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Gene Dmel\Mnn1

General Information
Symbol	Dmel\Mnn1	Species	D. melanogaster
Name	Menin 1	Annotation symbol	CG13778
Feature type	protein_coding_gene	FlyBase ID	FBgn0031885
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	MEN1, menin
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27D7-27D7	Sequence location	2L:7,056,301..7,063,586 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Menin 1 is referred to in FlyBase by the symbol Dmel\Mnn1 (CG13778, FBgn0031885). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence for 14 unique biological process terms, many of which group under: response to stress; response to DNA damage stimulus; single-organism developmental process; biological regulation; DNA repair; response to abiotic stimulus; response to stimulus; response to ionizing radiation; determination of adult lifespan; post-embryonic organ morphogenesis; cell cycle; system development; primary metabolic process; response to decreased oxygen levels; proboscis development. 22 alleles are reported. The phenotypes of these alleles are annotated with: adult thorax; chaeta; distiproboscis; wing. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Menin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 2L:7056301..7063586.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02	Controlled Vocabulary Terms interstrand cross-link repair
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27D7-27D7   Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mnn1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mnn1-RA FBtr0079401  NM_078774   4275   763 Mnn1-RB FBtr0079402  NM_164739   1927   530 Mnn1-RC FBtr0110978  NM_001042877   5196   763
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mnn1-PA   FBpp0079029   82.9   763   5.96     NP_523498   AAF52480 Mnn1-PB   FBpp0079030   59.0   530   5.63     NP_723252   AAN10623 Mnn1-PC   FBpp0110277   82.9   763   5.96     NP_001036342   ABI31296
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Menin (IPR007747)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52480   AE014134 AAN10623   AB040816 BAA94341   AE014134 ABI31296   AC007977   AY084134 AAL89872   BE978103   BG641233   BI168561   BI215073   BI215403   BP550849   BP557662   BP557663   BT003213 AAO24968   CO179287   CO188019   CO189757   CO282002   CO283910   CO284494   CO293949   CO295741   CO301396   CO301554   CO305313   CO312051   CO314945   CO319562   CO319963   CO320850   CO326798   CO344199   EC065517   EC078758   EC089876   EC227345   EC233336   EC241745   EC245872   EC247277   EC248338   EC250309   EC257448   EL875127   EL875128   GH945231   GH945257   GH955404   GH956299   GH960510   GH960673   GH960947   GH974839   GH978891   GH980632   GH983148
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SXU2 Q9VM47 Q7KXY9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Guru et al., 2001) Comment:maternally deposited organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 10   parasegment 4 -- parasegment 14   (Guru et al., 2001) Comment:not observed stage 5-9 embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 14   ectoderm | lateral   (Guru et al., 2001) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 15   anterior spiracle primordium   (Guru et al., 2001) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism   (Guru et al., 2001) Comment:0-2 hr AEL; short isoform embryonic stage 9 -- 15   organism   (Guru et al., 2001) Comment:4-12 hr AEL; long isoform embryonic stage 15 -- P-stage   organism | faint   (Guru et al., 2001) adult stage | female   organism   (Guru et al., 2001) Comment:short isoform; no signal in males
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
MLL1/2 complex inferred from direct assay (Mohan et al., 2011) nucleus inferred from direct assay (Cerrato et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    37 head, mated 4-day male    34 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male  (37) head, mated 4-day male  (34) head, mated 20-day male  (32) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    37 head, mated 4-day male    34 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    37 head, mated 4-day male    34 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    37 head, mated 4-day male    34 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male  (37) head, mated 4-day male  (34) head, mated 20-day male  32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    37 head, mated 4-day male    34 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    8 central nervous system, pupae P8    12 head, virgin 1-day female    22 head, virgin 4-day female    21 head, virgin 20-day female    16 head, mated 1-day female    22 head, mated 4-day female    19 head, mated 20-day female    16 head, mated 1-day male    37 head, mated 4-day male    34 head, mated 20-day male    32 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    3 digestive system, 4-day adult    5 digestive system, 20-day adult    4 fat body, larvae L3 wandering    1 fat body, white prepupae    3 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    25 ovary, mated 4-day female    21 testis, mated 4-day male    3 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    10 embryo 04-06hr    9 embryo 06-08hr    10 embryo 08-10hr    10 embryo 10-12hr    7 embryo 12-14hr    8 embryo 14-16hr    7 embryo 16-18hr    8 embryo 18-20hr    7 embryo 20-22hr    11 embryo 22-24hr    14 larva L1    6 larva L2    5 larva L3 12hr old    3 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    7 white prepupae new    8 white prepupae 12hr    6 white prepupae 24hr    12 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    9 adult male 05day    10 adult male 30day    8 adult female 01day    10 adult female 05day    17 adult female 30day    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    10 Schneider line 2 Sg4    7 embryonic 1182-4H    7 embryonic GM2    6 embryonic Kc167    8 embryonic S1    11 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    7 wing disc ML-DmD8    5 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    7 wing disc ML-DmD32    12 haltere disc ML-DmD17-c3    6 eye-antennal disc ML-DmD11    4 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    5 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    10 tumorous blood cells mbn2    11 ovary fGS/OSS    9 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    19 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    4 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    19 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    19 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE21276 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031885 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13778-RB;CG13778-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | conditional | embryonic stage, with Scer\GAL4nos.PG Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa lethal | embryonic stage | heat sensitive Mnn1e30 lethal | embryonic stage | heat sensitive, with Scer\GAL4arm.PS Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa lethal | embryonic stage | heat sensitive, with Scer\GAL4hs.PB Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa lethal | embryonic stage | heat sensitive, with Scer\GAL4nos.PG Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa lethal | embryonic stage | heat sensitive, with Scer\GAL4αTub84B.PL Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa lethal | embryonic stage | heat sensitive (with Df(2L)spdj2) Mnn1e30 Mnn1e173 lethal | pharate adult stage P14, with Scer\GAL469B Mnn1Scer\UAS.cCa lethal | pharate adult stage P14, with Scer\GAL4da.G32 Mnn1Scer\UAS.cCa lethal | pharate adult stage P14, with Scer\GAL4elav-C155 Mnn1Scer\UAS.cCa lethal | pharate adult stage P14, with Scer\GAL4how-24B Mnn1Scer\UAS.cCa lethal | pharate adult stage P14, with Scer\GAL4Rapgap1-OK6 Mnn1Scer\UAS.cCa viable Mnn1e30 Mnn1e173 Mnn1e200 Mnn1Δ46 Mnn1Δ79 viable, with Scer\GAL448Y Mnn1Scer\UAS.cCa viable, with Scer\GAL4AB1 Mnn1Scer\UAS.cCa viable, with Scer\GAL4C1003 Mnn1Scer\UAS.cCa viable, with Scer\GAL4da.G32 Mnn1Scer\UAS.cCa viable, with Scer\GAL4dimm-929 Mnn1Scer\UAS.cCa viable, with Scer\GAL4dpp.blk1 Mnn1Scer\UAS.cCa viable, with Scer\GAL4ey.PH Mnn1Scer\UAS.cCa viable, with Scer\GAL4GMR.PF Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cCa Mnn1Scer\UAS.cPa viable, with Scer\GAL4LE Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa viable, with Scer\GAL4pnr-MD237 Mnn1GD8117 Mnn1Scer\UAS.cCa viable, with Scer\GAL4twi.PG Mnn1Scer\UAS.cCa viable (with Df(2L)J-H) Mnn1Δ46 Mnn1Δ79 viable (with Df(2L)Mnn1Δ65) Mnn1Δ46 Mnn1Δ79 Sterility Allele fertile Mnn1e30 Mnn1e173 Mnn1e200 Mnn1Δ46 Mnn1Δ79 fertile (with Df(2L)J-H) Mnn1Δ46 Mnn1Δ79 fertile (with Df(2L)Mnn1Δ65) Mnn1Δ46 Mnn1Δ79 Other Phenotypes Allele chemical sensitive Mnn1e30 Mnn1e173 chemical sensitive, with Scer\GAL4αTub84B.PL Mnn1Scer\UAS.cPa DNA repair defective Mnn1e200 melanotic mass phenotype, with Scer\GAL469B Mnn1Scer\UAS.cCa melanotic mass phenotype, with Scer\GAL4da.G32 Mnn1Scer\UAS.cCa melanotic mass phenotype, with Scer\GAL4elav-C155 Mnn1Scer\UAS.cCa melanotic mass phenotype, with Scer\GAL4how-24B Mnn1Scer\UAS.cCa melanotic mass phenotype, with Scer\GAL4Rapgap1-OK6 Mnn1Scer\UAS.cCa radiation sensitive Mnn1e200 short lived, with Scer\GAL469B Mnn1Scer\UAS.cCa short lived | male Mnn1Δ46 Mnn1Δ79 short lived | male (with Mnn1Δ46) Mnn1Δ79 short lived | male (with Mnn1Δ79) Mnn1Δ46 stress response defective Mnn1e30 Mnn1e173 stress response defective, with Scer\GAL4nos.PG Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa stress response defective, with Scer\GAL4αTub84B.PL Mnn1dsRNA.Scer\UAS Mnn1Scer\UAS.cPa wild-type Mnn1+113 Phenotype manifest in Allele adult thorax, with Scer\GAL469B Mnn1Scer\UAS.cCa adult thorax, with Scer\GAL4pnr-MD237 Mnn1Scer\UAS.cCa chaeta, with Scer\GAL4pnr-MD237 Mnn1Scer\UAS.cCa distiproboscis, with Scer\GAL469B Mnn1Scer\UAS.cCa distiproboscis, with Scer\GAL4da.G32 Mnn1Scer\UAS.cCa distiproboscis, with Scer\GAL4elav-C155 Mnn1Scer\UAS.cCa distiproboscis, with Scer\GAL4how-24B Mnn1Scer\UAS.cCa distiproboscis, with Scer\GAL4Rapgap1-OK6 Mnn1Scer\UAS.cCa wing, with Scer\GAL469B Mnn1Scer\UAS.cCa wing, with Scer\GAL4how-24B Mnn1Scer\UAS.cCa
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Mnn1 Class Mutagen Stocks Known lesion Mnn1DG30701 P-element activity 1 -- Mnn1GS9609 1 Yes Mnn1NP2688 1 -- Mnn1Δ46 amorphic allele - genetic evidence Delta2-3 0 Yes Mnn1Δ79 amorphic allele - genetic evidence Delta2-3 0 Yes Mnn1+113 Delta2-3 0 Yes Mnn1+84 Delta2-3 0 Yes Mnn1e173 loss of function allele P-element activity 0 Yes Mnn1e200 Delta2-3 0 Yes Mnn1e30 loss of function allele P-element activity 0 Yes Mnn1EP-GE11370 P-element activity 0 Yes Mnn1P553.15 Delta2-3 0 Yes Mnn1Δ65 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mnn1 Class Mutagen Stocks Known lesion Mnn1GD8117 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mnn1GL00018 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mnn1JF01775 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mnn1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Mnn1KK101050 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mnn1NIG.13778R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mnn1Scer\UAS.cCa in vitro construct - regulatory fusion 0 Yes Mnn1Scer\UAS.cPa in vitro construct - regulatory fusion 0 Yes Mnn1Scer\UAS.P\T.cBa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7030 (Ryder, 2004.4.26) Df(2L)spdj2 (Papaconstantinou et al., 2005)
Partially disrupted in	Df(2L)Mnn1e200 (Busygina et al., 2004) Df(2L)Mnn1Δ65 (Cerrato et al., 2006) Df(2L)P556.15 (Busygina et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8117} NA P{KK101050} NA P{NIG.13778R} NA P{TRiP.GL00018} NA P{TRiP.JF01775} NA P{UAS-Mnn1.C} NA P{UAS-Mnn1.P} NA P{UAS-Mnn1.RNAi} NA P{UASp-Mnn1.B} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}Mnn1NP2688 No miscellaneous insertions P{5'wHy}Mnn1Δ79 NA P{wHy}Mnn1DG30701 NA insertion of mobile activating element P{EP}Mnn1EP-GE11370 NA P{GSV6}Mnn1GS9609 NA insertion of enhancer trap P{lacW}milte200 No P{lacW}miltP553.15 No
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Cerrato et al., 2006) imaginal disc fusion, thorax closure inferred from mutant phenotype (Cerrato et al., 2006) interstrand cross-link repair inferred from mutant phenotype (Marek et al., 2008) mitotic G1 DNA damage checkpoint inferred from mutant phenotype (Busygina et al., 2006) negative regulation of JNK cascade inferred from genetic interaction with Jra (Cerrato et al., 2006) nucleotide-excision repair inferred from mutant phenotype (Busygina et al., 2004) positive regulation of JNK cascade inferred from genetic interaction with kay (Cerrato et al., 2006) proboscis development inferred from mutant phenotype (Cerrato et al., 2006) response to DNA damage stimulus inferred from mutant phenotype (Busygina et al., 2004) response to heat inferred from mutant phenotype (Papaconstantinou et al., 2005) response to hypoxia inferred from mutant phenotype (Papaconstantinou et al., 2005) response to ionizing radiation inferred from mutant phenotype (Busygina et al., 2004) response to oxidative stress inferred from mutant phenotype (Papaconstantinou et al., 2005) response to salt stress inferred from mutant phenotype (Papaconstantinou et al., 2005)
Cellular Component
CV term Evidence References
MLL1/2 complex inferred from direct assay (Mohan et al., 2011) nucleus inferred from direct assay (Cerrato et al., 2006)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
histone H3-K4 methylation inferred by curator from GO:0044665 (Mohan et al., 2011)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Mnn1 - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - BCAS2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - CG8043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Jupiter anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Rrp40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - ash2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mohan et al., 2011) Mnn1 - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Mnn1 - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mnn1 allele Gene References unspecified Jra (Cerrato et al., 2006) kay (Cerrato et al., 2006) pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60139 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031885 DroID - A comprehensive database of gene and protein interactions. • FBgn0031885 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33991
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65HSH0 Dipteran inclusive ortholog search EOG637RP4 Insect inclusive ortholog search EOG69KDKP Arthropod inclusive ortholog search EOG6KD525 Metazoa inclusive ortholog search EOG6NSG4Q
Orthologs in Drosophila Species (EOG65HSH0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mnn1     Drosophila simulans   Dsim\GD23452 Y   Drosophila sechellia   Dsec\GM16311 Y   Drosophila erecta   Dere\GG10459 Y   Drosophila yakuba   Dyak\GE14373 Y   Drosophila ananassae   Dana\GF20766 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12519 Y   Drosophila persimilis   Dper\GL14105 Y   Drosophila willistoni   Dwil\GK24291 Y   Drosophila virilis   Dvir\GJ16255 Y   Drosophila mojavensis   Dmoj\GI14382 Y   Drosophila grimshawi   Dgri\GH10098 Y
Orthologs in non-Drosophila Dipterans (EOG637RP4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005686   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005553   Anopheles gambiae Malaria mosquito  Agam\AGAP008130   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000921
Orthologs in non-Dipteran Insects (EOG69KDKP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410989   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003205   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20238   Atta cephalotes Leafcutter ant  Acep\ACEP11070   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13233   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19108   Linepithema humile Argentine ant  Lhum\LH23617   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23971   Solenopsis invicta Red fire ant  Sinv\SINV19066   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001212   Bombyx mori Silkmoth  Bmor\BGIBMGA010655   Pediculus humanus Human body louse  Phum\PHUM350950   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07870
Orthologs in non-Insect Arthropods (EOG6KD525)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MT-CYB   Daphnia pulex Water flea  Dpux\Zyx   Ixodes scapularis Deer tick  Isca\ISCW004039
Orthologs in non-Arthropod Metazoa (EOG6NSG4Q)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018899gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022464gn   Danio rerio Zebrafish  Drer\men1   Danio rerio Zebrafish  Drer\men1   Xenopus tropicalis Western clawed frog  Xtro\men1   Mus musculus House mouse  Mmus\Men1   Rattus norvegicus Norway rat  Rnor\Men1   Homo sapiens Human  Hsap\MEN1
Human Orthologs (1)
Gene OMIM HGNC Hsap\MEN1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23452 Drosophila sechellia Dsec\GM16311 Drosophila erecta Dere\GG10459 Drosophila yakuba Dyak\GE14373 Drosophila ananassae Dana\GF20766 Drosophila pseudoobscura pseudoobscura Dpse\GA12519 Drosophila persimilis Dper\GL14105 Drosophila willistoni Dwil\GK24291 Drosophila virilis Dvir\GJ16255 Drosophila mojavensis Dmoj\GI14382 Drosophila grimshawi Dgri\GH10098
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	31220 y1 v1; P{TRiP.JF01775}attP2 21335 y1 w67c23; P{wHy}Mnn1DG30701 35150 y1 sc* v1; P{TRiP.GL00018}attP2
Kyoto	104289 w*; P{GawB}Mnn1NP2688 / CyO 201917 y1 w67c23; P{GSV6}Mnn1GS9609/SM1
VDRC	v17701 w1118; P{GD8117}v17701
Genomic Clones ( 2 )
	BACR13J07 BACR39J17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE21276 RE21791
Other clones	DPiM_RE21276
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE09345 SD12525
Other clones	32191 54813 75427 104281 118967 174316 174573 183302 bs73h07 CK01.75A.D10 EC257448 EK036140 EK045108 EK058945 EK159316 EK164801 EK166160 EK180858 EK181406 EK205223 EK211508 EK227762 EK238461 EK248209 EK279154 EK281601 EK288501 EP04648 EP18835 FGM209E08 FGM310E07 IP15170 RP004081729 RP004098073 RP004213855 RP004232054 RP004232288 RP004239526 RP004255430 RP004355719 RP004539159 RP004542612 RP004544784
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031885 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33991
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: menin CG13778 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of menin CG13778 was sequence comparison (date:000414). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078774 NM_164739 NM_001042877 RefSeq (Proteins) • NP_523498 NP_723252 NP_001036342 DDBJ / EMBL / GenBank • AAF52480 AAL89872 AAN10623 AAO24968 AB040816 ABI31296 AC007977 AY084134 BAA94341 BI215073 BI215403 BT003213 Entrez Gene - A searchable database of RefSeq genes. • 33991 UniProtKB/TrEMBL • Q7KXY9 Q8SXU2 Q9VM47
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Menin (IPR007747) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE21276
Linkouts
	BioGRID - A database of protein and genetic interactions • 60139 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0031885 DroID - A comprehensive database of gene and protein interactions. • FBgn0031885 DRSC - Results from RNAi screens. • FBgn0031885 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031885 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13778-RB;CG13778-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031885 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33991 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33991 modMine - Data generated by the modENCODE project. • FBgn0031885
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG13778 (Ni et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Mohan et al., 2011) CG33266 (Guru et al., 2001) MEN1 (Vidal and Cagan, 2006, Maruyama, 2000.3.29, Kottemann et al., 2006, Marek et al., 2008) menin (Cerrato et al., 2004, Maruyama et al., 2000, Fortini et al., 2000, ) Menin1 (Guru et al., 2001) Mnn1 (Busygina et al., 2004, Pezzulo et al., 2012, Furrer et al., 2010, Papaconstantinou et al., 2005, Cerrato et al., 2006, Bakal et al., 2007, Junion et al., 2007, Yan et al., 2010, Busygina et al., 2006, Marek et al., 2008, Zhang et al., 2012, Japanese National Institute of Genetics, 2012.5.21) mnn1 (Cerrato et al., 2006)
Name Synonym	menin (Cerrato et al., 2006) Menin 1 (Gregory et al., 2007) Menin1 (Barmina et al., 2005, Mohan et al., 2011)
Secondary FlyBase IDs
	FBgn0053266
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Pezzulo et al., 2012, PLoS ONE 7(8): e43777 Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster. [FBrf0219363] Zhang et al., 2012, Cell Death Dis. 3: 266 The EIF4EBP3 translational repressor is a marker of CDC73 tumor suppressor haploinsufficiency in a parathyroid cancer syndrome. [FBrf0217356] Mohan et al., 2011, Mol. Cell. Biol. 31(21): 4310--4318 The COMPASS Family of H3K4 Methylases in Drosophila. [FBrf0216343] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...