FlyBase Gene Report: Dmel\Mnn1

General Information

Symbol

Dmel\Mnn1

Species

D. melanogaster

Name

Menin 1

Annotation Symbol

CG13778

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031885

Gene Model Status

Stock Availability

9 publicly available

Gene Snapshot

Menin 1 (Mnn1) encodes a protein that regulates the response of several stresses including hypoxia, hyperosmolarity, heat shock, and oxidative stress. It is important during the mitotic G1 DNA damage checkpoint in a process mediated by the product of CHES-1-like. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

menin, MEN1

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:7,056,301..7,063,586 [+]

Recombination map

2-24

RefSeq locus

NT_033779 REGION:7056301..7063586

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (26 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

contributes_to histone-lysine N-methyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

enables transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

enables Y-form DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (18 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in cellular response to DNA damage stimulus

inferred from mutant phenotype

(Busygina et al., 2004)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Cerrato et al., 2006)

involved_in imaginal disc fusion, thorax closure

inferred from mutant phenotype

(Cerrato et al., 2006)

involved_in interstrand cross-link repair

inferred from mutant phenotype

(Marek et al., 2008)

involved_in mitotic G1 DNA damage checkpoint

inferred from mutant phenotype

(Busygina et al., 2006)

involved_in negative regulation of JNK cascade

inferred from genetic interaction with FLYBASE:Jra; FB:FBgn0001291

(Cerrato et al., 2006)

involved_in nucleotide-excision repair

inferred from mutant phenotype

(Busygina et al., 2004)

involved_in positive regulation of JNK cascade

inferred from genetic interaction with FLYBASE:kay; FB:FBgn0001297

(Cerrato et al., 2006)

involved_in proboscis development

inferred from mutant phenotype

(Cerrato et al., 2006)

involved_in response to heat

inferred from mutant phenotype

(Papaconstantinou et al., 2005)

involved_in response to hypoxia

inferred from mutant phenotype

(Papaconstantinou et al., 2005)

involved_in response to ionizing radiation

inferred from mutant phenotype

(Busygina et al., 2004)

involved_in response to oxidative stress

inferred from mutant phenotype

(Papaconstantinou et al., 2005)

involved_in response to salt stress

inferred from mutant phenotype

(Papaconstantinou et al., 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in histone H3-K4 methylation

inferred by curator from GO:0044665

(Mohan et al., 2011)

involved_in negative regulation of cell cycle

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of cell population proliferation

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of MLL1/2 complex

inferred from direct assay

(Mohan et al., 2011)

located_in nucleus

inferred from direct assay

(Cerrato et al., 2006)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

part_of histone methyltransferase complex

inferred from biological aspect of ancestor with PANTHER:PTN000976222

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

OTHER PROTEIN-LYSINE N-METHYLTRANSFERASES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Menin

Summaries

Gene Group (FlyBase)

TRX COMPLEX -: The Trithorax (Trx) complex is a COMPASS-like complex that mediates methylation of histone H3K4. (Adapted from FBrf0216343).
OTHER PROTEIN-LYSINE N-METHYLTRANSFERASES -: The 'Other protein-lysine N-methyltransferases' is a collection of protein-lysine N-methyltransferases that do not fit into any of the other major groups.

Summary (Interactive Fly)

conserved chromatin factor that modulates Jun activity in a manner dependent on the cellular context - tumor suppressor that functions in maintenance of genomic integrity - controls stress responses

Interactive Fly

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\Mnn1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0079401

4275

763

FBtr0079402

1927

530

FBtr0110978

5196

763

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0079029

82.9

763

5.96

FBpp0079030

59.0

530

5.63

FBpp0110277

82.9

763

5.96

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

763 aa isoforms: Mnn1-PA, Mnn1-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Menin

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mnn1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mnn1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Guru et al., 2001)

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 10

parasegment 4 -- parasegment 14

Comment: not observed stage 5-9

(Guru et al., 2001)

embryonic stage 11 -- 14

ectoderm | lateral

(Guru et al., 2001)

embryonic stage 15

anterior spiracle primordium

(Guru et al., 2001)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

Comment: 0-2 hr AEL; short isoform

(Guru et al., 2001)

embryonic stage 9 -- 15

Comment: 4-12 hr AEL; long isoform

(Guru et al., 2001)

embryonic stage 15 -- P-stage

organism | faint

(Guru et al., 2001)

adult stage | female

Comment: short isoform; no signal in males

(Guru et al., 2001)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of MLL1/2 complex

inferred from direct assay

(Mohan et al., 2011)

located_in nucleus

inferred from direct assay

(Cerrato et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mnn1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mnn1

View exonic expression by tissue for Dmel\Mnn1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031885

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031885

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG13778-RB;CG13778-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13778

Flygut - An atlas of the Drosophila adult midgut

FBgn0031885

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 14 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mnn1

Transgenic constructs containing regulatory region of Mnn1

Deletions and Duplications ( 5 )

Disrupted in

(Ryder, 2004.4.26)

(Papaconstantinou et al., 2005)

Partially disrupted in

Df(2L)Mnn1^Δ65

(Cerrato et al., 2006)

Df(2L)Mnn1^e200

(Busygina et al., 2004)

(Busygina et al., 2004)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | conditional | embryonic stage, with Scer\GAL4^nos.PG

lethal | embryonic stage | heat sensitive, with Scer\GAL4^nos.PG

lethal - all die before end of embryonic stage | heat sensitive

Mnn1^e30

lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4^arm.PS

lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4^hs.PB

lethal - all die before end of embryonic stage | heat sensitive, with Scer\GAL4^αTub84B.PL

lethal - all die before end of embryonic stage | heat sensitive (with Df(2L)spd^j2)

lethal - all die before end of P-stage, with Scer\GAL4^69B

Mnn1^UAS.cCa

lethal - all die before end of P-stage, with Scer\GAL4^da.G32

Mnn1^UAS.cCa

lethal - all die before end of P-stage, with Scer\GAL4^elav-C155

Mnn1^UAS.cCa

lethal - all die before end of P-stage, with Scer\GAL4^how-24B

Mnn1^UAS.cCa

lethal - all die before end of P-stage, with Scer\GAL4^RapGAP1-OK6

Mnn1^UAS.cCa

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mnn1^GD8117

viable, with Scer\GAL4^48Y

Mnn1^UAS.cCa

viable, with Scer\GAL4^AB1

Mnn1^UAS.cCa

viable, with Scer\GAL4^C1003

Mnn1^UAS.cCa

viable, with Scer\GAL4^da.G32

Mnn1^UAS.cCa

viable, with Scer\GAL4^dimm-929

Mnn1^UAS.cCa

viable, with Scer\GAL4^dpp.blk1

Mnn1^UAS.cCa

viable, with Scer\GAL4^ey.PH

Mnn1^UAS.cCa

viable, with Scer\GAL4^GMR.PF

viable, with Scer\GAL4^LE

viable, with Scer\GAL4^Mef2.PR

Mnn1^GD8117

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Mnn1^GD8117

viable, with Scer\GAL4^twi.PG

Mnn1^UAS.cCa

viable (with Df(2L)J-H)

viable (with Df(2L)Mnn1^Δ65)

Sterility

Allele

fertile (with Df(2L)J-H)

fertile (with Df(2L)Mnn1^Δ65)

Other Phenotypes

Allele

chemical sensitive

chemical sensitive, with Scer\GAL4^αTub84B.PL

Mnn1^UAS.cPa

DNA repair defective

Mnn1^e200

melanotic mass phenotype, with Scer\GAL4^69B

Mnn1^UAS.cCa

melanotic mass phenotype, with Scer\GAL4^da.G32

Mnn1^UAS.cCa

melanotic mass phenotype, with Scer\GAL4^elav-C155

Mnn1^UAS.cCa

melanotic mass phenotype, with Scer\GAL4^how-24B

Mnn1^UAS.cCa

melanotic mass phenotype, with Scer\GAL4^RapGAP1-OK6

Mnn1^UAS.cCa

radiation sensitive

Mnn1^e200

short lived, with Scer\GAL4^69B

Mnn1^UAS.cCa

short lived | male

short lived | male (with Mnn1^Δ46)

Mnn1^Δ79

short lived | male (with Mnn1^Δ79)

Mnn1^Δ46

some die during embryonic stage | heat sensitive

Mnn1^e30

some die during embryonic stage | heat sensitive, with Scer\GAL4^arm.PS

some die during embryonic stage | heat sensitive, with Scer\GAL4^hs.PB

some die during embryonic stage | heat sensitive, with Scer\GAL4^αTub84B.PL

some die during embryonic stage | heat sensitive (with Df(2L)spd^j2)

some die during pharate adult stage, with Scer\GAL4^69B

Mnn1^UAS.cCa

some die during pharate adult stage, with Scer\GAL4^da.G32

Mnn1^UAS.cCa

some die during pharate adult stage, with Scer\GAL4^elav-C155

Mnn1^UAS.cCa

some die during pharate adult stage, with Scer\GAL4^how-24B

Mnn1^UAS.cCa

some die during pharate adult stage, with Scer\GAL4^RapGAP1-OK6

Mnn1^UAS.cCa

stress response defective

stress response defective, with Scer\GAL4^nos.PG

stress response defective, with Scer\GAL4^αTub84B.PL

Mnn1⁺¹¹³

Phenotype manifest in

Allele

adult thorax, with Scer\GAL4^69B

Mnn1^UAS.cCa

adult thorax, with Scer\GAL4^pnr-MD237

Mnn1^UAS.cCa

chaeta, with Scer\GAL4^pnr-MD237

Mnn1^UAS.cCa

distiproboscis, with Scer\GAL4^69B

Mnn1^UAS.cCa

distiproboscis, with Scer\GAL4^da.G32

Mnn1^UAS.cCa

distiproboscis, with Scer\GAL4^elav-C155

Mnn1^UAS.cCa

distiproboscis, with Scer\GAL4^how-24B

Mnn1^UAS.cCa

distiproboscis, with Scer\GAL4^RapGAP1-OK6

Mnn1^UAS.cCa

wing, with Scer\GAL4^69B

Mnn1^UAS.cCa

wing, with Scer\GAL4^how-24B

Mnn1^UAS.cCa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

1

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

Rattus norvegicus (Norway rat) (1)

13 of 13

Yes

Yes

Xenopus tropicalis (Western clawed frog) (1)

12 of 12

Yes

Yes

Danio rerio (Zebrafish) (1)

12 of 15

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904TZ )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501ZI )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY005419

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07012

Mayetiola destructor

Hessian fly

Mdes\Mdes005033

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005553

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005686

Anopheles darlingi

American malaria mosquito

Adar\ADAC009526

Anopheles gambiae

Malaria mosquito

Agam\AGAP008130

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000921

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W045P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010655

Danaus plexippus

Monarch butterfly

Dple\DPOGS208567-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL004301

Apis florea

Little honeybee

Aflo\2627811316

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002189

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003205

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07870

Pediculus humanus

Human body louse

Phum\PHUM350950

Rhodnius prolixus

Kissing bug

Rpro\RPRC009423

Cimex lectularius

Bed bug

Clec\CLEC006376

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001212

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_01890

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_16270

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0424 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008989

Ixodes scapularis

Black-legged tick

Isca\ISCW004039

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78800.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g13940

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303383

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_63144

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G066V )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000001396

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

multiple endocrine neoplasia, type I

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of multiple endocrine neoplasia type 1

CEA

(Busygina et al., 2004)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

model of multiple endocrine neoplasia type 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

14 of 15

MULTIPLE ENDOCRINE NEOPLASIA, TYPE I; MEN1

multiple endocrine neoplasia type 1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Cerrato et al., 2006)

enhanceable

(Cerrato et al., 2006)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Cerrato et al., 2006)

enhanceable

(Cerrato et al., 2006)

suppressible

(Gregory et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60139

DroID - A comprehensive database of gene and protein interactions.

FBgn0031885

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33991

MIST (genetic) - An integrated Molecular Interaction Database

Mnn1

MIST (protein-protein) - An integrated Molecular Interaction Database

Mnn1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-24

Cytogenetic map

Sequence location

2L:7,056,301..7,063,586 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

27D7-27D7

Limits computationally determined from genome sequence between P{PZ}snRNP70K⁰²¹⁰⁷ and P{PZ}wg⁰²⁶⁵⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-24

(FlyBase, 2016)

2-23.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

31220

y¹ v¹; P{TRiP.JF01775}attP2

35150

y¹ sc^* v¹ sev²¹; P{TRiP.GL00018}attP2

80730

y¹ sc^* v¹ sev²¹; P{TOE.GS01520}attP40

51862

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03436}attP40

76459

y¹ sc^* v¹ sev²¹; P{TKO.GS00633}attP40/CyO

104289

w^*; P{GawB}Mnn1^NP2688 / CyO

201917

y¹ w^67c23; P{GSV6}Mnn1^GS9609/SM1

v110376

P{KK101050}VIE-260B

v17701

w¹¹¹⁸; P{GD8117}v17701

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (46)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE21276

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031885

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031885

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33991

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: menin CG13778

(FlyBase, 1996-)

Source for database merge of

Additional comments

Source for identity of menin CG13778 was sequence comparison ( date:000414 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33991

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031885

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031885

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Mnn1_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13778

Flygut - An atlas of the Drosophila adult midgut

FBgn0031885

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33991

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007870

InterPro - A database of protein families, domains and functional sites

Menin

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG13778

modMine - A data warehouse for the modENCODE project

FBgn0031885

Linkouts

BioGRID - A database of protein and genetic interactions.

60139

DPiM - Drosophila Protein interaction map

FBgn0031885

DroID - A comprehensive database of gene and protein interactions.

FBgn0031885

DRSC - Results frm RNAi screens

FBgn0031885

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0031885

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG13778-RB;CG13778-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031885

FlyMine - An integrated database for Drosophila genomics

FBgn0031885

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

33991

MIST (genetic) - An integrated Molecular Interaction Database

Mnn1

MIST (protein-protein) - An integrated Molecular Interaction Database

Mnn1

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG13778

(Mohan et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008)

CG33266

(Guru et al., 2001)

MEN1

(Mills, 2010, Marek et al., 2008, Kottemann et al., 2006, Vidal and Cagan, 2006, Maruyama, 2000.3.29)

Menin

(Shilatifard, 2012, Schuettengruber et al., 2011)

Menin1

(Guru et al., 2001)

Mnn

(Štětina et al., 2015)

menin

(Cerrato et al., 2004, Fortini et al., 2000, Maruyama et al., 2000)

mnn1

(Sturgill et al., 2007, Cerrato et al., 2006)

Name Synonyms

Menin 1

(Piunti and Shilatifard, 2016, Gregory et al., 2007)

Menin1

(Mohan et al., 2011, Barmina et al., 2005)

menin

(Cerrato et al., 2006)

Secondary FlyBase IDs

FBgn0053266

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (75)