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Gene Dmel\Marcal1

General Information
Symbol	Dmel\Marcal1	Species	D. melanogaster
Name	Marcal1	Annotation symbol	CG3753
Feature type	protein_coding_gene	FlyBase ID	FBgn0031655
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25B4-25B4	Sequence location	2L:4,955,519..4,958,292 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Marcal1 is referred to in FlyBase by the symbol Dmel\Marcal1 (CG3753, FBgn0031655). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: helicase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: chromatin modification. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: DEAD-like helicase; Helicase, C-terminal; HepA-related; SNF2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626531_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Marcal1. Gene sequence location is 2L:4955519..4958292.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA02718 BKN20240
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25B4-25B4   Limits computationally determined from genome sequence between P{lacW}l(2)k10004k10004&P{EP}CG3036EP963 and P{PZ}l(2)0571405714
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Marcal1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST data suggest additional 5' exon
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Marcal1-RA FBtr0078992  NM_135039   2401   755
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Marcal1-PA   FBpp0078631   84.6   755   9.38     NP_608883   AAF52182
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) Helicase, C-terminal (IPR001650) HepA-related (IPR010003) DEAD-like helicase (IPR014001)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246841   AE014134 AAF52182   AI108613   AI108869   BI243213   BI243477   BI358134   BI483980   BI485941   BI486003   BT011033   CL528263   CO183840   CO194141   CO194740   CO269046   CO287607   EC197203   EV581339   GH748123   GH749466   GH749841   GH750306   GH751310   GH754997   GH755104   GH756576   GH758999   GH760493   GH774010   GH775439   GH775474   GH775758   GH777878   GH780207   GH781150   GH782059   GH785673   GH786051   GH786235   GH786763   GH787257   GH790195   GH790977   GH791854   GH792273   GH796588   GH796858   GH797551   GH797632   GH798140   GH799406   GH799535   GH799695   GH799894   GH802015   GH802613   GH806543   GH808526   GH809378   GH812761   GH814002   GH815003   GH815124   GH816692   GH818223   GH818353   GH818388   GH818669   GH819188   GH819254   GH819884   GH820176   GH820804   GH820976   GH821525   GH823620   GH824848   GH824955   GH825160   GH826224   GH828269   GH828392   GH828631   GH830401   GH831870   GH835151   GH836978   GH839607   GH839896   GH842204   GH842779   GH843254   GH843389   GH843844   GH844024   GH844450   GH846051   GH852020   GH852763   GH853371   GH853867   GH857646   GH859861   GH859948   GH861682   GH862629   GH863736   GH864308   GH864523   GH864830   GH866032   GH869904   GH870153   GH872662   GH873527   GH873856   GH874291   GH877584   GH878179   GH879123   GH881554   GH883477   GH885034   GH885668   GH885770   GH886317   GH886481   GH887143   GH888418   GH889382   GH889547   GH890259   GH891432   GH892947   GH893248   GH895391   GH895823   GH898703   GH900838   GH902901   GH904705   GH904995   GH906015   GH906663   GH907025   GH907286   GH907452   GH907563   GH908360   GH912881   GH914412   GH917379   GH917779   GH918125   GH918690   GH919236   GH919519   GH921702   GH921789   GH923675   GH924078   GH924194   GH925005   GH925139   GH925572   GH928536   GH928798   GH929485   GH929682   GH930693   GH932702   GH933088   GH933503   GH935572   GH935738   GH937999   GH938295   GH940008
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMX6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031655    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031655 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031655 expression level Developmental Stage   Expression Level embryo 00-02hr    1862 embryo 02-04hr    1019 embryo 04-06hr    2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1862) embryo 02-04hr  (1019) embryo 04-06hr  (2077) embryo 06-08hr  (1316) embryo 08-10hr  (671) embryo 10-12hr  (322) embryo 12-14hr  (169) embryo 14-16hr  (118) embryo 16-18hr  (111) embryo 18-20hr  105 embryo 20-22hr    83 embryo 22-24hr  (109) larva L1  (190) larva L2  (141) larva L3 12hr old  (111) larva L3 puffstage 1-2  (184) larva L3 puffstage 3-6  (253) larva L3 puffstage 7-9  (290) white prepupae new  (268) white prepupae 12hr  (314) white prepupae 24hr  (384) pupae 2d postWPP  (295) pupae 3d postWPP  (219) pupae 4d postWPP  (165) adult male 01day  (286) adult male 05day  (375) adult male 30day  (345) adult female 01day  (451) adult female 05day  (1106) adult female 30day  (1095) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1862) embryo 02-04hr    1019 embryo 04-06hr  (2077) embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1862 embryo 02-04hr    1019 embryo 04-06hr    2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1862 embryo 02-04hr    1019 embryo 04-06hr    2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031655 expression level Developmental Stage   Expression Level embryo 00-02hr    1862 embryo 02-04hr    1019 embryo 04-06hr    2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1862) embryo 02-04hr  (1019) embryo 04-06hr  (2077) embryo 06-08hr  (1316) embryo 08-10hr  (671) embryo 10-12hr  (322) embryo 12-14hr  (169) embryo 14-16hr  118 embryo 16-18hr  111 embryo 18-20hr  105 embryo 20-22hr    83 embryo 22-24hr  109 larva L1  (190) larva L2  141 larva L3 12hr old  111 larva L3 puffstage 1-2  (184) larva L3 puffstage 3-6  (253) larva L3 puffstage 7-9  (290) white prepupae new  (268) white prepupae 12hr  (314) white prepupae 24hr  (384) pupae 2d postWPP  (295) pupae 3d postWPP  (219) pupae 4d postWPP  (165) adult male 01day  (286) adult male 05day  (375) adult male 30day  (345) adult female 01day  (451) adult female 05day  (1106) adult female 30day  (1095) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1862 embryo 02-04hr    1019 embryo 04-06hr  2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1862 embryo 02-04hr    1019 embryo 04-06hr    2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1862 embryo 02-04hr    1019 embryo 04-06hr    2077 embryo 06-08hr    1316 embryo 08-10hr    671 embryo 10-12hr    322 embryo 12-14hr    169 embryo 14-16hr    118 embryo 16-18hr    111 embryo 18-20hr    105 embryo 20-22hr    83 embryo 22-24hr    109 larva L1    190 larva L2    141 larva L3 12hr old    111 larva L3 puffstage 1-2    184 larva L3 puffstage 3-6    253 larva L3 puffstage 7-9    290 white prepupae new    268 white prepupae 12hr    314 white prepupae 24hr    384 pupae 2d postWPP    295 pupae 3d postWPP    219 pupae 4d postWPP    165 adult male 01day    286 adult male 05day    375 adult male 30day    345 adult female 01day    451 adult female 05day    1106 adult female 30day    1095 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031655    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031655 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031655 expression level Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031655 expression level Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    51.4 Larval Midgut    3.9 Larval Hindgut    22.1 Larval Malpighian Tubules    34.8 Larval Fat Body    22.6 Larval Salivary Gland    9.1 Larval Trachea    23.775 Larval Carcass no informative data Adult Head no informative data Adult Eye    12.675 Adult Brain    22.3 Adult Thoracic-Abdominal Ganglion    25.4 Adult Crop    29.1 Adult Midgut no informative data Adult Hindgut    21 Adult Malpighian Tubules    26.4 Adult Fat Body    20.5 Adult Salivary Gland no informative data Adult Heart    13.325 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    150.6 Adult Testis    47.1 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    12.675   NA  Brain    22.3   51.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    25.4   NA  Crop    29.1   3.9  Midgut    no informative data   22.1  Hindgut    21   34.8  Malpighian Tubules    26.4   22.6  Fat Body    20.5   9.1  Salivary Gland    no informative data   NA  Heart    13.325   23.775  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    22.2   NA  Ovary    150.6   NA  Testis    47.1   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031655 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3753-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Marcal1GD11065 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Marcal1GD11065 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Marcal1GD11065
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Marcal1 Class Mutagen Stocks Known lesion Marcal1f05123 1 Yes Marcal1KG09850 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Marcal1 Class Mutagen Stocks Known lesion Marcal1GD11065 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Marcal1HMS00587 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7021 (Ryder, 2004.4.26) Df(2L)Exel8012 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11065} NA P{TRiP.HMS00587} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Marcal1KG09850 NA PBac{WH}Marcal1f05123 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000330, InterPro:IPR001650, InterPro:IPR010003 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR000330 (FlyBase Curators et al., 2004-) helicase activity inferred from sequence or structural similarity with EMBL:U41534 (FlyBase, 1992-)
Biological Process
CV term Evidence References
chromatin modification inferred from electronic annotation with InterPro:IPR010003 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR010003 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Marcal1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031655 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33709
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23602 Dere\GG25032 Dgri\GH11691 Dmoj\GI17136 Dper\GL26533 Dpse\GA17662 Dsec\GM18506 Dsim\GD23310 Dvir\GJ16178 Dwil\GK24475 Dyak\GE11268
Curated drosophilid orthologs	Dpse\GA17662
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006963-PA Aedes aegypti (mosquito) AGAP008426-PA Anopheles gambiae (mosquito) XP_624010.2 Apis mellifera (honey bee) XP_001945056.1 Acyrthosiphon pisum (pea aphid) At1g48310.1 Arabidopsis thaliana (wall cress) 184347 Branchiostoma floridae (lancelet) 236966 Branchiostoma floridae (lancelet) XP_001900899.1 Brugia malayi (roundworm nematode) BGIBMGA009112-PA Bombyx mori (silk worm) ENSBTAP00000005013 Bos taurus (bovine) CE30606 Caenorhabditis elegans (worm) ENSCAFP00000021329 Canis familiaris (dog) ENSCINP00000018923 Ciona intestinalis (sea squirt) JA06530 Caenorhabditis japonica (nematode) CMR070C Cyanidioschyzon merolae (red alga) CPIJ015879 Culex pipens (mosquito) ENSCPOP00000011002 Cavia porcellus (guinea pig) 172906 Chlamidomonas reinhardtii (green alga) RP01162 Caenorhabditis remanei (nematode) ENSCSAVP00000010962 Ciona savignyi (sedentary tunicate) 109109 Capitella spl (polychaete worm) DDB0214904 Dictyostelium discoideum (amoeba) ENSECAP00000005977 Equus caballus (horse) ENSGACP00000008040 Gymnopilus aculeatus (mushroom) ENSGALP00000018686 Gallus gallus (chicken) 194392 Hypsipyla robusta (cedar shoot borer) ENSP00000349823 Homo sapiens (human) ISCW023702-PA Ixodes scapularis (deer tick) 138707 Lottia gigantea (owl limpet) 9161 Monocosta brevicollis (choanoflagellate) ENSMODP00000019401 Monodelphis domestica (gray opossum) ENSMMUP00000025671 Macaca mulatta (rhesus monkey) ENSMUSP00000047589 Mus musculus (house mouse) 80671 Nematostella vectensis (starlet anemone) ENSORLP00000020604 Oryzias latipes (japanese killifish) LOC_Os07g44210.1 Oryza sativa (asian rice) 26819 Ostreococcus tauri (green alga) PF13_0308 Plasmodium falciparum (protozoal parasite) PHUM001242-PA Pediculus humanus (human body louse) 107791 Physcomitrella patens (moss) ENSPPYP00000014699 Pongo pygmaeus (orangutan) 228966 Populus trichocarpa (black cottonwood) ENSPTRP00000040756 Pan troglodytes (chimpanzee) PVX_114850 Plasmodium vivax (protozoal parasite) ENSRNOP00000022459 Rattus norvegicus (norway rat) 5052111 Sorghum bicolor (sorghum) Smp_131000 Schistosoma mansoni (trematode parasite) XP_967843.1 Tribolium castaneum (red flour beetle) Tc00.1047053504131.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019566 Tetraodon nigroviridis (green spotted pufferfish) TP04_0886 Theileria parva (parasitic protozoan) 263934 Thalassiosira pseudonana (marine diatom) ENSTRUP00000026994 Takifugu rubripes (pufferfish Takifugu) 3822.m00632 Tetrahymena thermophila (ciliate protozoa) 86647.m00167 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000000989 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13257 NV24466 NV19220 LH13530 ISCW023702 FBgn0229087 FBgn0226435 FBgn0203363 FBgn0194696 FBgn0173413 JGI_V11_232046 FBgn0077673 FBgn0164115 FBgn0139880 FBgn0119171 FBgn0117161 FBgn0100596 CPIJ015879 BGIBMGA009112 ACYPI000862 GB17968 AGAP008426 AAEL006963 PHUM440690 GLEAN_05426
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	16492 y1; P{SUPor-P}Marcal1KG09850/CyO 33709 y1 sc* v1; P{TRiP.HMS00587}attP2
Harvard	- PBac{WH}Marcal1f05123
VDRC	v34701 w1118; P{GD11065}v34701 v34702 w1118; P{GD11065}v34702/CyO
Genomic Clones ( 2 )
	BACR13M11 BACR40I04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 175 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE44811
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH07814 GH08172 LD05865 RE40780 RE41131 RE66975 RE69305 RE69368
Other clones	Dmel_dig_008832_0650_1867 EC26515 EC37515 EC39147 EK066301 EK093430 RP003010116 RP003022763 RP003030297 RP003033347 RP003038071 RP003039163 RP003048452 RP003058355 RP003061705 RP003071330 RP003075247 RP003076388 RP003084583 RP003089490 RP003091410 RP003105387 RP003108668 RP003116908 RP003119579 RP003121771 RP003122523 RP003123314 RP003123507 RP003125372 RP003129802 RP003133572 RP003138034 RP003143228 RP003143863 RP003153462 RP003158878 RP003160201 RP003160687 RP003162019 RP003164871 RP003176725 RP003179036 RP003182545 RP003190041 RP003200166 RP003201108 RP003202721 RP003207412 RP003208779 RP003209043 RP003209548 RP003211981 RP003215348 RP003218394 RP003218618 RP003224355 RP003225542 RP003226487 RP003227169 RP003233958 RP003235814 RP003245419 RP003253249 RP003259104 RP003260734 RP003262110 RP003263103 RP003266484 RP003266801 RP003269329 RP003271139 RP003273055 RP003281291 RP003282728 RP003284608 RP003287120 RP003287206 RP003293202 RP003297494 RP003300651 RP003306008 RP003306928 RP003307686 RP003311775 RP003316835 RP003319348 RP003319589 RP003321566 RP003332061 RP003333239 RP003335269 RP003342654 RP003347942 RP003348648 RP003356422 RP003357731 RP003358161 RP003358634 RP003370921 RP003375024 RP003385563 RP003395156 RP003404489 RP003409959 RP003415132 RP003418393 RP003424131 RP003427124 RP003433196 RP003437640 RP003442057 RP003444556 RP003445603 RP003455881 RP003464597 RP003473107 RP003484708 RP003486126 RP003494391 RP003497193 RP003499654 RP003499689 RP003503387 RP003505583 RP003506929 RP003508636 RP003510831 RP003515237 RP003516885 RP003521825 RP003523658 RP003527821 RP003538389 RP003541839 RP003551031 RP003558086 RP003561966 RP003565745 RP003569211 RP003570628 RP003571214 RP003573188 RP003574599 RP003576666 RP003577327 RP003578628 RP003586051 RP003594210 RP003595466 RP003595757 RP003597324 RP003597948 RP003607211 RP003608342 RP003610437 RP003618603 RP003618854 RP003621161 RP003624634 RP003631009 RP003645053 RP003647839 RP003649902 RP003660746 RP003664229
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031655 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33709
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Mutants show reduced egg laying and hatching implying that Marcal1 acts as a maternal component. In addition, mutants have an abnormal eye structure and temperature-sensitive sterility and lethality. (Cho et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135039 RefSeq (Proteins) • NP_608883 DDBJ / EMBL / GenBank • AAF52182 AAF52182.2 BI358134 CL528263 Entrez Gene - A searchable database of RefSeq genes. • 33709 UniProtKB/TrEMBL • Q9VMX6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SNF2-related (IPR000330) Helicase, C-terminal (IPR001650) HepA-related (IPR010003) DEAD-like helicase (IPR014001)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031655 DRSC - Results from RNAi screens. • FBgn0031655 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031655 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3753-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031655 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33709 InParanoid A subset of ortholog calls from InParanoid. • AAEL006963-PA Aedes aegypti (mosquito) AGAP008426-PA Anopheles gambiae (mosquito) XP_624010.2 Apis mellifera (honey bee) XP_001945056.1 Acyrthosiphon pisum (pea aphid) At1g48310.1 Arabidopsis thaliana (wall cress) 184347 Branchiostoma floridae (lancelet) 236966 Branchiostoma floridae (lancelet) XP_001900899.1 Brugia malayi (roundworm nematode) BGIBMGA009112-PA Bombyx mori (silk worm) ENSBTAP00000005013 Bos taurus (bovine) CE30606 Caenorhabditis elegans (worm) ENSCAFP00000021329 Canis familiaris (dog) ENSCINP00000018923 Ciona intestinalis (sea squirt) JA06530 Caenorhabditis japonica (nematode) CMR070C Cyanidioschyzon merolae (red alga) CPIJ015879 Culex pipens (mosquito) ENSCPOP00000011002 Cavia porcellus (guinea pig) 172906 Chlamidomonas reinhardtii (green alga) RP01162 Caenorhabditis remanei (nematode) ENSCSAVP00000010962 Ciona savignyi (sedentary tunicate) 109109 Capitella spl (polychaete worm) DDB0214904 Dictyostelium discoideum (amoeba) ENSECAP00000005977 Equus caballus (horse) ENSGACP00000008040 Gymnopilus aculeatus (mushroom) ENSGALP00000018686 Gallus gallus (chicken) 194392 Hypsipyla robusta (cedar shoot borer) ENSP00000349823 Homo sapiens (human) ISCW023702-PA Ixodes scapularis (deer tick) 138707 Lottia gigantea (owl limpet) 9161 Monocosta brevicollis (choanoflagellate) ENSMODP00000019401 Monodelphis domestica (gray opossum) ENSMMUP00000025671 Macaca mulatta (rhesus monkey) ENSMUSP00000047589 Mus musculus (house mouse) 80671 Nematostella vectensis (starlet anemone) ENSORLP00000020604 Oryzias latipes (japanese killifish) LOC_Os07g44210.1 Oryza sativa (asian rice) 26819 Ostreococcus tauri (green alga) PF13_0308 Plasmodium falciparum (protozoal parasite) PHUM001242-PA Pediculus humanus (human body louse) 107791 Physcomitrella patens (moss) ENSPPYP00000014699 Pongo pygmaeus (orangutan) 228966 Populus trichocarpa (black cottonwood) ENSPTRP00000040756 Pan troglodytes (chimpanzee) PVX_114850 Plasmodium vivax (protozoal parasite) ENSRNOP00000022459 Rattus norvegicus (norway rat) 5052111 Sorghum bicolor (sorghum) Smp_131000 Schistosoma mansoni (trematode parasite) XP_967843.1 Tribolium castaneum (red flour beetle) Tc00.1047053504131.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000019566 Tetraodon nigroviridis (green spotted pufferfish) TP04_0886 Theileria parva (parasitic protozoan) 263934 Thalassiosira pseudonana (marine diatom) ENSTRUP00000026994 Takifugu rubripes (pufferfish Takifugu) 3822.m00632 Tetrahymena thermophila (ciliate protozoa) 86647.m00167 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000000989 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33709 modMine - Data generated by the modENCODE project. • FBgn0031655 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13257 NV24466 NV19220 LH13530 ISCW023702 FBgn0229087 FBgn0226435 FBgn0203363 FBgn0194696 FBgn0173413 JGI_V11_232046 FBgn0077673 FBgn0164115 FBgn0139880 FBgn0119171 FBgn0117161 FBgn0100596 CPIJ015879 BGIBMGA009112 ACYPI000862 GB17968 AGAP008426 AAEL006963 PHUM440690 GLEAN_05426
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG3753 (Mount, 2001.8.14, Cho et al., 2004, Jafar-Nejad et al., 2006, Schneiderman et al., 2009, Ni et al., 2010.12.1) Marca1 (Schneiderman et al., 2009) Marcal1
Name Synonym	dsmarcal1 (Cho et al., 2004) Marcal1
Secondary FlyBase IDs
References ( 16 )
Research paper	Schneiderman et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(34): 14472--14477 The XNP remodeler targets dynamic chromatin in Drosophila. [FBrf0208542]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Mount, 2001.8.14, Intron annotations. Intron annotations. [FBrf0137489]
Abstract	Jafar-Nejad et al., 2006, A. Dros. Res. Conf. 47: 828B Genetic and biochemical analysis of SMARCAL1. [FBrf0189542] Cho et al., 2004, A. Dros. Res. Conf. 45: 272B Developing a Fly Model for Schimke Immuno-osseous Dysplasia. [FBrf0174056]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Dunn, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126662]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]