SP1070, CT26172
transmembrane protein involved in Notch-dependent cell fate assignation during asymmetric mitosis - essential to direct asymmetric endosome motility - required for tracheal inflation
Please see the JBrowse view of Dmel\uif for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\uif using the Feature Mapper tool.
uif is first detected in stage 5 embryos in cells that are fated to become ectodermal and are absent in mesodermal and neurectodermal precursors. In late stage embryos, it persists in ectodermal tissues and is very strong in the tracheal system.
uif protein is first detected in stage 7 embryos in the cephalic furrow and ventral furrow. In late stage embryos, is persists in ectodermal tissues and is very strong in the tracheal system. It is also detected in the epidermis, foregut, hindgut, and salivary gland. In larvae, it is found at high levels in the epidermis, foregut, and hindgut. It is present at high levels in imaginal discs and at lower levels in the epidermis.
GBrowse - Visual display of RNA-Seq signals
View Dmel\uif in GBrowse 22-24
2-22.7
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: uif SP1070
Source for identity of: SP1070 CG9138
Source for identity of SP1070 CG9138 was sequence comparison ( date:000414 ).
Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.
The gene is named "uninflatable" based upon the defective tracheal inflation phenotype of mutants.
