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Gene Dmel\CG3355

General Information
Symbol	Dmel\CG3355	Species	D. melanogaster
Name		Annotation symbol	CG3355
Feature type	protein_coding_gene	FlyBase ID	FBgn0031619
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25A2-25A2	Sequence location	2L:4,651,403..4,652,877 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG3355 (FBgn0031619). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase activity. It is reported to be involved in the biological process: proteolysis. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase S1/S6, chymotrypsin/Hap; Peptidase S1/S6, chymotrypsin/Hap, active site; Peptidase S1A, chymotrypsin-type; Peptidase cysteine/serine, trypsin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1626903_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG3355. Gene sequence location is 2L:4651403..4652877.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN31428 HFA00598
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25A2-25A2   Limits computationally determined from genome sequence between P{lacW}Tps1k08903&P{EP}morgueEP1184 and P{lacW}l(2)k10004k10004&P{EP}CG3036EP963
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG3355 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Atypical cDNA: retained intron (RE64759). DGC cloneappears problematic [DGC: RE64759 ]: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG3355-RA FBtr0077376  NM_135004   1133   314 CG3355-RB FBtr0100560  NM_164594   1399   216
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG3355-PA   FBpp0077068   34.5   314   9.36     NP_608848   AAF50993 CG3355-PB   FBpp0100012   24.1   216   9.46     NP_723001   AAN10335
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1/S6, chymotrypsin/Hap (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Peptidase cysteine/serine, trypsin-like (IPR009003) Peptidase S1/S6, chymotrypsin/Hap, active site (IPR018114)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF50993   AE014134 AAN10335   AI257533   AI258019   AI258804   AI259139   AI259460   AI260027   AI293812   AI294838   AI296902   AI297646   AY118411 AAM48440   BG639270   BI240352   BI482108   BT125897   CK131437   CK445269   CK656950   CK657294   CK658130   CK658315   CK658434   CK658976   CK659882   CK660385   CK660772   CK661870   EL884497
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MT30 Q9VR15 Q2PDW5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031619    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031619 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed during early larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031619 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2    42933 larva L3 12hr old    8784 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new    7246 white prepupae 12hr    13855 white prepupae 24hr    4391 pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr  (112) embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1  (694) larva L2  (42933) larva L3 12hr old  (8784) larva L3 puffstage 1-2  (196) larva L3 puffstage 3-6  (384) larva L3 puffstage 7-9  (658) white prepupae new  (7246) white prepupae 12hr  (13855) white prepupae 24hr  (4391) pupae 2d postWPP  (987) pupae 3d postWPP  (126) pupae 4d postWPP  (297) adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2  (42933) larva L3 12hr old  (8784) larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new  (7246) white prepupae 12hr  (13855) white prepupae 24hr  (4391) pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2  (42933) larva L3 12hr old    8784 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new    7246 white prepupae 12hr  (13855) white prepupae 24hr    4391 pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2    42933 larva L3 12hr old    8784 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new    7246 white prepupae 12hr    13855 white prepupae 24hr    4391 pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031619 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2    42933 larva L3 12hr old    8784 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new    7246 white prepupae 12hr    13855 white prepupae 24hr    4391 pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr  112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1  (694) larva L2  (42933) larva L3 12hr old  (8784) larva L3 puffstage 1-2  (196) larva L3 puffstage 3-6  (384) larva L3 puffstage 7-9  (658) white prepupae new  (7246) white prepupae 12hr  (13855) white prepupae 24hr  (4391) pupae 2d postWPP  (987) pupae 3d postWPP  126 pupae 4d postWPP  (297) adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2  (42933) larva L3 12hr old  (8784) larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new  (7246) white prepupae 12hr  (13855) white prepupae 24hr  (4391) pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2  (42933) larva L3 12hr old    8784 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new    7246 white prepupae 12hr  13855 white prepupae 24hr    4391 pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    1 embryo 06-08hr    4 embryo 08-10hr    2 embryo 10-12hr    10 embryo 12-14hr    15 embryo 14-16hr    112 embryo 16-18hr    32 embryo 18-20hr    4 embryo 20-22hr    3 embryo 22-24hr    3 larva L1    694 larva L2    42933 larva L3 12hr old    8784 larva L3 puffstage 1-2    196 larva L3 puffstage 3-6    384 larva L3 puffstage 7-9    658 white prepupae new    7246 white prepupae 12hr    13855 white prepupae 24hr    4391 pupae 2d postWPP    987 pupae 3d postWPP    126 pupae 4d postWPP    297 adult male 01day    5 adult male 05day    4 adult male 30day    6 adult female 01day    36 adult female 05day    0 adult female 30day    1 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031619    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031619 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031619 expression level Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031619 expression level Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    4.65 Larval Midgut    1.2 Larval Hindgut    3.2 Larval Malpighian Tubules    1.3 Larval Fat Body no informative data Larval Salivary Gland    2.4 Larval Trachea    77.425 Larval Carcass no informative data Adult Head    1.7 Adult Eye    1.3 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.7 Adult Crop    5.8 Adult Midgut    2.9 Adult Hindgut    1.7 Adult Malpighian Tubules    3.2 Adult Fat Body    5.8 Adult Salivary Gland    6.1 Adult Heart    0.85 Adult VirginFemale Spermatheca    2.5 Adult InseminatedFemale Spermatheca    5.4 Adult Ovary    2.4 Adult Testis    2.3 Adult Male Accessory Gland no informative data Adult Carcass    2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.7   NA  Eye    1.3   NA  Brain    1.9   4.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.7   NA  Crop    5.8   1.2  Midgut    2.9   3.2  Hindgut    1.7   1.3  Malpighian Tubules    3.2   no informative data  Fat Body    5.8   2.4  Salivary Gland    6.1   NA  Heart    0.85   77.425  Trachea    NA   NA  VirginFemale Spermatheca    2.5   NA  InseminatedFemale Spermatheca    5.4   NA  Ovary    2.4   NA  Testis    2.3   NA  Male Accessory Gland    no informative data   no informative data  Carcass    2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031619 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3355-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG3355GD5100 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG3355 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG3355 Class Mutagen Stocks Known lesion CG3355GD5100 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG3355KK111428 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5100} NA P{KK111428} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity inferred from sequence or structural similarity with UniProtKB:P97435 (FlyBase, 1992-) non-traceable author statement (Ross et al., 2003)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 (FlyBase Curators et al., 2004-) non-traceable author statement (Ross et al., 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG3355 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59856 DroID - A comprehensive database of gene and protein interactions. • FBgn0031619 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33667
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21354 Dere\GG25012 Dgri\GH13131 Dmoj\GI22815 Dper\GL14423 Dpse\GA17401 Dsec\GM18483 Dsim\GD23293 Dvir\GJ23363 Dwil\GK23752 Dyak\GE18301
Curated drosophilid orthologs	Dpse\GA17401
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • 57333 Branchiostoma floridae (lancelet) ENSBTAP00000028354 Bos taurus (bovine) 18116 Capitella spl (polychaete worm) 110109 Hypsipyla robusta (cedar shoot borer) 190772 Hypsipyla robusta (cedar shoot borer) ENSMUSP00000110196 Mus musculus (house mouse) 229711 Nematostella vectensis (starlet anemone) ENSPPYP00000011026 Pongo pygmaeus (orangutan) ENSPPYP00000012784 Pongo pygmaeus (orangutan) 79471 Phytophthora ramorum (sudden oak death pathogen) 139137 Phytophthora sojae (root rot pathogen) ENSRNOP00000001540 Rattus norvegicus (norway rat) ENSXETP00000035000 Xenopus tropicalis (frog) ENSXETP00000038951 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235726 FBgn0225714 FBgn0210464 FBgn0194679 FBgn0173390 FBgn0077414 FBgn0152028 FBgn0145542 FBgn0120608 FBgn0117141 FBgn0098356
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v102284 P{KK111428}VIE-260B v13037 w1118; P{GD5100}v13037 v13036 w1118; P{GD5100}v13036/CyO
Genomic Clones ( 1 )
	BACR37J18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE64759
Other clones	MIP25735
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP01735 LP02087 LP02482 LP02877 LP03575 LP03701 LP05934 LP06589 LP07043 LP08305 LP11019 LP11991 LP14283 LP14730 LP15162 LP15348 LP16343 LP17993 LP18922 LP19630 LP21638 LP22825 LP23479 RE37179
Other clones	IP15783
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031619 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33667
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135004 NM_164594 RefSeq (Proteins) • NP_608848 NP_723001 DDBJ / EMBL / GenBank • AAF50993 AAF50993.1 AAM48440 AAN10335 AY118411 BI482108 Entrez Gene - A searchable database of RefSeq genes. • 33667 UniProtKB/TrEMBL • Q2PDW5 Q8MT30 Q9VR15
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1/S6, chymotrypsin/Hap (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Peptidase cysteine/serine, trypsin-like (IPR009003) Peptidase S1/S6, chymotrypsin/Hap, active site (IPR018114)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59856 DroID - A comprehensive database of gene and protein interactions. • FBgn0031619 DRSC - Results from RNAi screens. • FBgn0031619 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031619 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3355-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031619 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33667 InParanoid A subset of ortholog calls from InParanoid. • 57333 Branchiostoma floridae (lancelet) ENSBTAP00000028354 Bos taurus (bovine) 18116 Capitella spl (polychaete worm) 110109 Hypsipyla robusta (cedar shoot borer) 190772 Hypsipyla robusta (cedar shoot borer) ENSMUSP00000110196 Mus musculus (house mouse) 229711 Nematostella vectensis (starlet anemone) ENSPPYP00000011026 Pongo pygmaeus (orangutan) ENSPPYP00000012784 Pongo pygmaeus (orangutan) 79471 Phytophthora ramorum (sudden oak death pathogen) 139137 Phytophthora sojae (root rot pathogen) ENSRNOP00000001540 Rattus norvegicus (norway rat) ENSXETP00000035000 Xenopus tropicalis (frog) ENSXETP00000038951 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33667 modMine - Data generated by the modENCODE project. • FBgn0031619 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0235726 FBgn0225714 FBgn0210464 FBgn0194679 FBgn0173390 FBgn0077414 FBgn0152028 FBgn0145542 FBgn0120608 FBgn0117141 FBgn0098356
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG3355 (Keleman et al., 2009.8.5, Chatterjee et al., 2011) SP21 (Ross et al., 2003)
Name Synonym
Secondary FlyBase IDs
References ( 14 )
Research paper	Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Ross et al., 2003, Gene 304(1-2): 117--131 Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. [FBrf0155784] Zinke et al., 2002, EMBO J. 21(22): 6162--6173 Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. [FBrf0151960]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Gong, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126669]