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Gene Dmel\Tango1

General Information
Symbol	Dmel\Tango1	Species	D. melanogaster
Name	Transport and Golgi organization 1	Annotation symbol	CG11098
Feature type	protein_coding_gene	FlyBase ID	FBgn0031842
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	TANGO1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26F3-26F5	Sequence location	2L:6,649,430..6,654,574 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transport and Golgi organization 1 is referred to in FlyBase by the symbol Dmel\Tango1 (CG11098, FBgn0031842). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: Golgi organization; protein secretion. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Src homology-3 domain. Summary of modENCODE Temporal Expression Profile: Moderatey high expression at all stages of development. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval/adult salivary gland, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult ovary, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635997_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Tango1. Gene sequence location is 2L:6649430..6654574.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References FlyBase Curators, 2010-, Gene Ontology (GO) annotation review.
FB2012_01	Sequence features BKN24017 HFA02127
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26F3-26F5
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Tango1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	The final "intron" predicted by one EST is suspicious. It is short and does not have conserved splice junctions and was not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Tango1-RA FBtr0079295  NM_135214   4637   1430 Tango1-RC FBtr0303224  NM_164697   4479   1430
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Tango1-PA   FBpp0078925   159.1   1430   4.37     NP_609058   AAF52414 Tango1-PC   FBpp0292316   159.1   1430   4.37     NP_723198   AAF52413
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141364   AA942193   AE014134 AAF52413   AE014134 AAF52414   AI064657   AI106813   AI135356   AI543268   AW942835   AY075391 AAL68225   BF491518   BF497475   BG632079   BG632275   BG639996   BG640707   BI635614   BI640955   BT003314 AAO25074   CO185423   CO189533   CO269019   CO276044   CO300491   CO300900   CO314828   CO322584   CO332952   EC057009   EC063636   EC067893   EC073909   EC079873   EC081346   EC208588   EC211036   EC222224   EC223524   EC228255   EC234388   EC237462   EC241186   EC244057   EC247184   EC257531   EL872892   EL872893   EV580665   EV598108
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VMA7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031842    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031842 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Moderatey high expression at all stages of development. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031842 expression level Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    2106 embryo 04-06hr    2390 embryo 06-08hr    3371 embryo 08-10hr    3259 embryo 10-12hr    2801 embryo 12-14hr    3511 embryo 14-16hr    2941 embryo 16-18hr    2498 embryo 18-20hr    2323 embryo 20-22hr    1772 embryo 22-24hr    1755 larva L1    1746 larva L2    2719 larva L3 12hr old    2085 larva L3 puffstage 1-2    1823 larva L3 puffstage 3-6    2470 larva L3 puffstage 7-9    2752 white prepupae new    3021 white prepupae 12hr    1864 white prepupae 24hr    2290 pupae 2d postWPP    2445 pupae 3d postWPP    1807 pupae 4d postWPP    1795 adult male 01day    2362 adult male 05day    2577 adult male 30day    2245 adult female 01day    1974 adult female 05day    2971 adult female 30day    2939 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr  (2106) embryo 04-06hr  (2390) embryo 06-08hr  (3371) embryo 08-10hr  (3259) embryo 10-12hr  (2801) embryo 12-14hr  (3511) embryo 14-16hr  (2941) embryo 16-18hr  (2498) embryo 18-20hr  (2323) embryo 20-22hr  (1772) embryo 22-24hr  (1755) larva L1  (1746) larva L2  (2719) larva L3 12hr old  (2085) larva L3 puffstage 1-2  (1823) larva L3 puffstage 3-6  (2470) larva L3 puffstage 7-9  (2752) white prepupae new  (3021) white prepupae 12hr  (1864) white prepupae 24hr  (2290) pupae 2d postWPP  (2445) pupae 3d postWPP  (1807) pupae 4d postWPP  (1795) adult male 01day  (2362) adult male 05day  (2577) adult male 30day  (2245) adult female 01day  (1974) adult female 05day  (2971) adult female 30day  (2939) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr  (2106) embryo 04-06hr  (2390) embryo 06-08hr  (3371) embryo 08-10hr  (3259) embryo 10-12hr  (2801) embryo 12-14hr  (3511) embryo 14-16hr  (2941) embryo 16-18hr  (2498) embryo 18-20hr  (2323) embryo 20-22hr  (1772) embryo 22-24hr  (1755) larva L1  (1746) larva L2  (2719) larva L3 12hr old  (2085) larva L3 puffstage 1-2  (1823) larva L3 puffstage 3-6  (2470) larva L3 puffstage 7-9  (2752) white prepupae new  (3021) white prepupae 12hr  (1864) white prepupae 24hr  (2290) pupae 2d postWPP  (2445) pupae 3d postWPP  (1807) pupae 4d postWPP  (1795) adult male 01day  (2362) adult male 05day  (2577) adult male 30day  (2245) adult female 01day  (1974) adult female 05day  (2971) adult female 30day  (2939) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    2106 embryo 04-06hr    2390 embryo 06-08hr    3371 embryo 08-10hr    3259 embryo 10-12hr    2801 embryo 12-14hr    3511 embryo 14-16hr    2941 embryo 16-18hr    2498 embryo 18-20hr    2323 embryo 20-22hr    1772 embryo 22-24hr    1755 larva L1    1746 larva L2    2719 larva L3 12hr old    2085 larva L3 puffstage 1-2    1823 larva L3 puffstage 3-6    2470 larva L3 puffstage 7-9    2752 white prepupae new    3021 white prepupae 12hr    1864 white prepupae 24hr    2290 pupae 2d postWPP    2445 pupae 3d postWPP    1807 pupae 4d postWPP    1795 adult male 01day    2362 adult male 05day    2577 adult male 30day    2245 adult female 01day    1974 adult female 05day    2971 adult female 30day    2939 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    2106 embryo 04-06hr    2390 embryo 06-08hr    3371 embryo 08-10hr    3259 embryo 10-12hr    2801 embryo 12-14hr    3511 embryo 14-16hr    2941 embryo 16-18hr    2498 embryo 18-20hr    2323 embryo 20-22hr    1772 embryo 22-24hr    1755 larva L1    1746 larva L2    2719 larva L3 12hr old    2085 larva L3 puffstage 1-2    1823 larva L3 puffstage 3-6    2470 larva L3 puffstage 7-9    2752 white prepupae new    3021 white prepupae 12hr    1864 white prepupae 24hr    2290 pupae 2d postWPP    2445 pupae 3d postWPP    1807 pupae 4d postWPP    1795 adult male 01day    2362 adult male 05day    2577 adult male 30day    2245 adult female 01day    1974 adult female 05day    2971 adult female 30day    2939 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031842 expression level Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    2106 embryo 04-06hr    2390 embryo 06-08hr    3371 embryo 08-10hr    3259 embryo 10-12hr    2801 embryo 12-14hr    3511 embryo 14-16hr    2941 embryo 16-18hr    2498 embryo 18-20hr    2323 embryo 20-22hr    1772 embryo 22-24hr    1755 larva L1    1746 larva L2    2719 larva L3 12hr old    2085 larva L3 puffstage 1-2    1823 larva L3 puffstage 3-6    2470 larva L3 puffstage 7-9    2752 white prepupae new    3021 white prepupae 12hr    1864 white prepupae 24hr    2290 pupae 2d postWPP    2445 pupae 3d postWPP    1807 pupae 4d postWPP    1795 adult male 01day    2362 adult male 05day    2577 adult male 30day    2245 adult female 01day    1974 adult female 05day    2971 adult female 30day    2939 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr  (2106) embryo 04-06hr  (2390) embryo 06-08hr  (3371) embryo 08-10hr  (3259) embryo 10-12hr  (2801) embryo 12-14hr  (3511) embryo 14-16hr  (2941) embryo 16-18hr  (2498) embryo 18-20hr  (2323) embryo 20-22hr  (1772) embryo 22-24hr  (1755) larva L1  (1746) larva L2  (2719) larva L3 12hr old  (2085) larva L3 puffstage 1-2  (1823) larva L3 puffstage 3-6  (2470) larva L3 puffstage 7-9  (2752) white prepupae new  (3021) white prepupae 12hr  (1864) white prepupae 24hr  (2290) pupae 2d postWPP  (2445) pupae 3d postWPP  (1807) pupae 4d postWPP  (1795) adult male 01day  (2362) adult male 05day  (2577) adult male 30day  (2245) adult female 01day  (1974) adult female 05day  (2971) adult female 30day  (2939) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3404) embryo 02-04hr  2106 embryo 04-06hr  2390 embryo 06-08hr  (3371) embryo 08-10hr  (3259) embryo 10-12hr  (2801) embryo 12-14hr  (3511) embryo 14-16hr  (2941) embryo 16-18hr  (2498) embryo 18-20hr  2323 embryo 20-22hr  1772 embryo 22-24hr  1755 larva L1  1746 larva L2  (2719) larva L3 12hr old  2085 larva L3 puffstage 1-2  1823 larva L3 puffstage 3-6  2470 larva L3 puffstage 7-9  (2752) white prepupae new  (3021) white prepupae 12hr  1864 white prepupae 24hr  2290 pupae 2d postWPP  2445 pupae 3d postWPP  1807 pupae 4d postWPP  1795 adult male 01day  2362 adult male 05day  (2577) adult male 30day  2245 adult female 01day  1974 adult female 05day  (2971) adult female 30day  (2939) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    2106 embryo 04-06hr    2390 embryo 06-08hr    3371 embryo 08-10hr    3259 embryo 10-12hr    2801 embryo 12-14hr    3511 embryo 14-16hr    2941 embryo 16-18hr    2498 embryo 18-20hr    2323 embryo 20-22hr    1772 embryo 22-24hr    1755 larva L1    1746 larva L2    2719 larva L3 12hr old    2085 larva L3 puffstage 1-2    1823 larva L3 puffstage 3-6    2470 larva L3 puffstage 7-9    2752 white prepupae new    3021 white prepupae 12hr    1864 white prepupae 24hr    2290 pupae 2d postWPP    2445 pupae 3d postWPP    1807 pupae 4d postWPP    1795 adult male 01day    2362 adult male 05day    2577 adult male 30day    2245 adult female 01day    1974 adult female 05day    2971 adult female 30day    2939 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3404 embryo 02-04hr    2106 embryo 04-06hr    2390 embryo 06-08hr    3371 embryo 08-10hr    3259 embryo 10-12hr    2801 embryo 12-14hr    3511 embryo 14-16hr    2941 embryo 16-18hr    2498 embryo 18-20hr    2323 embryo 20-22hr    1772 embryo 22-24hr    1755 larva L1    1746 larva L2    2719 larva L3 12hr old    2085 larva L3 puffstage 1-2    1823 larva L3 puffstage 3-6    2470 larva L3 puffstage 7-9    2752 white prepupae new    3021 white prepupae 12hr    1864 white prepupae 24hr    2290 pupae 2d postWPP    2445 pupae 3d postWPP    1807 pupae 4d postWPP    1795 adult male 01day    2362 adult male 05day    2577 adult male 30day    2245 adult female 01day    1974 adult female 05day    2971 adult female 30day    2939 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031842    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031842 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval/adult salivary gland, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult ovary, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031842 expression level Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland    1392.9 Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut    508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland    1359 Adult Heart    429.925 Adult VirginFemale Spermatheca    593.9 Adult InseminatedFemale Spermatheca    620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland    925 Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland  (1392.9) Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut  508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland  (1359) Adult Heart    429.925 Adult VirginFemale Spermatheca  (593.9) Adult InseminatedFemale Spermatheca  (620.4) Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland  (925) Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland  (1392.9) Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut    508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland  (1359) Adult Heart    429.925 Adult VirginFemale Spermatheca    593.9 Adult InseminatedFemale Spermatheca    620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland    925 Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland    1392.9 Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut    508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland    1359 Adult Heart    429.925 Adult VirginFemale Spermatheca    593.9 Adult InseminatedFemale Spermatheca    620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland    925 Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031842 expression level Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland    1392.9 Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut    508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland    1359 Adult Heart    429.925 Adult VirginFemale Spermatheca    593.9 Adult InseminatedFemale Spermatheca    620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland    925 Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland  (1392.9) Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut  508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland  (1359) Adult Heart    429.925 Adult VirginFemale Spermatheca  593.9 Adult InseminatedFemale Spermatheca  620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland  (925) Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland  1392.9 Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut    508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland  1359 Adult Heart    429.925 Adult VirginFemale Spermatheca    593.9 Adult InseminatedFemale Spermatheca    620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland    925 Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    288.3 Larval Midgut    425.2 Larval Hindgut    392.5 Larval Malpighian Tubules    376 Larval Fat Body    359.6 Larval Salivary Gland    1392.9 Larval Trachea    308.575 Larval Carcass    411.1 Adult Head    280.7 Adult Eye    334.975 Adult Brain    344.1 Adult Thoracic-Abdominal Ganglion    346.8 Adult Crop    340.3 Adult Midgut    508.7 Adult Hindgut    355.1 Adult Malpighian Tubules    279.7 Adult Fat Body    486.1 Adult Salivary Gland    1359 Adult Heart    429.925 Adult VirginFemale Spermatheca    593.9 Adult InseminatedFemale Spermatheca    620.4 Adult Ovary    371 Adult Testis    294.3 Adult Male Accessory Gland    925 Adult Carcass    378.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    280.7   NA  Eye    334.975   NA  Brain    344.1   288.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    346.8   NA  Crop    340.3   425.2  Midgut    508.7   392.5  Hindgut    355.1   376  Malpighian Tubules    279.7   359.6  Fat Body    486.1   1392.9  Salivary Gland    1359   NA  Heart    429.925   308.575  Trachea    NA   NA  VirginFemale Spermatheca    593.9   NA  InseminatedFemale Spermatheca    620.4   NA  Ovary    371   NA  Testis    294.3   NA  Male Accessory Gland    925   411.1  Carcass    378.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031842 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11098-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 Tango1GD956 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Tango1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Tango1 Class Mutagen Stocks Known lesion Tango1GD956 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Tango1T:SV5\V5 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD956} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data on: 2011-06-28)
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
Golgi organization inferred from mutant phenotype (Bard et al., 2006) protein secretion inferred from mutant phenotype (Bard et al., 2006)
Cellular Component
CV term Evidence References
endoplasmic reticulum exit site inferred from direct assay (Wendler et al., 2010) Golgi apparatus inferred from direct assay (Bard et al., 2006)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Tango1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0031842 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33930
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14453 Dere\GG10426 Dgri\GH13341 Dmoj\GI17727 Dper\GL25582 Dpse\GA10757 Dsec\GM16194 Dsim\GD23423 Dvir\GJ17554 Dwil\GK24259 Dyak\GE14032
Curated drosophilid orthologs	Dpse\GA10757
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002691-PA Aedes aegypti (mosquito) AGAP007919-PA Anopheles gambiae (mosquito) XP_395569.3 Apis mellifera (honey bee) XP_001948151.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000025055 Bos taurus (bovine) ENSCAFP00000020504 Canis familiaris (dog) ENSCINP00000021460 Ciona intestinalis (sea squirt) CPIJ004366 Culex pipens (mosquito) ENSCPOP00000006968 Cavia porcellus (guinea pig) 225110 Capitella spl (polychaete worm) ENSECAP00000014846 Equus caballus (horse) ENSGALP00000015343 Gallus gallus (chicken) ENSP00000340900 Homo sapiens (human) 233267 Lottia gigantea (owl limpet) LmjF07.0960 Leishmania major (virus) ENSMODP00000035265 Monodelphis domestica (gray opossum) ENSMMUP00000001368 Macaca mulatta (rhesus monkey) ENSMUSP00000064801 Mus musculus (house mouse) XP_001602455.1 Nasonia vitripennis (wasp) ENSOANP00000022091 Ornithorynchus anatinus (platypus) ENSORLP00000015067 Oryzias latipes (japanese killifish) PHUM008790-PA Pediculus humanus (human body louse) ENSPPYP00000000201 Pongo pygmaeus (orangutan) ENSPTRP00000051129 Pan troglodytes (chimpanzee) Smp_027870 Schistosoma mansoni (trematode parasite) XP_968468.2 Tribolium castaneum (red flour beetle) ENSTNIP00000019494 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015585 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13358 LH15503 ISCW003300 FBgn0231662 FBgn0226220 FBgn0204724 FBgn0194806 FBgn0171110 FBgn0070813 FBgn0163166 FBgn0140468 FBgn0120817 FBgn0102735 FBgn0091480 CPIJ004366 BGIBMGA010574 ACYPI001938 GB14241 AGAP007919 AAEL002691 PB25521 PHUM350960 GLEAN_12129
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v7625 w1118; P{GD956}v7625/TM3 v21594 w1118; P{GD956}v21594/TM3
Genomic Clones ( 1 )
	BACR25K24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 23 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02877 LD26265
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11651 AT28278 GH13052 SD11847 SD17011 SD24001
Other clones	CK01628 Dmel_dig_020329_0659_1617 Dmel_neb_016099_0906_2551 EK009327 EK044461 EK093328 EK119523 EK178346 EK179624 EK188433 EK237912 EK305233 GH06040 IP04737 SD09973
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031842 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33930
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Tango1 CG11098 (Bard et al., 2006)
Source for database merge of
Additional comments
Other Comments
	dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion. (Bard et al., 2006) dsRNA directed against Tango1 inhibits protein secretion in S2 cells and results in fusion of Golgi membranes with the endoplasmic reticulum in more than 50% of the treated cells. (Bard et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135214 NM_164697 RefSeq (Proteins) • NP_609058 NP_723198 DDBJ / EMBL / GenBank • AA942193 AAF52413 AAF52414 AAL68225 AAO25074 AI064657 AW942835 AY075391 BG632079 BT003314 Entrez Gene - A searchable database of RefSeq genes. • 33930 UniProtKB/TrEMBL • Q9VMA7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0031842 DRSC - Results from RNAi screens. • FBgn0031842 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031842 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11098-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031842 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33930 InParanoid A subset of ortholog calls from InParanoid. • AAEL002691-PA Aedes aegypti (mosquito) AGAP007919-PA Anopheles gambiae (mosquito) XP_395569.3 Apis mellifera (honey bee) XP_001948151.1 Acyrthosiphon pisum (pea aphid) ENSBTAP00000025055 Bos taurus (bovine) ENSCAFP00000020504 Canis familiaris (dog) ENSCINP00000021460 Ciona intestinalis (sea squirt) CPIJ004366 Culex pipens (mosquito) ENSCPOP00000006968 Cavia porcellus (guinea pig) 225110 Capitella spl (polychaete worm) ENSECAP00000014846 Equus caballus (horse) ENSGALP00000015343 Gallus gallus (chicken) ENSP00000340900 Homo sapiens (human) 233267 Lottia gigantea (owl limpet) LmjF07.0960 Leishmania major (virus) ENSMODP00000035265 Monodelphis domestica (gray opossum) ENSMMUP00000001368 Macaca mulatta (rhesus monkey) ENSMUSP00000064801 Mus musculus (house mouse) XP_001602455.1 Nasonia vitripennis (wasp) ENSOANP00000022091 Ornithorynchus anatinus (platypus) ENSORLP00000015067 Oryzias latipes (japanese killifish) PHUM008790-PA Pediculus humanus (human body louse) ENSPPYP00000000201 Pongo pygmaeus (orangutan) ENSPTRP00000051129 Pan troglodytes (chimpanzee) Smp_027870 Schistosoma mansoni (trematode parasite) XP_968468.2 Tribolium castaneum (red flour beetle) ENSTNIP00000019494 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000015585 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33930 modMine - Data generated by the modENCODE project. • FBgn0031842 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13358 LH15503 ISCW003300 FBgn0231662 FBgn0226220 FBgn0204724 FBgn0194806 FBgn0171110 FBgn0070813 FBgn0163166 FBgn0140468 FBgn0120817 FBgn0102735 FBgn0091480 CPIJ004366 BGIBMGA010574 ACYPI001938 GB14241 AGAP007919 AAEL002691 PB25521 PHUM350960 GLEAN_12129
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG11098 (Bard et al., 2006, Milchanowski et al., 2004, Wendler et al., 2010, Andersen and Tapon, 2008) TANGO1 (Bard et al., 2006, Wendler et al., 2010) Tango1
Name Synonym	transport and Golgi organisation 1 (Wendler et al., 2010) Transport and Golgi organization 1 (Bard et al., 2006)
Secondary FlyBase IDs
References ( 12 )
Research paper	Wendler et al., 2010, EMBO J. 29(2): 304--314 A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. [FBrf0209739] Andersen and Tapon, 2008, J. Biol. Chem. 283(45): 31256--31267 Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. [FBrf0207382] Bard et al., 2006, Nature 439(7076): 604--607 Functional genomics reveals genes involved in protein secretion and Golgi organization. [FBrf0191232] Milchanowski et al., 2004, Genetics 168(1): 325--339 Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis. [FBrf0180297]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase analysis	FlyBase Curators, 2010-, Gene Ontology (GO) annotation review. Gene Ontology (GO) annotation review. [FBrf0216433] FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]