Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp60C using the Feature Mapper tool.
Hsp60C transcript is expressed at a consistant low level in follicle cells through oogenesis stage S12. Hsp60C transcript is expressed at low levels in the germarium, and at early stages of oogenesis in nurse cells, follicle cells, and oocytes. The level of Hsp60C transcript increases in nurse cells and oocytes increased until oogenesis stage S10B, after which, a decline was seen first in oocytes then in nurse cells. Hsp60C transcript is largely absent in mature oocytes, although some localised signal can be detected in the region where the future micropyle will develop.
Hsp60C protein is localized in striated muscles surrounding the egg chamber, and in oviduct muscles; and in follicle cells, nurse cells, and oocytes. Hsp60C protein is specifically localized to the A bands of striated muscles that enwrap the ovariole and individual egg chambers, and the striated muscles of the oviduct. Hsp60C protein localizes to the external face of follicle cells. At oogenesis stage S10-11, Hsp60C protein is present in nurse cell cytoplasm, where it overlaps the distribution of F-actin, particularly near the cell membrane. It also appears to colocalize with the actin skeleton surrounding the nuclei of nurse cells. Less expression is observed in oocytes. After oogenesis stage 13, Hsp60C is largely absent from oocytes, and in nurse cells is concentrated in a small region of the nurse cell-oocyte junction that will form the micropyle of the mature oocyte.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hsp60C in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hsp60C CG7235