FB2025_02 , released April 17, 2025
Gene: Dmel\Pvf2
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General Information
Symbol
Dmel\Pvf2
Species
D. melanogaster
Name
PDGF- and VEGF-related factor 2
Annotation Symbol
CG13780
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031888
Gene Model Status
Current
Stock Availability
36 publicly available
Gene Summary
PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Vegf27Cb, VEGF, Pvf, DmVEGF-2

Key Links
Genomic Location
Cytogenetic map
27E1-27E1
Sequence location
Recombination map
2-25
RefSeq locus
NT_033779 REGION:7069536..7084635
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (16 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables chemoattractant activity
inferred from mutant phenotype
(Wood et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables growth factor activity
inferred from electronic annotation with InterPro:IPR000072
(InterPro Project Members, 2004-)
enables vascular endothelial growth factor receptor binding
inferred from sequence or structural similarity with UniProtKB:P15692
(Cho et al., 2002)
Biological Process (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in glial cell migration
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Learte et al., 2008)
involved_in hemocyte migration
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Parsons and Foley, 2013, Wood et al., 2006)
inferred from expression pattern
(Cho et al., 2002)
inferred from genetic interaction with FLYBASE:Pvf1; FB:FBgn0030964,FLYBASE:Pvf3; FB:FBgn0085407
(Cho et al., 2002)
involved_in hemocyte proliferation
inferred from mutant phenotype
(Munier et al., 2002)
involved_in lymph gland development
inferred from mutant phenotype
(Ferguson and Martinez-Agosto, 2017)
involved_in negative regulation of humoral immune response
inferred from mutant phenotype
(Tsuzuki et al., 2014)
acts_upstream_of_positive_effect neuron remodeling
inferred from mutant phenotype
(Lopez-Bellido et al., 2019)
involved_in positive regulation of cell migration
inferred from mutant phenotype
(Harris et al., 2007)
involved_in positive regulation of cell size
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Sims et al., 2009)
involved_in positive regulation of innate immune response
inferred from mutant phenotype
(Tsuzuki et al., 2014)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Harris et al., 2007)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Cho et al., 2002)
(Read, 2018)
inferred from direct assay
(Tsuzuki et al., 2014)
inferred from mutant phenotype
(Ragab et al., 2011, Sims et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in hemocyte migration
inferred from biological aspect of ancestor with PANTHER:PTN001094163
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from direct assay
(Tsuzuki et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR000072
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Gene Group (FlyBase)
PDGF- AND VEGF-RELATED FACTORS -
PDGF- and VEGF-related factors bind and activate the PDGF/VEGF-receptor related receptor tyrosine kinase, Pvr. (Adapted from FBrf0221727.)
Summary (Interactive Fly)

ligands that orchestrate migratory patterns of hemocytes at the embryonic ventral midline - essential cell autonomously for proper positioning of the salivary glands

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pvf2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VM43)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pvf2-RA
FBtr0079423
NM_078775
2102
405
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pvf2-PA
FBpp0079051
46.9
405
8.62
Q9VM43
NP_523499
AAF52484
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pvf2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.87

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ventral midline of embryo
(Wheeler et al., 2009)
embryonic stage 9 -- 11
posterior ectoderm | restricted
(Cho et al., 2002)
embryonic hindgut
(Cho et al., 2002)
embryonic stage 9 -- 15
embryonic foregut
(Cho et al., 2002)
embryonic stage 11 -- 12
cardiogenic mesoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
embryonic stage 11 -- 13
larval ventral nerve cord
(Cho et al., 2002)
Malpighian tubule
(Cho et al., 2002)
embryonic stage 12 -- 15
ventral midline of embryo
(Wood et al., 2006)
embryonic stage 13 -- 14
ventral midline of embryo | dorsal
(Evans et al., 2010)
embryonic stage 13 -- 16
embryonic foregut
(Fisher et al., 2012)
embryonic leading edge cell
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic salivary gland duct
(Fisher et al., 2012)
embryonic stomatogastric nervous system
(Fisher et al., 2012)
larval circulatory system
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
embryonic stage 14
embryonic/larval dorsal vessel
(Wood et al., 2006)
Additional Descriptive Data

Pvf2 expression is restricted to the dorsal side of the midline in stage 13,14 embryos.

(Evans et al., 2010)

Pvf2 is expressed in the ventral midline starting at embryonic stage 12. Levels are strongest at stage 14. Over the next two hours of development, RNA levels decrease in a wave from anterior to posterior such that by stage 15 it is expressed in small, segmentally repeated points along the posterior region of the ventral nerve cord. These points of expression correspond to locations at which hemocytes cluster at the midline at this stage.

(Wood et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in extracellular space
inferred from direct assay
(Tsuzuki et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pvf2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pvf2
Transgenic constructs containing regulatory region of Pvf2
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(2L)Exel7030
(Ryder, 2004.4.26)
Df(2L)Mnn1Δ65
(Cerrato et al., 2006)
Gene partially disrupted in
Df(2L)Pvf2-3
(Parsons and Foley, 2013)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Tret1.PS
lethal - all die before end of larval stage, with Scer\GAL4nSyb.PS
lethal - all die before end of P-stage, with Scer\GAL4Hml.Δ
lethal - all die before end of pupal stage, with Scer\GAL4da.G32
lethal - all die before end of pupal stage, with Scer\GAL4e33C
lethal - all die before end of second instar larval stage
partially lethal, with Scer\GAL4NP5130
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal eclosion rhythm, with Scer\GAL4phtm.PU
abnormal locomotor behavior | adult stage, with Scer\GAL4Gli-rL82
abnormal locomotor behavior | adult stage, with Scer\GAL4NP2222
decreased occurrence of cell division | adult stage
increased cell number, with Scer\GAL4alrm.PD
increased cell number, with Scer\GAL4elav.PLu
increased cell number, with Scer\GAL4Gli-rL82
increased cell number, with Scer\GAL4GMR14F11
increased cell number, with Scer\GAL4GMR83E12
increased cell number, with Scer\GAL4GMR90C03
increased cell number, with Scer\GAL4moody.SPG
increased cell number, with Scer\GAL4NP2222
increased cell number, with Scer\GAL4NP3233
increased cell number, with Scer\GAL4nrv2.PS
increased cell number, with Scer\GAL4nrv2.PS, Scer\GAL80R90C03.PK
increased cell number, with Scer\GAL4repo, Scer\GAL80alrm.PS
increased cell number, with Scer\GAL4repo, Scer\GAL80moody.PZ
increased cell number, with Scer\GAL4repo, Scer\GAL80nrv2.PR
increased cell number, with Scer\GAL4repo, Scer\GAL80Tret1.PW
increased cell number, with Scer\GAL4repo, Scer\GAL80Tret1.PW, Scer\GAL80moody.PZ
increased cell number | adult stage, with Scer\GAL4repo
increased cell number | larval stage, with Scer\GAL4Hml.Δ
increased cell number | P-stage, with Scer\GAL4repo
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
majority die during larval stage, with Scer\GAL4Hml.Δ
short lived, with Scer\GAL4Gli-rL82
short lived, with Scer\GAL4NP2222
short lived, with Scer\GAL4nrv2.PS
some die during pupal stage, with Scer\GAL4da.G32
some die during pupal stage, with Scer\GAL4e33C
Phenotype manifest in
Allele
adult central nervous system, with Scer\GAL4repo
adult midgut
adult midgut, with Scer\GAL4NP5130
adult plasmatocyte | adult stage | increased number, with Scer\GAL4repo
central nervous system, with Scer\GAL4alrm.PD
central nervous system, with Scer\GAL4elav.PLu
central nervous system, with Scer\GAL4Gli-rL82
central nervous system, with Scer\GAL4GMR14F11
central nervous system, with Scer\GAL4GMR83E12
central nervous system, with Scer\GAL4GMR90C03
central nervous system, with Scer\GAL4moody.SPG
central nervous system, with Scer\GAL4NP2222
central nervous system, with Scer\GAL4NP3233
central nervous system, with Scer\GAL4nrv2.PS
central nervous system, with Scer\GAL4nrv2.PS, Scer\GAL80R90C03.PK
central nervous system, with Scer\GAL4repo, Scer\GAL80alrm.PS
central nervous system, with Scer\GAL4repo, Scer\GAL80moody.PZ
central nervous system, with Scer\GAL4repo, Scer\GAL80nrv2.PR
central nervous system, with Scer\GAL4repo, Scer\GAL80Tret1.PW
central nervous system, with Scer\GAL4repo, Scer\GAL80Tret1.PW, Scer\GAL80moody.PZ
embryonic/larval crystal cell, with Scer\GAL4e33C
embryonic/larval hemocyte
embryonic/larval hemocyte, with Scer\GAL4en-e16E
embryonic/larval hemocyte, with Scer\GAL4sim.PS
embryonic/larval hemocyte | increased number, with Scer\GAL4da.G32
embryonic/larval hemocyte | increased number, with Scer\GAL4e33C
embryonic/larval hemocyte | increased number | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval plasmatocyte, with Scer\GAL4e33C
embryonic/larval plasmatocyte | P-stage | increased number, with Scer\GAL4repo
enterocyte, with Scer\GAL4NP5130
enteroendocrine cell | increased number, with Scer\GAL4NP5130
hemocyte, with Scer\GAL4btl.PS
intestinal stem cell, with Scer\GAL4NP5130
lamellocyte | increased number | larval stage, with Scer\GAL4Hml.Δ
larval ventral nerve cord | embryonic stage, with Scer\GAL4en-e16E
lipid droplet | larval stage, with Scer\GAL4Hml.Δ
plasmatocyte | increased number, with Scer\GAL4alrm.PD
plasmatocyte | increased number, with Scer\GAL4elav.PLu
plasmatocyte | increased number, with Scer\GAL4Gli-rL82
plasmatocyte | increased number, with Scer\GAL4GMR14F11
plasmatocyte | increased number, with Scer\GAL4GMR83E12
plasmatocyte | increased number, with Scer\GAL4GMR90C03
plasmatocyte | increased number, with Scer\GAL4moody.SPG
plasmatocyte | increased number, with Scer\GAL4NP2222
plasmatocyte | increased number, with Scer\GAL4NP3233
plasmatocyte | increased number, with Scer\GAL4nrv2.PS
plasmatocyte | increased number, with Scer\GAL4nrv2.PS, Scer\GAL80R90C03.PK
plasmatocyte | increased number, with Scer\GAL4repo, Scer\GAL80alrm.PS
plasmatocyte | increased number, with Scer\GAL4repo, Scer\GAL80moody.PZ
plasmatocyte | increased number, with Scer\GAL4repo, Scer\GAL80nrv2.PR
plasmatocyte | increased number, with Scer\GAL4repo, Scer\GAL80Tret1.PW
plasmatocyte | increased number, with Scer\GAL4repo, Scer\GAL80Tret1.PW, Scer\GAL80moody.PZ
pupal central nervous system, with Scer\GAL4repo
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
Hsap\VEGFA
2 of 14
Yes
Yes
Hsap\VEGFB
2 of 14
Yes
Yes
Hsap\VEGFC
2 of 14
Yes
Yes
Hsap\VEGFD
2 of 14
Yes
Yes
Hsap\PDGFA
1 of 14
No
No
Hsap\PDGFB
1 of 14
No
No
Hsap\PDGFC
1 of 14
No
No
Hsap\PGF
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (9)
Rnor\Vegfa
2 of 14
Yes
Yes
Rnor\Vegfb
2 of 14
Yes
Yes
Rnor\Vegfc
2 of 14
Yes
Yes
Rnor\Vegfd
2 of 14
Yes
Yes
Rnor\Pdgfa
1 of 14
No
No
Rnor\Pdgfb
1 of 14
No
No
Rnor\Pdgfc
1 of 14
No
No
Rnor\Pdgfd
1 of 14
No
No
Rnor\Pgf
1 of 14
No
No
Mus musculus (laboratory mouse) (8)
Mmus\Vegfa
2 of 14
Yes
Yes
Mmus\Vegfb
2 of 14
Yes
Yes
Mmus\Vegfd
2 of 14
Yes
Yes
Mmus\Pdgfa
1 of 14
No
No
Mmus\Pdgfb
1 of 14
No
No
Mmus\Pdgfc
1 of 14
No
No
Mmus\Pgf
1 of 14
No
No
Mmus\Vegfc
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\pdgfb
2 of 13
Yes
No
Xtro\vegfa
2 of 13
Yes
Yes
Xtro\vegfd
2 of 13
Yes
Yes
Xtro\vegfb
1 of 13
No
No
Xtro\vegfc
1 of 13
No
Yes
Danio rerio (Zebrafish) (13)
Drer\pdgfbb
2 of 14
Yes
No
Drer\pgfb
2 of 14
Yes
No
Drer\si:ch211-79m20.1
2 of 14
Yes
No
Drer\vegfaa
2 of 14
Yes
No
Drer\vegfab
2 of 14
Yes
No
Drer\vegfba
2 of 14
Yes
No
Drer\vegfbb
2 of 14
Yes
No
Drer\vegfc
2 of 14
Yes
Yes
Drer\vegfd
2 of 14
Yes
Yes
Drer\pdgfaa
1 of 14
No
No
Drer\pdgfab
1 of 14
No
No
Drer\pdgfba
1 of 14
No
No
Drer\pgfa
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\pvf-1
2 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP009549
4 of 12
Yes
No
Agam\AgaP_AGAP000574
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pvf2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
Pvf3
4 of 13
Pvf1
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    VEGFC; vascular endothelial growth factor C
    model of  hereditary lymphedema ID
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Pvf2 - P58IPK
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Show/hide secondary interactors 
    (data from AllianceMine provided by esyN)
    esyN Network Key:
    Suppression
    Enhancement
    Other Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    PGRP-LE
    suppressible
    Pvf2
    (Winkler et al., 2021)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-25
    Cytogenetic map
    27E1-27E1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    27E1-27E1
    Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    27C-27C
    (Larsen, 2002.2.19)
    27D6-27D6
    (Roos, 2001.6.13)
    Experimentally Determined Recombination Data
    Location

    2-25

    (FlyBase, 2016)

    2-23.2

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (36)
    Genomic Clones (23)
    cDNA Clones (20)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Tsuzuki et al., 2014)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Pvf2 has a role in controlling the embryonic migration of blood cells.

          (Cho et al., 2002)
          Relationship to Other Genes
          Source for database merge of
          Additional comments

          "smi27E" may correspond to "Pvf2"; the P{lArB}smi27E1 insertion is 41bp downstream of "Pvf2".

          (Anholt et al., 2003)
          Nomenclature History
          Source for database identify of

          Source for identity of: Pvf2 CG13780

          (Rorth and Roos, 2001.8.16)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (16)
          Reported As
          Symbol Synonym
          CG13780
          (National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Mosallanejad et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Cho et al., 2002, Munier et al., 2002, Heino et al., 2001, Roos, 2001.6.14)
          DmVEGF-2
          (Heino et al., 2001)
          PV2
          (Bunt et al., 2007)
          PVF
          (Starz-Gaiano and Montell, 2004, Reif and Cyster, 2002)
          PVF2
          (Sopko and Perrimon, 2013, Hidalgo et al., 2011, McDonald et al., 2006, Montell, 2006, McDonald et al., 2004)
          PVFs
          (Ribeiro et al., 2003)
          Pvf
          (Zhang et al., 2013, Sims et al., 2009)
          Pvf2
          (Balakireva et al., 2024, Li et al., 2024, Zhou et al., 2024, Heigwer et al., 2023, Josserand et al., 2023, Xu et al., 2023, Koranteng et al., 2022, Liu et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Yu et al., 2022, DeAngelis et al., 2021, Millet-Boureima et al., 2021, Pan and O'Connor, 2021, Bakshi and Joshi, 2020, Cho et al., 2020, Nakajima et al., 2020, Pan et al., 2020, Ramond et al., 2020, Ramond et al., 2020, Zhou et al., 2020, Araki et al., 2019, Banerjee et al., 2019, Hall et al., 2019, Mele and Johnson, 2019, Douglas, 2018, Doupé et al., 2018, Jia et al., 2018, Read, 2018, Swevers et al., 2018, Ferguson and Martinez-Agosto, 2017, Liu and Jin, 2017, Matsubayashi et al., 2017, Transgenic RNAi Project members, 2017-, Ou et al., 2016, Parsons and Foley, 2016, Toggweiler et al., 2016, Vanha-Aho et al., 2016, Doggett et al., 2015, Morán et al., 2015, Pasco et al., 2015, Ratheesh et al., 2015, Sansone et al., 2015, Bilak et al., 2014, Shlyueva et al., 2014, Tsuzuki et al., 2014, Wang et al., 2014, Mbodj et al., 2013, Parsons and Foley, 2013, Weavers and Skaer, 2013, Bond and Foley, 2012, Kelsey et al., 2012, Fauvarque and Williams, 2011, Marcu et al., 2011, Ragab et al., 2011, Razzell et al., 2011, Evans et al., 2010, Moreira et al., 2010, Siekhaus et al., 2010, Bond and Foley, 2009, Sims et al., 2009, Wheeler et al., 2009, Wu et al., 2009, Choi et al., 2008, Harris et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Cerrato et al., 2006, Wood et al., 2006, Johansson et al., 2005, Munier et al., 2002)
          VEGF
          (Dormann and Weijer, 2003, Traver and Zon, 2002)
          VEGF-2
          (Evans et al., 2003)
          VEGF27Cb
          (Larsen, 2002.2.19)
          Vegf27Cb
          (Cho et al., 2002, Cho et al., 2002)
          pvf2
          (Turingan et al., 2024, Destalminil-Letourneau et al., 2021, Higareda Alvear et al., 2021, Ghosh et al., 2020, Liu et al., 2017, Xu et al., 2017, Ikmi et al., 2014, Zhang et al., 2013, Bunt et al., 2010, Learte et al., 2008, McDonald et al., 2003)
          Name Synonyms
          PDGF- and VEGF-receptor related factor 2
          (Zeitouni et al., 2007)
          PDGF- and VEGF-related factor 2
          (Marcu et al., 2011)
          VEGF-related factor 2
          (Boutros et al., 2002)
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 36 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (170)