FB2021_01, released Feb 18, 2021

Gene: Dmel\MICU1

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General Information
Symbol
Dmel\MICU1
Species
D. melanogaster
Name
Mitochondrial calcium uptake 1
Annotation Symbol
CG4495
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031893
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
27E4-27E4
Sequence location
2L:7,182,234..7,185,529 [+]
Recombination map

2-25

RefSeq locus
NT_033779 REGION:7182234..7185529
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables calcium ion binding
inferred from sequence or structural similarity with UniProtKB:Q9BPX6
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000265479
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in anesthesia-resistant memory
inferred from mutant phenotype
(Drago and Davis, 2016)
involved_in calcium import into the mitochondrion
inferred from mutant phenotype
(Drago and Davis, 2016)
involved_in medium-term memory
inferred from mutant phenotype
(Drago and Davis, 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in calcium import into the mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000265479
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in mitochondrial calcium ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000265479
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of mitochondrial calcium ion concentration
inferred from sequence or structural similarity with UniProtKB:Q9BPX6
(assigned by UniProt )
(UniProt Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of uniplex complex
inferred from sequence or structural similarity with UniProtKB:Q9BPX6
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN000265479
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the MICU1 family. MICU1 subfamily. (A2VEI2)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MITOCHONDRIAL CALCIUM UNIPORTER COMPLEX -
The mitochondrial calcium uniporter complex is a Ca2+-activated channel that mediates the import of Ca2+ ions from the cytosol into the mitochondrion. (Adapted from FBrf0233624).
Protein Function (UniProtKB)
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (Probable). During development, required in alpha/beta or gamma mushroom body neurons to support olfactory intermediate-term memory in the adult (PubMed:27568554).
(UniProt, A2VEI2)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\MICU1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
MICU1-RA
FBtr0079405
NM_135256
1915
524
MICU1-RB
FBtr0113028
NM_001103640
1928
525
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
MICU1-PA
FBpp0079033
60.3
524
8.03
NP_609100
AAF52489
MICU1-PB
FBpp0111941
60.3
525
7.52
NP_001097110
ABV53641
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MICU1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\MICU1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of MICU1
Transgenic constructs containing regulatory region of MICU1
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation
Gene disrupted in
Df(2L)Exel8019
(Ryder, 2004.4.26)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MICU1
13 of 15
Yes
Yes
Hsap\MICU2
1 of 15
No
No
Hsap\MICU3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Micu1
14 of 15
Yes
Yes
Mmus\Micu2
1 of 15
No
No
Mmus\Micu3
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Micu1
10 of 13
Yes
Yes
Rnor\Micu2
1 of 13
No
No
Rnor\Micu3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\micu1
11 of 12
Yes
Yes
Xtro\micu2
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\micu1
12 of 15
Yes
Yes
Drer\micu2
1 of 15
No
No
Drer\micu3a
1 of 15
No
No
Drer\micu3b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\micu-1
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT4G32060
7 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906V6 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001487
Drosophila simulans
Dsim\GD23455
Drosophila sechellia
Dsec\GM16344
Drosophila erecta
Dere\GG10463
Drosophila yakuba
Dyak\GE14428
Drosophila ananassae
Dana\GF20809
Drosophila pseudoobscura pseudoobscura
Dpse\GA27743
Drosophila persimilis
Dper\GL14118
Drosophila willistoni
Dwil\GK24295
Drosophila virilis
Dvir\GJ20826
Drosophila mojavensis
Dmoj\GI23634
Drosophila grimshawi
Dgri\GH13723
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509C1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017842
Glossina morsitans
Tsetse fly
Gmor\GMOY009939
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10160
Mayetiola destructor
Hessian fly
Mdes\Mdes014693
Mayetiola destructor
Hessian fly
Mdes\Mdes007704
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010116
Anopheles darlingi
American malaria mosquito
Adar\ADAC002455
Anopheles gambiae
Malaria mosquito
Agam\AGAP009117
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000774
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0ACF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009975
Danaus plexippus
Monarch butterfly
Dple\DPOGS202456-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015655
Heliconius melpomene
Postman butterfly
Hmel\HMEL015652
Apis florea
Little honeybee
Aflo\2788219396
Apis mellifera
Western honey bee
Amel\GB49936
Apis mellifera
Western honey bee
Amel\GB49935
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15439
Bombus terrestris
Buff-tailed bumblebee
Bter\15208276
Linepithema humile
Argentine ant
Lhum\LH12733
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e2b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG017774
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07264
Tribolium castaneum
Red flour beetle
Tcas\TC014040
Pediculus humanus
Human body louse
Phum\PHUM468410
Rhodnius prolixus
Kissing bug
Rpro\RPRC001251
Rhodnius prolixus
Kissing bug
Rpro\RPRC001249
Cimex lectularius
Bed bug
Clec\CLEC007382
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005123
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08182
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0A8S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002697
Ixodes scapularis
Black-legged tick
Isca\ISCW021152
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83056.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g03440
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_202030
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05UE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cbara1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005140
Gallus gallus
Domestic chicken
Ggal\MICU1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG4704
6 of 10
MICU3
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
MICU1GD4927
model of  myopathy with extrapyramidal signs
CEA
(M'Angale and Staveley, 2017)
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
MICU1; mitochondrial calcium uptake 1
model of  myopathy with extrapyramidal signs
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
MICU1GD4927
model of  myopathy with extrapyramidal signs
is ameliorated by BuffyUAS.cQa
(M'Angale and Staveley, 2017)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MICU1; mitochondrial calcium uptake 1
13 of 15
605084
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Interactions Browser
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
MICU1
suppressible
Buffy
(M'Angale and Staveley, 2017)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
EMRE|MCU
suppressible
MICU1
(Tufi et al., 2019)
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map

2-25

Cytogenetic map
27E4-27E4
Sequence location
2L:7,182,234..7,185,529 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
27E4-27E4
Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

2-25

(FlyBase, 2016)

2-23.6

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (8)
Genomic Clones (20)
cDNA Clones (44)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: MICU1 CG4495

(Drago and Davis, 2016)
Source for database merge of
Additional comments
Other Comments

MICU1 is required in the mushroom body neurons during development for normal intermediate-term olfactory memory in adult flies.

(Drago and Davis, 2016)
Origin and Etymology
Discoverer
Etymology

Gene is named "MICU1" based on orthology to human gene.

(Drago and Davis, 2016)
Identification
External Crossreferences and Linkouts ( 34 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (3)
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (35)