FlyBase Gene Report: Dmel\CG7236

General Information

Symbol

Dmel\CG7236

Species

D. melanogaster

Name

Annotation Symbol

CG7236

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031730

Gene Model Status

Current

Stock Availability

3 publicly available

Enzyme Name (EC)

Cyclin-dependent kinase (2.7.11.22)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

AC018104

Key Links

Genomic Location

Cytogenetic map

25F3-25F3

Sequence location

2L:5,706,374..5,713,791 [+]

Recombination map

2-17

RefSeq locus

NT_033779 REGION:5706374..5713791

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables cyclin-dependent protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Liu and Kipreos, 2000)

enables protein kinase activity

inferred from sequence or structural similarity with HGNC:11411

(FlyBase Curators, 2008-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein phosphorylation

inferred from sequence or structural similarity

(Liu and Kipreos, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with HGNC:11411

(FlyBase Curators, 2008-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with HGNC:11411

(FlyBase Curators, 2008-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000623091

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from sequence or structural similarity with HGNC:11411

(FlyBase Curators, 2008-)

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + a protein = ADP + a phosphoprotein (2.7.11.22)

Summaries

Gene Group (FlyBase)

CYCLIN DEPENDENT KINASES -: Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG7236 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VMN3)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG7236-RB

FBtr0302950

NM_001201773

1540

435

CG7236-RC

FBtr0343387

NM_135106

1613

438

CG7236-RD

FBtr0343388

NM_001298705

1482

412

CG7236-RE

FBtr0343389

NM_001298706

1739

421

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CG7236-PB

FBpp0292076

49.9

435

9.13

NP_001188702

ADV36952

CG7236-PC

FBpp0310041

50.4

438

8.81

NP_608950

AAF52279

CG7236-PD

FBpp0310042

47.3

412

9.15

NP_001285634

AHN54149

CG7236-PE

FBpp0310043

48.4

421

9.15

NP_001285635

AHN54150

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG7236 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CG7236 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG7236

View exonic expression by tissue for Dmel\CG7236

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031730

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33798/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031730

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031730

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031730

Flygut - An atlas of the Drosophila adult midgut

FBgn0031730

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG7236

Transgenic constructs containing regulatory region of CG7236

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)Exel6013

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CDKL1

12 of 15

Yes

Hsap\CDKL4

11 of 15

Yes

Hsap\CDKL2

5 of 15

Yes

Hsap\CDKL3

3 of 15

Yes

Hsap\CDKL5

3 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cdkl1

13 of 15

Yes

Mmus\Cdkl4

11 of 15

Yes

Mmus\Cdkl2

3 of 15

Yes

Mmus\Cdkl3

3 of 15

Yes

Mmus\Cdkl5

3 of 15

Yes

Mmus\Rac1

1 of 15

Rattus norvegicus (Norway rat) (6)

Rnor\Cdkl1

12 of 13

Yes

Rnor\Cdkl4

3 of 13

Yes

Rnor\Cdkl5

3 of 13

Yes

Rnor\Cdkl2

2 of 13

Yes

Rnor\Cdkl3

2 of 13

Yes

Rnor\LOC108348323

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (3)

Xtro\cdkl1

11 of 12

Yes

Xtro\cdkl2

3 of 12

Yes

Xtro\cdkl5

2 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\cdkl1

12 of 15

Yes

Drer\cdkl5

3 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\cdkl-1

13 of 15

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CDKL5; cyclin dependent kinase like 5

model of developmental and epileptic encephalopathy 2

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CDKL1; cyclin dependent kinase like 1

12 of 15

603441

CDKL4; cyclin dependent kinase like 4

11 of 15

CDKL2; cyclin dependent kinase like 2

5 of 15

603442

CDKL3; cyclin dependent kinase like 3

3 of 15

608459

CDKL5; cyclin dependent kinase like 5

3 of 15

300203

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 2; DEE2

developmental and epileptic encephalopathy 2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59966

DroID - A comprehensive database of gene and protein interactions.

FBgn0031730

MIST (protein-protein) - An integrated Molecular Interaction Database

CG7236

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-17

Cytogenetic map

25F3-25F3

Sequence location

2L:5,706,374..5,713,791 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

25F3-25F3

Limits computationally determined from genome sequence between P{lacW}Hel25E^k11511 and P{lacW}l(2)k06502^k06502

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-17

(FlyBase, 2016)

2-18.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27505

y¹ v¹; P{TRiP.JF02655}attP2

VDRC

v342392

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00307}attP40/CyO-GFP

v341673

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00774}attP40/CyO-GFP

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP11357

Other clones

DPiM_IP11357

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031730

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031730

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33798

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CG7236 AC018104

(Butler, 2000.11.13)

Additional comments

Other Comments

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the mitotic index, and multinucleate cells are seen.

(Bettencourt-Dias et al., 2004)

dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

(Echard et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: binucleate cells.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33798

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VMN3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VMN3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031730

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031730

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33798/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031730

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031730

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031730

Flygut - An atlas of the Drosophila adult midgut

FBgn0031730

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33798

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7236

MARRVEL_MODEL - MARRVEL (model organism gene)

33798

modMine - A data warehouse for the modENCODE project

FBgn0031730

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VMN3

Linkouts

BioGRID - A database of protein and genetic interactions.

59966

DroID - A comprehensive database of gene and protein interactions.

FBgn0031730

DRSC - Results frm RNAi screens

FBgn0031730

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031730

FlyMine - An integrated database for Drosophila genomics

FBgn0031730

MIST (protein-protein) - An integrated Molecular Interaction Database

CG7236

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

AC018104

(Liu and Kipreos, 2000)

CG7236

(Robinson et al., 2020, Wu et al., 2020, Joyce et al., 2012, Liu et al., 2009, Perkins et al., 2009, Yin et al., 2008, Stanyon et al., 2004)

CG7236/Cdk1l

(Yin et al., 2013)

KKIALRE

(Morrison et al., 2000)

Name Synonyms

Secondary FlyBase IDs

FBgn0043013

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (32)

The following external sites may use different assemblies or annotations than FlyBase.

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