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Gene Dmel\KFase

General Information
Symbol	Dmel\KFase	Species	D. melanogaster
Name	Kynurenine formamidase	Annotation symbol	CG9542
Feature type	protein_coding_gene	FlyBase ID	FBgn0031821
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26D9-26D9	Sequence location	2L:6,487,342..6,488,756 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Kynurenine formamidase is referred to in FlyBase by the symbol Dmel\KFase (CG9542, FBgn0031821). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: arylformamidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: metabolic process. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Alpha/beta hydrolase fold-3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval fat body, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638866_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG9542. Gene sequence location is 2L:6487342..6488756.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms tryptophan catabolic process to kynurenine
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26D9-26D9   Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\KFase for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) KFase-RA FBtr0079265  NM_135192   1002   300 KFase-RB FBtr0339785     1363   300
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein KFase-PA   FBpp0078895   34.9   300   6.13     NP_609036   AAF52391 KFase-PB   FBpp0308832   34.9   300   6.13
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Kynurenine formamidase (IPR027519) Alpha/beta hydrolase fold-3 (IPR013094)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52391   AY089670 AAL90408   BI367621   BI569533   BI613182   BI618202   BI628571   BI629221   CO192022   CO324573   EC200851
UniProtKB/Swiss-Prot	Q9VMC9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
colocalizes_with prefoldin complex inferred from direct assay (Guruharsha et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval fat body, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye    820.475 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye  (820.475) Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye    820.475 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye    820.475 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye    820.475 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye  (820.475) Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye    820.475 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    17.9 Larval Midgut    7.1 Larval Hindgut    14 Larval Malpighian Tubules    10 Larval Fat Body    360.1 Larval Salivary Gland    30.8 Larval Trachea    69.55 Larval Carcass    335.375 Adult Head    261.7 Adult Eye    820.475 Adult Brain    21.9 Adult Thoracic-Abdominal Ganglion    13.1 Adult Crop    68.9 Adult Midgut    3.9 Adult Hindgut    7.1 Adult Malpighian Tubules    7.2 Adult Fat Body    40.8 Adult Salivary Gland    2.9 Adult Heart    24.6 Adult VirginFemale Spermatheca    21.9 Adult InseminatedFemale Spermatheca    24.2 Adult Ovary    2 Adult Testis    109.9 Adult Male Accessory Gland    25.2 Adult Carcass    134.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    261.7   NA  Eye    820.475   NA  Brain    21.9   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    68.9   7.1  Midgut    3.9   no informative data  Hindgut    7.1   no informative data  Malpighian Tubules    7.2   360.1  Fat Body    no informative data   no informative data  Salivary Gland    2.9   NA  Heart    no informative data   69.55  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    2   NA  Testis    109.9   NA  Male Accessory Gland    no informative data   335.375  Carcass    134.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male  (27) head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male  27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    7 central nervous system, larvae L3    2 central nervous system, pupae P8    3 head, virgin 1-day female    22 head, virgin 4-day female    12 head, virgin 20-day female    14 head, mated 1-day female    18 head, mated 4-day female    9 head, mated 20-day female    8 head, mated 1-day male    27 head, mated 4-day male    17 head, mated 20-day male    23 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    2 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    17 fat body, white prepupae    1 fat body, pupae P8    2 carcass, larvae L3 wandering    4 carcass, 1-day adult    7 carcass, 4-day adult    5 carcass, 20-day adult    4 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    17 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout the larval period, during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    9 embryo 16-18hr    13 embryo 18-20hr    12 embryo 20-22hr    5 embryo 22-24hr    5 larva L1    7 larva L2    4 larva L3 12hr old    25 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    6 white prepupae new    4 white prepupae 12hr    6 white prepupae 24hr    5 pupae 2d postWPP    25 pupae 3d postWPP    25 pupae 4d postWPP    16 adult male 01day    18 adult male 05day    14 adult male 30day    11 adult female 01day    10 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    3 embryonic 1182-4H    0 embryonic GM2    1 embryonic Kc167    2 embryonic S1    4 embryonic S3    1 leg disc CME L1    2 wing disc CME-W2    12 wing disc ML-DmD8    1 wing disc ML-DmD9    19 wing disc ML-DmD16-c3    3 wing disc ML-DmD21    2 wing disc ML-DmD32    14 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    3 mixed discs ML-DmD4-c1    1 CNS ML-DmBG1-c1    6 CNS ML-DmBG2-c2    2 tumorous blood cells mbn2    3 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3  (32) Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3  (30) Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3  32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3  30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    25 Ethanol 10% 3 hrs, larvae L3    30 Caffeine 1.5 mg/ml 4 hrs, larvae L3    23 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • RH42281 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031821 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9542-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 KFaseGD14245 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of KFase Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of KFase Class Mutagen Stocks Known lesion KFaseGD14245 in vitro construct - RNAi in vitro construct - regulatory fusion 5 Yes KFaseKK102976 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes KFaseNIG.9542R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0256SH0256 No insertion of mobile activating element P{EPgy2}EY00633 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
arylformamidase activity inferred from direct assay (Han et al., 2012)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
colocalizes_with prefoldin complex inferred from direct assay (Guruharsha et al., 2011)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
tryptophan catabolic process to kynurenine inferred from electronic annotation with InterPro:IPR027519 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
KFase - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) KFase - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) KFase - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) KFase - CG13993 experimental knowledge based (Guruharsha et al., 2011) KFase - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) KFase - CG7048 experimental knowledge based (Guruharsha et al., 2011) KFase - CG7770 experimental knowledge based (Guruharsha et al., 2011) KFase - CoVb anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) KFase - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) KFase - mgr experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions KFase allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031821 DroID - A comprehensive database of gene and protein interactions. • FBgn0031821 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33907
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6M0FMW Dipteran inclusive ortholog search EOG65X851 Insect inclusive ortholog search EOG6WDC7R Arthropod inclusive ortholog search EOG6W3R3V Metazoa inclusive ortholog search EOG6T7MXD
Orthologs in Drosophila Species (EOG6M0FMW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\KFase     Drosophila simulans   Dsim\GD22571 Y   Drosophila sechellia   Dsec\GM17933 Y   Drosophila erecta   Dere\GG23617 Y   Drosophila yakuba   Dyak\GE18436 Y   Drosophila ananassae   Dana\GF15705 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21868 Y   Drosophila persimilis   Dper\GL26102 Y   Drosophila willistoni   Dwil\GK18691 Y   Drosophila virilis   Dvir\GJ17896 Y   Drosophila mojavensis   Dmoj\GI17287 Y   Drosophila grimshawi   Dgri\GH13248 Y
Orthologs in non-Drosophila Dipterans (EOG65X851)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004509   Anopheles gambiae Malaria mosquito  Agam\AGAP009433   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001121
Orthologs in non-Dipteran Insects (EOG6WDC7R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45372   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG015814   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16152   Atta cephalotes Leafcutter ant  Acep\ACEP18351   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16601   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12413   Linepithema humile Argentine ant  Lhum\LH12530   Linepithema humile Argentine ant  Lhum\LH12531   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21396   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21397   Acyrthosiphon pisum Pea aphid  Apim\ACYPI38182   Bombyx mori Silkmoth  Bmor\BGIBMGA007856   Bombyx mori Silkmoth  Bmor\BGIBMGA007854   Tribolium castaneum Red flour beetle  Tcas\TC011070   Tribolium castaneum Red flour beetle  Tcas\TC011071
Orthologs in non-Insect Arthropods (EOG6W3R3V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_315847   Ixodes scapularis Deer tick  Isca\ISCW007881
Orthologs in non-Arthropod Metazoa (EOG6T7MXD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y73B6BL.45   Caenorhabditis elegans Nematode  Cele\Y45F10A.3   Caenorhabditis elegans Nematode  Cele\D2024.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008079gn   Danio rerio Zebrafish  Drer\CU929356.4   Danio rerio Zebrafish  Drer\afmid   Xenopus tropicalis Western clawed frog  Xtro\afmid   Gallus gallus Domestic chicken  Ggal\AFMID   Mus musculus House mouse  Mmus\Afmid   Homo sapiens Human  Hsap\AFMID
Human Orthologs (1)
Gene OMIM HGNC Hsap\AFMID
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22571 Drosophila sechellia Dsec\GM17933 Drosophila erecta Dere\GG23617 Drosophila yakuba Dyak\GE18436 Drosophila ananassae Dana\GF15705 Drosophila pseudoobscura pseudoobscura Dpse\GA21868 Drosophila persimilis Dper\GL26102 Drosophila willistoni Dwil\GK18691 Drosophila virilis Dvir\GJ17896 Drosophila mojavensis Dmoj\GI17287 Drosophila grimshawi Dgri\GH13248
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
VDRC	v27018 w1118 P{GD14245}v27018 v45620 w1118; P{GD14245}v45620 v45622 w1118; P{GD14245}v45622 v45619 w1118; P{GD14245}v45619/TM3 v45621 w1118; P{GD14245}v45621/TM3
Genomic Clones ( 1 )
	BACR37F23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 9 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH42281
Other clones	DPiM_RH42281
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE53424 RH01627 RH48792 RH57018 RH58056
Other clones	EC32616 EK194253
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031821 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33907
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: KFase CG9542 (Han et al., 2012)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135192 RefSeq (Proteins) • NP_609036 DDBJ / EMBL / GenBank • AAF52391 AAL90408 AY089670 BI613182 Entrez Gene - A searchable database of RefSeq genes. • 33907 UniProtKB/Swiss-Prot • Q9VMC9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Kynurenine formamidase (IPR027519) Alpha/beta hydrolase fold-3 (IPR013094) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH42281
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031821 DroID - A comprehensive database of gene and protein interactions. • FBgn0031821 DRSC - Results from RNAi screens. • FBgn0031821 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031821 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9542-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031821 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33907 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33907 modMine - Data generated by the modENCODE project. • FBgn0031821
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG9542 (Japanese National Institute of Genetics, 2012.5.21, Guruharsha et al., 2011, Keleman et al., 2009.8.5) KFase (Han et al., 2012)
Name Synonym	kynurenine formamidase (Han et al., 2012) Kynurenine formamidase
Secondary FlyBase IDs
References ( 14 )
Research paper	Han et al., 2012, Biochem. J. 446(2): 253--260 Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. [FBrf0219141] Guruharsha et al., 2011, Cell 147(3): 690--703 A Protein Complex Network of Drosophila melanogaster. [FBrf0216491]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]