CT26314
IGcam membrane protein - binds Hedgehog and mediates Hedgehog response
Please see the JBrowse view of Dmel\ihog for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Homodimer. Heterotetramer; 2 iHog chains bind 2 hh chains when facilitated by heparin, heparin is required to promote high-affinity interactions between hh and iHog.
The first Fibronectin type-III domain mediates a specific interaction with Hh protein, in vitro. The second Fibronectin type-III domain is additionally required for in vivo signaling activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ihog using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\ihog in GBrowse 22-23
2-22.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: iHog CG9211
The gene is named "interference Hedgehog"due to the fact that dsRNA against this gene reduces the response to hh signalling.