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Gene Dmel\CG11050

General Information
Symbol	Dmel\CG11050	Species	D. melanogaster
Name		Annotation symbol	CG11050
Feature type	protein_coding_gene	FlyBase ID	FBgn0031836
Gene Model Status	Current	Stock availability	8 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26F1-26F1	Sequence location	2L:6,611,023..6,617,117 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11050 (FBgn0031836). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: metal ion binding; phosphoric diester hydrolase activity. The biological processes in which it is involved are not known. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: HD domain; Metal-dependent phosphohydrolase, HD domain; Metal-dependent phosphohydrolase, HD subdomain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval fat body, larval salivary gland, larval trachea, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641169_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG11050. Gene sequence location is 2L:6611023..6617117.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA02125 BKN29034
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26F1-26F1   Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11050 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD22339 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11050-RA FBtr0079291  NM_135208   2098   388 CG11050-RB FBtr0079292  NM_164694   2056   388 CG11050-RC FBtr0079293  NM_164695   1910   388
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11050-PA   FBpp0078921   42.5   388   6.69     NP_609052   AAF52408 CG11050-PB   FBpp0078922   42.5   388   6.69     NP_723193   AAN10588 CG11050-PC   FBpp0078923   42.5   388   6.69     NP_723194   AAN10589
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metal-dependent phosphohydrolase, HD domain (IPR003607) Metal-dependent phosphohydrolase, HD subdomain (IPR006674) HD domain (IPR023279)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263560   AA539414   AA539552   AA697565   AA817170   AA949633   AA979068   AE014134 AAF52408   AE014134 AAN10588   AE014134 AAN10589   AI135365   AI406130   AI546346   AW942634   AY119602 AAM50256   BI164820   BI165384   BI165404   BI166261   BI166488   BI169392   BI171352   BI173574   BI214423   BI215184   BI229319   BI230288   BI230916   BI236617   BI236749   BI237588   BI239991   BI240303   BI243300   BI357905   BI361295   BI362285   BI363729   BI363816   BI364055   BI365379   BI366027   BI368602   BI369215   BI374955   BI374985   BI481723   BI481733   BI484110   BI485238   BI564161   BI573102   BI574230   BI576438   BI583475   BI585461   BI586795   BI591035   BI609064   BI612890   BI614175   BI614403   BI618815   BI622601   BI624242   BI624703   BI628130   BI628543   BP544138   BP544139   BT001654 AAN71409   BZ286369   CK445190   CK662022   CO176800   CO185949   CO264955   CO266951   CO269320   CO272649   CO272844   CO281293   CO296085   CO296230   CO296281   CO302331   CO305299   CO305424   CO312624   CO317106   CO317168   CO320551   CO322015   CO322402   CO323780   CO324103   CO329535   CO331012   CO342289   CZ472639   CZ479997   CZ486945   EC057543   EC061241   EC074421   EC074507   EC074699   EC078063   EC078845   EC079052   EC083293   EC087157   EC194728   EC197927   EC203403   EC204231   EC211430   EC217565   EC231671   EC233605   EC237009   EC238585   EC244670   EC246683   EC247789   EC249225   EC250180   EC250575   ES693364   FD586396   FD586945   FD586960   FD587269   GH739624   GH739828   GH740288   GH740468   GH741148   GH741431   GH742016   GH742796   GH743089   GH743733   GH743772   GH744210   GH744868   GH745255   GH745589   GH746209   GH746854   GH761687   GH761689   GH762029   GH762410   GH762517   GH762626   GH763575   GH763695   GH763776   GH763876   GH764380   GH764502   GH764854   GH765142   GH765954   GH766459   GH766551   GH767191   GH767842   GH768255   GH768748   GH769086   GH779183   GH779385
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IGQ9 Q8MRI6 Q9VMB3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031836    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031836 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031836 expression level Developmental Stage   Expression Level embryo 00-02hr    5769 embryo 02-04hr    9324 embryo 04-06hr    8544 embryo 06-08hr    6832 embryo 08-10hr    4720 embryo 10-12hr    3509 embryo 12-14hr    2695 embryo 14-16hr    2400 embryo 16-18hr    2216 embryo 18-20hr    2688 embryo 20-22hr    2894 embryo 22-24hr    3061 larva L1    2147 larva L2    1807 larva L3 12hr old    1765 larva L3 puffstage 1-2    2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP    6080 adult male 01day    3886 adult male 05day    3052 adult male 30day    3288 adult female 01day    5153 adult female 05day    4252 adult female 30day    4676 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5769) embryo 02-04hr  (9324) embryo 04-06hr  (8544) embryo 06-08hr  (6832) embryo 08-10hr  (4720) embryo 10-12hr  (3509) embryo 12-14hr  (2695) embryo 14-16hr  (2400) embryo 16-18hr  (2216) embryo 18-20hr  (2688) embryo 20-22hr  (2894) embryo 22-24hr  (3061) larva L1  (2147) larva L2  (1807) larva L3 12hr old  (1765) larva L3 puffstage 1-2  (2195) larva L3 puffstage 3-6  (1171) larva L3 puffstage 7-9  (761) white prepupae new  (772) white prepupae 12hr  (1238) white prepupae 24hr  (774) pupae 2d postWPP  (899) pupae 3d postWPP  (1355) pupae 4d postWPP  (6080) adult male 01day  (3886) adult male 05day  (3052) adult male 30day  (3288) adult female 01day  (5153) adult female 05day  (4252) adult female 30day  (4676) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5769) embryo 02-04hr  (9324) embryo 04-06hr  (8544) embryo 06-08hr  (6832) embryo 08-10hr  (4720) embryo 10-12hr  (3509) embryo 12-14hr  (2695) embryo 14-16hr  (2400) embryo 16-18hr  (2216) embryo 18-20hr  (2688) embryo 20-22hr  (2894) embryo 22-24hr  (3061) larva L1  (2147) larva L2  (1807) larva L3 12hr old  (1765) larva L3 puffstage 1-2  (2195) larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP  (6080) adult male 01day  (3886) adult male 05day  (3052) adult male 30day  (3288) adult female 01day  (5153) adult female 05day  (4252) adult female 30day  (4676) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5769 embryo 02-04hr    9324 embryo 04-06hr    8544 embryo 06-08hr    6832 embryo 08-10hr    4720 embryo 10-12hr    3509 embryo 12-14hr    2695 embryo 14-16hr    2400 embryo 16-18hr    2216 embryo 18-20hr    2688 embryo 20-22hr    2894 embryo 22-24hr    3061 larva L1    2147 larva L2    1807 larva L3 12hr old    1765 larva L3 puffstage 1-2    2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP    6080 adult male 01day    3886 adult male 05day    3052 adult male 30day    3288 adult female 01day    5153 adult female 05day    4252 adult female 30day    4676 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5769 embryo 02-04hr    9324 embryo 04-06hr    8544 embryo 06-08hr    6832 embryo 08-10hr    4720 embryo 10-12hr    3509 embryo 12-14hr    2695 embryo 14-16hr    2400 embryo 16-18hr    2216 embryo 18-20hr    2688 embryo 20-22hr    2894 embryo 22-24hr    3061 larva L1    2147 larva L2    1807 larva L3 12hr old    1765 larva L3 puffstage 1-2    2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP    6080 adult male 01day    3886 adult male 05day    3052 adult male 30day    3288 adult female 01day    5153 adult female 05day    4252 adult female 30day    4676 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031836 expression level Developmental Stage   Expression Level embryo 00-02hr    5769 embryo 02-04hr    9324 embryo 04-06hr    8544 embryo 06-08hr    6832 embryo 08-10hr    4720 embryo 10-12hr    3509 embryo 12-14hr    2695 embryo 14-16hr    2400 embryo 16-18hr    2216 embryo 18-20hr    2688 embryo 20-22hr    2894 embryo 22-24hr    3061 larva L1    2147 larva L2    1807 larva L3 12hr old    1765 larva L3 puffstage 1-2    2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP    6080 adult male 01day    3886 adult male 05day    3052 adult male 30day    3288 adult female 01day    5153 adult female 05day    4252 adult female 30day    4676 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5769) embryo 02-04hr  (9324) embryo 04-06hr  (8544) embryo 06-08hr  (6832) embryo 08-10hr  (4720) embryo 10-12hr  (3509) embryo 12-14hr  (2695) embryo 14-16hr  (2400) embryo 16-18hr  (2216) embryo 18-20hr  (2688) embryo 20-22hr  (2894) embryo 22-24hr  (3061) larva L1  (2147) larva L2  (1807) larva L3 12hr old  (1765) larva L3 puffstage 1-2  (2195) larva L3 puffstage 3-6  (1171) larva L3 puffstage 7-9  (761) white prepupae new  (772) white prepupae 12hr  (1238) white prepupae 24hr  (774) pupae 2d postWPP  (899) pupae 3d postWPP  (1355) pupae 4d postWPP  (6080) adult male 01day  (3886) adult male 05day  (3052) adult male 30day  (3288) adult female 01day  (5153) adult female 05day  (4252) adult female 30day  (4676) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5769) embryo 02-04hr  (9324) embryo 04-06hr  (8544) embryo 06-08hr  (6832) embryo 08-10hr  (4720) embryo 10-12hr  (3509) embryo 12-14hr  (2695) embryo 14-16hr  2400 embryo 16-18hr  2216 embryo 18-20hr  (2688) embryo 20-22hr  (2894) embryo 22-24hr  (3061) larva L1  2147 larva L2  1807 larva L3 12hr old  1765 larva L3 puffstage 1-2  2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP  (6080) adult male 01day  (3886) adult male 05day  (3052) adult male 30day  (3288) adult female 01day  (5153) adult female 05day  (4252) adult female 30day  (4676) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5769 embryo 02-04hr    9324 embryo 04-06hr    8544 embryo 06-08hr    6832 embryo 08-10hr    4720 embryo 10-12hr    3509 embryo 12-14hr    2695 embryo 14-16hr    2400 embryo 16-18hr    2216 embryo 18-20hr    2688 embryo 20-22hr    2894 embryo 22-24hr    3061 larva L1    2147 larva L2    1807 larva L3 12hr old    1765 larva L3 puffstage 1-2    2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP    6080 adult male 01day    3886 adult male 05day    3052 adult male 30day    3288 adult female 01day    5153 adult female 05day    4252 adult female 30day    4676 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5769 embryo 02-04hr    9324 embryo 04-06hr    8544 embryo 06-08hr    6832 embryo 08-10hr    4720 embryo 10-12hr    3509 embryo 12-14hr    2695 embryo 14-16hr    2400 embryo 16-18hr    2216 embryo 18-20hr    2688 embryo 20-22hr    2894 embryo 22-24hr    3061 larva L1    2147 larva L2    1807 larva L3 12hr old    1765 larva L3 puffstage 1-2    2195 larva L3 puffstage 3-6    1171 larva L3 puffstage 7-9    761 white prepupae new    772 white prepupae 12hr    1238 white prepupae 24hr    774 pupae 2d postWPP    899 pupae 3d postWPP    1355 pupae 4d postWPP    6080 adult male 01day    3886 adult male 05day    3052 adult male 30day    3288 adult female 01day    5153 adult female 05day    4252 adult female 30day    4676 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031836    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031836 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval fat body, larval salivary gland, larval trachea, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031836 expression level Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut    548.4 Larval Hindgut    467.3 Larval Malpighian Tubules    520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head    877.9 Adult Eye    1393.825 Adult Brain    607.5 Adult Thoracic-Abdominal Ganglion    713.2 Adult Crop    593.4 Adult Midgut    814 Adult Hindgut    630.1 Adult Malpighian Tubules    1096.6 Adult Fat Body    986.7 Adult Salivary Gland    899.4 Adult Heart    912.175 Adult VirginFemale Spermatheca    645.8 Adult InseminatedFemale Spermatheca    854.6 Adult Ovary    506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass    1086.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut  (548.4) Larval Hindgut    467.3 Larval Malpighian Tubules  520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head  (877.9) Adult Eye  (1393.825) Adult Brain  (607.5) Adult Thoracic-Abdominal Ganglion  (713.2) Adult Crop  (593.4) Adult Midgut  (814) Adult Hindgut  (630.1) Adult Malpighian Tubules  (1096.6) Adult Fat Body  (986.7) Adult Salivary Gland  (899.4) Adult Heart  (912.175) Adult VirginFemale Spermatheca  (645.8) Adult InseminatedFemale Spermatheca  (854.6) Adult Ovary  506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass  (1086.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut    548.4 Larval Hindgut    467.3 Larval Malpighian Tubules    520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head    877.9 Adult Eye  (1393.825) Adult Brain    607.5 Adult Thoracic-Abdominal Ganglion    713.2 Adult Crop    593.4 Adult Midgut    814 Adult Hindgut    630.1 Adult Malpighian Tubules  (1096.6) Adult Fat Body    986.7 Adult Salivary Gland    899.4 Adult Heart    912.175 Adult VirginFemale Spermatheca    645.8 Adult InseminatedFemale Spermatheca    854.6 Adult Ovary    506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass  (1086.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut    548.4 Larval Hindgut    467.3 Larval Malpighian Tubules    520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head    877.9 Adult Eye    1393.825 Adult Brain    607.5 Adult Thoracic-Abdominal Ganglion    713.2 Adult Crop    593.4 Adult Midgut    814 Adult Hindgut    630.1 Adult Malpighian Tubules    1096.6 Adult Fat Body    986.7 Adult Salivary Gland    899.4 Adult Heart    912.175 Adult VirginFemale Spermatheca    645.8 Adult InseminatedFemale Spermatheca    854.6 Adult Ovary    506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass    1086.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031836 expression level Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut    548.4 Larval Hindgut    467.3 Larval Malpighian Tubules    520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head    877.9 Adult Eye    1393.825 Adult Brain    607.5 Adult Thoracic-Abdominal Ganglion    713.2 Adult Crop    593.4 Adult Midgut    814 Adult Hindgut    630.1 Adult Malpighian Tubules    1096.6 Adult Fat Body    986.7 Adult Salivary Gland    899.4 Adult Heart    912.175 Adult VirginFemale Spermatheca    645.8 Adult InseminatedFemale Spermatheca    854.6 Adult Ovary    506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass    1086.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut  548.4 Larval Hindgut    467.3 Larval Malpighian Tubules  520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head  (877.9) Adult Eye  (1393.825) Adult Brain  607.5 Adult Thoracic-Abdominal Ganglion  713.2 Adult Crop  593.4 Adult Midgut  814 Adult Hindgut  630.1 Adult Malpighian Tubules  (1096.6) Adult Fat Body  (986.7) Adult Salivary Gland  (899.4) Adult Heart  (912.175) Adult VirginFemale Spermatheca  645.8 Adult InseminatedFemale Spermatheca  (854.6) Adult Ovary  506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass  (1086.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut    548.4 Larval Hindgut    467.3 Larval Malpighian Tubules    520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head    877.9 Adult Eye  1393.825 Adult Brain    607.5 Adult Thoracic-Abdominal Ganglion    713.2 Adult Crop    593.4 Adult Midgut    814 Adult Hindgut    630.1 Adult Malpighian Tubules  1096.6 Adult Fat Body    986.7 Adult Salivary Gland    899.4 Adult Heart    912.175 Adult VirginFemale Spermatheca    645.8 Adult InseminatedFemale Spermatheca    854.6 Adult Ovary    506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass  1086.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    280.05 Larval Midgut    548.4 Larval Hindgut    467.3 Larval Malpighian Tubules    520.3 Larval Fat Body    215.5 Larval Salivary Gland    161.4 Larval Trachea    274.225 Larval Carcass    477.5 Adult Head    877.9 Adult Eye    1393.825 Adult Brain    607.5 Adult Thoracic-Abdominal Ganglion    713.2 Adult Crop    593.4 Adult Midgut    814 Adult Hindgut    630.1 Adult Malpighian Tubules    1096.6 Adult Fat Body    986.7 Adult Salivary Gland    899.4 Adult Heart    912.175 Adult VirginFemale Spermatheca    645.8 Adult InseminatedFemale Spermatheca    854.6 Adult Ovary    506.8 Adult Testis    35.8 Adult Male Accessory Gland    252.3 Adult Carcass    1086.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    877.9   NA  Eye    1393.825   NA  Brain    607.5   280.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    713.2   NA  Crop    593.4   548.4  Midgut    814   467.3  Hindgut    630.1   520.3  Malpighian Tubules    1096.6   215.5  Fat Body    986.7   161.4  Salivary Gland    899.4   NA  Heart    912.175   274.225  Trachea    NA   NA  VirginFemale Spermatheca    645.8   NA  InseminatedFemale Spermatheca    854.6   NA  Ovary    506.8   NA  Testis    35.8   NA  Male Accessory Gland    252.3   477.5  Carcass    1086.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031836 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11050-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG11050GD5342 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of CG11050 Class Mutagen Stocks Known lesion CG11050CB-6980-3 1 -- CG11050d02137 P-element activity 1 -- CG11050e02171 piggyBac transposase 1 -- CG11050EY00203 P-element activity 1 -- CG11050f04404 piggyBac transposase 1 -- CG11050NP2084 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11050 Class Mutagen Stocks Known lesion CG11050GD5342 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11050KK109034 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5342} NA P{KK109034} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG11050EY00203 NA P{XP}CG11050d02137 NA insertion of enhancer trap P{lacW}l(2)SH1605SH1605 No insertion of enhancer trap binary system P{GawB}CG11050NP2084 No miscellaneous insertions P{RS3}CG11050CB-6980-3 NA PBac{RB}CG11050e02171 NA PBac{WH}CG11050f04404 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
metal ion binding inferred from electronic annotation with InterPro:IPR006674 (FlyBase Curators et al., 2004-) phosphoric diester hydrolase activity inferred from electronic annotation with InterPro:IPR006674 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11050 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031836 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33924
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15555 Dere\GG10422 Dgri\GH13875 Dmoj\GI17427 Dper\GL25580 Dpse\GA10728 Dsec\GM16183 Dsim\GD23421 Dvir\GJ18362 Dwil\GK24540 Dyak\GE13999
Curated drosophilid orthologs	Dpse\GA10728
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011081-PB Aedes aegypti (mosquito) At2g23820.2 Arabidopsis thaliana (wall cress) ENSBTAP00000004334 Bos taurus (bovine) cn04168 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000011838 Cavia porcellus (guinea pig) ENSP00000381220 Homo sapiens (human) ENSMODP00000022080 Monodelphis domestica (gray opossum) ENSMMUP00000020085 Macaca mulatta (rhesus monkey) LOC_Os02g08260.1 Oryza sativa (asian rice) ENSPPYP00000019020 Pongo pygmaeus (orangutan) 656718 Populus trichocarpa (black cottonwood) ENSPTRP00000056628 Pan troglodytes (chimpanzee) 4807945 Sorghum bicolor (sorghum) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12264 NV18353 LH22047 ISCW024426 FBgn0231630 FBgn0226500 FBgn0205521 FBgn0194804 FBgn0171099 JGI_V11_307447 FBgn0070784 FBgn0163164 FBgn0140171 FBgn0121351 FBgn0102731 FBgn0092580 BGIBMGA003527 GB15154 AGAP012582 AGAP010140 AAEL015219 AAEL011081 PHUM455410 GLEAN_08897
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	14815 y1 w67c23; P{EPgy2}CG11050EY00203
Harvard	- P{XP}CG11050d02137 - PBac{RB}CG11050e02171 - PBac{WH}CG11050f04404
Kyoto	124269 w1118; P{RS3}CG11050CB-6980-3 104082 w*; P{GawB}CG11050NP2084 / CyO
VDRC	v107837 P{KK109034}VIE-260B v12371 w1118; P{GD5342}v12371
Genomic Clones ( 1 )
	BACR25K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 142 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22339 RE44531
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH13064 GH26335 HL02789 LD07086 LD17526 LD17737 LD29594 LD33330 LD47905 LP14301 LP21933 RE04568 RE05267 RE05293 RE06325 RE06627 RE08966 RE10551 RE13105 RE16182 RE16522 RE20224 RE21524 RE27078 RE32690 RE32857 RE33837 RE36630 RE37116 RE40885 RE45454 RE46811 RE48659 RE48766 RE49091 RE50666 RE51459 RE54602 RE55334 RE62652 RE62685 RE64322 RE64333 RE67145 RE68535 RH04740 RH08806 RH13804 RH22095 RH22976 RH25049 RH26894 RH32996 RH35887 RH41879 RH43487 RH43765 RH49735 RH54502 RH56446 RH56977 RH63768 RH64310
Other clones	62199 145596 145687 165301 172910 190930 EK014629 EK051031 EK094126 EK107933 EK108533 EK141030 EK148018 EK156402 EK183926 EK187017 EK188048 EK191443 EK192535 EK212644 EK213105 EK213306 EK229529 EK248114 EK248549 EK267133 EK267242 EK286055 EK293048 EK297227 EP14406 FGC024C07 RM01019 RM01319 RM01519 RM01719 RP001001188 RP001003219 RP001003446 RP001007914 RP001008167 RP001008913 RP001009846 RP001009991 RP001012213 RP001012357 RP001013934 RP001019126 RP001019790 RP001022558 RP001022934 RP001023253 RP001023337 RP001024674 RP001025138 RP001029078 RP001030262 RP001032429 RP001033887 RP001035432 RP001040008 RP001040616 RP001040926 RP001042167 RP001045223 RP001046684 RP001047471 RP001047754 RP001050171 RP001050498 RP001052014 RP001052114 RP001052641 RP001053587 RP001055478 RP001055493 RP001056262
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031836 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33924
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG11050 BcDNA:LD22339 (FlyBase, 1996-)
Additional comments	Source for merge of CG11050 BcDNA:LD22339 was a shared cDNA (date:020730). (FlyBase, 1996-)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135208 NM_164694 NM_164695 RefSeq (Proteins) • NP_609052 NP_723193 NP_723194 DDBJ / EMBL / GenBank • AA817170 AAF52408 AAM50256 AAN10588 AAN10589 AAN71409 AW942634 AY119602 BI357905 BT001654 BZ286369 CZ472639 CZ479997 CZ486945 Entrez Gene - A searchable database of RefSeq genes. • 33924 UniProtKB/TrEMBL • Q8IGQ9 Q8MRI6 Q9VMB3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metal-dependent phosphohydrolase, HD domain (IPR003607) Metal-dependent phosphohydrolase, HD subdomain (IPR006674) HD domain (IPR023279)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031836 DRSC - Results from RNAi screens. • FBgn0031836 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031836 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11050-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031836 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33924 InParanoid A subset of ortholog calls from InParanoid. • AAEL011081-PB Aedes aegypti (mosquito) At2g23820.2 Arabidopsis thaliana (wall cress) ENSBTAP00000004334 Bos taurus (bovine) cn04168 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000011838 Cavia porcellus (guinea pig) ENSP00000381220 Homo sapiens (human) ENSMODP00000022080 Monodelphis domestica (gray opossum) ENSMMUP00000020085 Macaca mulatta (rhesus monkey) LOC_Os02g08260.1 Oryza sativa (asian rice) ENSPPYP00000019020 Pongo pygmaeus (orangutan) 656718 Populus trichocarpa (black cottonwood) ENSPTRP00000056628 Pan troglodytes (chimpanzee) 4807945 Sorghum bicolor (sorghum) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33924 modMine - Data generated by the modENCODE project. • FBgn0031836 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12264 NV18353 LH22047 ISCW024426 FBgn0231630 FBgn0226500 FBgn0205521 FBgn0194804 FBgn0171099 JGI_V11_307447 FBgn0070784 FBgn0163164 FBgn0140171 FBgn0121351 FBgn0102731 FBgn0092580 BGIBMGA003527 GB15154 AGAP012582 AGAP010140 AAEL015219 AAEL011081 PHUM455410 GLEAN_08897
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	BcDNA:LD22339   CG11050 (Shigenobu et al., 2006, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0063152
References ( 13 )
Research paper	Shigenobu et al., 2006, Proc. Natl. Acad. Sci. USA 103(37): 13728--13733 Molecular characterization of embryonic gonads by gene expression profiling in Drosophila melanogaster. [FBrf0193273] Borras, 2003, Genetics 163(2): 637--645 Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). [FBrf0157243]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]