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Gene Dmel\CG7236

General Information
Symbol	Dmel\CG7236	Species	D. melanogaster
Name		Annotation symbol	CG7236
Feature type	protein_coding_gene	FlyBase ID	FBgn0031730
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	25F3-25F3	Sequence location	2L:5,708,449..5,713,648 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG7236 (FBgn0031730). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cyclin-dependent protein kinase activity. There is experimental evidence that it is involved in the biological process: cytokinesis. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1626477_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG7236. Gene sequence location is 2L:5708449..5713648.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Yin et al., 2008, BMC Bioinformatics 9: 264 Sequence features BKN50736 BKN28139 HFA03037 BKN50618
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 25F3-25F3   Limits computationally determined from genome sequence between P{lacW}Hel25Ek11511 and P{lacW}l(2)k06502k06502
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG7236 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG7236-RA FBtr0079133  NM_135106   1601   501 CG7236-RB FBtr0302950  NM_001201773   1484   435
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG7236-PA   FBpp0078764   57.9   501   9.62     NP_608950   AAF52279 CG7236-PB   FBpp0292076   49.9   435   9.13     NP_001188702   ADV36952
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52279   AE014134 ADV36952   BT025101   EC053992   EC056442
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMN3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031730    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031730 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031730 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr  (142) embryo 14-16hr  (362) embryo 16-18hr  (303) embryo 18-20hr  (255) embryo 20-22hr  (167) embryo 22-24hr  (159) larva L1  (146) larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr  (113) pupae 2d postWPP  (286) pupae 3d postWPP    92 pupae 4d postWPP  (178) adult male 01day  (154) adult male 05day  (153) adult male 30day  (218) adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031730 expression level Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr  142 embryo 14-16hr  (362) embryo 16-18hr  (303) embryo 18-20hr  (255) embryo 20-22hr  (167) embryo 22-24hr  (159) larva L1  (146) larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr  113 pupae 2d postWPP  (286) pupae 3d postWPP    92 pupae 4d postWPP  (178) adult male 01day  (154) adult male 05day  (153) adult male 30day  (218) adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4 embryo 02-04hr    0 embryo 04-06hr    1 embryo 06-08hr    8 embryo 08-10hr    12 embryo 10-12hr    46 embryo 12-14hr    142 embryo 14-16hr    362 embryo 16-18hr    303 embryo 18-20hr    255 embryo 20-22hr    167 embryo 22-24hr    159 larva L1    146 larva L2    61 larva L3 12hr old    17 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    39 white prepupae new    36 white prepupae 12hr    38 white prepupae 24hr    113 pupae 2d postWPP    286 pupae 3d postWPP    92 pupae 4d postWPP    178 adult male 01day    154 adult male 05day    153 adult male 30day    218 adult female 01day    57 adult female 05day    16 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031730    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031730 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031730 expression level Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031730 expression level Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.475 Larval Midgut    1.2 Larval Hindgut    0.8 Larval Malpighian Tubules    0.9 Larval Fat Body    1.2 Larval Salivary Gland    1.7 Larval Trachea    1.225 Larval Carcass    1.4 Adult Head no informative data Adult Eye    8.525 Adult Brain    0.8 Adult Thoracic-Abdominal Ganglion    8.5 Adult Crop    1.2 Adult Midgut    1.2 Adult Hindgut    1.2 Adult Malpighian Tubules    1.2 Adult Fat Body    2.4 Adult Salivary Gland    2.3 Adult Heart    0.7 Adult VirginFemale Spermatheca    1.3 Adult InseminatedFemale Spermatheca    1 Adult Ovary    0.8 Adult Testis    1.8 Adult Male Accessory Gland    1.5 Adult Carcass    3.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    8.525   NA  Brain    0.8   0.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    8.5   NA  Crop    1.2   1.2  Midgut    1.2   0.8  Hindgut    1.2   0.9  Malpighian Tubules    1.2   1.2  Fat Body    2.4   1.7  Salivary Gland    2.3   NA  Heart    0.7   1.225  Trachea    NA   NA  VirginFemale Spermatheca    1.3   NA  InseminatedFemale Spermatheca    1   NA  Ovary    0.8   NA  Testis    1.8   NA  Male Accessory Gland    1.5   1.4  Carcass    3.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031730 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7236-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG7236 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG7236 Class Mutagen Stocks Known lesion CG7236JF02655 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG7236GD12178 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6013 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12178} NA P{TRiP.JF02655} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Kiger et al., 2003, Echard et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cyclin-dependent protein kinase activity inferred from sequence or structural similarity (Liu and Kipreos, 2000) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Liu and Kipreos, 2000) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG7236 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59966 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031730 DroID - A comprehensive database of gene and protein interactions. • FBgn0031730 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33798
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15577 Dere\GG25090 Dgri\GH11042 Dmoj\GI17559 Dper\GL26377 Dpse\GA20202 Dsec\GM18566 Dsim\GD23357 Dvir\GJ15594 Dwil\GK14689 Dyak\GE25570
Curated drosophilid orthologs	Dpse\GA20202
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004700-PA Aedes aegypti (mosquito) AGAP003180-PA Anopheles gambiae (mosquito) XP_394980.3 Apis mellifera (honey bee) XP_001949199.1 Acyrthosiphon pisum (pea aphid) 275907 Branchiostoma floridae (lancelet) XP_001894642.1 Brugia malayi (roundworm nematode) BGIBMGA004790-PA Bombyx mori (silk worm) ENSBTAP00000035910 Bos taurus (bovine) CN19041 Caenorhabditis brenneri (small nematode) CBP29873 Caenorhabditis briggsae (nematode) CE20258 Caenorhabditis elegans (worm) ENSCAFP00000021096 Canis familiaris (dog) ENSCINP00000005062 Ciona intestinalis (sea squirt) JA02297 Caenorhabditis japonica (nematode) CPIJ003291 Culex pipens (mosquito) ENSCPOP00000013038 Cavia porcellus (guinea pig) 102300 Chlamidomonas reinhardtii (green alga) RP48545 Caenorhabditis remanei (nematode) ENSCSAVP00000001669 Ciona savignyi (sedentary tunicate) 1740 Capitella spl (polychaete worm) 44967 Daphnia pulex (daphnia) ENSDARP00000044356 Danio rerio (zebra fish) ENSECAP00000020528 Equus caballus (horse) ENSGACP00000016956 Gymnopilus aculeatus (mushroom) ENSGALP00000020061 Gallus gallus (chicken) 131725 Hypsipyla robusta (cedar shoot borer) ENSP00000378476 Homo sapiens (human) 161601 Lottia gigantea (owl limpet) 14620 Monocosta brevicollis (choanoflagellate) ENSMODP00000010962 Monodelphis domestica (gray opossum) ENSMMUP00000003514 Macaca mulatta (rhesus monkey) ENSMUSP00000021377 Mus musculus (house mouse) 80454 Nematostella vectensis (starlet anemone) XP_001600503.1 Nasonia vitripennis (wasp) ENSOANP00000022034 Ornithorynchus anatinus (platypus) ENSORLP00000001542 Oryzias latipes (japanese killifish) PHUM002173-PA Pediculus humanus (human body louse) ENSPPYP00000013932 Pongo pygmaeus (orangutan) 44042 Phytophthora ramorum (sudden oak death pathogen) 128726 Phytophthora sojae (root rot pathogen) ENSPTRP00000057909 Pan troglodytes (chimpanzee) ENSRNOP00000006374 Rattus norvegicus (norway rat) Smp_124130 Schistosoma mansoni (trematode parasite) XP_001181116.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001198562.1 Strongylocentrotus purpuratus (purple sea urchin) XP_787618.1 Strongylocentrotus purpuratus (purple sea urchin) 19575 Trichoplax adhaerens (metazoa) XP_973379.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022539 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024107 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057731 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16089 LH10767 ISCW009619 FBgn0242634 FBgn0216695 FBgn0202785 FBgn0194743 FBgn0173473 JGI_V11_44967 FBgn0080197 FBgn0163959 FBgn0140303 FBgn0118523 FBgn0117219 FBgn0092602 CPIJ003291 BGIBMGA004790 ACYPI005204 GB13450 AGAP003180 AAEL004700 PB22828 PHUM420100 GLEAN_09252
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Bloomington	27505 y1 v1; P{TRiP.JF02655}attP2
Genomic Clones ( 1 )
	BACR07G15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP11357
Other clones	DPiM_IP11357
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	EC053992 EC056442
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031730 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33798
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG7236 AC018104 (Butler, 2000.11.13)
Additional comments
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the mitotic index, and multinucleate cells are seen. (Bettencourt-Dias et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135106 NM_001201773 RefSeq (Proteins) • NP_608950 NP_001188702 DDBJ / EMBL / GenBank • AAF52279 ADV36952 Entrez Gene - A searchable database of RefSeq genes. • 33798 UniProtKB/TrEMBL • Q9VMN3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59966 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031730 DroID - A comprehensive database of gene and protein interactions. • FBgn0031730 DRSC - Results from RNAi screens. • FBgn0031730 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031730 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7236-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031730 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33798 InParanoid A subset of ortholog calls from InParanoid. • AAEL004700-PA Aedes aegypti (mosquito) AGAP003180-PA Anopheles gambiae (mosquito) XP_394980.3 Apis mellifera (honey bee) XP_001949199.1 Acyrthosiphon pisum (pea aphid) 275907 Branchiostoma floridae (lancelet) XP_001894642.1 Brugia malayi (roundworm nematode) BGIBMGA004790-PA Bombyx mori (silk worm) ENSBTAP00000035910 Bos taurus (bovine) CN19041 Caenorhabditis brenneri (small nematode) CBP29873 Caenorhabditis briggsae (nematode) CE20258 Caenorhabditis elegans (worm) ENSCAFP00000021096 Canis familiaris (dog) ENSCINP00000005062 Ciona intestinalis (sea squirt) JA02297 Caenorhabditis japonica (nematode) CPIJ003291 Culex pipens (mosquito) ENSCPOP00000013038 Cavia porcellus (guinea pig) 102300 Chlamidomonas reinhardtii (green alga) RP48545 Caenorhabditis remanei (nematode) ENSCSAVP00000001669 Ciona savignyi (sedentary tunicate) 1740 Capitella spl (polychaete worm) 44967 Daphnia pulex (daphnia) ENSDARP00000044356 Danio rerio (zebra fish) ENSECAP00000020528 Equus caballus (horse) ENSGACP00000016956 Gymnopilus aculeatus (mushroom) ENSGALP00000020061 Gallus gallus (chicken) 131725 Hypsipyla robusta (cedar shoot borer) ENSP00000378476 Homo sapiens (human) 161601 Lottia gigantea (owl limpet) 14620 Monocosta brevicollis (choanoflagellate) ENSMODP00000010962 Monodelphis domestica (gray opossum) ENSMMUP00000003514 Macaca mulatta (rhesus monkey) ENSMUSP00000021377 Mus musculus (house mouse) 80454 Nematostella vectensis (starlet anemone) XP_001600503.1 Nasonia vitripennis (wasp) ENSOANP00000022034 Ornithorynchus anatinus (platypus) ENSORLP00000001542 Oryzias latipes (japanese killifish) PHUM002173-PA Pediculus humanus (human body louse) ENSPPYP00000013932 Pongo pygmaeus (orangutan) 44042 Phytophthora ramorum (sudden oak death pathogen) 128726 Phytophthora sojae (root rot pathogen) ENSPTRP00000057909 Pan troglodytes (chimpanzee) ENSRNOP00000006374 Rattus norvegicus (norway rat) Smp_124130 Schistosoma mansoni (trematode parasite) XP_001181116.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001198562.1 Strongylocentrotus purpuratus (purple sea urchin) XP_787618.1 Strongylocentrotus purpuratus (purple sea urchin) 19575 Trichoplax adhaerens (metazoa) XP_973379.2 Tribolium castaneum (red flour beetle) ENSTNIP00000022539 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024107 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057731 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33798 modMine - Data generated by the modENCODE project. • FBgn0031730 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16089 LH10767 ISCW009619 FBgn0242634 FBgn0216695 FBgn0202785 FBgn0194743 FBgn0173473 JGI_V11_44967 FBgn0080197 FBgn0163959 FBgn0140303 FBgn0118523 FBgn0117219 FBgn0092602 CPIJ003291 BGIBMGA004790 ACYPI005204 GB13450 AGAP003180 AAEL004700 PB22828 PHUM420100 GLEAN_09252
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	AC018104 (Liu and Kipreos, 2000, ) CG7236 (Yin et al., 2008, Perkins et al., 2009) KKIALRE (Morrison et al., 2000)
Name Synonym
Secondary FlyBase IDs
	FBgn0043013
References ( 18 )
Research paper	Yin et al., 2008, BMC Bioinformatics 9: 264 Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. [FBrf0215894] Bettencourt-Dias et al., 2004, Nature 432(7020): 980--987 Genome-wide survey of protein kinases required for cell cycle progression. [FBrf0184171] Echard et al., 2004, Curr. Biol. 14(18): 1685--1693 Terminal cytokinesis events uncovered after an RNAi screen. [FBrf0180064] Kiger et al., 2003, J. Biol. 2(4): 27 A functional genomic analysis of cell morphology using RNA interference. [FBrf0167741] Halfon et al., 2002, Genome Res. 12(7): 1019--1028 Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. [FBrf0151337] Liu and Kipreos, 2000, Molec. Biol. Evol. 17(7): 1061--1074 Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. [FBrf0128813]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Morrison et al., 2000, J. Cell Biol. 150(2): Table S1. Drosophila protein kinases and phosphatases. [FBrf0132098]
Personal communication to FlyBase	Perkins et al., 2009, Update to TRiP stock collection. Update to TRiP stock collection. [FBrf0208864] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Butler, 2000.11.13, New genes. New genes. [FBrf0132133]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]