FlyBase Gene Report: Dmel\Wwox

General Information

Symbol

Dmel\Wwox

Species

D. melanogaster

Name

WW domain containing oxidoreductase

Annotation Symbol

CG7221

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031972

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

WW domain containing oxidoreductase (Wwox) encodes a protein that contributes to homeostasis by regulating the balance between oxidative phosphorylation and glycolysis. It modulates the cell death mediated by the product of egr, which is accompanied by an increase in levels of reactive oxygen species. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

DmWWOX

Key Links

Genomic Location

Cytogenetic map

28D3-28D3

Sequence location

2L:7,999,670..8,004,286 [-]

Recombination map

2-29

RefSeq locus

NT_033779 REGION:7999670..8004286

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in defense response to Gram-negative bacterium

inferred from mutant phenotype

(Berkey et al., 2009)

involved_in regulation of reactive oxygen species metabolic process

inferred from mutant phenotype

(O'Keefe et al., 2011)

involved_in response to ionizing radiation

inferred from mutant phenotype

(O'Keefe et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(O'Keefe et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the short-chain dehydrogenases/reductases (SDR) family. (Q9VLU5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling (By similarity).

(UniProt, Q9VLU5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Wwox for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VLU5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Wwox-RA

FBtr0079550

NM_135327

1502

409

Wwox-RB

FBtr0343384

NM_001298806

1440

409

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Wwox-PA

FBpp0079172

46.5

409

7.54

FBpp0310039

46.5

409

7.54

Q9VLU5

NP_001285735

AHN54249

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

409 aa isoforms: Wwox-PA, Wwox-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Wwox using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Wwox_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.38

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(O'Keefe et al., 2005)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Wwox in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Wwox

View exonic expression by tissue for Dmel\Wwox

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031972

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34090/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031972

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031972

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031972

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7221

Flygut - An atlas of the Drosophila adult midgut

FBgn0031972

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Wwox

Transgenic constructs containing regulatory region of Wwox

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Wwox^GD12175

viable, with Scer\GAL4^da.G32

viable, with Scer\GAL4^Mef2.PR

Wwox^GD12175

viable, with Scer\GAL4^pnr-MD237

Wwox^GD12175

viable, with Scer\GAL4^tin.CΔ4

Wwox^GD12175

Sterility

Allele

fertile

Wwox^f04545

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\WWOX

14 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

3 of 14

2 of 14

Yes

Hsap\HSD17B7

2 of 14

Yes

Hsap\C2orf81

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (17)

Rnor\Wwox

6 of 14

Yes

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

3 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Itch

1 of 14

Rnor\LOC500227

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (17)

Mmus\Wwox

14 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

2 of 14

1 of 14

Yes

Mmus\Cbr1

1 of 14

Mmus\Cbr3

1 of 14

Mmus\Hsd17b7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\wwox

6 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (31)

Drer\wwox

13 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Drer\si:ch211-107o10.3

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

Drer\si:dkey-174n20.1

4 of 14

4 of 14

3 of 14

3 of 14

2 of 14

Yes

Drer\dhrs12lb

2 of 14

Yes

Drer\hsd17b7

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\DC2.5

13 of 14

Yes

Cele\dhs-7

13 of 14

Yes

Cele\K10H10.6

13 of 14

Yes

Cele\E04F6.15

12 of 14

Yes

Cele\dhs-8

11 of 14

Yes

Cele\F32A5.8

11 of 14

Yes

5 of 14

4 of 14

4 of 14

4 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP008423

12 of 12

Yes

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (31)

Atha\AT4G11410

8 of 13

Yes

Atha\AT4G23420

8 of 13

Yes

Atha\AT5G50130

8 of 13

Yes

Atha\Tic32-IVa

8 of 13

Yes

7 of 13

7 of 13

7 of 13

6 of 13

5 of 13

5 of 13

5 of 13

3 of 13

Yes

Atha\AT5G15940

3 of 13

Yes

Atha\AT1G01800

2 of 13

Atha\AT4G09750

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\ENV9

9 of 13

Yes

Scer\PBR1

3 of 13

Yes

Scer\YKL107W

3 of 13

Yes

Scer\ERG27

1 of 13

Yes

Scer\YMR226C

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPCC736.13

7 of 12

Yes

Spom\SPAC19A8.06

2 of 12

Spom\erg27

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\ygfF

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Wwox. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

8 of 13

naz

8 of 13

7 of 13

6 of 13

2 of 13

2 of 13

2 of 13

2 of 13

scu

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

sro

1 of 13

Su(dx)

1 of 13

yki

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, WWOX-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Wwox^GD12175

model of cancer

CEA

(Choo et al., 2015)

Wwox^KK108459

model of cancer

CEA

(Choo et al., 2015)

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

WWOX; WW domain containing oxidoreductase

model of autosomal recessive spinocerebellar ataxia 12

IEA

(FlyBase, 2019-)

model of esophageal cancer

IEA

(FlyBase, 2019-)

model of developmental and epileptic encephalopathy 28

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Wwox^GD12175

model of cancer

is exacerbated by ND-23^GD11167

(Choo et al., 2015)

is exacerbated by ND-42^GD6220

(Choo et al., 2015)

is exacerbated by ND-75^KK108222

(Choo et al., 2015)

Wwox^KK108459

ameliorates carcinoma

modeled by scrib¹

(O'Keefe et al., 2015)

model of cancer

is exacerbated by COX5A^GD5167

(Choo et al., 2015)

is exacerbated by COX5B^GD6659

(Choo et al., 2015)

is exacerbated by ND-23^GD11167

(Choo et al., 2015)

is exacerbated by ND-42^GD6220

(Choo et al., 2015)

is exacerbated by ND-75^KK108222

(Choo et al., 2015)

is exacerbated by UQCR-Q^KK108730

(Choo et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

WWOX; WW domain containing oxidoreductase

14 of 14

WW DOMAIN-CONTAINING OXIDOREDUCTASE; WWOX

DHRS13; dehydrogenase/reductase 13

5 of 14

616157

RDH11; retinol dehydrogenase 11

5 of 14

607849

RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROME; RDJCSS

RDH12; retinol dehydrogenase 12

5 of 14

608830

LEBER CONGENITAL AMAUROSIS 13; LCA13

Leber congenital amaurosis 13

RDH13; retinol dehydrogenase 13

5 of 14

RDH14; retinol dehydrogenase 14

5 of 14

616796

DHRSX; dehydrogenase/reductase X-linked

3 of 14

301034

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE 1DD; CDG1DD

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brat

suppressible

Wwox

(Hussain et al., 2017)

COX5A

suppressible

Wwox

(Choo et al., 2015)

COX5A

enhanceable

Wwox

(Choo et al., 2015)

COX5B

suppressible

Wwox

(Choo et al., 2015)

COX5B

enhanceable

Wwox

(Choo et al., 2015)

Idh3b

suppressible

Wwox

(O'Keefe et al., 2011)

Idh3b

enhanceable

Wwox

(O'Keefe et al., 2011)

ND-23

enhanceable

Wwox

(Choo et al., 2015)

ND-23

suppressible

Wwox

(Choo et al., 2015)

ND-42

enhanceable

Wwox

(Choo et al., 2015)

ND-42

suppressible

Wwox

(Choo et al., 2015)

ND-75

enhanceable

Wwox

(Choo et al., 2015)

ND-75

suppressible

Wwox

(Choo et al., 2015)

Sod1

enhanceable

Wwox

(O'Keefe et al., 2011)

UQCR-Q

enhanceable

Wwox

(Choo et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60224

DroID - A comprehensive database of gene and protein interactions.

FBgn0031972

MIST (genetic) - An integrated Molecular Interaction Database

34090

MIST (protein-protein) - An integrated Molecular Interaction Database

34090

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VLU5

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-29

Cytogenetic map

28D3-28D3

Sequence location

2L:7,999,670..8,004,286 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

28D3-28D3

Limits computationally determined from genome sequence between P{EP}CG7231^EP2510 and P{lacW}l(2)k10210^k10210

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-29

(FlyBase, 2016)

2-26.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

51747

y¹ v¹; P{TRiP.HMC03298}attP2

44546

y¹ v¹; P{TRiP.HMC02942}attP40

84884

y¹ w^*; TI{CRIMIC.TG4.2}Wwox^{CR01347-TG4.2}

77229

y¹ sc^* v¹ sev²¹; P{TOE.GS01042}attP40

11020

7221R-3

HMC03298

y¹ v¹; P{TRiP.HMC03298}attP2

HMC02942

y¹ v¹; P{TRiP.HMC02942}attP40

M2L-0574

y¹ w¹¹¹⁸; Wwox^SK2 P{neoFRT}40A/CyO-Tb

M2L-0575

y¹ w¹¹¹⁸; Wwox^SK3 P{neoFRT}40A/CyO-Tb

VDRC

v108350

P{KK108459}VIE-260B

v22536

w¹¹¹⁸; P{GD12175}v22536

More stocks available...

Genomic Clones (6)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (142)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD03827

Other clones

DPiM_LD03827

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031972

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031972

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

These mutant flies are viable and fertile with no obvious phenotype however they are sensitive to ionising radiation.

(O'Keefe et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG7221 anon- EST:Posey177

(Bayraktaroglu, 2000.11.2)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Wwox CG7221

(O'Keefe, 2006.6.6)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Name Synonyms

WW domain containing oxidoreductase

Wwox

(O'Keefe, 2006.6.6)

Secondary FlyBase IDs

FBgn0025543

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34090

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VLU5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VLU5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2J7F1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VLU5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031972

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34090/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031972

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031972

FlyMine - An integrated database for Drosophila genomics

FBgn0031972

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7221

MARRVEL_MODEL - MARRVEL (model organism gene)

34090

Linkouts

BioGRID - A database of protein and genetic interactions.

60224

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031972

DroID - A comprehensive database of gene and protein interactions.

FBgn0031972

DRSC - Results frm RNAi screens

FBgn0031972

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Wwox_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031972

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031972

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7221

Flygut - An atlas of the Drosophila adult midgut

FBgn0031972

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0031972

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034016

MIST (genetic) - An integrated Molecular Interaction Database

34090

MIST (protein-protein) - An integrated Molecular Interaction Database

34090

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VLU5

References (60)

The following external sites may use different assemblies or annotations than FlyBase.

0.38

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