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Gene Dmel\TpnC25D

General Information
Symbol	Dmel\TpnC25D	Species	D. melanogaster
Name	Troponin C at 25D	Annotation symbol	CG6514
Feature type	protein_coding_gene	FlyBase ID	FBgn0031692
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	DmTpnCII
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25D1-25D1	Sequence location	2L:5,218,255..5,219,055 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Troponin C at 25D is referred to in FlyBase by the symbol Dmel\TpnC25D (CG6514, FBgn0031692). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium ion binding. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand; EF-hand-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, adult heart, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, larval/adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1632633_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TpnC25D. Gene sequence location is 2L:5218255..5219055.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA02965 BKN24574 BKN46098
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25D1-25D1   Limits computationally determined from genome sequence between P{lacW}l(2)k11206k11206 and P{lacW}tkvk16713&P{lacW}l(2)k01302k01302
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TpnC25D for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TpnC25D-RA FBtr0079063  NM_135071   646   149
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TpnC25D-PA   FBpp0078699   16.8   149   3.77     NP_608915   AAF52229
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EF-Hand 1, calcium-binding site (IPR018247) EF-HAND 2 (IPR018249) Calcium-binding EF-hand (IPR002048) EF-hand-like domain (IPR011992) EF-hand (IPR018248)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52229   AF083303   AY113496 AAM29501   AY283601 AAQ21104   BI163681   BI367513   BI570945   BX048884   CO293552   CO306815   EC090237   EC212597   EC237684   EC237690   GH749048   GH758523   GH772083   GH772656   GH773805   GH780614   GH781040   GH783410   GH787946   GH791162   GH796014   GH799253   GH802281   GH804160   GH811674   GH812319   GH817392   GH818569   GH820184   GH822108   GH825790   GH833894   GH837867   GH838116   GH838135   GH846011   GH848026   GH850723   GH858186   GH865998   GH868801   GH879392   GH886240   GH887704   GH892762   GH894675   GH897739   GH903551   GH913513   GH914122   GH916721   GH918318   GH918483   GH919325   GH921341   GH939498   GH940647
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMT2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031692    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031692 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031692 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr    2972 embryo 18-20hr    5484 embryo 20-22hr    9143 embryo 22-24hr    10102 larva L1    8593 larva L2    5300 larva L3 12hr old    12041 larva L3 puffstage 1-2    7714 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP    2021 pupae 3d postWPP    19533 pupae 4d postWPP    27980 adult male 01day    15239 adult male 05day    6671 adult male 30day    5278 adult female 01day    10356 adult female 05day    1452 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr  (430) embryo 16-18hr  (2972) embryo 18-20hr  (5484) embryo 20-22hr  (9143) embryo 22-24hr  (10102) larva L1  (8593) larva L2  (5300) larva L3 12hr old  (12041) larva L3 puffstage 1-2  (7714) larva L3 puffstage 3-6  (1654) larva L3 puffstage 7-9  (463) white prepupae new  (127) white prepupae 12hr  (477) white prepupae 24hr  (128) pupae 2d postWPP  (2021) pupae 3d postWPP  (19533) pupae 4d postWPP  (27980) adult male 01day  (15239) adult male 05day  (6671) adult male 30day  (5278) adult female 01day  (10356) adult female 05day  (1452) adult female 30day  (1418) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr  (2972) embryo 18-20hr  (5484) embryo 20-22hr  (9143) embryo 22-24hr  (10102) larva L1  (8593) larva L2  (5300) larva L3 12hr old  (12041) larva L3 puffstage 1-2  (7714) larva L3 puffstage 3-6  (1654) larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP  (2021) pupae 3d postWPP  (19533) pupae 4d postWPP  (27980) adult male 01day  (15239) adult male 05day  (6671) adult male 30day  (5278) adult female 01day  (10356) adult female 05day  1452 adult female 30day  1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr    2972 embryo 18-20hr    5484 embryo 20-22hr    9143 embryo 22-24hr  10102 larva L1    8593 larva L2    5300 larva L3 12hr old  (12041) larva L3 puffstage 1-2    7714 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP    2021 pupae 3d postWPP  (19533) pupae 4d postWPP  (27980) adult male 01day  (15239) adult male 05day    6671 adult male 30day    5278 adult female 01day  10356 adult female 05day    1452 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr    2972 embryo 18-20hr    5484 embryo 20-22hr    9143 embryo 22-24hr    10102 larva L1    8593 larva L2    5300 larva L3 12hr old    12041 larva L3 puffstage 1-2    7714 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP    2021 pupae 3d postWPP    19533 pupae 4d postWPP    27980 adult male 01day    15239 adult male 05day    6671 adult male 30day    5278 adult female 01day    10356 adult female 05day    1452 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031692 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr    2972 embryo 18-20hr    5484 embryo 20-22hr    9143 embryo 22-24hr    10102 larva L1    8593 larva L2    5300 larva L3 12hr old    12041 larva L3 puffstage 1-2    7714 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP    2021 pupae 3d postWPP    19533 pupae 4d postWPP    27980 adult male 01day    15239 adult male 05day    6671 adult male 30day    5278 adult female 01day    10356 adult female 05day    1452 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr  (430) embryo 16-18hr  (2972) embryo 18-20hr  (5484) embryo 20-22hr  (9143) embryo 22-24hr  (10102) larva L1  (8593) larva L2  (5300) larva L3 12hr old  (12041) larva L3 puffstage 1-2  (7714) larva L3 puffstage 3-6  (1654) larva L3 puffstage 7-9  (463) white prepupae new  127 white prepupae 12hr  (477) white prepupae 24hr  128 pupae 2d postWPP  (2021) pupae 3d postWPP  (19533) pupae 4d postWPP  (27980) adult male 01day  (15239) adult male 05day  (6671) adult male 30day  (5278) adult female 01day  (10356) adult female 05day  (1452) adult female 30day  (1418) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr  (2972) embryo 18-20hr  (5484) embryo 20-22hr  (9143) embryo 22-24hr  (10102) larva L1  (8593) larva L2  (5300) larva L3 12hr old  (12041) larva L3 puffstage 1-2  (7714) larva L3 puffstage 3-6  1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP  2021 pupae 3d postWPP  (19533) pupae 4d postWPP  (27980) adult male 01day  (15239) adult male 05day  (6671) adult male 30day  (5278) adult female 01day  (10356) adult female 05day  1452 adult female 30day  1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr    2972 embryo 18-20hr    5484 embryo 20-22hr    9143 embryo 22-24hr  10102 larva L1    8593 larva L2    5300 larva L3 12hr old  12041 larva L3 puffstage 1-2    7714 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP    2021 pupae 3d postWPP  19533 pupae 4d postWPP  (27980) adult male 01day  15239 adult male 05day    6671 adult male 30day    5278 adult female 01day  10356 adult female 05day    1452 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    12 embryo 04-06hr    6 embryo 06-08hr    11 embryo 08-10hr    23 embryo 10-12hr    42 embryo 12-14hr    38 embryo 14-16hr    430 embryo 16-18hr    2972 embryo 18-20hr    5484 embryo 20-22hr    9143 embryo 22-24hr    10102 larva L1    8593 larva L2    5300 larva L3 12hr old    12041 larva L3 puffstage 1-2    7714 larva L3 puffstage 3-6    1654 larva L3 puffstage 7-9    463 white prepupae new    127 white prepupae 12hr    477 white prepupae 24hr    128 pupae 2d postWPP    2021 pupae 3d postWPP    19533 pupae 4d postWPP    27980 adult male 01day    15239 adult male 05day    6671 adult male 30day    5278 adult female 01day    10356 adult female 05day    1452 adult female 30day    1418 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031692    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031692 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult crop, adult heart, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, larval/adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031692 expression level Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass    1045.925 Adult Head    1710.1 Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart    622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland    543.5 Adult Carcass    553.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass  (1045.925) Adult Head  (1710.1) Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  (687.5) Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart  (622) Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland  (543.5) Adult Carcass  (553.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass  1045.925 Adult Head  (1710.1) Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart    622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland    543.5 Adult Carcass    553.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass    1045.925 Adult Head    1710.1 Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart    622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland    543.5 Adult Carcass    553.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031692 expression level Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass    1045.925 Adult Head    1710.1 Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart    622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland    543.5 Adult Carcass    553.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass  (1045.925) Adult Head  (1710.1) Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop  687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart  622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland  543.5 Adult Carcass  553.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass  1045.925 Adult Head  1710.1 Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart    622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland    543.5 Adult Carcass    553.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.3 Larval Midgut    150.5 Larval Hindgut    117.5 Larval Malpighian Tubules    9.4 Larval Fat Body    3.3 Larval Salivary Gland    4.6 Larval Trachea    45.8 Larval Carcass    1045.925 Adult Head    1710.1 Adult Eye    333.35 Adult Brain    23 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    687.5 Adult Midgut    433.2 Adult Hindgut    210.1 Adult Malpighian Tubules    9.6 Adult Fat Body    25.7 Adult Salivary Gland no informative data Adult Heart    622 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    17.6 Adult Ovary    0.3 Adult Testis    41.4 Adult Male Accessory Gland    543.5 Adult Carcass    553.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1710.1   NA  Eye    333.35   NA  Brain    23   1.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    687.5   150.5  Midgut    433.2   117.5  Hindgut    210.1   9.4  Malpighian Tubules    9.6   3.3  Fat Body    25.7   4.6  Salivary Gland    no informative data   NA  Heart    622   45.8  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    17.6   NA  Ovary    0.3   NA  Testis    41.4   NA  Male Accessory Gland    543.5   1045.925  Carcass    553.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031692 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6514-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for TpnC25D Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 TpnC25DGD11945 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of TpnC25D Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TpnC25D Class Mutagen Stocks Known lesion TpnC25DGD11945 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6011 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11945} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
calcium ion binding inferred from sequence or structural similarity with UniProtKB:P02593 (FlyBase, 1992-) non-traceable author statement (Herranz, 2003.4.25)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TpnC25D allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031692 DroID - A comprehensive database of gene and protein interactions. • FBgn0031692 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33752
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14383 Dere\GG25060 Dgri\GH21490 Dmoj\GI24238 Dper\GL19565 Dpse\TpnCII Dsec\GM18540 Dsim\GD23329 Dvir\TpnCII Dwil\GK21094 Dyak\GE25333
Curated drosophilid orthologs	Dpse\TpnCII (Herranz et al., 2005) Dsub\TpnCII (Herranz et al., 2005) Dvir\TpnCII (Herranz et al., 2005)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012114-PA Aedes aegypti (mosquito) AGAP009330-PA Anopheles gambiae (mosquito) NP_001011653.1 Apis mellifera (honey bee) XP_001949161.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008861-PA Bombyx mori (silk worm) CPIJ004798 Culex pipens (mosquito) 112309 Daphnia pulex (daphnia) XP_001606710.1 Nasonia vitripennis (wasp) PHUM000235-PA Pediculus humanus (human body louse) XP_972441.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15533 NV11095 LH12676 ISCW008598 FBgn0242412 FBgn0223086 FBgn0067465 FBgn0194715 FBgn0173447 JGI_V11_304330 JGI_V11_112309 FBgn0079650 FBgn0157163 FBgn0146961 FBgn0128952 FBgn0117189 FBgn0091410 CPIJ004798 BGIBMGA008861 ACYPI000699 GB19642 AGAP009330 AAEL012114 AAEL009336 PHUM494800 GLEAN_06493
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v27649 w1118; P{GD11945}v27649
Genomic Clones ( 2 )
	BACR06K07 BACR25K01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE53289
Other clones	DPiM_RE53289
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE03143 RH05745
Other clones	EK203363 EK252455 RP003043464 RP003060066 RP003074760 RP003084498 RP003090832 RP003111788 RP003113069 RP003114249 RP003115996 RP003190468 RP003205951 RP003206500 RP003208557 RP003216757 RP003225616 RP003240990 RP003248006 RP003254002 RP003268046 RP003268556 RP003272415 RP003279814 RP003287556 RP003291665 RP003298203 RP003309191 RP003343743 RP003385292 RP003399474 RP003426757 RP003444481 RP003488224 RP003494150 RP003494602 RP003500956 RP003507230 RP003533907 RP003566486 RP003606656 RP003614311 RP003622754 RP003630858 RP003631878 RP003642864 RP003665720 RP003672594 RP003674795
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031692 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33752
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6514 anon-EST:Posey103 (Bayraktaroglu, 2000.11.2) Source for merge of: CG6514 BcDNA:RE53289 (FlyBase, 1996-)
Additional comments	Source for merge of CG6514 BcDNA:RE53289 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	The Hrp59 protein binds preferentially to a subset of mRNAs, including TpnC25D mRNA. (Kiesler et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135071 RefSeq (Proteins) • NP_608915 DDBJ / EMBL / GenBank • AAF52229 AAM29501 AAQ21104 AF083303 AY113496 AY283601 BI367513 Entrez Gene - A searchable database of RefSeq genes. • 33752 UniProtKB/TrEMBL • Q9VMT2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EF-Hand 1, calcium-binding site (IPR018247) EF-HAND 2 (IPR018249) Calcium-binding EF-hand (IPR002048) EF-hand-like domain (IPR011992) EF-hand (IPR018248)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031692 DroID - A comprehensive database of gene and protein interactions. • FBgn0031692 DRSC - Results from RNAi screens. • FBgn0031692 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031692 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6514-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031692 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33752 InParanoid A subset of ortholog calls from InParanoid. • AAEL012114-PA Aedes aegypti (mosquito) AGAP009330-PA Anopheles gambiae (mosquito) NP_001011653.1 Apis mellifera (honey bee) XP_001949161.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008861-PA Bombyx mori (silk worm) CPIJ004798 Culex pipens (mosquito) 112309 Daphnia pulex (daphnia) XP_001606710.1 Nasonia vitripennis (wasp) PHUM000235-PA Pediculus humanus (human body louse) XP_972441.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33752 modMine - Data generated by the modENCODE project. • FBgn0031692 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15533 NV11095 LH12676 ISCW008598 FBgn0242412 FBgn0223086 FBgn0067465 FBgn0194715 FBgn0173447 JGI_V11_304330 JGI_V11_112309 FBgn0079650 FBgn0157163 FBgn0146961 FBgn0128952 FBgn0117189 FBgn0091410 CPIJ004798 BGIBMGA008861 ACYPI000699 GB19642 AGAP009330 AAEL012114 AAEL009336 PHUM494800 GLEAN_06493
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-EST:Posey103   BcDNA:RE53289   CG6514 (Foley and O'Farrell, 2004, Apidianakis et al., 2005, Hekmat-Scafe et al., 2005, Montana and Littleton, 2006, Cammarato et al., 2011) DmTpnC25D (Herranz et al., 2004) DmTpnCII (Herranz et al., 2004, Herranz et al., 2005) TnC (Nongthomba et al., 2004) TNC25D (Diaz-Castillo and Golic, 2007) TpnC25D (Kiesler et al., 2005) TpnC II (Herranz et al., 2004) TpnCII (Herranz et al., 2005)
Name Synonym	TpnC25D (Cammarato et al., 2011) Troponin C at 25D
Secondary FlyBase IDs
	FBgn0025551 FBgn0062999
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...