraquat 10 mM 48 hrs, 4-day adult
66
Rotenone 2 μg 12 hrs, larvae L3
36
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
21
cold shock, 4-day adult
17
heat shock, 4-day adult
44
Cadmium 50 mM 6 hrs, larvae L3
36
Cadmium 50 mM 12 hrs, larvae L3
31
Cadmium 50 mM 48 hrs, 4-day adult
40
Cadmium 100 mM 48 hrs, 4-day adult
50
Copper 0.5 mM 12 hrs, larvae L3
15
Copper 15 mM 48 hrs, 4-day adult
21
Zinc 5 mM 12 hrs, larvae L3
17
Zinc 4.5 mM 48 hrs, 4-day adult
29
Ethanol 2.5% 3 hrs, larvae L3
69
Ethanol 5% 3 hrs, larvae L3
30
Ethanol 10% 3 hrs, larvae L3
33
Caffeine 1.5 mg/ml 4 hrs, larvae L3
27
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
41
Caffeine 25 mg/ml 48 hrs, 4-day adult
20
Paraquat 5 mM 48 hrs, 4-day adult
55
Paraquat 10 mM 48 hrs, 4-day adult
66
Rotenone 2 μg 12 hrs, larvae L3
36
Rotenone 8 μg 12 hrs, larvae L3
31
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 1 ) For All Classical Alleles Show Allele of
CG3702 Class Mutagen Stocks Known lesion CG3702G19606 1 --
Alleles Carried on Transgenic Constructs
( 4 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs characterization construct
Insertions insertion of mobile activating element
Gene Ontology: Function, Process
& Cellular Component ( 0 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 0 terms ) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (47)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6HQF3W )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG608NH6 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6JDG34 )
Apis mellifera
Western honey bee
Amel\GB53088
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007016
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH18228
Atta cephalotes
Leafcutter ant
Acep\ACEP19500
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO21208
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL20911
Linepithema humile
Argentine ant
Lhum\LH15903
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB18954
Solenopsis invicta
Red fire ant
Sinv\SINV14651
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG66T1GR )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6MSRRF )
Caenorhabditis elegans
Nematode
Y
Caenorhabditis elegans
Nematode
Y
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (2)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 2 )Bloomington VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 278 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 2 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 20 )Research paper Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Blanco et al., 2010, BMC Dev. Biol. 10: 94Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Gorchakov et al., 2010, Russ. J. Genet. 46(10): 1263--1266Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome. [FBrf0215196] Mourikis et al., 2010, BMC Dev. Biol. 10: 107Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Gorchakov et al., 2009, Genes Dev. 23(19): 2266--2271Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X. [FBrf0209136] Freeman et al., 2003, Neuron 38(4): 567--580Unwrapping glial biology: gcm target genes regulating glial development, diversification, and function. [FBrf0160527] Supplementary material Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Wittkopp et al., 2008, Nat. Genet. 40(3): Supplementary Information [FBrf0208881] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Personal communication to FlyBase Bellen, 2009.4.8, BDGP_2009_0408.GenExel.xmlBDGP_2009_0408.GenExel.xml [FBrf0207636] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping projectDPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data.Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348 ). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file)Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] Stock list Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.RNAi stocks available from NIG-FLY. [FBrf0218457] Website Fisher et al., 2012, BDGP insitu homepageBDGP insitu homepage [FBrf0219073]