Gene Dmel\CG14043

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General Information

Symbol

Dmel\CG14043

Species

D. melanogaster

Name

Annotation symbol

CG14043

Feature type

protein_coding_gene

FlyBase ID

FBgn0031659

Gene Model Status

Current

Stock availability

3 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

25B5-25B5

Sequence location

2L:4,971,702..4,973,687 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG14043 (FBgn0031659). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: KIF-1 binding protein; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1638140_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG14043. Gene sequence location is 2L:4971702..4973687.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25B5-25B5

Limits computationally determined from genome sequence between P{PZ}l(2)05714⁰⁵⁷¹⁴ and P{lacW}l(2)k10001^k10001

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG14043 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG14043-RA

FBtr0078995

NM_135042

1986

600

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG14043-PA

FBpp0078634

69.7

600

5.12

NP_608886

AAF52187

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Tetratricopeptide-like helical (IPR011990)

KIF-1 binding protein (IPR022083)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VMX1

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint & ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		(551.4)
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		185.5
Larval Midgut		115.1
Larval Hindgut		136
Larval Malpighian Tubules		210.6
Larval Fat Body		183.8
Larval Salivary Gland		208.2
Larval Trachea		132.75
Larval Carcass		111.375
Adult Head		102.9
Adult Eye		83.7
Adult Brain		172.2
Adult Thoracic-Abdominal Ganglion		204.2
Adult Crop		139.7
Adult Midgut		112
Adult Hindgut		113.3
Adult Malpighian Tubules		202.5
Adult Fat Body		95.6
Adult Salivary Gland		142.3
Adult Heart		86.1
Adult VirginFemale Spermatheca		166.3
Adult InseminatedFemale Spermatheca		166.5
Adult Ovary		219.9
Adult Testis		551.4
Adult Male Accessory Gland		112.2
Adult Carcass		75.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	102.9
NA	Eye	83.7
NA	Brain	172.2
185.5	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	204.2
NA	Crop	139.7
115.1	Midgut	112
136	Hindgut	113.3
210.6	Malpighian Tubules	202.5
183.8	Fat Body	95.6
208.2	Salivary Gland	142.3
NA	Heart	86.1
132.75	Trachea	NA
NA	VirginFemale Spermatheca	166.3
NA	InseminatedFemale Spermatheca	166.5
NA	Ovary	219.9
NA	Testis	551.4
NA	Male Accessory Gland	112.2
111.375	Carcass	75.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		91
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(28)
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		(91)
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		91
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		91
accessory gland, mated 4-day male		12
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		91
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		(91)
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		91
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		28
central nervous system, larvae L3		12
central nervous system, pupae P8		11
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		6
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		5
head, mated 1-day male		9
head, mated 4-day male		7
head, mated 20-day male		9
salivary gland, larvae L3 wandering		3
salivary gland, white prepupae		7
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		7
digestive system, 4-day adult		6
digestive system, 20-day adult		7
fat body, larvae L3 wandering		3
fat body, white prepupae		9
fat body, pupae P8		8
carcass, larvae L3 wandering		8
carcass, 1-day adult		4
carcass, 4-day adult		5
carcass, 20-day adult		4
ovary, virgin 4-day female		25
ovary, mated 4-day female		19
testis, mated 4-day male		91
accessory gland, mated 4-day male		12
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		45
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		33
adult male 05day		46
adult male 30day		46
adult female 01day		22
adult female 05day		30
adult female 30day		33
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(45)
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		(27)
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		(32)
pupae 2d postWPP		(32)
pupae 3d postWPP		(27)
pupae 4d postWPP		24
adult male 01day		(33)
adult male 05day		(46)
adult male 30day		(46)
adult female 01day		22
adult female 05day		(30)
adult female 30day		(33)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		45
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		33
adult male 05day		46
adult male 30day		46
adult female 01day		22
adult female 05day		30
adult female 30day		33
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		45
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		33
adult male 05day		46
adult male 30day		46
adult female 01day		22
adult female 05day		30
adult female 30day		33
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		45
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		33
adult male 05day		46
adult male 30day		46
adult female 01day		22
adult female 05day		30
adult female 30day		33
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(45)
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		(33)
adult male 05day		(46)
adult male 30day		(46)
adult female 01day		22
adult female 05day		30
adult female 30day		(33)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		45
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		33
adult male 05day		46
adult male 30day		46
adult female 01day		22
adult female 05day		30
adult female 30day		33
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		45
embryo 02-04hr		12
embryo 04-06hr		9
embryo 06-08hr		15
embryo 08-10hr		19
embryo 10-12hr		27
embryo 12-14hr		16
embryo 14-16hr		17
embryo 16-18hr		15
embryo 18-20hr		12
embryo 20-22hr		9
embryo 22-24hr		10
larva L1		19
larva L2		19
larva L3 12hr old		15
larva L3 puffstage 1-2		16
larva L3 puffstage 3-6		20
larva L3 puffstage 7-9		22
white prepupae new		20
white prepupae 12hr		26
white prepupae 24hr		32
pupae 2d postWPP		32
pupae 3d postWPP		27
pupae 4d postWPP		24
adult male 01day		33
adult male 05day		46
adult male 30day		46
adult female 01day		22
adult female 05day		30
adult female 30day		33
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		38
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(38)
Schneider line 2 Sg4		(32)
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		(43)
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		(32)
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		38
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		38
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		38
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(38)
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		(43)
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		38
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		38
Schneider line 2 Sg4		32
embryonic 1182-4H		18
embryonic GM2		21
embryonic Kc167		10
embryonic S1		19
embryonic S3		18
leg disc CME L1		25
wing disc CME-W2		16
wing disc ML-DmD8		14
wing disc ML-DmD9		19
wing disc ML-DmD16-c3		26
wing disc ML-DmD21		43
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		21
antennal disc ML-DmD20-c5		32
mixed discs ML-DmD4-c1		25
CNS ML-DmBG1-c1		17
CNS ML-DmBG2-c2		21
tumorous blood cells mbn2		12
ovary fGS/OSS		12
ovary OSC		8
ovary OSS		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		7
cold shock, 4-day adult		6
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		13
Cadmium 50 mM 12 hrs, larvae L3		10
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		18
Copper 0.5 mM 12 hrs, larvae L3		7
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		4
Zinc 4.5 mM 48 hrs, 4-day adult		11
Ethanol 2.5% 3 hrs, larvae L3		22
Ethanol 5% 3 hrs, larvae L3		12
Ethanol 10% 3 hrs, larvae L3		10
Caffeine 1.5 mg/ml 4 hrs, larvae L3		10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		17
Caffeine 25 mg/ml 48 hrs, 4-day adult		6
Paraquat 5 mM 48 hrs, 4-day adult		23
Paraquat 10 mM 48 hrs, 4-day adult		20
Rotenone 2 μg 12 hrs, larvae L3		12
Rotenone 8 μg 12 hrs, larvae L3		11
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RE35653

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031659

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14043-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG14043^GD8205

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG14043	Class	Mutagen	Stocks	Known lesion
CG14043^EY03612			1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG14043	Mutagen	Stocks	Known lesion
CG14043^GD8205	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG14043^KK101761	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG14043^NIG.14043R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)Exel7021

(Ryder, 2004.4.26)

Df(2L)Exel8012

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD8205}

P{KK101761}

P{NIG.14043R}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{SUPor-P}KG09216

insertion of mobile activating element

P{EPgy2}CG14043^EY03612

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG14043 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

59898

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0031659

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

33714

Orthologs

OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6THWCM

Dipteran inclusive ortholog search

EOG61NTV7

Insect inclusive ortholog search

EOG6NGFGT

Arthropod inclusive ortholog search

EOG631ZD6

Metazoa inclusive ortholog search

EOG68DCNG

Orthologs in Drosophila Species (EOG6THWCM)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12722

Drosophila persimilis

Dper\GL26491

Drosophila willistoni

Dwil\GK24585

Drosophila virilis

Dvir\GJ16246

Drosophila mojavensis

Dmoj\GI14307

Drosophila grimshawi

Dgri\GH10090

Orthologs in non-Drosophila Dipterans (EOG61NTV7)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Anopheles gambiae

Malaria mosquito

Agam\AGAP009536

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014388

Orthologs in non-Dipteran Insects (EOG6NGFGT)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB53238

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG006588

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH14951

Atta cephalotes

Leafcutter ant

Acep\ACEP17929

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO23182

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO13473

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL14533

Linepithema humile

Argentine ant

Lhum\LH19551

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB17902

Solenopsis invicta

Red fire ant

Sinv\SINV18480

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000296

Bombyx mori

Silkmoth

Bmor\BGIBMGA010526

Pediculus humanus

Human body louse

Phum\PHUM612460

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07564

Orthologs in non-Insect Arthropods (EOG631ZD6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Deer tick

Isca\ISCW018552

Ixodes scapularis

Deer tick

Isca\ISCW009900

Orthologs in non-Arthropod Metazoa (EOG68DCNG)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003899gn

Danio rerio

Zebrafish

Drer\kbp

Xenopus tropicalis

Western clawed frog

Xtro\kiaa1279

Gallus gallus

Domestic chicken

Ggal\kbp

Mus musculus

House mouse

Mmus\Kbp

Rattus norvegicus

Norway rat

Rnor\LOC606294

Homo sapiens

Human

Hsap\KIAA1279

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\KIAA1279

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12722

Drosophila persimilis

Dper\GL26491

Drosophila willistoni

Dwil\GK24585

Drosophila virilis

Dvir\GJ16246

Drosophila mojavensis

Dmoj\GI14307

Drosophila grimshawi

Dgri\GH10090

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

Bloomington

15664

y¹ w^67c23; P{EPgy2}CG14043^EY03612

VDRC

v103620

P{KK101761}VIE-260B

v17351

w¹¹¹⁸; P{GD8205}v17351

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 28 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE35653

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0031659

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

33714

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_135042

RefSeq (Proteins)

•

NP_608886

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

33714

UniProtKB/Swiss-Prot

•

Q9VMX1

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Tetratricopeptide-like helical (IPR011990)

KIF-1 binding protein (IPR022083)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RE35653

Linkouts

BioGRID - A database of protein and genetic interactions

•

59898

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0031659

DRSC - Results from RNAi screens.

•

FBgn0031659

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031659

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG14043-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0031659

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

33714

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

33714

modMine - Data generated by the modENCODE project.

•

FBgn0031659

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG14043

(Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 14 )

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
Gene Disruption Project members, 2001-, (Computer file): (Computer file) [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations.: Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]