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FB2025_05
,
released December 11, 2025
Hsp64
Please see the JBrowse view of Dmel\Hsp60C for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp60C using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Hsp60C transcript is expressed at a consistant low level in follicle cells through oogenesis stage S12. Hsp60C transcript is expressed at low levels in the germarium, and at early stages of oogenesis in nurse cells, follicle cells, and oocytes. The level of Hsp60C transcript increases in nurse cells and oocytes increased until oogenesis stage S10B, after which, a decline was seen first in oocytes then in nurse cells. Hsp60C transcript is largely absent in mature oocytes, although some localised signal can be detected in the region where the future micropyle will develop.
Hsp60C is expressed in the developing trachea, initially at embryonic stage 14-15 in the posterior part of the dorsal tracheal trunk. Expression is observed in the transverse connectives and primary branches of tracheal trunks beginning at stage 16; expression in the developing posterior spiracles begins at stage 15. Strong expression is observed in the entire tracheal system by embryonic stage 16, persisting through the third larval instar. Additional third instar larval expression is observed in the prothoracic gland; in the gut, most intensely in the proventriculus; and in the brain lobes. Faint expression is observed in most tissues from embryonic stage 16 through the third larval instar. In the adult male reproductive system, low levels of expression are observed in hub and spermatogonial cells and spermatocytes, while higher levels are observed in spermatids and sperm, and in the ejaculatory duct; no expression is detected in cells of the vas deferens or accessory glands.
Hsp60C protein is localized in striated muscles surrounding the egg chamber, and in oviduct muscles; and in follicle cells, nurse cells, and oocytes. Hsp60C protein is specifically localized to the A bands of striated muscles that enwrap the ovariole and individual egg chambers, and the striated muscles of the oviduct. Hsp60C protein localizes to the external face of follicle cells. At oogenesis stage S10-11, Hsp60C protein is present in nurse cell cytoplasm, where it overlaps the distribution of F-actin, particularly near the cell membrane. It also appears to colocalize with the actin skeleton surrounding the nuclei of nurse cells. Less expression is observed in oocytes. After oogenesis stage 13, Hsp60C is largely absent from oocytes, and in nurse cells is concentrated in a small region of the nurse cell-oocyte junction that will form the micropyle of the mature oocyte.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Hsp60C in JBrowse2-17
2-18.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hsp60C CG7235
