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Gene Dmel\CG18304

General Information
Symbol	Dmel\CG18304	Species	D. melanogaster
Name		Annotation symbol	CG18304
Feature type	protein_coding_gene	FlyBase ID	FBgn0031869
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27C4-27C6	Sequence location	2L:6,932,685..6,942,814 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG18304 (FBgn0031869). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: structural constituent of ribosome. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: translation. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ribosomal protein L29; Spectrin repeat. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1639778_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG18304. Gene sequence location is 2L:6932685..6942814.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN26008 HFA02664
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27C4-27C6   Limits computationally determined from genome sequence between P{lacW}xl6k00230&P{EP}Hrb27CEP748 and P{PZ}smt304841&P{PZ}smt304493
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG18304 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG18304-RA FBtr0079367  NM_135239   6392   1895 CG18304-RB FBtr0306285     6164   1819
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG18304-PA   FBpp0078995   212.9   1895   9.94     NP_609083   AAF52458 CG18304-PB   FBpp0297395   205.1   1819   10.01
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spectrin repeat (IPR002017) Ribosomal protein L29 (IPR001854)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52458   BH759261   CO188466   CO190698   CO274480   CO286501   CO286808   CO291628   CO292378   CO292443   CO309796   CO329134   CO332932   CO339943   CZ474328   EC064550   EC080654   EC080918   EC195286   EC212379   EC235464   EC241407   EC243974   EC251199   EC258111   EW712643
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VM67
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031869    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031869 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031869 expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr    1451 embryo 16-18hr    1678 embryo 18-20hr    1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP    2510 pupae 3d postWPP    4808 pupae 4d postWPP    1823 adult male 01day    2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr  (126) embryo 06-08hr  (274) embryo 08-10hr  (128) embryo 10-12hr  (306) embryo 12-14hr  (737) embryo 14-16hr  (1451) embryo 16-18hr  (1678) embryo 18-20hr  (1571) embryo 20-22hr  (1029) embryo 22-24hr  (1082) larva L1  (652) larva L2  (630) larva L3 12hr old  (950) larva L3 puffstage 1-2  (295) larva L3 puffstage 3-6  (208) larva L3 puffstage 7-9  (152) white prepupae new  (132) white prepupae 12hr  (203) white prepupae 24hr  (385) pupae 2d postWPP  (2510) pupae 3d postWPP  (4808) pupae 4d postWPP  (1823) adult male 01day  (2087) adult male 05day  (1193) adult male 30day  (839) adult female 01day  (1106) adult female 05day  (144) adult female 30day  (132) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr  1451 embryo 16-18hr  (1678) embryo 18-20hr  (1571) embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP  (2510) pupae 3d postWPP  (4808) pupae 4d postWPP  (1823) adult male 01day  (2087) adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr    1451 embryo 16-18hr    1678 embryo 18-20hr    1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP    2510 pupae 3d postWPP    4808 pupae 4d postWPP    1823 adult male 01day    2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr    1451 embryo 16-18hr    1678 embryo 18-20hr    1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP    2510 pupae 3d postWPP    4808 pupae 4d postWPP    1823 adult male 01day    2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031869 expression level Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr    1451 embryo 16-18hr    1678 embryo 18-20hr    1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP    2510 pupae 3d postWPP    4808 pupae 4d postWPP    1823 adult male 01day    2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr  126 embryo 06-08hr  (274) embryo 08-10hr  128 embryo 10-12hr  (306) embryo 12-14hr  (737) embryo 14-16hr  (1451) embryo 16-18hr  (1678) embryo 18-20hr  (1571) embryo 20-22hr  (1029) embryo 22-24hr  (1082) larva L1  (652) larva L2  (630) larva L3 12hr old  (950) larva L3 puffstage 1-2  (295) larva L3 puffstage 3-6  (208) larva L3 puffstage 7-9  (152) white prepupae new  132 white prepupae 12hr  (203) white prepupae 24hr  (385) pupae 2d postWPP  (2510) pupae 3d postWPP  (4808) pupae 4d postWPP  (1823) adult male 01day  (2087) adult male 05day  (1193) adult male 30day  (839) adult female 01day  (1106) adult female 05day  (144) adult female 30day  132 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr  1451 embryo 16-18hr  1678 embryo 18-20hr  1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP  (2510) pupae 3d postWPP  (4808) pupae 4d postWPP  1823 adult male 01day  2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr    1451 embryo 16-18hr    1678 embryo 18-20hr    1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP    2510 pupae 3d postWPP    4808 pupae 4d postWPP    1823 adult male 01day    2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11 embryo 02-04hr    41 embryo 04-06hr    126 embryo 06-08hr    274 embryo 08-10hr    128 embryo 10-12hr    306 embryo 12-14hr    737 embryo 14-16hr    1451 embryo 16-18hr    1678 embryo 18-20hr    1571 embryo 20-22hr    1029 embryo 22-24hr    1082 larva L1    652 larva L2    630 larva L3 12hr old    950 larva L3 puffstage 1-2    295 larva L3 puffstage 3-6    208 larva L3 puffstage 7-9    152 white prepupae new    132 white prepupae 12hr    203 white prepupae 24hr    385 pupae 2d postWPP    2510 pupae 3d postWPP    4808 pupae 4d postWPP    1823 adult male 01day    2087 adult male 05day    1193 adult male 30day    839 adult female 01day    1106 adult female 05day    144 adult female 30day    132 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031869    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031869 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031869 expression level Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031869 expression level Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    0.875 Larval Midgut no informative data Larval Hindgut    27 Larval Malpighian Tubules    5.7 Larval Fat Body no informative data Larval Salivary Gland    3.2 Larval Trachea    3.425 Larval Carcass    47.9 Adult Head    24.9 Adult Eye    2.225 Adult Brain    3.6 Adult Thoracic-Abdominal Ganglion    6.3 Adult Crop    71.3 Adult Midgut no informative data Adult Hindgut    45 Adult Malpighian Tubules    4.9 Adult Fat Body    5.7 Adult Salivary Gland    2.5 Adult Heart    34.9 Adult VirginFemale Spermatheca    6.2 Adult InseminatedFemale Spermatheca    4.4 Adult Ovary    4.1 Adult Testis    18.5 Adult Male Accessory Gland    92.8 Adult Carcass    60 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    24.9   NA  Eye    2.225   NA  Brain    3.6   0.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.3   NA  Crop    71.3   no informative data  Midgut    no informative data   27  Hindgut    45   5.7  Malpighian Tubules    4.9   no informative data  Fat Body    5.7   3.2  Salivary Gland    2.5   NA  Heart    34.9   3.425  Trachea    NA   NA  VirginFemale Spermatheca    6.2   NA  InseminatedFemale Spermatheca    4.4   NA  Ovary    4.1   NA  Testis    18.5   NA  Male Accessory Gland    92.8   47.9  Carcass    60 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031869 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18304-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG18304GD8815 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CG18304 Class Mutagen Stocks Known lesion CG18304KG00684 P-element activity 2 -- CG18304c04215 1 -- CG18304d05119 P-element activity 1 -- CG18304MI00083 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG18304 Class Mutagen Stocks Known lesion CG18304GD8815 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC108 (Deal and Cook, 2005.7.11) Df(2L)Exel7029 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8815} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}CG18304MI00083 NA P{SUPor-P}CG18304KG00684 NA PBac{PB}CG18304c04215 NA insertion of mobile activating element P{XP}CG18304d05119 NA insertion of enhancer trap P{lacW}l(2)SH0435SH0435 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from electronic annotation with InterPro:IPR001854 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
translation inferred from electronic annotation with InterPro:IPR001854 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
ribosome inferred from electronic annotation with InterPro:IPR001854 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG18304 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60120 DroID - A comprehensive database of gene and protein interactions. • FBgn0031869 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33969
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14469 Dere\GG23569 Dmoj\GI17741 Dper\GL25601 Dpse\GA14882 Dsec\GM13732 Dsim\GD22530 Dvir\GJ17565 Dwil\GK24249 Dyak\GE18392
Curated drosophilid orthologs	Dpse\GA14882
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002070-PA Aedes aegypti (mosquito) XP_001120597.1 Apis mellifera (honey bee) 87034 Branchiostoma floridae (lancelet) BGIBMGA002652-PA Bombyx mori (silk worm) ENSBTAP00000012453 Bos taurus (bovine) CBP28560 Caenorhabditis briggsae (nematode) CE43250 Caenorhabditis elegans (worm) JA16145 Caenorhabditis japonica (nematode) CPIJ001977 Culex pipens (mosquito) ENSCPOP00000012555 Cavia porcellus (guinea pig) RP30883 Caenorhabditis remanei (nematode) ENSGALP00000021759 Gallus gallus (chicken) 178970 Hypsipyla robusta (cedar shoot borer) ENSP00000237536 Homo sapiens (human) XP_001602115.1 Nasonia vitripennis (wasp) ENSORLP00000003248 Oryzias latipes (japanese killifish) PHUM009890-PA Pediculus humanus (human body louse) PP04888 Pristionchus pacificus (nematode) ENSPPYP00000010114 Pongo pygmaeus (orangutan) ENSPTRP00000056223 Pan troglodytes (chimpanzee) Smp_134570 Schistosoma mansoni (trematode parasite) XP_001193324.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968604.2 Tribolium castaneum (red flour beetle) ENSTRUP00000033707 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18713 LH21219 ISCW011692 ISCW005901 FBgn0235810 FBgn0226210 FBgn0193931 FBgn0168663 FBgn0074909 FBgn0163185 FBgn0140482 FBgn0118844 FBgn0115713 FBgn0091496 CPIJ001977 BGIBMGA002652 ACYPI41167 GB14067 AAEL002070 PB25831 PHUM454570 GLEAN_13627
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	30614 y1 w*; Mi{MIC}CG18304MI00083 13554 y1; P{SUPor-P}CG18304KG00684/CyO; ry506
Harvard	- P{XP}CG18304d05119 - PBac{PB}CG18304c04215
Kyoto	114375 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}CG18304KG00684 P{neoFRT}40A/CyO y+
VDRC	v19189 w1118; P{GD8815}v19189 v19191 w1118; P{GD8815}v19191
Genomic Clones ( 2 )
	BACR13J07 BACR20B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	12958 70434 70851 97076 280550 CK01.50A.F7 CK01.61B.H5 CK01.61B.H7 EC258111 EK040324 EK049232 EK063016 EK063931 EK114236 EK197839 EK200027 EK200206 EK219336 EK292104 EK305163 EP09710
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031869 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33969
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG18304 CG13774 (Whitfield, 2000.12.15)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135239 RefSeq (Proteins) • NP_609083 DDBJ / EMBL / GenBank • AAF52458 BH759261 CZ474328 Entrez Gene - A searchable database of RefSeq genes. • 33969 UniProtKB/TrEMBL • Q9VM67
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spectrin repeat (IPR002017) Ribosomal protein L29 (IPR001854)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60120 DroID - A comprehensive database of gene and protein interactions. • FBgn0031869 DRSC - Results from RNAi screens. • FBgn0031869 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031869 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18304-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031869 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33969 InParanoid A subset of ortholog calls from InParanoid. • AAEL002070-PA Aedes aegypti (mosquito) XP_001120597.1 Apis mellifera (honey bee) 87034 Branchiostoma floridae (lancelet) BGIBMGA002652-PA Bombyx mori (silk worm) ENSBTAP00000012453 Bos taurus (bovine) CBP28560 Caenorhabditis briggsae (nematode) CE43250 Caenorhabditis elegans (worm) JA16145 Caenorhabditis japonica (nematode) CPIJ001977 Culex pipens (mosquito) ENSCPOP00000012555 Cavia porcellus (guinea pig) RP30883 Caenorhabditis remanei (nematode) ENSGALP00000021759 Gallus gallus (chicken) 178970 Hypsipyla robusta (cedar shoot borer) ENSP00000237536 Homo sapiens (human) XP_001602115.1 Nasonia vitripennis (wasp) ENSORLP00000003248 Oryzias latipes (japanese killifish) PHUM009890-PA Pediculus humanus (human body louse) PP04888 Pristionchus pacificus (nematode) ENSPPYP00000010114 Pongo pygmaeus (orangutan) ENSPTRP00000056223 Pan troglodytes (chimpanzee) Smp_134570 Schistosoma mansoni (trematode parasite) XP_001193324.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968604.2 Tribolium castaneum (red flour beetle) ENSTRUP00000033707 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33969 modMine - Data generated by the modENCODE project. • FBgn0031869 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18713 LH21219 ISCW011692 ISCW005901 FBgn0235810 FBgn0226210 FBgn0193931 FBgn0168663 FBgn0074909 FBgn0163185 FBgn0140482 FBgn0118844 FBgn0115713 FBgn0091496 CPIJ001977 BGIBMGA002652 ACYPI41167 GB14067 AAEL002070 PB25831 PHUM454570 GLEAN_13627
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG13774   CG18304 (Joshi et al., 2007, Mourikis et al., 2010, Wasbrough et al., 2010)
Name Synonym
Secondary FlyBase IDs
	FBgn0031870
References ( 19 )
Research paper	Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Personal communication to FlyBase	Bellen, 2010.3.31, BDGP_2010_0401.GDP.xml BDGP_2010_0401.GDP.xml [FBrf0210427] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Deal and Cook, 2005.7.11, Isolation and characterization of Df(2L)BSC108. Isolation and characterization of Df(2L)BSC108. [FBrf0188652] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Whitfield, 2000.12.15, Deleted protein_ids - part 1. Deleted protein_ids - part 1. [FBrf0132190]
Abstract	Joshi et al., 2007, Europ. Dros. Res. Conf. 20: A037 A Cytogenetical Analysis of the 27 C4-28B4 Wnt Region of Drosophila melanogaster. [FBrf0199599]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]