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Gene Dmel\Dim1

General Information
Symbol	Dmel\Dim1	Species	D. melanogaster
Name	Dim1	Annotation symbol	CG3058
Feature type	protein_coding_gene	FlyBase ID	FBgn0031601
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	24F1-24F1	Sequence location	2L:4,403,251..4,403,955 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dim1 is referred to in FlyBase by the symbol Dmel\Dim1 (CG3058, FBgn0031601). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic spindle organization; neurogenesis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Thioredoxin-like fold; mRNA splicing factor, thioredoxin-like U5 snRNP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1627900_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dim1. Gene sequence location is 2L:4403251..4403955.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 24F1-24F1   Limits computationally determined from genome sequence between P{lacW}Tps1k08903&P{EP}morgueEP1184 and P{lacW}l(2)k10004k10004&P{EP}CG3036EP963
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dim1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dim1-RA FBtr0077435  NM_134986   606   142
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dim1-PA   FBpp0077125   16.8   142   5.64     NP_608830   AAF51017
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • mRNA splicing factor, thioredoxin-like U5 snRNP (IPR004123) Thioredoxin-like fold (IPR012336)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF51017   AK340741   AY071048 AAL48670   BI171867   BP552692   BP552693   CO181262   CO274712   DQ440368   EC072116   EV586970
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SZ87
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    244.175 Larval Midgut    116.8 Larval Hindgut    91.1 Larval Malpighian Tubules    203 Larval Fat Body    140.5 Larval Salivary Gland    128.5 Larval Trachea    174.975 Larval Carcass    94.65 Adult Head    122.7 Adult Eye    168.325 Adult Brain    212.9 Adult Thoracic-Abdominal Ganglion    279.9 Adult Crop    95.1 Adult Midgut    202.8 Adult Hindgut    118.5 Adult Malpighian Tubules    131.2 Adult Fat Body    105.5 Adult Salivary Gland    219 Adult Heart    119.15 Adult VirginFemale Spermatheca    106.3 Adult InseminatedFemale Spermatheca    105.8 Adult Ovary    193.9 Adult Testis    161.5 Adult Male Accessory Gland    122.6 Adult Carcass    97.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    122.7   NA  Eye    168.325   NA  Brain    212.9   244.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    279.9   NA  Crop    95.1   116.8  Midgut    202.8   91.1  Hindgut    118.5   203  Malpighian Tubules    131.2   140.5  Fat Body    105.5   128.5  Salivary Gland    219   NA  Heart    119.15   174.975  Trachea    NA   NA  VirginFemale Spermatheca    106.3   NA  InseminatedFemale Spermatheca    105.8   NA  Ovary    193.9   NA  Testis    161.5   NA  Male Accessory Gland    122.6   94.65  Carcass    97.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female    30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8  (27) carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female  (30) testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female    30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female    30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female    30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8  27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female  30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female    30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    22 central nervous system, pupae P8    16 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    10 head, mated 1-day female    6 head, mated 4-day female    10 head, mated 20-day female    5 head, mated 1-day male    11 head, mated 4-day male    13 head, mated 20-day male    15 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    9 fat body, larvae L3 wandering    4 fat body, white prepupae    11 fat body, pupae P8    27 carcass, larvae L3 wandering    16 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    4 ovary, virgin 4-day female    24 ovary, mated 4-day female    30 testis, mated 4-day male    20 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    54 embryo 04-06hr    67 embryo 06-08hr    58 embryo 08-10hr    52 embryo 10-12hr    42 embryo 12-14hr    35 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    33 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    37 pupae 2d postWPP    38 pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day    26 adult female 01day    28 adult female 05day    35 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (54) embryo 04-06hr  (67) embryo 06-08hr  (58) embryo 08-10hr  (52) embryo 10-12hr  (42) embryo 12-14hr  (35) embryo 14-16hr  (31) embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (33) white prepupae new  (37) white prepupae 12hr  (35) white prepupae 24hr  (37) pupae 2d postWPP  (38) pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day  26 adult female 01day  (28) adult female 05day  (35) adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    54 embryo 04-06hr    67 embryo 06-08hr    58 embryo 08-10hr    52 embryo 10-12hr    42 embryo 12-14hr    35 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    33 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    37 pupae 2d postWPP    38 pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day    26 adult female 01day    28 adult female 05day    35 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    54 embryo 04-06hr    67 embryo 06-08hr    58 embryo 08-10hr    52 embryo 10-12hr    42 embryo 12-14hr    35 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    33 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    37 pupae 2d postWPP    38 pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day    26 adult female 01day    28 adult female 05day    35 adult female 30day    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    54 embryo 04-06hr    67 embryo 06-08hr    58 embryo 08-10hr    52 embryo 10-12hr    42 embryo 12-14hr    35 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    33 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    37 pupae 2d postWPP    38 pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day    26 adult female 01day    28 adult female 05day    35 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (42) embryo 02-04hr  (54) embryo 04-06hr  (67) embryo 06-08hr  (58) embryo 08-10hr  (52) embryo 10-12hr  (42) embryo 12-14hr  (35) embryo 14-16hr  31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (33) white prepupae new  (37) white prepupae 12hr  (35) white prepupae 24hr  (37) pupae 2d postWPP  (38) pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day  26 adult female 01day  28 adult female 05day  (35) adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    54 embryo 04-06hr    67 embryo 06-08hr    58 embryo 08-10hr    52 embryo 10-12hr    42 embryo 12-14hr    35 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    33 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    37 pupae 2d postWPP    38 pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day    26 adult female 01day    28 adult female 05day    35 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    42 embryo 02-04hr    54 embryo 04-06hr    67 embryo 06-08hr    58 embryo 08-10hr    52 embryo 10-12hr    42 embryo 12-14hr    35 embryo 14-16hr    31 embryo 16-18hr    24 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    14 larva L1    20 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    33 white prepupae new    37 white prepupae 12hr    35 white prepupae 24hr    37 pupae 2d postWPP    38 pupae 3d postWPP    24 pupae 4d postWPP    16 adult male 01day    21 adult male 05day    23 adult male 30day    26 adult female 01day    28 adult female 05day    35 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    43 embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3    31 leg disc CME L1    29 wing disc CME-W2    31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    27 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4  (43) embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3  (31) leg disc CME L1  (29) wing disc CME-W2  (31) wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (33) wing disc ML-DmD21  (31) wing disc ML-DmD32    10 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1  (27) CNS ML-DmBG2-c2  (28) tumorous blood cells mbn2    21 ovary fGS/OSS  (30) ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    43 embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3    31 leg disc CME L1    29 wing disc CME-W2    31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    27 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    43 embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3    31 leg disc CME L1    29 wing disc CME-W2    31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    27 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    43 embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3    31 leg disc CME L1    29 wing disc CME-W2    31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    27 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4  (43) embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3  31 leg disc CME L1  29 wing disc CME-W2  31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3  (33) wing disc ML-DmD21  31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1  27 CNS ML-DmBG2-c2  28 tumorous blood cells mbn2    21 ovary fGS/OSS  30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    43 embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3    31 leg disc CME L1    29 wing disc CME-W2    31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    27 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    23 Schneider line 2 Sg4    43 embryonic 1182-4H    12 embryonic GM2    12 embryonic Kc167    15 embryonic S1    13 embryonic S3    31 leg disc CME L1    29 wing disc CME-W2    31 wing disc ML-DmD8    17 wing disc ML-DmD9    22 wing disc ML-DmD16-c3    33 wing disc ML-DmD21    31 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    22 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    27 CNS ML-DmBG2-c2    28 tumorous blood cells mbn2    21 ovary fGS/OSS    30 ovary OSC    17 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  (27) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3  27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    7 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    19 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    27 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    16 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    11 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    25 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE13747 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031601 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3058-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Dim1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Dim1GD10115 lethal | pupal stage, with Scer\GAL4pnr-MD237 Dim1GD10115 viable Dim1f03902 Sterility Allele fertile Dim1f03902 Other Phenotypes Allele neuroanatomy defective | larval stage Dim1GD10115 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage Dim1GD10115 ganglion mother cell | larval stage Dim1GD10115
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Dim1 Class Mutagen Stocks Known lesion Dim1f03902 piggyBac transposase 2 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dim1 Class Mutagen Stocks Known lesion Dim1GD10115 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dim1KK107558 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dim1NIG.3058R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel8011 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK107558} NA P{NIG.3058R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Dim1f03902 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitosis inferred from electronic annotation with InterPro:IPR004123 (FlyBase Curators et al., 2004-) mRNA splicing, via spliceosome inferred by curator from GO:0071011 (Herold et al., 2009) inferred from sequence or structural similarity with NCBI:NP_006692 AND inferred from sequence or structural similarity with Saccharomyces DIB1 (Mount and Salz, 2000)
Cellular Component
CV term Evidence References
small nuclear ribonucleoprotein complex inferred from sequence or structural similarity with NCBI:NP_006692 AND inferred from sequence or structural similarity with Saccharomyces DIB1 (Mount and Salz, 2000) U5 snRNP inferred from sequence or structural similarity with NCBI:NP_006692 (Mount and Salz, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dim1 - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Dim1 - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - Df31 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Dim1 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - Inos anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - Moe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - Nlp experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Dim1 - Nsun2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - Sh3β experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Dim1 - Tep4 experimental knowledge based (Guruharsha et al., 2011) Dim1 - capt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - cher anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - eIF-4B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Dim1 - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dim1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59839 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031601 DroID - A comprehensive database of gene and protein interactions. • FBgn0031601 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33645
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W0Z0M Dipteran inclusive ortholog search EOG673Q1P Insect inclusive ortholog search EOG6RBPG6 Arthropod inclusive ortholog search EOG62JM7X Metazoa inclusive ortholog search EOG654NVB
Orthologs in Drosophila Species (EOG6W0Z0M)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dim1     Drosophila simulans   Dsim\GD23285 Y   Drosophila sechellia   Dsec\GM18471 Y   Drosophila erecta   Dere\GG25001 Y   Drosophila yakuba   Dyak\GE18287 Y   Drosophila ananassae   Dana\GF21189 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15896 Y   Drosophila persimilis   Dper\GL15133 Y   Drosophila willistoni   Dwil\GK24348 Y   Drosophila virilis   Dvir\GJ19964 Y   Drosophila mojavensis   Dmoj\GI22095 Y   Drosophila grimshawi   Dgri\GH10125 Y
Orthologs in non-Drosophila Dipterans (EOG673Q1P)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006401   Anopheles gambiae Malaria mosquito  Agam\AGAP008298   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801577
Orthologs in non-Dipteran Insects (EOG6RBPG6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC551974   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010828   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010527   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15357   Atta cephalotes Leafcutter ant  Acep\ACEP12889   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15794   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19645   Linepithema humile Argentine ant  Lhum\LH22937   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25659   Solenopsis invicta Red fire ant  Sinv\SINV17488   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006109   Bombyx mori Silkmoth  Bmor\BGIBMGA009307   Pediculus humanus Human body louse  Phum\PHUM148260   Tribolium castaneum Red flour beetle  Tcas\Txnl4a
Orthologs in non-Insect Arthropods (EOG62JM7X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\amoA   Ixodes scapularis Deer tick  Isca\ISCW018739
Orthologs in non-Arthropod Metazoa (EOG654NVB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002257gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004782gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018588gn   Danio rerio Zebrafish  Drer\CH73-41E3.4   Danio rerio Zebrafish  Drer\txnl4a   Xenopus tropicalis Western clawed frog  Xtro\txnl4a   Xenopus tropicalis Western clawed frog  Xtro\txnl4b   Gallus gallus Domestic chicken  Ggal\TXNL4A   Gallus gallus Domestic chicken  Ggal\TXNL4B   Mus musculus House mouse  Mmus\Txnl4b   Mus musculus House mouse  Mmus\Txnl4a   Rattus norvegicus Norway rat  Rnor\Txnl4b   Rattus norvegicus Norway rat  Rnor\RGD1560212_predicted   Homo sapiens Human  Hsap\TXNL4B   Homo sapiens Human  Hsap\TXNL4A
Human Orthologs (2)
Gene OMIM HGNC Hsap\TXNL4B     Hsap\TXNL4A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23285 Drosophila sechellia Dsec\GM18471 Drosophila erecta Dere\GG25001 Drosophila yakuba Dyak\GE18287 Drosophila ananassae Dana\GF21189 Drosophila pseudoobscura pseudoobscura Dpse\GA15896 Drosophila persimilis Dper\GL15133 Drosophila willistoni Dwil\GK24348 Drosophila virilis Dvir\GJ19964 Drosophila mojavensis Dmoj\GI22095 Drosophila grimshawi Dgri\GH10125
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	18709 w1118; PBac{WH}Dim1f03902
Harvard	- PBac{WH}Dim1f03902
VDRC	v107291 P{KK107558}VIE-260B v21258 w1118; P{GD10115}v21258 v21259 w1118; P{GD10115}v21259
Genomic Clones ( 1 )
	BACR28K16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 6 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE13747
Other clones	DPiM_RE13747
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	Dmel_neb_013826_0194_2660 EC13915 EK115223 FGM220C01
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031601 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33645
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG3058 BcDNA:RE13747 (FlyBase, 1996-)
Additional comments	Source for merge of CG3058 BcDNA:RE13747 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_134986 RefSeq (Proteins) • NP_608830 DDBJ / EMBL / GenBank • AAF51017 AAL48670 AY071048 BI171867 Entrez Gene - A searchable database of RefSeq genes. • 33645 UniProtKB/TrEMBL • Q8SZ87
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • mRNA splicing factor, thioredoxin-like U5 snRNP (IPR004123) Thioredoxin-like fold (IPR012336) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE13747
Linkouts
	BioGRID - A database of protein and genetic interactions • 59839 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031601 DroID - A comprehensive database of gene and protein interactions. • FBgn0031601 DRSC - Results from RNAi screens. • FBgn0031601 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031601 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3058-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031601 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33645 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33645 modMine - Data generated by the modENCODE project. • FBgn0031601
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	BcDNA:RE13747   CG3058 (Goshima et al., 2007, Somma et al., 2008, Keleman et al., 2009.8.5, Herold et al., 2009, Japanese National Institute of Genetics, 2012.5.21) Dim1 (Goshima et al., 2007, Neumüller et al., 2011) U5-15kD (Yoshimura et al., 2006)
Name Synonym	CG3058 (Somma et al., 2008) Dim1
Secondary FlyBase IDs
	FBgn0047167
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...