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Gene Dmel\CG5261

General Information
Symbol	Dmel\CG5261	Species	D. melanogaster
Name		Annotation symbol	CG5261
Feature type	protein_coding_gene	FlyBase ID	FBgn0031912
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	27F4-27F4	Sequence location	2L:7,426,866..7,430,329 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5261 (FBgn0031912). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: dihydrolipoyllysine-residue acetyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process: acetyl-CoA biosynthetic process from pyruvate. 9 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: 2-oxo acid dehydrogenase, lipoyl-binding site; 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; Chloramphenicol acetyltransferase-like domain; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; E3 binding; Single hybrid motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1638067_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG5261. Gene sequence location is 2L:7426866..7430329.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 27F4-27F4   Limits computationally determined from genome sequence between P{PZ}cuc10607 and P{EP}EP2419EP2419&P{EP}EP575
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5261 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5261-RA FBtr0079445  NM_164749   1955   421 CG5261-RB FBtr0079444  NM_135274   2331   512 CG5261-RC FBtr0332526  NM_001273264   2078   473 CG5261-RD FBtr0332527  NM_001273265   2126   489 CG5261-RE FBtr0332528  NM_001273266   2147   496 CG5261-RF FBtr0332529  NM_001273267   2195   512
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5261-PA   FBpp0079073   44.1   421   9.25     NP_723274   AAF52515 CG5261-PB   FBpp0079072   54.3   512   10.17     NP_609118   AAF52514 CG5261-PC   FBpp0304794   50.3   473   9.98     NP_001260193   AGB92729 CG5261-PD   FBpp0304795   51.7   489   10.03     NP_001260194   AGB92730 CG5261-PE   FBpp0304796   52.8   496   10.13     NP_001260195   AGB92731 CG5261-PF   FBpp0304797   54.3   512   10.17     NP_001260196   AGB92732
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Biotin/lipoyl attachment (IPR000089) 2-oxoacid dehydrogenase acyltransferase, catalytic domain (IPR001078) 2-oxo acid dehydrogenase, lipoyl-binding site (IPR003016) E3 binding (IPR004167) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (IPR006257) Single hybrid motif (IPR011053) Chloramphenicol acetyltransferase-like domain (IPR023213) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05261
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA802314   AE014134 AAF52514   AE014134 AAF52515   AE014134 AGB92729   AE014134 AGB92730   AE014134 AGB92731   AE014134 AGB92732   AI064624   AI113498   AI134996   AI238572   AI259166   AI259281   AI292480   AI296787   AI402813   AI402972   AI403204   AI404139   AI405526   AI406133   AI406187   AI406188   AI513710   AI516930   AI532979   AI945050   AI946292   AQ254813   AX093997   BE662061   BE979015   BF487081   BF487444   BF499584   BF499880   BF501223   BF503934   BG633417   BG634588   BI142051   BI164061   BI171383   BI232591   BI238013   BI241430   BI241509   BI243685   BI355107   BI373944   BI375111   BI483047   BI564298   BI564572   BI568116   BI568491   BI568514   BI570899   BI571269   BI571282   BI571316   BI571869   BI571944   BI574997   BI575155   BI578154   BI580995   BI580996   BI582220   BI582402   BI582443   BI582456   BI583755   BI584161   BI584392   BI604805   BI605971   BI612067   BI612594   BI612853   BI614790   BI619088   BI621107   BI623229   BI627144   BI632706   BI641025   BP556265   BT023873   BT024948   CK132317   CK658562   CK658990   CK659395   CK661560   CK662240   CL943543   CO153538   CO179276   CO181624   CO184034   CO187474   CO262157   CO262896   CO269146   CO275348   CO278503   CO280712   CO282136   CO284769   CO290725   CO291140   CO296038   CO299135   CO299837   CO302700   CO304887   CO308674   CO310477   CO317293   CO325285   CO327032   CO328268   CO329194   CO337112   CO341677   DN154284   EC061172   EC065761   EC067194   EC071178   EC074443   EC075010   EC077881   EC081937   EC194914   EC195076   EC195077   EC196633   EC203184   EC204132   EC205625   EC206365   EC206366   EC206573   EC207315   EC208098   EC212238   EC219439   EC221504   EC222210   EC222285   EC222452   EC222679   EC224662   EC227741   EC228780   EC230874   EC231063   EC234580   EC236188   EC238236   EC242581   EC244059   EC244409   EC245691   EC255986   EC259878   EC259933   EC266365   EC266954   EL871532   EL871533   EL871639   EL871640   EL884891   EL884892   EL885012   EL885013   EL885137   EL885138   EV575634   EV576554   EV582553   EV585244   EV589863   GH754107   GH850695   GH936243
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KTK9 Q9VM14
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    650.65 Larval Midgut    639 Larval Hindgut    1399.9 Larval Malpighian Tubules    926 Larval Fat Body    590.4 Larval Salivary Gland    866.4 Larval Trachea    631.55 Larval Carcass    1528.25 Adult Head    1266.4 Adult Eye    1426.275 Adult Brain    1064.3 Adult Thoracic-Abdominal Ganglion    1598.7 Adult Crop    1101.8 Adult Midgut    689.7 Adult Hindgut    1598.5 Adult Malpighian Tubules    2131.1 Adult Fat Body    2002 Adult Salivary Gland    1336.9 Adult Heart    1923.575 Adult VirginFemale Spermatheca    2051 Adult InseminatedFemale Spermatheca    1782 Adult Ovary    602.1 Adult Testis    1139.2 Adult Male Accessory Gland    436.2 Adult Carcass    2672.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (650.65) Larval Midgut  (639) Larval Hindgut  (1399.9) Larval Malpighian Tubules  (926) Larval Fat Body  (590.4) Larval Salivary Gland  (866.4) Larval Trachea  (631.55) Larval Carcass  (1528.25) Adult Head  (1266.4) Adult Eye  (1426.275) Adult Brain  (1064.3) Adult Thoracic-Abdominal Ganglion  (1598.7) Adult Crop  (1101.8) Adult Midgut  (689.7) Adult Hindgut  (1598.5) Adult Malpighian Tubules  (2131.1) Adult Fat Body  (2002) Adult Salivary Gland  (1336.9) Adult Heart  (1923.575) Adult VirginFemale Spermatheca  (2051) Adult InseminatedFemale Spermatheca  (1782) Adult Ovary  (602.1) Adult Testis  (1139.2) Adult Male Accessory Gland    436.2 Adult Carcass  (2672.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    650.65 Larval Midgut    639 Larval Hindgut  (1399.9) Larval Malpighian Tubules    926 Larval Fat Body    590.4 Larval Salivary Gland    866.4 Larval Trachea    631.55 Larval Carcass  (1528.25) Adult Head  (1266.4) Adult Eye  (1426.275) Adult Brain  1064.3 Adult Thoracic-Abdominal Ganglion  (1598.7) Adult Crop  (1101.8) Adult Midgut    689.7 Adult Hindgut  (1598.5) Adult Malpighian Tubules  (2131.1) Adult Fat Body  (2002) Adult Salivary Gland  (1336.9) Adult Heart  (1923.575) Adult VirginFemale Spermatheca  (2051) Adult InseminatedFemale Spermatheca  (1782) Adult Ovary    602.1 Adult Testis  (1139.2) Adult Male Accessory Gland    436.2 Adult Carcass  (2672.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    650.65 Larval Midgut    639 Larval Hindgut    1399.9 Larval Malpighian Tubules    926 Larval Fat Body    590.4 Larval Salivary Gland    866.4 Larval Trachea    631.55 Larval Carcass    1528.25 Adult Head    1266.4 Adult Eye    1426.275 Adult Brain    1064.3 Adult Thoracic-Abdominal Ganglion    1598.7 Adult Crop    1101.8 Adult Midgut    689.7 Adult Hindgut    1598.5 Adult Malpighian Tubules    2131.1 Adult Fat Body    2002 Adult Salivary Gland    1336.9 Adult Heart    1923.575 Adult VirginFemale Spermatheca    2051 Adult InseminatedFemale Spermatheca    1782 Adult Ovary    602.1 Adult Testis    1139.2 Adult Male Accessory Gland    436.2 Adult Carcass    2672.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    650.65 Larval Midgut    639 Larval Hindgut    1399.9 Larval Malpighian Tubules    926 Larval Fat Body    590.4 Larval Salivary Gland    866.4 Larval Trachea    631.55 Larval Carcass    1528.25 Adult Head    1266.4 Adult Eye    1426.275 Adult Brain    1064.3 Adult Thoracic-Abdominal Ganglion    1598.7 Adult Crop    1101.8 Adult Midgut    689.7 Adult Hindgut    1598.5 Adult Malpighian Tubules    2131.1 Adult Fat Body    2002 Adult Salivary Gland    1336.9 Adult Heart    1923.575 Adult VirginFemale Spermatheca    2051 Adult InseminatedFemale Spermatheca    1782 Adult Ovary    602.1 Adult Testis    1139.2 Adult Male Accessory Gland    436.2 Adult Carcass    2672.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  650.65 Larval Midgut  639 Larval Hindgut  (1399.9) Larval Malpighian Tubules  (926) Larval Fat Body  590.4 Larval Salivary Gland  (866.4) Larval Trachea  631.55 Larval Carcass  (1528.25) Adult Head  (1266.4) Adult Eye  (1426.275) Adult Brain  (1064.3) Adult Thoracic-Abdominal Ganglion  (1598.7) Adult Crop  (1101.8) Adult Midgut  689.7 Adult Hindgut  (1598.5) Adult Malpighian Tubules  (2131.1) Adult Fat Body  (2002) Adult Salivary Gland  (1336.9) Adult Heart  (1923.575) Adult VirginFemale Spermatheca  (2051) Adult InseminatedFemale Spermatheca  (1782) Adult Ovary  602.1 Adult Testis  (1139.2) Adult Male Accessory Gland    436.2 Adult Carcass  (2672.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    650.65 Larval Midgut    639 Larval Hindgut  1399.9 Larval Malpighian Tubules    926 Larval Fat Body    590.4 Larval Salivary Gland    866.4 Larval Trachea    631.55 Larval Carcass  1528.25 Adult Head  1266.4 Adult Eye  1426.275 Adult Brain  1064.3 Adult Thoracic-Abdominal Ganglion  1598.7 Adult Crop  1101.8 Adult Midgut    689.7 Adult Hindgut  1598.5 Adult Malpighian Tubules  (2131.1) Adult Fat Body  (2002) Adult Salivary Gland  1336.9 Adult Heart  (1923.575) Adult VirginFemale Spermatheca  (2051) Adult InseminatedFemale Spermatheca  (1782) Adult Ovary    602.1 Adult Testis  1139.2 Adult Male Accessory Gland    436.2 Adult Carcass  (2672.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    650.65 Larval Midgut    639 Larval Hindgut    1399.9 Larval Malpighian Tubules    926 Larval Fat Body    590.4 Larval Salivary Gland    866.4 Larval Trachea    631.55 Larval Carcass    1528.25 Adult Head    1266.4 Adult Eye    1426.275 Adult Brain    1064.3 Adult Thoracic-Abdominal Ganglion    1598.7 Adult Crop    1101.8 Adult Midgut    689.7 Adult Hindgut    1598.5 Adult Malpighian Tubules    2131.1 Adult Fat Body    2002 Adult Salivary Gland    1336.9 Adult Heart    1923.575 Adult VirginFemale Spermatheca    2051 Adult InseminatedFemale Spermatheca    1782 Adult Ovary    602.1 Adult Testis    1139.2 Adult Male Accessory Gland    436.2 Adult Carcass    2672.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1266.4   NA  Eye    1426.275   NA  Brain    1064.3   650.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1598.7   NA  Crop    1101.8   639  Midgut    689.7   1399.9  Hindgut    1598.5   926  Malpighian Tubules    2131.1   590.4  Fat Body    2002   866.4  Salivary Gland    1336.9   NA  Heart    1923.575   631.55  Trachea    NA   NA  VirginFemale Spermatheca    2051   NA  InseminatedFemale Spermatheca    1782   NA  Ovary    602.1   NA  Testis    1139.2   NA  Male Accessory Gland    436.2   1528.25  Carcass    2672.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    53 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    132 head, virgin 4-day female    72 head, virgin 20-day female    61 head, mated 1-day female    100 head, mated 4-day female    55 head, mated 20-day female    51 head, mated 1-day male    136 head, mated 4-day male    70 head, mated 20-day male    63 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    55 digestive system, 4-day adult    45 digestive system, 20-day adult    38 fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8    38 carcass, larvae L3 wandering    23 carcass, 1-day adult    248 carcass, 4-day adult    93 carcass, 20-day adult    67 ovary, virgin 4-day female    39 ovary, mated 4-day female    36 testis, mated 4-day male    107 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (53) central nervous system, larvae L3    20 central nervous system, pupae P8  (33) head, virgin 1-day female  (132) head, virgin 4-day female  (72) head, virgin 20-day female  (61) head, mated 1-day female  (100) head, mated 4-day female  (55) head, mated 20-day female  (51) head, mated 1-day male  (136) head, mated 4-day male  (70) head, mated 20-day male  (63) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult  (55) digestive system, 4-day adult  (45) digestive system, 20-day adult  (38) fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8  (38) carcass, larvae L3 wandering    23 carcass, 1-day adult  (248) carcass, 4-day adult  (93) carcass, 20-day adult  (67) ovary, virgin 4-day female  (39) ovary, mated 4-day female  (36) testis, mated 4-day male  (107) accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    53 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female  (132) head, virgin 4-day female    72 head, virgin 20-day female    61 head, mated 1-day female    100 head, mated 4-day female    55 head, mated 20-day female    51 head, mated 1-day male  (136) head, mated 4-day male    70 head, mated 20-day male    63 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    55 digestive system, 4-day adult    45 digestive system, 20-day adult    38 fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8    38 carcass, larvae L3 wandering    23 carcass, 1-day adult  (248) carcass, 4-day adult    93 carcass, 20-day adult    67 ovary, virgin 4-day female    39 ovary, mated 4-day female    36 testis, mated 4-day male  107 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    53 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    132 head, virgin 4-day female    72 head, virgin 20-day female    61 head, mated 1-day female    100 head, mated 4-day female    55 head, mated 20-day female    51 head, mated 1-day male    136 head, mated 4-day male    70 head, mated 20-day male    63 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    55 digestive system, 4-day adult    45 digestive system, 20-day adult    38 fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8    38 carcass, larvae L3 wandering    23 carcass, 1-day adult    248 carcass, 4-day adult    93 carcass, 20-day adult    67 ovary, virgin 4-day female    39 ovary, mated 4-day female    36 testis, mated 4-day male    107 accessory gland, mated 4-day male    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    53 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    132 head, virgin 4-day female    72 head, virgin 20-day female    61 head, mated 1-day female    100 head, mated 4-day female    55 head, mated 20-day female    51 head, mated 1-day male    136 head, mated 4-day male    70 head, mated 20-day male    63 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    55 digestive system, 4-day adult    45 digestive system, 20-day adult    38 fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8    38 carcass, larvae L3 wandering    23 carcass, 1-day adult    248 carcass, 4-day adult    93 carcass, 20-day adult    67 ovary, virgin 4-day female    39 ovary, mated 4-day female    36 testis, mated 4-day male    107 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (53) central nervous system, larvae L3    20 central nervous system, pupae P8  (33) head, virgin 1-day female  (132) head, virgin 4-day female  (72) head, virgin 20-day female  (61) head, mated 1-day female  (100) head, mated 4-day female  (55) head, mated 20-day female  (51) head, mated 1-day male  (136) head, mated 4-day male  (70) head, mated 20-day male  (63) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult  (55) digestive system, 4-day adult  (45) digestive system, 20-day adult  (38) fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8  (38) carcass, larvae L3 wandering    23 carcass, 1-day adult  (248) carcass, 4-day adult  (93) carcass, 20-day adult  (67) ovary, virgin 4-day female  (39) ovary, mated 4-day female  (36) testis, mated 4-day male  (107) accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    53 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female  132 head, virgin 4-day female    72 head, virgin 20-day female    61 head, mated 1-day female    100 head, mated 4-day female    55 head, mated 20-day female    51 head, mated 1-day male  136 head, mated 4-day male    70 head, mated 20-day male    63 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    55 digestive system, 4-day adult    45 digestive system, 20-day adult    38 fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8    38 carcass, larvae L3 wandering    23 carcass, 1-day adult  (248) carcass, 4-day adult    93 carcass, 20-day adult    67 ovary, virgin 4-day female    39 ovary, mated 4-day female    36 testis, mated 4-day male  107 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    53 central nervous system, larvae L3    20 central nervous system, pupae P8    33 head, virgin 1-day female    132 head, virgin 4-day female    72 head, virgin 20-day female    61 head, mated 1-day female    100 head, mated 4-day female    55 head, mated 20-day female    51 head, mated 1-day male    136 head, mated 4-day male    70 head, mated 20-day male    63 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    55 digestive system, 4-day adult    45 digestive system, 20-day adult    38 fat body, larvae L3 wandering    14 fat body, white prepupae    17 fat body, pupae P8    38 carcass, larvae L3 wandering    23 carcass, 1-day adult    248 carcass, 4-day adult    93 carcass, 20-day adult    67 ovary, virgin 4-day female    39 ovary, mated 4-day female    36 testis, mated 4-day male    107 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr    33 embryo 08-10hr    39 embryo 10-12hr    56 embryo 12-14hr    56 embryo 14-16hr    72 embryo 16-18hr    76 embryo 18-20hr    108 embryo 20-22hr    168 embryo 22-24hr    171 larva L1    165 larva L2    180 larva L3 12hr old    179 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    40 white prepupae 24hr    48 pupae 2d postWPP    95 pupae 3d postWPP    295 pupae 4d postWPP    468 adult male 01day    441 adult male 05day    255 adult male 30day    164 adult female 01day    317 adult female 05day    95 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr  (33) embryo 08-10hr  (39) embryo 10-12hr  (56) embryo 12-14hr  (56) embryo 14-16hr  (72) embryo 16-18hr  (76) embryo 18-20hr  (108) embryo 20-22hr  (168) embryo 22-24hr  (171) larva L1  (165) larva L2  (180) larva L3 12hr old  (179) larva L3 puffstage 1-2  (70) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (35) white prepupae new  (35) white prepupae 12hr  (40) white prepupae 24hr  (48) pupae 2d postWPP  (95) pupae 3d postWPP  (295) pupae 4d postWPP  (468) adult male 01day  (441) adult male 05day  (255) adult male 30day  (164) adult female 01day  (317) adult female 05day  (95) adult female 30day  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr    33 embryo 08-10hr    39 embryo 10-12hr    56 embryo 12-14hr    56 embryo 14-16hr    72 embryo 16-18hr    76 embryo 18-20hr  (108) embryo 20-22hr  (168) embryo 22-24hr  (171) larva L1  (165) larva L2  (180) larva L3 12hr old  (179) larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    40 white prepupae 24hr    48 pupae 2d postWPP    95 pupae 3d postWPP  (295) pupae 4d postWPP  (468) adult male 01day  (441) adult male 05day  (255) adult male 30day  (164) adult female 01day  (317) adult female 05day    95 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr    33 embryo 08-10hr    39 embryo 10-12hr    56 embryo 12-14hr    56 embryo 14-16hr    72 embryo 16-18hr    76 embryo 18-20hr    108 embryo 20-22hr    168 embryo 22-24hr    171 larva L1    165 larva L2    180 larva L3 12hr old    179 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    40 white prepupae 24hr    48 pupae 2d postWPP    95 pupae 3d postWPP    295 pupae 4d postWPP    468 adult male 01day    441 adult male 05day    255 adult male 30day    164 adult female 01day    317 adult female 05day    95 adult female 30day    80 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr    33 embryo 08-10hr    39 embryo 10-12hr    56 embryo 12-14hr    56 embryo 14-16hr    72 embryo 16-18hr    76 embryo 18-20hr    108 embryo 20-22hr    168 embryo 22-24hr    171 larva L1    165 larva L2    180 larva L3 12hr old    179 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    40 white prepupae 24hr    48 pupae 2d postWPP    95 pupae 3d postWPP    295 pupae 4d postWPP    468 adult male 01day    441 adult male 05day    255 adult male 30day    164 adult female 01day    317 adult female 05day    95 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr  (33) embryo 08-10hr  (39) embryo 10-12hr  (56) embryo 12-14hr  (56) embryo 14-16hr  (72) embryo 16-18hr  (76) embryo 18-20hr  (108) embryo 20-22hr  (168) embryo 22-24hr  (171) larva L1  (165) larva L2  (180) larva L3 12hr old  (179) larva L3 puffstage 1-2  (70) larva L3 puffstage 3-6  (48) larva L3 puffstage 7-9  (35) white prepupae new  (35) white prepupae 12hr  (40) white prepupae 24hr  (48) pupae 2d postWPP  (95) pupae 3d postWPP  (295) pupae 4d postWPP  (468) adult male 01day  (441) adult male 05day  (255) adult male 30day  (164) adult female 01day  (317) adult female 05day  (95) adult female 30day  (80) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr    33 embryo 08-10hr    39 embryo 10-12hr    56 embryo 12-14hr    56 embryo 14-16hr    72 embryo 16-18hr    76 embryo 18-20hr  108 embryo 20-22hr  (168) embryo 22-24hr  (171) larva L1  (165) larva L2  (180) larva L3 12hr old  (179) larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    40 white prepupae 24hr    48 pupae 2d postWPP    95 pupae 3d postWPP  (295) pupae 4d postWPP  (468) adult male 01day  (441) adult male 05day  (255) adult male 30day  (164) adult female 01day  (317) adult female 05day    95 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    23 embryo 04-06hr    19 embryo 06-08hr    33 embryo 08-10hr    39 embryo 10-12hr    56 embryo 12-14hr    56 embryo 14-16hr    72 embryo 16-18hr    76 embryo 18-20hr    108 embryo 20-22hr    168 embryo 22-24hr    171 larva L1    165 larva L2    180 larva L3 12hr old    179 larva L3 puffstage 1-2    70 larva L3 puffstage 3-6    48 larva L3 puffstage 7-9    35 white prepupae new    35 white prepupae 12hr    40 white prepupae 24hr    48 pupae 2d postWPP    95 pupae 3d postWPP    295 pupae 4d postWPP    468 adult male 01day    441 adult male 05day    255 adult male 30day    164 adult female 01day    317 adult female 05day    95 adult female 30day    80 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    27 embryonic GM2    82 embryonic Kc167    55 embryonic S1    43 embryonic S3    36 leg disc CME L1    26 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    40 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    33 ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (32) Schneider line 2 Sg4  (40) embryonic 1182-4H  (27) embryonic GM2  (82) embryonic Kc167  (55) embryonic S1  (43) embryonic S3  (36) leg disc CME L1  26 wing disc CME-W2  (41) wing disc ML-DmD8  (30) wing disc ML-DmD9  (32) wing disc ML-DmD16-c3  (44) wing disc ML-DmD21  (40) wing disc ML-DmD32    20 haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  (33) ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    27 embryonic GM2    82 embryonic Kc167    55 embryonic S1    43 embryonic S3    36 leg disc CME L1    26 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    40 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    33 ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    27 embryonic GM2    82 embryonic Kc167    55 embryonic S1    43 embryonic S3    36 leg disc CME L1    26 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    40 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    33 ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    27 embryonic GM2    82 embryonic Kc167    55 embryonic S1    43 embryonic S3    36 leg disc CME L1    26 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    40 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    33 ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  32 Schneider line 2 Sg4  (40) embryonic 1182-4H  27 embryonic GM2  (82) embryonic Kc167  (55) embryonic S1  (43) embryonic S3  (36) leg disc CME L1  26 wing disc CME-W2  (41) wing disc ML-DmD8  30 wing disc ML-DmD9  32 wing disc ML-DmD16-c3  (44) wing disc ML-DmD21  (40) wing disc ML-DmD32    20 haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1  (39) CNS ML-DmBG2-c2    25 tumorous blood cells mbn2  (33) ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    27 embryonic GM2    82 embryonic Kc167    55 embryonic S1    43 embryonic S3    36 leg disc CME L1    26 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    40 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    33 ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    27 embryonic GM2    82 embryonic Kc167    55 embryonic S1    43 embryonic S3    36 leg disc CME L1    26 wing disc CME-W2    41 wing disc ML-DmD8    30 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    44 wing disc ML-DmD21    40 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    23 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    39 CNS ML-DmBG2-c2    25 tumorous blood cells mbn2    33 ovary fGS/OSS    12 ovary OSC    22 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    27 heat shock, 4-day adult    83 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    82 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    51 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    59 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    87 Ethanol 10% 3 hrs, larvae L3    94 Caffeine 1.5 mg/ml 4 hrs, larvae L3    62 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    79 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    70 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  (27) heat shock, 4-day adult  (83) Cadmium 50 mM 6 hrs, larvae L3  (68) Cadmium 50 mM 12 hrs, larvae L3  (32) Cadmium 50 mM 48 hrs, 4-day adult  (82) Cadmium 100 mM 48 hrs, 4-day adult  (49) Copper 0.5 mM 12 hrs, larvae L3  (51) Copper 15 mM 48 hrs, 4-day adult  (34) Zinc 5 mM 12 hrs, larvae L3  (36) Zinc 4.5 mM 48 hrs, 4-day adult  (59) Ethanol 2.5% 3 hrs, larvae L3  (80) Ethanol 5% 3 hrs, larvae L3  (87) Ethanol 10% 3 hrs, larvae L3  (94) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (62) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult  (32) Paraquat 5 mM 48 hrs, 4-day adult  (79) Paraquat 10 mM 48 hrs, 4-day adult  (94) Rotenone 2 μg 12 hrs, larvae L3  (70) Rotenone 8 μg 12 hrs, larvae L3  (92) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    27 heat shock, 4-day adult    83 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    82 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    51 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    59 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    87 Ethanol 10% 3 hrs, larvae L3    94 Caffeine 1.5 mg/ml 4 hrs, larvae L3    62 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    79 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    70 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    27 heat shock, 4-day adult    83 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    82 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    51 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    59 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    87 Ethanol 10% 3 hrs, larvae L3    94 Caffeine 1.5 mg/ml 4 hrs, larvae L3    62 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    79 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    70 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    27 heat shock, 4-day adult    83 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    82 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    51 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    59 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    87 Ethanol 10% 3 hrs, larvae L3    94 Caffeine 1.5 mg/ml 4 hrs, larvae L3    62 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    79 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    70 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (35) cold shock, 4-day adult  27 heat shock, 4-day adult  (83) Cadmium 50 mM 6 hrs, larvae L3  (68) Cadmium 50 mM 12 hrs, larvae L3  32 Cadmium 50 mM 48 hrs, 4-day adult  (82) Cadmium 100 mM 48 hrs, 4-day adult  (49) Copper 0.5 mM 12 hrs, larvae L3  (51) Copper 15 mM 48 hrs, 4-day adult  (34) Zinc 5 mM 12 hrs, larvae L3  (36) Zinc 4.5 mM 48 hrs, 4-day adult  (59) Ethanol 2.5% 3 hrs, larvae L3  (80) Ethanol 5% 3 hrs, larvae L3  (87) Ethanol 10% 3 hrs, larvae L3  (94) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (62) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (43) Caffeine 25 mg/ml 48 hrs, 4-day adult  32 Paraquat 5 mM 48 hrs, 4-day adult  (79) Paraquat 10 mM 48 hrs, 4-day adult  (94) Rotenone 2 μg 12 hrs, larvae L3  (70) Rotenone 8 μg 12 hrs, larvae L3  (92) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    27 heat shock, 4-day adult    83 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    82 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    51 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    59 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    87 Ethanol 10% 3 hrs, larvae L3    94 Caffeine 1.5 mg/ml 4 hrs, larvae L3    62 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    79 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    70 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    35 cold shock, 4-day adult    27 heat shock, 4-day adult    83 Cadmium 50 mM 6 hrs, larvae L3    68 Cadmium 50 mM 12 hrs, larvae L3    32 Cadmium 50 mM 48 hrs, 4-day adult    82 Cadmium 100 mM 48 hrs, 4-day adult    49 Copper 0.5 mM 12 hrs, larvae L3    51 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    36 Zinc 4.5 mM 48 hrs, 4-day adult    59 Ethanol 2.5% 3 hrs, larvae L3    80 Ethanol 5% 3 hrs, larvae L3    87 Ethanol 10% 3 hrs, larvae L3    94 Caffeine 1.5 mg/ml 4 hrs, larvae L3    62 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    43 Caffeine 25 mg/ml 48 hrs, 4-day adult    32 Paraquat 5 mM 48 hrs, 4-day adult    79 Paraquat 10 mM 48 hrs, 4-day adult    94 Rotenone 2 μg 12 hrs, larvae L3    70 Rotenone 8 μg 12 hrs, larvae L3    92 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031912 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5261-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele wild-type, with Scer\GAL4ap-md544 CG5261EP816 Phenotype manifest in Allele wing | posterior compartment, with Scer\GAL4en-e16E CG5261UY48 CG5261UY669
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of CG5261 Class Mutagen Stocks Known lesion CG5261EY12882 P-element activity 2 -- CG5261CB-6300-3 1 -- CG5261EP816 P-element activity 0 -- CG5261UY48 P-element activity 0 -- CG5261UY669 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5261 Class Mutagen Stocks Known lesion CG5261GD16843 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5261HMS02170 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG5261KK102893 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes CG5261NIG.5261R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7031 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16843} NA P{KK102893} NA P{NIG.5261R} NA P{TRiP.HMS02170} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG5261EP816 NA P{EP}EP2380 NA P{EPgy2}CG5261EY12882 NA P{EPgy2}EY03970 NA P{GSV1}EP-603EP-603 NA P{Mae-UAS.6.11}CG5261UY48 NA P{Mae-UAS.6.11}CG5261UY669 NA miscellaneous insertions P{RS3}CG5261CB-6300-3 NA insertion of enhancer trap P{lacW}l(2)SH0288SH0288 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
dihydrolipoyllysine-residue acetyltransferase activity inferred from sequence or structural similarity with UniProtKB:P08461 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P10515 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
acetyl-CoA biosynthetic process from pyruvate inferred from sequence or structural similarity with UniProtKB:P10515 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial pyruvate dehydrogenase complex inferred from sequence or structural similarity with UniProtKB:P08461 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P10515 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG5261 - Atu experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG5261 - CG10494 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG5261 - CG10581 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG10877 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG11095 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG12162 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG13295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG14767 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG31472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG31546 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - CG7430 experimental knowledge based (Guruharsha et al., 2011) CG5261 - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - Mbs anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - bic anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - hyx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - pdgy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG5261 - sax anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5261 allele Gene References CG5261EP816 pnr (Pena-Rangel et al., 2002) unspecified H (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60166 DroID - A comprehensive database of gene and protein interactions. • FBgn0031912 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34021
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG679FTG Dipteran inclusive ortholog search EOG6N8RDW Insect inclusive ortholog search EOG6DZ0QN Arthropod inclusive ortholog search EOG60P2P6 Metazoa inclusive ortholog search EOG6JX771
Orthologs in Drosophila Species (EOG679FTG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG5261     Drosophila simulans   Dsim\GD23472 Y   Drosophila sechellia   Dsec\GM16455 Y   Drosophila erecta   Dere\GG10480 Y   Drosophila yakuba   Dyak\GE14551 Y   Drosophila ananassae   Dana\GF15860 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18768 Y   Drosophila persimilis   Dper\GL25816 Y   Drosophila willistoni   Dwil\GK24306 Y   Drosophila virilis   Dvir\GJ20958 Y   Drosophila mojavensis   Dmoj\GI23773 Y   Drosophila grimshawi   Dgri\GH13735 Y
Orthologs in non-Drosophila Dipterans (EOG6N8RDW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004294   Anopheles gambiae Malaria mosquito  Agam\AGAP007975   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802308
Orthologs in non-Dipteran Insects (EOG6DZ0QN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44983   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005082   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25986   Atta cephalotes Leafcutter ant  Acep\ACEP19864   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12576   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15730   Linepithema humile Argentine ant  Lhum\LH15090   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23911   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001374   Bombyx mori Silkmoth  Bmor\BGIBMGA008984   Pediculus humanus Human body louse  Phum\PHUM042350   Tribolium castaneum Red flour beetle  Tcas\TC005597
Orthologs in non-Insect Arthropods (EOG60P2P6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_71252   Daphnia pulex Water flea  Dpux\JGI_V11_188759   Ixodes scapularis Deer tick  Isca\ISCW013310   Ixodes scapularis Deer tick  Isca\ISCW013308   Ixodes scapularis Deer tick  Isca\ISCW016738
Orthologs in non-Arthropod Metazoa (EOG6JX771)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F23B12.5   Caenorhabditis elegans Nematode  Cele\C30H6.7   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020757gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012373gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021058gn   Danio rerio Zebrafish  Drer\dlat   Danio rerio Zebrafish  Drer\pdhx   Xenopus tropicalis Western clawed frog  Xtro\pdhx   Xenopus tropicalis Western clawed frog  Xtro\dlat   Gallus gallus Domestic chicken  Ggal\API5   Gallus gallus Domestic chicken  Ggal\DLAT   Mus musculus House mouse  Mmus\Pdhx   Mus musculus House mouse  Mmus\Dlat   Rattus norvegicus Norway rat  Rnor\Dlat   Rattus norvegicus Norway rat  Rnor\Pdhx   Homo sapiens Human  Hsap\DLAT   Homo sapiens Human  Hsap\PDHX
Human Orthologs (2)
Gene OMIM HGNC Hsap\DLAT     Hsap\PDHX
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23472 Drosophila sechellia Dsec\GM16455 Drosophila erecta Dere\GG10480 Drosophila yakuba Dyak\GE14551 Drosophila ananassae Dana\GF15860 Drosophila pseudoobscura pseudoobscura Dpse\GA18768 Drosophila persimilis Dper\GL25816 Drosophila willistoni Dwil\GK24306 Drosophila virilis Dvir\GJ20958 Drosophila mojavensis Dmoj\GI23773 Drosophila grimshawi Dgri\GH13735
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	40922 y1 v1; P{TRiP.HMS02170}attP40/CyO 20846 y1 w67c23; P{EPgy2}CG5261EY12882/CyO
Kyoto	124034 w1118; P{RS3}CG5261CB-6300-3 114681 yd2 w1118 P{ey-FLP.N}2; P{EPgy2}CG5261EY12882 P{neoFRT}40A/CyO y+
VDRC	v48939 w1118; P{GD16843}v48939
Genomic Clones ( 1 )
	BACR30I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 170 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT21758 IP16013
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05172 AT14175 AT14654 AT16488 AT22243 AT30841 GH05089 GH09823 GH12603 GH14641 GH15393 GH22111 GH22321 GH22595 GH23744 GH25549 GH26338 GH26408 GH26409 GH26766 GH27534 GM04187 GM29525 LP02517 LP02660 LP10867 LP13755 LP15570 LP16369 LP17130 LP21158 LP22304 RE03631 RE13141 RE28680 RE34369 RE38494 RE38594 RE41395 RE61414 RE62846 RE65882 RE71979 RH05685 RH06111 RH06124 RH06161 RH07174 RH07265 RH20179 RH20454 RH20522 RH20545 RH22440 RH23139 RH23577 RH27554 RH28434 RH36182 RH39492 RH40056 RH40083 RH40452 RH41522 RH41840 RH44259 RH50058 RH52404 RH55331 RH61874 RH68367 RH70284 RH72008 SD04642 SD16046 SD24084 SD26552
Other clones	14806 16526 17618 18002 39721 41716 44415 50648 52057 56658 61123 67343 70780 79079 80103 122191 123825 156030 159863 163267 179760 190152 287449 297411 bs08d06 bs19a06 bs23b07 bs85f03 CK01.2C.E3 CK01.26A.E5 CK01.26A.H5 CK01.33C.B2 CK01.33C.B4 CK01.36B.E11 CK01.75B.H11 CK01.96C.E6 CK01.98C.E12 CK01.98D.F1 CK01.99D.F7 CK01.103A.F8 CK01.112D.C4 CK01.123A.G1 Dmel_dig_002060_0628_1455 Dmel_dig_003329_0668_0769 Dmel_dig_005886_0645_1702 Dmel_dig_017786_0713_2031 Dmel_neb_004312_0363_3742 EC14750 EC26965 EC255986 EC259878 EC259933 EK029928 EK058932 EK074951 EK076239 EK084524 EK086656 EK093725 EK117231 EK130221 EK154657 EK159616 EK166750 EK174614 EK176723 EK184733 EK196029 EK209026 EK212549 EK221805 EK246649 EK259064 EK267628 EK292227 EN02316 EN13844 EP05529 EP08845 EP12935 FGM302D07 GH26680 IP03618 IP03718 IP16113 IP16213 IP16313 RH01032 RP003190241 RP003365116 RP003544165
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031912 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34021
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG5261 anon-WO0118547.121 (FlyBase, 1996-) Source for merge of: CG5261 EP816 (Mueller et al., 2005)
Additional comments	Source for merge of CG5261 anon-WO0118547.121 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila ESTs AI259166 and AI296787. Sequence similarity to Dihydrolpamide acetyltransferase component of pyruvate dehydrogenase (human). Probable intron in gene represented by EST AI259166. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135274 NM_164749 NM_001273264 NM_001273265 NM_001273266 NM_001273267 RefSeq (Proteins) • NP_609118 NP_723274 NP_001260193 NP_001260194 NP_001260195 NP_001260196 DDBJ / EMBL / GenBank • AAF52514 AAF52515 AGB92729 AGB92730 AGB92731 AGB92732 AI259166 AI296787 AI405526 AI945050 AI946292 AQ254813 AX093997 BE662061 BF487081 CL943543 Entrez Gene - A searchable database of RefSeq genes. • 34021 UniProtKB/TrEMBL • Q7KTK9 Q9VM14
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Biotin/lipoyl attachment (IPR000089) 2-oxoacid dehydrogenase acyltransferase, catalytic domain (IPR001078) 2-oxo acid dehydrogenase, lipoyl-binding site (IPR003016) E3 binding (IPR004167) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (IPR006257) Single hybrid motif (IPR011053) Chloramphenicol acetyltransferase-like domain (IPR023213) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05261
Linkouts
	BioGRID - A database of protein and genetic interactions • 60166 DroID - A comprehensive database of gene and protein interactions. • FBgn0031912 DRSC - Results from RNAi screens. • FBgn0031912 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031912 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5261-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031912 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34021 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34021 modMine - Data generated by the modENCODE project. • FBgn0031912
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	anon-WO0118547.121   CG5261 (Levine and Begun, 2008, Beller et al., 2006, Stuart et al., 2007, Molnar et al., 2006, Dorus et al., 2006, Raymond et al., 2004, Andersen and Tapon, 2008, Liu et al., 2009, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Cammarato et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1) DLAT (Saj et al., 2010) EP816   EP(2)0816 (Pena-Rangel et al., 2002)
Name Synonym	Dihydrolipoyllysine-residue acetyltransferase (Liu et al., 2009)
Secondary FlyBase IDs
	FBgn0062231 FBgn0062641
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 10 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...