Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Binds to eIF4E1 using a novel tripartite interface in the C-terminal domain comprising a canonical helix which engages the eIF4E1 dorsal surface, a non-canonical helix which engages the eIF4E1 lateral surface and an auxiliary helix that lies anti-parallel to the canonical helix on the eIF4E1 dorsal surface. The tripartite binding mode compromises its ability to compete with eIF4G1 for binding to eIF4E1 but once bound, the complex is very stable and is resistant to competition by eIF4G1.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mxt using the Feature Mapper tool.
mxt protein is expressed throughout oogenesis with particularly high levels in germline stem cells and cystoblasts. mxt protein is predominantly cytoplasmic but gradually accumulates in the perinuclear nuage. Around stage 8 it disappears from the nuage but remains in nurse cell and oocyte cytoplasm. At this time it increases in follicle cells where it persists into late oogenesis. It is present in both columnar and stretched follicle cells. mxt protein is expressed throughout development on western blots but is only weakly expressed until embryonic stage 8-12.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mxt in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The gene is named "mextli" after the Aztec god of storms and war.