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Gene Dmel\Ncoa6

General Information
Symbol	Dmel\Ncoa6	Species	D. melanogaster
Name		Annotation symbol	CG14023
Feature type	protein_coding_gene	FlyBase ID	FBgn0031698
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25D5-25D6	Sequence location	2L:5,315,426..5,326,683 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Ncoa6 (CG14023, FBgn0031698). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: histone H3-K4 methylation. 5 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1640735_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG14023. Gene sequence location is 2L:5315426..5326683.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25D5-25D6   Limits computationally determined from genome sequence between P{lacW}vrik05901&P{PZ}cype03771 and P{lacW}Hel25Ek11511
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ncoa6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 gene_with_stop_codon_read_through ; SO:0000697 Stop-codon suppression (UGA) postulated; FBrf0216884.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ncoa6-RC FBtr0307040  NM_135077   9090   2265 Ncoa6-RD FBtr0307041  NM_001258955   9905   2266 Ncoa6-RF FBtr0329969  NM_001103618   9905   2467
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ncoa6-PC   FBpp0297883   243.6   2265   10.11     NP_608921   AAF52239 Ncoa6-PD   FBpp0297884   243.7   2266   10.11     NP_001245884   AFH03559 Ncoa6-PF   FBpp0303004   265.4   2467   7.61     NP_001097088   ABV53626
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390806   AA540880   AA803060   AA821115   AA821158   AA951580   AE014134 AAF52239   AE014134 ABV53626   AE014134 AFH03559   AW942088   AY118502 AAM49871   BI170309   BI353412   BP548287   BP550204   BP550205   BP550214   BP550215   CO155280   CO156485   CO189416   CO280959   CO283806   CO285032   CO292442   CO303096   CO303598   EC078388   EC204430   EC213524   EC229777   EC245265   EC245516   EC247402   EC261998   EC267620   EG974122   ES695528   EV582452   EV597782   EV598859   EW713215
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMS2 A8DYV5 Q8MSY0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
MLL3/4 complex inferred from direct assay (Mohan et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    29.85 Larval Midgut    10.4 Larval Hindgut    17.6 Larval Malpighian Tubules    17 Larval Fat Body    17.1 Larval Salivary Gland    21.1 Larval Trachea    20.75 Larval Carcass    12.1 Adult Head    13.5 Adult Eye    20.875 Adult Brain    39.3 Adult Thoracic-Abdominal Ganglion    29.6 Adult Crop    17.1 Adult Midgut    8.4 Adult Hindgut    13.1 Adult Malpighian Tubules    4.5 Adult Fat Body    14.9 Adult Salivary Gland    10 Adult Heart    13.95 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.4 Adult Ovary    32.6 Adult Testis    9.7 Adult Male Accessory Gland    10.5 Adult Carcass    18.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    20.875   NA  Brain    39.3   29.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    29.6   NA  Crop    17.1   no informative data  Midgut    8.4   17.6  Hindgut    no informative data   no informative data  Malpighian Tubules    4.5   no informative data  Fat Body    no informative data   21.1  Salivary Gland    no informative data   NA  Heart    13.95   20.75  Trachea    NA   NA  VirginFemale Spermatheca    2.1   NA  InseminatedFemale Spermatheca    1.4   NA  Ovary    32.6   NA  Testis    9.7   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    47 ovary, mated 4-day female    63 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (33) central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (47) ovary, mated 4-day female  (63) testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    47 ovary, mated 4-day female    63 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    47 ovary, mated 4-day female    63 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    47 ovary, mated 4-day female    63 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3  (33) central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (47) ovary, mated 4-day female  (63) testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    47 ovary, mated 4-day female    63 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    25 central nervous system, larvae L3    33 central nervous system, pupae P8    17 head, virgin 1-day female    10 head, virgin 4-day female    12 head, virgin 20-day female    8 head, mated 1-day female    13 head, mated 4-day female    12 head, mated 20-day female    9 head, mated 1-day male    16 head, mated 4-day male    19 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    5 digestive system, 1-day adult    5 digestive system, 4-day adult    9 digestive system, 20-day adult    8 fat body, larvae L3 wandering    6 fat body, white prepupae    11 fat body, pupae P8    8 carcass, larvae L3 wandering    19 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    47 ovary, mated 4-day female    63 testis, mated 4-day male    4 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr  26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr  26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    26 embryo 04-06hr    21 embryo 06-08hr    24 embryo 08-10hr    21 embryo 10-12hr    11 embryo 12-14hr    16 embryo 14-16hr    18 embryo 16-18hr    14 embryo 18-20hr    11 embryo 20-22hr    10 embryo 22-24hr    9 larva L1    9 larva L2    5 larva L3 12hr old    5 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    9 white prepupae new    10 white prepupae 12hr    9 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    6 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    8 adult male 30day    8 adult female 01day    16 adult female 05day    23 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (31) Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS  (34) ovary OSC  (30) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS  (34) ovary OSC  30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    31 Schneider line 2 Sg4    6 embryonic 1182-4H    21 embryonic GM2    14 embryonic Kc167    9 embryonic S1    22 embryonic S3    12 leg disc CME L1    10 wing disc CME-W2    10 wing disc ML-DmD8    16 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    14 wing disc ML-DmD21    7 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    17 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    17 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    16 ovary fGS/OSS    34 ovary OSC    30 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (27) cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult  (28) Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult  (48) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult  28 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    27 cold shock, 4-day adult    19 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    21 Cadmium 100 mM 48 hrs, 4-day adult    48 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    28 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031698 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14023-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ncoa6GD14752 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Ncoa6GD14752 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 Ncoa6GD14752
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ncoa6 Class Mutagen Stocks Known lesion Ncoa6e04200 piggyBac transposase 3 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ncoa6 Class Mutagen Stocks Known lesion Ncoa6GD14752 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ncoa6HMS00664 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ncoa6KK110204 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ncoa6NIG.14023R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6012 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.14023R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Ncoa6e04200 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
histone H3-K4 methylation inferred from direct assay (Mohan et al., 2011)
Cellular Component
CV term Evidence References
MLL3/4 complex inferred from direct assay (Mohan et al., 2011)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ncoa6 - Pa1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mohan et al., 2011) Ncoa6 - Utx anti tag coimmunoprecipitation, peptide massfingerprinting (Mohan et al., 2011) Ncoa6 - ash2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mohan et al., 2011) Ncoa6 - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ncoa6 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031698 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33761
Orthologs
OrthoDB Orthologs (7) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JT0S6 Dipteran inclusive ortholog search EOG6RFM36 Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6JT0S6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ncoa6     Drosophila sechellia   Dsec\GM18027     Drosophila erecta   Dere\GG24309 Y   Drosophila yakuba   Dyak\GE19004 Y
Orthologs in non-Drosophila Dipterans (EOG6RFM36)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP006601   Anopheles gambiae Malaria mosquito  Agam\AGAP007771   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802108
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22656 Drosophila erecta Dere\GG24309 Drosophila yakuba Dyak\GE19004 Drosophila ananassae Dana\GF15516 Drosophila pseudoobscura pseudoobscura Dpse\GA25686 Drosophila persimilis Dper\GL18557 Drosophila willistoni Dwil\GK24846 Drosophila virilis Dvir\GJ21770 Drosophila mojavensis Dmoj\GI10553 Drosophila grimshawi Dgri\GH13537
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	18236 w1118; PBac{RB}Ncoa6e04200/CyO 34964 y1 sc* v1; P{TRiP.HMS00664}attP2
Harvard	- PBac{RB}Ncoa6e04200
Kyoto	114514 yd2 w1118 P{ey-FLP.N}2; PBac{RB}Ncoa6e04200 P{neoFRT}40A/CyO y+
VDRC	v101908 P{KK110204}VIE-260B v36480 w1118; P{GD14752}v36480 v36482 w1118; P{GD14752}v36482
Genomic Clones ( 2 )
	BACR05M06 BACR25K01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD09783
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM06914 GM14613 GM14728 GM23528 LD20726 LD32183 RE11716
Other clones	Dmel_dig_012106_0642_0990 Dmel_neb_004556_0824_2955 Dmel_neb_005391_0872_3399 EK044226 EK155553 EK164464 EK168009 EK200205 EK240008 EK242208 EN05751 EN08148 FGH126A04 FGM105H03 FGM105H08
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031698 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33761
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ncoa6 CG14023 (Mohan et al., 2011)
Source for database merge of
Additional comments
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135077 NM_001103618 NM_001258955 RefSeq (Proteins) • NP_608921 NP_001097088 NP_001245884 DDBJ / EMBL / GenBank • AA390806 AAF52239 AAM49871 ABV53626 AFH03559 AW942088 AY118502 Entrez Gene - A searchable database of RefSeq genes. • 33761 UniProtKB/TrEMBL • A8DYV5 Q8MSY0 Q9VMS2
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031698 DRSC - Results from RNAi screens. • FBgn0031698 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031698 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14023-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031698 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33761 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33761 modMine - Data generated by the modENCODE project. • FBgn0031698
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG14023 (Jungreis et al., 2011, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Mohan et al., 2011, Jiang et al., 2009, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) dNCOA6 (Mohan et al., 2011) Ncoa6
Name Synonym
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Herz et al., 2012, Genes Dev. 26(23): 2604--2620 Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. [FBrf0220205] Mohan et al., 2011, Mol. Cell. Biol. 31(21): 4310--4318 The COMPASS Family of H3K4 Methylases in Drosophila. [FBrf0216343] Show all research papers ...