Gene Dmel\CG7371

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General Information

Symbol

Dmel\CG7371

Species

D. melanogaster

Name

Annotation symbol

CG7371

Feature type

protein_coding_gene

FlyBase ID

FBgn0031710

Gene Model Status

Current

Stock availability

8 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

25E5-25E5

Sequence location

2L:5,521,281..5,523,877 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG7371 (FBgn0031710). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 8 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Vps52/Sac2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval salivary gland, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1629923_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG7371. Gene sequence location is 2L:5521281..5523877.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25E5-25E5

Limits computationally determined from genome sequence between P{lacW}vri^k05901&P{PZ}cype⁰³⁷⁷¹ and P{lacW}Hel25E^k11511

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG7371 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG7371-RA

FBtr0079129

NM_135087

2147

662

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG7371-PA

FBpp0078760

77.4

662

6.61

NP_608931

AAF52254

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Vps52/Sac2 (IPR007258)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult thoracico-abdominal ganglion, larval salivary gland, adult male accessory gland.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		77.95
Larval Midgut		61.8
Larval Hindgut		67.5
Larval Malpighian Tubules		71.8
Larval Fat Body		95.8
Larval Salivary Gland		113.8
Larval Trachea		26.525
Larval Carcass		57.125
Adult Head		49.6
Adult Eye		39.825
Adult Brain		89
Adult Thoracic-Abdominal Ganglion		103.9
Adult Crop		82
Adult Midgut		49
Adult Hindgut		75.4
Adult Malpighian Tubules		44.6
Adult Fat Body		47.6
Adult Salivary Gland		69.6
Adult Heart		79.65
Adult VirginFemale Spermatheca		55.3
Adult InseminatedFemale Spermatheca		50.6
Adult Ovary		80.6
Adult Testis		52.1
Adult Male Accessory Gland		108.4
Adult Carcass		55.6
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	49.6
NA	Eye	39.825
NA	Brain	89
77.95	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	103.9
NA	Crop	82
61.8	Midgut	49
67.5	Hindgut	75.4
71.8	Malpighian Tubules	44.6
95.8	Fat Body	47.6
113.8	Salivary Gland	69.6
NA	Heart	79.65
26.525	Trachea	NA
NA	VirginFemale Spermatheca	55.3
NA	InseminatedFemale Spermatheca	50.6
NA	Ovary	80.6
NA	Testis	52.1
NA	Male Accessory Gland	108.4
57.125	Carcass	55.6

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		11
central nervous system, larvae L3		7
central nervous system, pupae P8		8
head, virgin 1-day female		5
head, virgin 4-day female		4
head, virgin 20-day female		6
head, mated 1-day female		4
head, mated 4-day female		4
head, mated 20-day female		4
head, mated 1-day male		7
head, mated 4-day male		7
head, mated 20-day male		10
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		5
digestive system, larvae L3 wandering		11
digestive system, 1-day adult		5
digestive system, 4-day adult		5
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		8
fat body, pupae P8		6
carcass, larvae L3 wandering		7
carcass, 1-day adult		5
carcass, 4-day adult		5
carcass, 20-day adult		5
ovary, virgin 4-day female		14
ovary, mated 4-day female		11
testis, mated 4-day male		18
accessory gland, mated 4-day male		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		22
embryo 02-04hr		19
embryo 04-06hr		11
embryo 06-08hr		13
embryo 08-10hr		17
embryo 10-12hr		15
embryo 12-14hr		17
embryo 14-16hr		11
embryo 16-18hr		12
embryo 18-20hr		9
embryo 20-22hr		10
embryo 22-24hr		14
larva L1		7
larva L2		9
larva L3 12hr old		7
larva L3 puffstage 1-2		10
larva L3 puffstage 3-6		12
larva L3 puffstage 7-9		19
white prepupae new		18
white prepupae 12hr		14
white prepupae 24hr		15
pupae 2d postWPP		16
pupae 3d postWPP		14
pupae 4d postWPP		10
adult male 01day		15
adult male 05day		18
adult male 30day		16
adult female 01day		9
adult female 05day		17
adult female 30day		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		15
Schneider line 2 Sg4		7
embryonic 1182-4H		8
embryonic GM2		12
embryonic Kc167		10
embryonic S1		16
embryonic S3		12
leg disc CME L1		7
wing disc CME-W2		15
wing disc ML-DmD8		8
wing disc ML-DmD9		10
wing disc ML-DmD16-c3		5
wing disc ML-DmD21		5
wing disc ML-DmD32		7
haltere disc ML-DmD17-c3		12
eye-antennal disc ML-DmD11		11
antennal disc ML-DmD20-c5		10
mixed discs ML-DmD4-c1		10
CNS ML-DmBG1-c1		11
CNS ML-DmBG2-c2		10
tumorous blood cells mbn2		12
ovary fGS/OSS		7
ovary OSC		9
ovary OSS		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		3
cold shock, 4-day adult		3
heat shock, 4-day adult		6
Cadmium 50 mM 6 hrs, larvae L3		5
Cadmium 50 mM 12 hrs, larvae L3		11
Cadmium 50 mM 48 hrs, 4-day adult		9
Cadmium 100 mM 48 hrs, 4-day adult		12
Copper 0.5 mM 12 hrs, larvae L3		2
Copper 15 mM 48 hrs, 4-day adult		8
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		11
Ethanol 5% 3 hrs, larvae L3		9
Ethanol 10% 3 hrs, larvae L3		4
Caffeine 1.5 mg/ml 4 hrs, larvae L3		7
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		7
Caffeine 25 mg/ml 48 hrs, 4-day adult		3
Paraquat 5 mM 48 hrs, 4-day adult		13
Paraquat 10 mM 48 hrs, 4-day adult		11
Rotenone 2 μg 12 hrs, larvae L3		8
Rotenone 8 μg 12 hrs, larvae L3		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

RE59171

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031710

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG7371-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

Other Phenotypes

Allele

planar polarity defective, with Scer\GAL4^pnr-MD237

CG7371^GD12217

visible, with Scer\GAL4^pnr-MD237

CG7371^GD12217

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

CG7371^GD12217

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of CG7371	Mutagen	Stocks	Known lesion
CG7371^f02109	piggyBac transposase	3	--
CG7371^9d1.Δ6	Delta2-3	0	Yes
CG7371^9d1.Δ76	Delta2-3	0	Yes

Alleles Carried on Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG7371	Mutagen	Stocks	Known lesion
CG7371^GD16409	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG7371^GD12217	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG7371^HMS01713	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG7371^KK102594	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG7371^NIG.7371R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Partially disrupted in

Df(2L)cl^9d1.Δ6

(Giordano et al., 2003)

Df(2L)cl^9d1.Δ76

(Giordano et al., 2003)

Disrupted in

Df(2L)Exel6012

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{WH}CG7371^f02109

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG7371 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

59942

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0031710

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

33774

Orthologs

OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6G7CHT

Dipteran inclusive ortholog search

EOG6B2T59

Insect inclusive ortholog search

EOG6KKWZ2

Arthropod inclusive ortholog search

EOG6TB2SB

Metazoa inclusive ortholog search

EOG65F8GB

Orthologs in Drosophila Species (EOG6G7CHT)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20303

Drosophila persimilis

Dper\GL25904

Drosophila willistoni

Dwil\GK15054

Drosophila virilis

Dvir\GJ17821

Drosophila mojavensis

Dmoj\GI21912

Drosophila grimshawi

Dgri\GH11452

Orthologs in non-Drosophila Dipterans (EOG6B2T59)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL014070

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012115

Anopheles gambiae

Malaria mosquito

Agam\AGAP009739

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ801433

Orthologs in non-Dipteran Insects (EOG6KKWZ2)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC412346

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG000202

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH22192

Atta cephalotes

Leafcutter ant

Acep\ACEP13624

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO20691

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL23220

Linepithema humile

Argentine ant

Lhum\LH20492

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB20327

Solenopsis invicta

Red fire ant

Sinv\SINV24176

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009728

Bombyx mori

Silkmoth

Bmor\BGIBMGA002965

Pediculus humanus

Human body louse

Phum\PHUM164360

Tribolium castaneum

Red flour beetle

Tcas\TC013395

Orthologs in non-Insect Arthropods (EOG6TB2SB)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\rbcL

Ixodes scapularis

Deer tick

Isca\ISCW015564

Orthologs in non-Arthropod Metazoa (EOG65F8GB)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\F08C6.3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_006460gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_000869gn

Danio rerio

Zebrafish

Drer\vps52

Xenopus tropicalis

Western clawed frog

Xtro\vps52

Mus musculus

House mouse

Mmus\ENSMUSG00000024319

Rattus norvegicus

Norway rat

Rnor\Vps52

Homo sapiens

Human

Hsap\VPS52

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\VPS52

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20303

Drosophila persimilis

Dper\GL25904

Drosophila willistoni

Dwil\GK15054

Drosophila virilis

Dvir\GJ17821

Drosophila mojavensis

Dmoj\GI21912

Drosophila grimshawi

Dgri\GH11452

Stocks & Reagents

Stocks Listed in FlyBase ( 8 )

Bloomington

18514

w¹¹¹⁸; PBac{WH}CG7371^f02109/CyO

38268

y¹ sc^* v¹; P{TRiP.HMS01713}attP40

Harvard

PBac{WH}CG7371^f02109

Kyoto

114529

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; PBac{WH}CG7371^f02109 P{neoFRT}40A/CyO y⁺

VDRC

v106958

P{KK102594}VIE-260B

v27985

w¹¹¹⁸; P{GD12217}v27985

v48711

w¹¹¹⁸; P{GD16409}v48711

v48712

w¹¹¹⁸; P{GD16409}v48712/TM3

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 12 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE59171

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0031710

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

33774

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

FlyBase curator comment: the insertion in the "d06812" Exelixis line (P{XP}CG6907^d06812) was originally assigned to the CG7371 gene in FBrf0179797, resulting in the "CG7371^d06812" (FBal0161041) allele. However, FBrf0184340 shows that the insertion is actually within CG6907.

(Bloomington Drosophila Stock Center, 2004.11.6)

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_135087

RefSeq (Proteins)

•

NP_608931

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

33774

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Vps52/Sac2 (IPR007258)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

RE59171

Linkouts

BioGRID - A database of protein and genetic interactions

•

59942

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0031710

DRSC - Results from RNAi screens.

•

FBgn0031710

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0031710

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG7371-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0031710

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

33774

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

33774

modMine - Data generated by the modENCODE project.

•

FBgn0031710

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG7371

(Keleman et al., 2009.8.5, Neely et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1)

Name Synonym

Secondary FlyBase IDs

References ( 19 )

Research paper

Neely et al., 2010, Cell 141(1): 142--153: A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. [FBrf0210524]
Giordano et al., 2003, Mol. Genet. Genomics 268(5): 692--697: The clot gene of Drosophila melanogaster encodes a conserved member of the Thioredoxin-like protein superfamily. [FBrf0155969]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila.: A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file): Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340]
Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase.: Exelixis insertion alleles that are not in FlyBase. [FBrf0179797]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
Gene Disruption Project members, 2001-, (Computer file): (Computer file) [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

FlyBase analysis

FlyBase, 1992-, FlyBase curation.: FlyBase curation. [FBrf0105495]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]

Curated genome annotation

FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.]: [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]