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Gene Dmel\Cyp4ac1

General Information
Symbol	Dmel\Cyp4ac1	Species	D. melanogaster
Name	Cyp4ac1	Annotation symbol	CG14032
Feature type	protein_coding_gene	FlyBase ID	FBgn0031693
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25D2-25D2	Sequence location	2L:5,264,001..5,265,899 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyp4ac1 is referred to in FlyBase by the symbol Dmel\Cyp4ac1 (CG14032, FBgn0031693). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: electron carrier activity. It is reported to be involved in the biological process: insecticide catabolic process; hormone metabolic process. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome P450; Cytochrome P450, E-class, group I; Cytochrome P450, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult fat body, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult heart, larval fat body, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634640_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cyp4ac1. Gene sequence location is 2L:5264001..5265899.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25D2-25D2   Limits computationally determined from genome sequence between P{lacW}tkvk16713&P{lacW}l(2)k01302k01302 and P{lacW}vrik05901&P{PZ}cype03771
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25D6-25D6     (Dunkov, 2000.6.29)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cyp4ac1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cyp4ac1-RA FBtr0079066  NM_135072   1666   509
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cyp4ac1-PA   FBpp0078701   59.2   509   7.11     NP_608916   AAF52232
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698190   AE014134 AAF52232   AI404516   AW941861   AY051602 AAK93026   CO294823   CO338073   EC267088
UniProtKB/Swiss-Prot	Q9VMS9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult fat body, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, adult heart, larval fat body, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body    535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland    662.5 Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body  535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland  (662.5) Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body    535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland    662.5 Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body    535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland    662.5 Adult Carcass    302.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body    535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland    662.5 Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body  535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland  662.5 Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body    535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland    662.5 Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.9 Larval Midgut    184.2 Larval Hindgut    29.7 Larval Malpighian Tubules    13.7 Larval Fat Body    430.2 Larval Salivary Gland    19.2 Larval Trachea    26.2 Larval Carcass    17.5 Adult Head    318.3 Adult Eye    112.825 Adult Brain    14.4 Adult Thoracic-Abdominal Ganglion    13.2 Adult Crop    12.1 Adult Midgut    393.5 Adult Hindgut    30.7 Adult Malpighian Tubules    6.5 Adult Fat Body    535.3 Adult Salivary Gland    9.5 Adult Heart    336.675 Adult VirginFemale Spermatheca    304.5 Adult InseminatedFemale Spermatheca    313.9 Adult Ovary    1.8 Adult Testis    62.6 Adult Male Accessory Gland    662.5 Adult Carcass    302.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    318.3   NA  Eye    112.825   NA  Brain    14.4   3.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    13.2   NA  Crop    no informative data   184.2  Midgut    393.5   29.7  Hindgut    30.7   no informative data  Malpighian Tubules    6.5   430.2  Fat Body    535.3   19.2  Salivary Gland    9.5   NA  Heart    336.675   26.2  Trachea    NA   NA  VirginFemale Spermatheca    304.5   NA  InseminatedFemale Spermatheca    313.9   NA  Ovary    1.8   NA  Testis    62.6   NA  Male Accessory Gland    662.5   17.5  Carcass    302.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male    33 head, mated 20-day male    39 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    37 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male  (33) head, mated 20-day male  (39) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering  (37) fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male    33 head, mated 20-day male    39 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    37 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male    33 head, mated 20-day male    39 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    37 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male    33 head, mated 20-day male    39 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    37 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male  (33) head, mated 20-day male  (39) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering  (37) fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male    33 head, mated 20-day male    39 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    37 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    20 head, virgin 4-day female    16 head, virgin 20-day female    22 head, mated 1-day female    14 head, mated 4-day female    21 head, mated 20-day female    20 head, mated 1-day male    19 head, mated 4-day male    33 head, mated 20-day male    39 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    15 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    37 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    0 carcass, 1-day adult    9 carcass, 4-day adult    10 carcass, 20-day adult    8 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed at stages throughout the larval period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old  (32) larva L3 puffstage 1-2  (41) larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old  32 larva L3 puffstage 1-2  (41) larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    1 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    13 larva L2    20 larva L3 12hr old    32 larva L3 puffstage 1-2    41 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    10 white prepupae new    4 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    2 adult male 01day    21 adult male 05day    21 adult male 30day    16 adult female 01day    7 adult female 05day    8 adult female 30day    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    3 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    9 ovary fGS/OSS    1 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    15 Cadmium 50 mM 48 hrs, 4-day adult    7 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    20 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_17
External Data & Images
Linkouts	BDGP expression data • GH24257 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14032-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Cyp4ac1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cyp4ac1 Class Mutagen Stocks Known lesion Cyp4ac1KK109621 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cyp4ac1GD906 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cyp4ac1NIG.14032R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6011 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD906} NA P{KK109621} NA P{NIG.14032R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from electronic annotation with InterPro:IPR001128 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Dunkov, 1999.11) non-traceable author statement (Dunkov, 2000.6.29, Swiss-Prot Project Members, 2000.5.1) heme binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) iron ion binding inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 (FlyBase Curators et al., 2004-) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
hormone metabolic process non-traceable author statement (Swiss-Prot Project Members, 2000.5.1) insecticide catabolic process non-traceable author statement (Swiss-Prot Project Members, 2000.5.1) oxidation-reduction process inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
intracellular membrane-bounded organelle non-traceable author statement (FlyBase, 1992-) membrane non-traceable author statement (Swiss-Prot Project Members, 2000.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cyp4ac1 - CG2010 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Cyp4ac1 - CG7277 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Cyp4ac1 - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Cyp4ac1 - sesB experimental knowledge based (Guruharsha et al., 2011) Cyp4ac1 - βTub56D experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cyp4ac1 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031693 DroID - A comprehensive database of gene and protein interactions. • FBgn0031693
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6282M9 Dipteran inclusive ortholog search EOG6KH33B Insect inclusive ortholog search EOG6HDRPR Arthropod inclusive ortholog search EOG65MKMJ Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6282M9)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cyp4ac1     Drosophila melanogaster fruit fly  Dmel\Cyp4ac3     Drosophila melanogaster fruit fly  Dmel\Cyp4ac2     Drosophila simulans   Dsim\GD23331   Y Drosophila simulans   Dsim\GD23332   Y Drosophila simulans   Dsim\GD23330   Y Drosophila sechellia   Dsec\GM18542   Y Drosophila sechellia   Dsec\GM18543   Y Drosophila erecta   Dere\GG25064   Y Drosophila erecta   Dere\GG25063   Y Drosophila erecta   Dere\GG25061 Y Y Drosophila yakuba   Dyak\GE25361   Y Drosophila yakuba   Dyak\GE25343   Y Drosophila yakuba   Dyak\GE25353   Y Drosophila ananassae   Dana\GF14384   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA26013   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA26012   Y Drosophila persimilis   Dper\GL19567   Y Drosophila persimilis   Dper\GL19566   Y Drosophila willistoni   Dwil\GK12963   Y Drosophila mojavensis   Dmoj\GI21924   Y Drosophila grimshawi   Dgri\GH13515   Y
Orthologs in non-Drosophila Dipterans (EOG6KH33B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015663 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001754 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016284 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ800265 Y
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (EOG65MKMJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_311385 Y Daphnia pulex Water flea  Dpux\JGI_V11_311383 Y Daphnia pulex Water flea  Dpux\mmoX Y Daphnia pulex Water flea  Dpux\JGI_V11_311386 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG25061
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v104515 P{KK109621}VIE-260B
Genomic Clones ( 2 )
	BACR05M06 BACR25K01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH24257
Other clones	DPiM_GH24257
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL03915
Other clones	EK207802 EN15910
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33754
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135072 RefSeq (Proteins) • NP_608916 DDBJ / EMBL / GenBank • AAF52232 AAK93026 AI404516 AW941861 AY051602 Entrez Gene - A searchable database of RefSeq genes. • 33754 UniProtKB/Swiss-Prot • Q9VMS9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome P450 (IPR001128) Cytochrome P450, E-class, group I (IPR002401) Cytochrome P450, conserved site (IPR017972) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH24257
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031693 DroID - A comprehensive database of gene and protein interactions. • FBgn0031693 DRSC - Results from RNAi screens. • FBgn0031693 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031693 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14032-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031693 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33754 modMine - Data generated by the modENCODE project. • FBgn0031693
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	4ac1 (Nelson, 2001.2.5) CG14032 (Labourier et al., 2002, Keleman et al., 2009.8.5) Cyp4ac1 (Niwa et al., 2011, Davies et al., 2006, King-Jones et al., 2006, Morozova et al., 2006, Japanese National Institute of Genetics, 2012.5.21) cyp4ac1 (Zhang et al., 2011)
Name Synonym	Cyp4ac1
Secondary FlyBase IDs
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 )
Recent research papers ( 2 )
	Niwa et al., 2011, Appl. Ent. Zool. 46(4): 533--543 Expressions of the cytochrome P450 monooxygenase gene Cyp4g1 and its homolog in the prothoracic glands of the fruit fly Drosophila melanogaster (Diptera: Drosophilidae) and the silkworm Bombyx mori (Lepidoptera: Bombycidae). [FBrf0216541] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Show all research papers ...