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Gene Dmel\jet

General Information
Symbol	Dmel\jet	Species	D. melanogaster
Name	jetlag	Annotation symbol	CG8873
Feature type	protein_coding_gene	FlyBase ID	FBgn0031652
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25B4-25B4	Sequence location	2L:4,948,202..4,949,751 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene jetlag is referred to in FlyBase by the symbol Dmel\jet (CG8873, FBgn0031652). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: circadian behavior; locomotor rhythm; entrainment of circadian clock by photoperiod. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: F-box domain, cyclin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1635474_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of jet. Gene sequence location is 2L:4948202..4949751.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN28329 HFA03116
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25B4-25B4   Limits computationally determined from genome sequence between P{lacW}l(2)k10004k10004&P{EP}CG3036EP963 and P{PZ}l(2)0571405714
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\jet for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) jet-RA FBtr0079057  NM_135036   1424   319 jet-RB FBtr0110896  NM_001042867   1212   313
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein jet-PA   FBpp0078693   36.1   319   8.21     NP_608880   AAF52178 jet-PB   FBpp0110196   35.1   313   8.21     NP_001036332   ABI31287
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • F-box domain, cyclin-like (IPR001810)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263998   AE014134 AAF52178   AE014134 ABI31287   AW941640   AY069367 AAL39512   BI483613   BI570277   BI590183   BT044179   CO326840   EC051352   EC223226   EC254443   FD586371   FD587125   GH741986   GH745377   GH768882   GH779720
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8T0E8 Q9VMY0 Q0E8T8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031652    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031652 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031652 expression level Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1104) embryo 02-04hr  (499) embryo 04-06hr  (903) embryo 06-08hr  (752) embryo 08-10hr  (739) embryo 10-12hr  (894) embryo 12-14hr  (514) embryo 14-16hr  (726) embryo 16-18hr  (679) embryo 18-20hr  (840) embryo 20-22hr  (564) embryo 22-24hr  (656) larva L1  (557) larva L2  (405) larva L3 12hr old  (385) larva L3 puffstage 1-2  (362) larva L3 puffstage 3-6  (406) larva L3 puffstage 7-9  (409) white prepupae new  (358) white prepupae 12hr  (696) white prepupae 24hr  (506) pupae 2d postWPP  (534) pupae 3d postWPP  (493) pupae 4d postWPP  (1050) adult male 01day  (804) adult male 05day  (793) adult male 30day  (884) adult female 01day  (949) adult female 05day  (751) adult female 30day  (766) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031652 expression level Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1104) embryo 02-04hr  (499) embryo 04-06hr  (903) embryo 06-08hr  (752) embryo 08-10hr  (739) embryo 10-12hr  (894) embryo 12-14hr  (514) embryo 14-16hr  (726) embryo 16-18hr  (679) embryo 18-20hr  (840) embryo 20-22hr  (564) embryo 22-24hr  (656) larva L1  (557) larva L2  (405) larva L3 12hr old  (385) larva L3 puffstage 1-2  (362) larva L3 puffstage 3-6  (406) larva L3 puffstage 7-9  (409) white prepupae new  (358) white prepupae 12hr  (696) white prepupae 24hr  (506) pupae 2d postWPP  (534) pupae 3d postWPP  (493) pupae 4d postWPP  (1050) adult male 01day  (804) adult male 05day  (793) adult male 30day  (884) adult female 01day  (949) adult female 05day  (751) adult female 30day  (766) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1104 embryo 02-04hr    499 embryo 04-06hr    903 embryo 06-08hr    752 embryo 08-10hr    739 embryo 10-12hr    894 embryo 12-14hr    514 embryo 14-16hr    726 embryo 16-18hr    679 embryo 18-20hr    840 embryo 20-22hr    564 embryo 22-24hr    656 larva L1    557 larva L2    405 larva L3 12hr old    385 larva L3 puffstage 1-2    362 larva L3 puffstage 3-6    406 larva L3 puffstage 7-9    409 white prepupae new    358 white prepupae 12hr    696 white prepupae 24hr    506 pupae 2d postWPP    534 pupae 3d postWPP    493 pupae 4d postWPP    1050 adult male 01day    804 adult male 05day    793 adult male 30day    884 adult female 01day    949 adult female 05day    751 adult female 30day    766 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031652    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031652 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031652 expression level Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031652 expression level Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    18.275 Larval Midgut    31.3 Larval Hindgut    19 Larval Malpighian Tubules    25.3 Larval Fat Body no informative data Larval Salivary Gland    22.5 Larval Trachea    21.4 Larval Carcass    7.95 Adult Head    30.9 Adult Eye    56.55 Adult Brain    32.2 Adult Thoracic-Abdominal Ganglion    25.6 Adult Crop    33.6 Adult Midgut    34.6 Adult Hindgut    30.7 Adult Malpighian Tubules    39.2 Adult Fat Body    31.8 Adult Salivary Gland    89.1 Adult Heart    23.875 Adult VirginFemale Spermatheca    34.1 Adult InseminatedFemale Spermatheca    29.9 Adult Ovary    33.7 Adult Testis no informative data Adult Male Accessory Gland    52.6 Adult Carcass    45.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    30.9   NA  Eye    56.55   NA  Brain    32.2   18.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25.6   NA  Crop    33.6   31.3  Midgut    34.6   19  Hindgut    30.7   25.3  Malpighian Tubules    39.2   no informative data  Fat Body    31.8   22.5  Salivary Gland    89.1   NA  Heart    23.875   21.4  Trachea    NA   NA  VirginFemale Spermatheca    34.1   NA  InseminatedFemale Spermatheca    29.9   NA  Ovary    33.7   NA  Testis    no informative data   NA  Male Accessory Gland    52.6   7.95  Carcass    45.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031652 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8873-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 jetGD14053 Other Phenotypes Allele photoperiod response variant jetc jetr Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of jet Class Mutagen Stocks Known lesion jetc spontaneous 1 Yes jetr spontaneous 1 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of jet Class Mutagen Stocks Known lesion jetGD14053 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes jetJF01506 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes jetKK108329 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes jetScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes jetT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC51 (Koh et al., 2006) Df(2L)Exel7021 (Ryder, 2004.4.26, Koh et al., 2006) Df(2L)Exel8012 (Ryder, 2004.4.26, Koh et al., 2006) Df(2L)sc19-1 (Koh et al., 2006) Df(2L)sc19-6 (Koh et al., 2006) Df(2L)sc19-7 (Koh et al., 2006) Df(2L)sc19-8 (Koh et al., 2006) Df(2L)sc19-10 (Koh et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14053} NA P{KK108329} NA P{TRiP.JF01506} NA P{UAS-jet.K} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
circadian behavior inferred from mutant phenotype (Koh et al., 2007) entrainment of circadian clock by photoperiod inferred from mutant phenotype (Koh et al., 2007, Koh et al., 2006) locomotor rhythm inferred from genetic interaction with tim (Peschel et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions jet allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031652 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33705
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21540 Dere\GG24339 Dgri\GH13593 Dmoj\GI23602 Dper\GL19490 Dpse\GA21382 Dsec\GM18060 Dsim\GD22679 Dvir\GJ20797 Dwil\GK24586 Dyak\GE18718
Curated drosophilid orthologs	Dpse\GA21382
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012126-PA Aedes aegypti (mosquito) AGAP009335-PA Anopheles gambiae (mosquito) 256698 Branchiostoma floridae (lancelet) 71474 Branchiostoma floridae (lancelet) XP_001893732.1 Brugia malayi (roundworm nematode) BGIBMGA007348-PA Bombyx mori (silk worm) ENSBTAP00000003249 Bos taurus (bovine) ENSCAFP00000014945 Canis familiaris (dog) ENSCINP00000027601 Ciona intestinalis (sea squirt) CPIJ015883 Culex pipens (mosquito) ENSCPOP00000015935 Cavia porcellus (guinea pig) ENSCSAVP00000019093 Ciona savignyi (sedentary tunicate) 118503 Capitella spl (polychaete worm) 315868 Daphnia pulex (daphnia) ENSDARP00000018234 Danio rerio (zebra fish) ENSECAP00000000406 Equus caballus (horse) ENSGACP00000003170 Gymnopilus aculeatus (mushroom) ENSGALP00000009102 Gallus gallus (chicken) ENSP00000358970 Homo sapiens (human) 207352 Lottia gigantea (owl limpet) ENSMODP00000014117 Monodelphis domestica (gray opossum) ENSMMUP00000004006 Macaca mulatta (rhesus monkey) ENSMUSP00000026256 Mus musculus (house mouse) 215872 Nematostella vectensis (starlet anemone) XP_001598990.1 Nasonia vitripennis (wasp) ENSOANP00000003152 Ornithorynchus anatinus (platypus) ENSORLP00000011671 Oryzias latipes (japanese killifish) ENSPPYP00000003025 Pongo pygmaeus (orangutan) 416255 Populus trichocarpa (black cottonwood) ENSPTRP00000050319 Pan troglodytes (chimpanzee) ENSRNOP00000026471 Rattus norvegicus (norway rat) 24236 Trichoplax adhaerens (metazoa) ENSTNIP00000022604 Tetraodon nigroviridis (green spotted pufferfish) 261556 Thalassiosira pseudonana (marine diatom) ENSTRUP00000030828 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000031072 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236112 FBgn0226546 FBgn0207934 FBgn0194076 FBgn0172967 JGI_V11_315868 FBgn0081370 FBgn0157089 FBgn0146328 FBgn0121069 FBgn0116471 FBgn0098540 CPIJ015883 BGIBMGA007348 AGAP009335 AAEL012126
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	27641 y1 w*; jetr 27642 y1 w*; jetc 31058 y1 v1; P{TRiP.JF01506}attP2
VDRC	v104399 P{KK108329}VIE-260B v45618 w1118 P{GD14053}v45618
Genomic Clones ( 2 )
	BACR13M11 BACR40I04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 13 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD07444
Other clones	FI04015
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE66530 RH02570 RH03767
Other clones	EC051352 EP04732 RM01392 RM01792 RP001004817 RP001008518 RP001052423 RP001056370
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031652 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33705
Antibody Information
Other Information
Discoverer
Etymology
	Named "jetlag" because mutants take longer to re-entrain to a new schedule than wild-type flies. (Koh et al., 2006)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: jet CG8873 (Koh et al., 2006)
Source for database merge of
Additional comments
Other Comments
	The jet product physically associates with the tim protein, and the association is stronger in light than in dark. (Koh et al., 2007) Encodes an F-box protein with leucine-rich repeats. (Koh et al., 2007) Mutations in jet result in reduced light sensitivity of the circadian clock: mutant flies show rhythmic behavior in constant light, reduced phase shifts in response to light pulses, and reduced light-dependent degradation of tim protein. (Koh et al., 2007) jet is required for light-induced degradation of the tim protein. (Koh et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135036 NM_001042867 RefSeq (Proteins) • NP_608880 NP_001036332 DDBJ / EMBL / GenBank • AA263998 AAF52178 AAF52178.2 AAL39512 ABI31287 AW941640 AY069367 Entrez Gene - A searchable database of RefSeq genes. • 33705 UniProtKB/TrEMBL • Q0E8T8 Q8T0E8 Q9VMY0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • F-box domain, cyclin-like (IPR001810)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031652 DRSC - Results from RNAi screens. • FBgn0031652 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031652 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8873-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031652 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 432457 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33705 InParanoid A subset of ortholog calls from InParanoid. • AAEL012126-PA Aedes aegypti (mosquito) AGAP009335-PA Anopheles gambiae (mosquito) 256698 Branchiostoma floridae (lancelet) 71474 Branchiostoma floridae (lancelet) XP_001893732.1 Brugia malayi (roundworm nematode) BGIBMGA007348-PA Bombyx mori (silk worm) ENSBTAP00000003249 Bos taurus (bovine) ENSCAFP00000014945 Canis familiaris (dog) ENSCINP00000027601 Ciona intestinalis (sea squirt) CPIJ015883 Culex pipens (mosquito) ENSCPOP00000015935 Cavia porcellus (guinea pig) ENSCSAVP00000019093 Ciona savignyi (sedentary tunicate) 118503 Capitella spl (polychaete worm) 315868 Daphnia pulex (daphnia) ENSDARP00000018234 Danio rerio (zebra fish) ENSECAP00000000406 Equus caballus (horse) ENSGACP00000003170 Gymnopilus aculeatus (mushroom) ENSGALP00000009102 Gallus gallus (chicken) ENSP00000358970 Homo sapiens (human) 207352 Lottia gigantea (owl limpet) ENSMODP00000014117 Monodelphis domestica (gray opossum) ENSMMUP00000004006 Macaca mulatta (rhesus monkey) ENSMUSP00000026256 Mus musculus (house mouse) 215872 Nematostella vectensis (starlet anemone) XP_001598990.1 Nasonia vitripennis (wasp) ENSOANP00000003152 Ornithorynchus anatinus (platypus) ENSORLP00000011671 Oryzias latipes (japanese killifish) ENSPPYP00000003025 Pongo pygmaeus (orangutan) 416255 Populus trichocarpa (black cottonwood) ENSPTRP00000050319 Pan troglodytes (chimpanzee) ENSRNOP00000026471 Rattus norvegicus (norway rat) 24236 Trichoplax adhaerens (metazoa) ENSTNIP00000022604 Tetraodon nigroviridis (green spotted pufferfish) 261556 Thalassiosira pseudonana (marine diatom) ENSTRUP00000030828 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000031072 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/jetlag.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33705 modMine - Data generated by the modENCODE project. • FBgn0031652 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236112 FBgn0226546 FBgn0207934 FBgn0194076 FBgn0172967 JGI_V11_315868 FBgn0081370 FBgn0157089 FBgn0146328 FBgn0121069 FBgn0116471 FBgn0098540 CPIJ015883 BGIBMGA007348 AGAP009335 AAEL012126
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG8873 (Koh et al., 2006, Koh et al., 2006, Peschel et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2008) jet (Koh et al., 2007, Koh et al., 2006, Van, 2006, Chen et al., 2011, Dolezelova et al., 2007, Knowles et al., 2009, Peschel et al., 2009, Sathyanarayanan et al., 2008, Yang et al., 2008, Dubruille et al., 2009, Tang et al., 2010) JET (Koh et al., 2007, Knowles et al., 2009)
Name Synonym	CG8873   jetlag (Koh et al., 2007, Koh et al., 2006, Peschel et al., 2006, Van, 2006, Dolezelova et al., 2007, Peschel et al., 2009) JETLAG (Koh et al., 2007) Jetlag (Knowles et al., 2009, Tang et al., 2010)
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Chen et al., 2011, Curr. Biol. 21(9): 719--729 QUASIMODO, a Novel GPI-Anchored Zona Pellucida Protein Involved in Light Input to the Drosophila Circadian Clock. [FBrf0213611] Tang et al., 2010, Neuron 66(3): 378--385 Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. [FBrf0210785] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...