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Gene Dmel\CG3008

General Information
Symbol	Dmel\CG3008	Species	D. melanogaster
Name		Annotation symbol	CG3008
Feature type	protein_coding_gene	FlyBase ID	FBgn0031643
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25B1-25B1	Sequence location	2L:4,883,298..4,885,669 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG3008 (FBgn0031643). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: protein kinase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: protein phosphorylation. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase-like domain; RIO kinase; RIO-like kinase; Serine/threonine-protein kinase Rio3. Summary of modENCODE Temporal Expression Profile: Moderatey high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633622_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG3008. Gene sequence location is 2L:4883298..4885669.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25B1-25B1   Limits computationally determined from genome sequence between P{lacW}l(2)k10004k10004&P{EP}CG3036EP963 and P{PZ}l(2)0571405714
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG3008 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG3008-RA FBtr0077389  NM_135027   2263   603
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG3008-PA   FBpp0077081   69.3   603   4.89     NP_608871   AAF50965
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RIO kinase (IPR000687) Protein kinase-like domain (IPR011009) RIO-like kinase (IPR018934) Serine/threonine-protein kinase Rio3 (IPR017406)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246823   AA820195   AA950238   AA951732   AE014134 AAF50965   AI064290   AY071312 AAL48934   BG632178   BI163475   BI170229   BI236263   BI237559   BI362712   BI485853   BI577380   BI579524   BI580604   BI606604   BI625480   BP545471   BP545472   CA807791   CK135758   CK659055   CO268180   CO271439   CO290515   CO298753   CO298818   CO321767   CO344216   CZ482623   EC058546   EC200368   EC218228   EC220438   EC242287   EC255074   EC255181   EV574847
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VR42
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    157.35 Larval Midgut    125 Larval Hindgut    124.6 Larval Malpighian Tubules    218.5 Larval Fat Body    125.7 Larval Salivary Gland    137.7 Larval Trachea    152.1 Larval Carcass    161.7 Adult Head    136.5 Adult Eye    108.325 Adult Brain    111.9 Adult Thoracic-Abdominal Ganglion    115.3 Adult Crop    161.8 Adult Midgut    135.8 Adult Hindgut    127.2 Adult Malpighian Tubules    167.7 Adult Fat Body    158.9 Adult Salivary Gland    117.6 Adult Heart    162.325 Adult VirginFemale Spermatheca    124 Adult InseminatedFemale Spermatheca    134.6 Adult Ovary    140.6 Adult Testis    54.6 Adult Male Accessory Gland    89.7 Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    136.5   NA  Eye    108.325   NA  Brain    111.9   157.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    115.3   NA  Crop    161.8   125  Midgut    135.8   124.6  Hindgut    127.2   218.5  Malpighian Tubules    167.7   125.7  Fat Body    158.9   137.7  Salivary Gland    117.6   NA  Heart    162.325   152.1  Trachea    NA   NA  VirginFemale Spermatheca    124   NA  InseminatedFemale Spermatheca    134.6   NA  Ovary    140.6   NA  Testis    54.6   NA  Male Accessory Gland    89.7   161.7  Carcass    200.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male    26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    40 digestive system, larvae L3 wandering    35 digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    35 carcass, larvae L3 wandering    28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    41 ovary, mated 4-day female    40 testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male  26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (40) digestive system, larvae L3 wandering  (35) digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8  (35) carcass, larvae L3 wandering  (28) carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female  (41) ovary, mated 4-day female  (40) testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male    26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    40 digestive system, larvae L3 wandering    35 digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    35 carcass, larvae L3 wandering    28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    41 ovary, mated 4-day female    40 testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male    26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    40 digestive system, larvae L3 wandering    35 digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    35 carcass, larvae L3 wandering    28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    41 ovary, mated 4-day female    40 testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male    26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    40 digestive system, larvae L3 wandering    35 digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    35 carcass, larvae L3 wandering    28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    41 ovary, mated 4-day female    40 testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male  26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae  (40) digestive system, larvae L3 wandering  (35) digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8  (35) carcass, larvae L3 wandering  28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female  (41) ovary, mated 4-day female  (40) testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male    26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    40 digestive system, larvae L3 wandering    35 digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    35 carcass, larvae L3 wandering    28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    41 ovary, mated 4-day female    40 testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    25 central nervous system, pupae P8    18 head, virgin 1-day female    19 head, virgin 4-day female    18 head, virgin 20-day female    13 head, mated 1-day female    18 head, mated 4-day female    17 head, mated 20-day female    12 head, mated 1-day male    24 head, mated 4-day male    22 head, mated 20-day male    26 salivary gland, larvae L3 wandering    9 salivary gland, white prepupae    40 digestive system, larvae L3 wandering    35 digestive system, 1-day adult    15 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    24 fat body, pupae P8    35 carcass, larvae L3 wandering    28 carcass, 1-day adult    23 carcass, 4-day adult    20 carcass, 20-day adult    20 ovary, virgin 4-day female    41 ovary, mated 4-day female    40 testis, mated 4-day male    23 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Moderatey high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr    27 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    29 white prepupae 12hr    29 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    24 adult male 30day    28 adult female 01day    29 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (39) embryo 02-04hr  (34) embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr  (27) embryo 10-12hr  (30) embryo 12-14hr    23 embryo 14-16hr  (28) embryo 16-18hr  (29) embryo 18-20hr    24 embryo 20-22hr  26 embryo 22-24hr  (30) larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  (28) white prepupae new  (29) white prepupae 12hr  (29) white prepupae 24hr  (33) pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day  26 adult male 05day    24 adult male 30day  (28) adult female 01day  (29) adult female 05day  (27) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr    27 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    29 white prepupae 12hr    29 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    24 adult male 30day    28 adult female 01day    29 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr    27 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    29 white prepupae 12hr    29 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    24 adult male 30day    28 adult female 01day    29 adult female 05day    27 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr    27 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    29 white prepupae 12hr    29 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    24 adult male 30day    28 adult female 01day    29 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (39) embryo 02-04hr  (34) embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr  27 embryo 10-12hr  30 embryo 12-14hr    23 embryo 14-16hr  28 embryo 16-18hr  29 embryo 18-20hr    24 embryo 20-22hr  26 embryo 22-24hr  30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6  26 larva L3 puffstage 7-9  28 white prepupae new  29 white prepupae 12hr  29 white prepupae 24hr  (33) pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day  26 adult male 05day    24 adult male 30day  28 adult female 01day  29 adult female 05day  27 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr    27 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    29 white prepupae 12hr    29 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    24 adult male 30day    28 adult female 01day    29 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    34 embryo 04-06hr    18 embryo 06-08hr    24 embryo 08-10hr    27 embryo 10-12hr    30 embryo 12-14hr    23 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    24 embryo 20-22hr    26 embryo 22-24hr    30 larva L1    21 larva L2    20 larva L3 12hr old    20 larva L3 puffstage 1-2    19 larva L3 puffstage 3-6    26 larva L3 puffstage 7-9    28 white prepupae new    29 white prepupae 12hr    29 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    19 adult male 01day    26 adult male 05day    24 adult male 30day    28 adult female 01day    29 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    101 Schneider line 2 Sg4    95 embryonic 1182-4H    105 embryonic GM2    110 embryonic Kc167    171 embryonic S1    84 embryonic S3    52 leg disc CME L1    112 wing disc CME-W2    261 wing disc ML-DmD8    100 wing disc ML-DmD9    97 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    109 wing disc ML-DmD32    106 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    164 antennal disc ML-DmD20-c5    147 mixed discs ML-DmD4-c1    110 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    90 ovary fGS/OSS    61 ovary OSC    87 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (101) Schneider line 2 Sg4  (95) embryonic 1182-4H  (105) embryonic GM2  (110) embryonic Kc167  (171) embryonic S1  (84) embryonic S3  (52) leg disc CME L1  (112) wing disc CME-W2  (261) wing disc ML-DmD8  (100) wing disc ML-DmD9  (97) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (109) wing disc ML-DmD32  (106) haltere disc ML-DmD17-c3  (97) eye-antennal disc ML-DmD11  (164) antennal disc ML-DmD20-c5  (147) mixed discs ML-DmD4-c1  (110) CNS ML-DmBG1-c1  (116) CNS ML-DmBG2-c2  (82) tumorous blood cells mbn2  (90) ovary fGS/OSS  (61) ovary OSC  (87) ovary OSS  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  101 Schneider line 2 Sg4    95 embryonic 1182-4H  105 embryonic GM2  (110) embryonic Kc167  (171) embryonic S1    84 embryonic S3    52 leg disc CME L1  (112) wing disc CME-W2  (261) wing disc ML-DmD8    100 wing disc ML-DmD9    97 wing disc ML-DmD16-c3    60 wing disc ML-DmD21  (109) wing disc ML-DmD32  106 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11  (164) antennal disc ML-DmD20-c5  (147) mixed discs ML-DmD4-c1  (110) CNS ML-DmBG1-c1  (116) CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    90 ovary fGS/OSS    61 ovary OSC    87 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    101 Schneider line 2 Sg4    95 embryonic 1182-4H    105 embryonic GM2    110 embryonic Kc167    171 embryonic S1    84 embryonic S3    52 leg disc CME L1    112 wing disc CME-W2    261 wing disc ML-DmD8    100 wing disc ML-DmD9    97 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    109 wing disc ML-DmD32    106 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    164 antennal disc ML-DmD20-c5    147 mixed discs ML-DmD4-c1    110 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    90 ovary fGS/OSS    61 ovary OSC    87 ovary OSS    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    101 Schneider line 2 Sg4    95 embryonic 1182-4H    105 embryonic GM2    110 embryonic Kc167    171 embryonic S1    84 embryonic S3    52 leg disc CME L1    112 wing disc CME-W2    261 wing disc ML-DmD8    100 wing disc ML-DmD9    97 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    109 wing disc ML-DmD32    106 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    164 antennal disc ML-DmD20-c5    147 mixed discs ML-DmD4-c1    110 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    90 ovary fGS/OSS    61 ovary OSC    87 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (101) Schneider line 2 Sg4  (95) embryonic 1182-4H  (105) embryonic GM2  (110) embryonic Kc167  (171) embryonic S1  (84) embryonic S3  (52) leg disc CME L1  (112) wing disc CME-W2  (261) wing disc ML-DmD8  (100) wing disc ML-DmD9  (97) wing disc ML-DmD16-c3  (60) wing disc ML-DmD21  (109) wing disc ML-DmD32  (106) haltere disc ML-DmD17-c3  (97) eye-antennal disc ML-DmD11  (164) antennal disc ML-DmD20-c5  (147) mixed discs ML-DmD4-c1  (110) CNS ML-DmBG1-c1  (116) CNS ML-DmBG2-c2  (82) tumorous blood cells mbn2  (90) ovary fGS/OSS  (61) ovary OSC  (87) ovary OSS  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  101 Schneider line 2 Sg4    95 embryonic 1182-4H  105 embryonic GM2  110 embryonic Kc167  (171) embryonic S1    84 embryonic S3    52 leg disc CME L1  112 wing disc CME-W2  (261) wing disc ML-DmD8    100 wing disc ML-DmD9    97 wing disc ML-DmD16-c3    60 wing disc ML-DmD21  109 wing disc ML-DmD32  106 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11  (164) antennal disc ML-DmD20-c5  (147) mixed discs ML-DmD4-c1  110 CNS ML-DmBG1-c1  116 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    90 ovary fGS/OSS    61 ovary OSC    87 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    101 Schneider line 2 Sg4    95 embryonic 1182-4H    105 embryonic GM2    110 embryonic Kc167    171 embryonic S1    84 embryonic S3    52 leg disc CME L1    112 wing disc CME-W2    261 wing disc ML-DmD8    100 wing disc ML-DmD9    97 wing disc ML-DmD16-c3    60 wing disc ML-DmD21    109 wing disc ML-DmD32    106 haltere disc ML-DmD17-c3    97 eye-antennal disc ML-DmD11    164 antennal disc ML-DmD20-c5    147 mixed discs ML-DmD4-c1    110 CNS ML-DmBG1-c1    116 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    90 ovary fGS/OSS    61 ovary OSC    87 ovary OSS    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    57 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (57) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3  (38) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (50) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (46) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    57 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    57 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    57 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (57) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult  (34) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3  (38) Ethanol 10% 3 hrs, larvae L3  26 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (37) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (50) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (46) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    57 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    19 cold shock, 4-day adult    10 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    21 Cadmium 50 mM 12 hrs, larvae L3    25 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    57 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    15 Zinc 4.5 mM 48 hrs, 4-day adult    34 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    38 Ethanol 10% 3 hrs, larvae L3    26 Caffeine 1.5 mg/ml 4 hrs, larvae L3    37 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    50 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    46 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE33807 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031643 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3008-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG3008 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG3008GD9987 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG3008 Class Mutagen Stocks Known lesion CG3008f00136 piggyBac transposase 1 -- CG3008G18059 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG3008 Class Mutagen Stocks Known lesion CG3008GD9987 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes CG3008GL00217 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3008HM04045 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG3008KK102721 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6010 (Ryder, 2004.4.26) Df(2L)Exel8012 (Ryder, 2004.4.26) Df(2L)Exel9062 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9987} NA P{KK102721} NA P{TRiP.GL00217} NA P{TRiP.HM04045} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Cf2KG05342 NA PBac{WH}CG3008f00136 NA insertion of mobile activating element P{EP}CG3008G18059 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000687, InterPro:IPR017406, InterPro:IPR018934 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Manning, 2002.11.16) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR000687, InterPro:IPR017406 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR017406 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG3008 - Art4 experimental knowledge based (Guruharsha et al., 2011) CG3008 - BI-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Bap60 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG10958 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG11190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG12264 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG12493 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG13630 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG14480 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG15118 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG15625 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG16817 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG17002 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG17029 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG17259 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG1889 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG2017 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG2064 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG3045 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG30491 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG32479 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG32698 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG34159 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG4169 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG5623 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG5792 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG7185 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG7542 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - CG8258 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CG9467 experimental knowledge based (Guruharsha et al., 2011) CG3008 - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Cctγ experimental knowledge based (Guruharsha et al., 2011) CG3008 - Cdc23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Cdk8 experimental knowledge based (Guruharsha et al., 2011) CG3008 - Chc experimental knowledge based (Guruharsha et al., 2011) CG3008 - Cnx99A experimental knowledge based (Guruharsha et al., 2011) CG3008 - Cpr67B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Cyp12d1-p experimental knowledge based (Guruharsha et al., 2011) CG3008 - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Fmo-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Glt experimental knowledge based (Guruharsha et al., 2011) CG3008 - Gp210 experimental knowledge based (Guruharsha et al., 2011) CG3008 - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Jon65Ai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - MED10 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED11 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED14 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED15 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED16 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED17 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED18 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED20 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED23 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED27 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED30 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED4 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED6 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED7 experimental knowledge based (Guruharsha et al., 2011) CG3008 - MED8 experimental knowledge based (Guruharsha et al., 2011) CG3008 - Mcm5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Mpcp experimental knowledge based (Guruharsha et al., 2011) CG3008 - Nacα experimental knowledge based (Guruharsha et al., 2011) CG3008 - Nmdar1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Nup358 experimental knowledge based (Guruharsha et al., 2011) CG3008 - Odc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - OstΔ experimental knowledge based (Guruharsha et al., 2011) CG3008 - Pa1 experimental knowledge based (Guruharsha et al., 2011) CG3008 - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) CG3008 - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Psi experimental knowledge based (Guruharsha et al., 2011) CG3008 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG3008 - RpS10b experimental knowledge based (Guruharsha et al., 2011) CG3008 - Rrp45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Ser7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - Sucb experimental knowledge based (Guruharsha et al., 2011) CG3008 - TER94 experimental knowledge based (Guruharsha et al., 2011) CG3008 - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - alrm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - bl experimental knowledge based (Guruharsha et al., 2011) CG3008 - boca experimental knowledge based (Guruharsha et al., 2011) CG3008 - bor experimental knowledge based (Guruharsha et al., 2011) CG3008 - dsh experimental knowledge based (Guruharsha et al., 2011) CG3008 - ebi experimental knowledge based (Guruharsha et al., 2011) CG3008 - fan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - fh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - ix experimental knowledge based (Guruharsha et al., 2011) CG3008 - l(1)G0156 experimental knowledge based (Guruharsha et al., 2011) CG3008 - phl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - ptip experimental knowledge based (Guruharsha et al., 2011) CG3008 - r experimental knowledge based (Guruharsha et al., 2011) CG3008 - scf experimental knowledge based (Guruharsha et al., 2011) CG3008 - shrb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG3008 - vkg experimental knowledge based (Guruharsha et al., 2011) CG3008 - α-Spec experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG3008 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031643 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33693
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6HDTD4 Dipteran inclusive ortholog search EOG6QC1DR Insect inclusive ortholog search EOG6GB62D Arthropod inclusive ortholog search EOG6B8GV9 Metazoa inclusive ortholog search EOG61VXW6
Orthologs in Drosophila Species (EOG6HDTD4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG3008     Drosophila simulans   Dsim\GD23306 Y   Drosophila sechellia   Dsec\GM18498 Y   Drosophila erecta   Dere\GG25025 Y   Drosophila yakuba   Dyak\GE18314 Y   Drosophila ananassae   Dana\GF23540 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15630 Y   Drosophila persimilis   Dper\GL18640 Y   Drosophila willistoni   Dwil\GK24469 Y   Drosophila virilis   Dvir\GJ16296 Y   Drosophila mojavensis   Dmoj\GI18109 Y   Drosophila grimshawi   Dgri\GH13229 Y
Orthologs in non-Drosophila Dipterans (EOG6QC1DR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009424   Anopheles gambiae Malaria mosquito  Agam\AGAP009993   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801957
Orthologs in non-Dipteran Insects (EOG6GB62D)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Bombyx mori Silkmoth  Bmor\BGIBMGA007413   Tribolium castaneum Red flour beetle  Tcas\TC005306
Orthologs in non-Insect Arthropods (EOG6B8GV9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_211091   Ixodes scapularis Deer tick  Isca\ISCW000554
Orthologs in non-Arthropod Metazoa (EOG61VXW6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\riok-3 Y Caenorhabditis elegans Nematode  Cele\riok-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005063gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002287gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004814gn Y Danio rerio Zebrafish  Drer\riok1 Y Danio rerio Zebrafish  Drer\riok3 Y Xenopus tropicalis Western clawed frog  Xtro\riok1 Y Xenopus tropicalis Western clawed frog  Xtro\riok3 Y Gallus gallus Domestic chicken  Ggal\RIOK3 Y Gallus gallus Domestic chicken  Ggal\RIOK1 Y Mus musculus House mouse  Mmus\Riok1 Y Mus musculus House mouse  Mmus\Riok3 Y Rattus norvegicus Norway rat  Rnor\Riok3 Y Rattus norvegicus Norway rat  Rnor\Riok1 Y Homo sapiens Human  Hsap\RIOK1 Y Homo sapiens Human  Hsap\RIOK3 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\RIOK1     Hsap\RIOK3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23306 Drosophila sechellia Dsec\GM18498 Drosophila erecta Dere\GG25025 Drosophila yakuba Dyak\GE18314 Drosophila ananassae Dana\GF23540 Drosophila pseudoobscura pseudoobscura Dpse\GA15630 Drosophila persimilis Dper\GL18640 Drosophila willistoni Dwil\GK24469 Drosophila virilis Dvir\GJ16296 Drosophila mojavensis Dmoj\GI18109 Drosophila grimshawi Dgri\GH13229
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	31736 y1 v1; P{TRiP.HM04045}attP2 27428 y1 w1118; P{EP}CG3008G18059 35313 y1 sc* v1; P{TRiP.GL00217}attP2
Harvard	- PBac{WH}CG3008f00136
VDRC	v103828 P{KK102721}VIE-260B v43732 w1118; P{GD9987}v43732 v52634 w1118; P{GD9987}v52634 v43731 w1118; P{GD9987}v43731/TM3
Genomic Clones ( 1 )
	BACR40I04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE33807
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04658 GH04739 LD05812 LD28721 LD32425 LP16505 RE02877 RE11620 RE32296 RE47353 RE69203 RE71047 RE73570 RE74820 RH73206
Other clones	Dmel_dig_011607_0651_3129 EK074216 EK090459 EK103436 EK173806 EK173925 EK186334 EP18856 ESG019c.E21_E02 FGC031E03 LD23681 RH65914
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031643 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33693
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135027 RefSeq (Proteins) • NP_608871 DDBJ / EMBL / GenBank • AAF50965 AAL48934 AY071312 BI237559 CZ482623 Entrez Gene - A searchable database of RefSeq genes. • 33693 UniProtKB/TrEMBL • Q9VR42
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RIO kinase (IPR000687) Protein kinase-like domain (IPR011009) RIO-like kinase (IPR018934) Serine/threonine-protein kinase Rio3 (IPR017406) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE33807
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031643 DRSC - Results from RNAi screens. • FBgn0031643 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031643 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3008-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031643 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33693 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33693 modMine - Data generated by the modENCODE project. • FBgn0031643
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG3008 (Gruenewald et al., 2009, Akdemir et al., 2007, Keleman et al., 2009.8.5, Brandt, 2006, Ni et al., 2008, Ni et al., 2011.7.19, Pflieger et al., 2008)
Name Synonym
Secondary FlyBase IDs
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Antosh et al., 2011, Aging 3(6): 576--583 New comparative genomics approach reveals a conserved health span signature across species. [FBrf0216594] Show all research papers ...