FB2020_01, released Feb 12, 2020

Gene: Dmel\Mnn1

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General Information
Symbol
Dmel\Mnn1
Species
D. melanogaster
Name
Menin 1
Annotation Symbol
CG13778
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031885
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

MEN1, menin

Key Links
Genomic Location
Cytogenetic map
27D7-27D7
Sequence location
2L:7,056,301..7,063,586 [+]
Recombination map

2-24

RefSeq locus
NT_033779 REGION:7056301..7063586
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
chromatin binding; double-stranded DNA binding; contributes_to histone-lysine N-methyltransferase activity; transcription regulatory region DNA binding; Y-form DNA binding
Summaries
Gene Group (FlyBase)
TRX COMPLEX -
The Trithorax (Trx) complex is a COMPASS-like complex that mediates methylation of histone H3K4. (Adapted from FBrf0216343).
OTHER PROTEIN-LYSINE N-METHYLTRANSFERASES -
The 'Other protein-lysine N-methyltransferases' is a collection of protein-lysine N-methyltransferases that do not fit into any of the other major groups.
Summary (Interactive Fly)

conserved chromatin factor that modulates Jun activity in a manner dependent on the cellular context - tumor suppressor that functions in maintenance of genomic integrity - controls stress responses

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Mnn1 or the JBrowse view of Dmel\Mnn1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mnn1-RA
FBtr0079401
NM_078774
4275
763
Mnn1-RB
FBtr0079402
NM_164739
1927
530
Mnn1-RC
FBtr0110978
NM_001042877
5196
763
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mnn1-PA
FBpp0079029
82.9
763
5.96
NP_523498
AAF52480
Mnn1-PB
FBpp0079030
59.0
530
5.63
NP_723252
AAN10623
Mnn1-PC
FBpp0110277
82.9
763
5.96
NP_001036342
ABI31296
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

763 aa isoforms: Mnn1-PA, Mnn1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mnn1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (27 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
chromatin binding
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
double-stranded DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
contributes_to histone-lysine N-methyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
transcription regulatory region DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
Y-form DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (18 terms)
Terms Based on Experimental Evidence (14 terms)
CV Term
Evidence
References
cellular response to DNA damage stimulus
inferred from mutant phenotype
(Busygina et al., 2004)
determination of adult lifespan
inferred from mutant phenotype
(Cerrato et al., 2006)
imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Cerrato et al., 2006)
interstrand cross-link repair
inferred from mutant phenotype
(Marek et al., 2008)
mitotic G1 DNA damage checkpoint
inferred from mutant phenotype
(Busygina et al., 2006)
negative regulation of JNK cascade
inferred from genetic interaction with FLYBASE:Jra; FB:FBgn0001291
(Cerrato et al., 2006)
nucleotide-excision repair
inferred from mutant phenotype
(Busygina et al., 2004)
positive regulation of JNK cascade
inferred from genetic interaction with FLYBASE:kay; FB:FBgn0001297
(Cerrato et al., 2006)
proboscis development
inferred from mutant phenotype
(Cerrato et al., 2006)
response to heat
inferred from mutant phenotype
(Papaconstantinou et al., 2005)
response to hypoxia
inferred from mutant phenotype
(Papaconstantinou et al., 2005)
response to ionizing radiation
inferred from mutant phenotype
(Busygina et al., 2004)
response to oxidative stress
inferred from mutant phenotype
(Papaconstantinou et al., 2005)
response to salt stress
inferred from mutant phenotype
(Papaconstantinou et al., 2005)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
histone H3-K4 methylation
inferred by curator from GO:0044665
(Mohan et al., 2011)
negative regulation of cell cycle
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of cell population proliferation
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
MLL1/2 complex
inferred from direct assay
(Mohan et al., 2011)
nucleus
inferred from direct assay
(Cerrato et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
chromatin
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
histone methyltransferase complex
inferred from biological aspect of ancestor with PANTHER:PTN000976222
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Guru et al., 2001)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 10
parasegment 4 -- parasegment 14

Comment: not observed stage 5-9

(Guru et al., 2001)
embryonic stage 11 -- 14
ectoderm | lateral
(Guru et al., 2001)
embryonic stage 15
anterior spiracle primordium
(Guru et al., 2001)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 4
organism

Comment: 0-2 hr AEL; short isoform

(Guru et al., 2001)
embryonic stage 9 -- 15
organism

Comment: 4-12 hr AEL; long isoform

(Guru et al., 2001)
embryonic stage 15 -- P-stage
organism | faint
(Guru et al., 2001)
adult stage | female
organism

Comment: short isoform; no signal in males

(Guru et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
MLL1/2 complex
inferred from direct assay
(Mohan et al., 2011)
nucleus
inferred from direct assay
(Cerrato et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mnn1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mnn1
Transgenic constructs containing regulatory region of Mnn1
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | conditional | embryonic stage, with Scer\GAL4nos.PG
lethal | embryonic stage | heat sensitive, with Scer\GAL4nos.PG
lethal - all die before end of embryonic stage | heat sensitive
lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4arm.PS
lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4hs.PB
lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4αTub84B.PL
lethal - all die before end of embryonic stage | heat sensitive (with Df(2L)spdj2)
lethal - all die before end of P-stage, with Scer\GAL469B
lethal - all die before end of P-stage, with Scer\GAL4da.G32
lethal - all die before end of P-stage, with Scer\GAL4elav-C155
lethal - all die before end of P-stage, with Scer\GAL4how-24B
lethal - all die before end of P-stage, with Scer\GAL4RapGAP1-OK6
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL448Y
viable, with Scer\GAL4AB1
viable, with Scer\GAL4C1003
viable, with Scer\GAL4da.G32
viable, with Scer\GAL4dimm-929
viable, with Scer\GAL4dpp.blk1
viable, with Scer\GAL4ey.PH
viable, with Scer\GAL4GMR.PF
viable, with Scer\GAL4LE
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4twi.PG
viable (with Df(2L)J-H)
viable (with Df(2L)Mnn1Δ65)
Sterility
Allele
fertile
fertile (with Df(2L)J-H)
fertile (with Df(2L)Mnn1Δ65)
Other Phenotypes
Allele
chemical sensitive
chemical sensitive, with Scer\GAL4αTub84B.PL
DNA repair defective
melanotic mass phenotype, with Scer\GAL469B
melanotic mass phenotype, with Scer\GAL4da.G32
melanotic mass phenotype, with Scer\GAL4elav-C155
melanotic mass phenotype, with Scer\GAL4how-24B
melanotic mass phenotype, with Scer\GAL4RapGAP1-OK6
radiation sensitive
short lived, with Scer\GAL469B
short lived | male
short lived | male (with Mnn1Δ46)
short lived | male (with Mnn1Δ79)
some die during embryonic stage | heat sensitive
some die during embryonic stage | heat sensitive, with Scer\GAL4arm.PS
some die during embryonic stage | heat sensitive, with Scer\GAL4hs.PB
some die during embryonic stage | heat sensitive, with Scer\GAL4αTub84B.PL
some die during embryonic stage | heat sensitive (with Df(2L)spdj2)
some die during pharate adult stage, with Scer\GAL469B
some die during pharate adult stage, with Scer\GAL4da.G32
some die during pharate adult stage, with Scer\GAL4elav-C155
some die during pharate adult stage, with Scer\GAL4how-24B
some die during pharate adult stage, with Scer\GAL4RapGAP1-OK6
stress response defective
stress response defective, with Scer\GAL4nos.PG
stress response defective, with Scer\GAL4αTub84B.PL
wild-type
Phenotype manifest in
Allele
adult thorax, with Scer\GAL469B
adult thorax, with Scer\GAL4pnr-MD237
chaeta, with Scer\GAL4pnr-MD237
distiproboscis, with Scer\GAL469B
distiproboscis, with Scer\GAL4da.G32
distiproboscis, with Scer\GAL4elav-C155
distiproboscis, with Scer\GAL4how-24B
distiproboscis, with Scer\GAL4RapGAP1-OK6
wing, with Scer\GAL469B
wing, with Scer\GAL4how-24B
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MEN1
13 of 15
Yes
Yes
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Men1
14 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Men1
12 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\men1
10 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\men1
10 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904TZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Mnn1
Drosophila simulans
Dsim\GD23452
Drosophila sechellia
Dsec\GM16311
Drosophila erecta
Dere\GG10459
Drosophila yakuba
Dyak\GE14373
Drosophila ananassae
Dana\GF20766
Drosophila pseudoobscura pseudoobscura
Dpse\GA12519
Drosophila persimilis
Dper\GL14105
Drosophila willistoni
Dwil\GK24291
Drosophila virilis
Dvir\GJ16255
Drosophila mojavensis
Dmoj\GI14382
Drosophila grimshawi
Dgri\GH10098
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501ZI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019032
Glossina morsitans
Tsetse fly
Gmor\GMOY005419
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07012
Mayetiola destructor
Hessian fly
Mdes\Mdes005033
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005553
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL005686
Anopheles darlingi
American malaria mosquito
Adar\ADAC009526
Anopheles gambiae
Malaria mosquito
Agam\AGAP008130
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000921
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W045P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010655
Danaus plexippus
Monarch butterfly
Dple\DPOGS208567-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004301
Apis florea
Little honeybee
Aflo\2627811316
Apis mellifera
Western honey bee
Amel\LOC410989
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21363
Bombus terrestris
Buff-tailed bumblebee
Bter\15215798
Linepithema humile
Argentine ant
Lhum\LH23617
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002189
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003205
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12262
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07870
Pediculus humanus
Human body louse
Phum\PHUM350950
Rhodnius prolixus
Kissing bug
Rpro\RPRC009423
Cimex lectularius
Bed bug
Clec\CLEC006376
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001212
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01890
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16270
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0424 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008989
Ixodes scapularis
Black-legged tick
Isca\ISCW004039
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78800.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g13940
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303383
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_63144
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G066V )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Men1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Men1_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001396
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
MEN1; menin 1
model of  multiple endocrine neoplasia type 1
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MEN1; menin 1
13 of 15
613733
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser
View in Interactions Browser
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Mnn1 - ash2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mohan et al., 2011)
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Mnn1
enhanceable
Jra
(Cerrato et al., 2006)
Mnn1
enhanceable
kay
(Cerrato et al., 2006)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Jra
suppressible
Mnn1
(Cerrato et al., 2006)
kay
enhanceable
Mnn1
(Cerrato et al., 2006)
pbl
suppressible
Mnn1
(Gregory et al., 2007)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map

2-24

Cytogenetic map
27D7-27D7
Sequence location
2L:7,056,301..7,063,586 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
27D7-27D7
Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

2-24

(FlyBase, 2016)

2-23.2

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (10)
Genomic Clones (16)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (46)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: menin CG13778

(FlyBase, 1996-)
Source for database merge of
Additional comments

Source for identity of menin CG13778 was sequence comparison ( date:000414 ).

(FlyBase, 1996-)
Other Comments
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 48 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
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