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Gene Dmel\CG8552

General Information
Symbol	Dmel\CG8552	Species	D. melanogaster
Name		Annotation symbol	CG8552
Feature type	protein_coding_gene	FlyBase ID	FBgn0031990
Gene Model Status	Current	Stock availability	16 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	28E7-28E9	Sequence location	2L:8,134,247..8,159,575 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8552 (FBgn0031990). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: phosphatidylcholine 1-acylhydrolase activity. The biological processes in which it is involved are not known. 17 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: DDHD; WWE domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624826_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG8552. Gene sequence location is 2L:8134247..8159575.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Controlled Vocabulary Terms adult stage germline cell Sequence features BKN20849 HFA03096 BKN45219 HFA03095
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 28E7-28E9   Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8552 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone LD21041 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8552-RA FBtr0079641  NM_135341   6570   2016 CG8552-RB FBtr0302595  NM_001201785   6443   663 CG8552-RC FBtr0303401  NM_001201786   6263   663
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8552-PA   FBpp0079257   214.2   2016   4.42     NP_609185   AAF52607 CG8552-PB   FBpp0291751   75.0   663   5.86     NP_001188714   ADV36964 CG8552-PC   FBpp0292462   75.0   663   5.86     NP_001188715   ADV36965
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WWE domain (IPR004170) DDHD (IPR004177)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA541202   AA820252   AE014134 AAF52607   AE014134 ADV36964   AE014134 ADV36965   AI109703   AI455370   AI513023   AI517069   AW942587   AY128444 AAM75037   AY394340   AY394341   AY394342   AY394343   AY394344   AY394345   AY394346   AY394347   AY394348   AY394349   AY394350   AY394351   AY394352   AY394353   AY394354   AY394355   AY394356   AY394357   AY394358   AY394359   AY394360   AY394363   AY394364   AY394365   AY394366   AY394367   AY394368   AY394369   AY394370   AY394371   AY394372   AY394373   AY394374   AY394375   AY394376   AY394377   AY394378   AY394379   AY394380   AY394381   AY394382   AY394383   BE662098   BF486125   BF506261   BG632462   BG633471   BG635328   BG636473   BG640681   BH809456   BT023778   BT100028   CK657235   CK658200   CO189426   CO263966   CO269637   CO275003   CO285727   CO291557   CO292401   CO294616   CO296239   CO299067   CO300069   CO301472   CO306431   CO314072   CO319284   CO319350   CO323081   CO323191   CO326326   CO328950   CO331812   CO333267   CO335411   CO335603   CO343780   CZ466867   CZ466868   CZ477957   CZ477958   CZ480412   CZ486791   CZ486803   CZ486804   CZ490254   DN154521   EC059696   EC060469   EC060831   EC062306   EC072449   EC074246   EC074641   EC078369   EC085313   EC200701   EC202643   EC203364   EC214149   EC216692   EC218787   EC220293   EC224053   EC228140   EC229773   EC235437   EC235866   EC240256   EC250212   EC258710   EC260092   EC260650   EC264992   EC266740   EV582744   EV586540   EV595155   GH950305
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MQQ8 Q9VLS7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage | male     (Arbeitman et al., 2004) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage | male   germline cell   (Arbeitman et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0031990    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0031990 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0031990 expression level Developmental Stage   Expression Level embryo 00-02hr    2032 embryo 02-04hr    4229 embryo 04-06hr    1830 embryo 06-08hr    1274 embryo 08-10hr    1499 embryo 10-12hr    1159 embryo 12-14hr    2503 embryo 14-16hr    2587 embryo 16-18hr    3038 embryo 18-20hr    2718 embryo 20-22hr    2769 embryo 22-24hr    3067 larva L1    1780 larva L2    2237 larva L3 12hr old    1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6    1527 larva L3 puffstage 7-9    1483 white prepupae new    1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP    1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day    2003 adult male 05day    1909 adult male 30day    1761 adult female 01day    1418 adult female 05day    2079 adult female 30day    1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2032) embryo 02-04hr  (4229) embryo 04-06hr  (1830) embryo 06-08hr  (1274) embryo 08-10hr  (1499) embryo 10-12hr  (1159) embryo 12-14hr  (2503) embryo 14-16hr  (2587) embryo 16-18hr  (3038) embryo 18-20hr  (2718) embryo 20-22hr  (2769) embryo 22-24hr  (3067) larva L1  (1780) larva L2  (2237) larva L3 12hr old  (1948) larva L3 puffstage 1-2  (1143) larva L3 puffstage 3-6  (1527) larva L3 puffstage 7-9  (1483) white prepupae new  (1541) white prepupae 12hr  (939) white prepupae 24hr  (1223) pupae 2d postWPP  (1584) pupae 3d postWPP  (1300) pupae 4d postWPP  (1109) adult male 01day  (2003) adult male 05day  (1909) adult male 30day  (1761) adult female 01day  (1418) adult female 05day  (2079) adult female 30day  (1958) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2032) embryo 02-04hr  (4229) embryo 04-06hr  (1830) embryo 06-08hr    1274 embryo 08-10hr  1499 embryo 10-12hr    1159 embryo 12-14hr  (2503) embryo 14-16hr  (2587) embryo 16-18hr  (3038) embryo 18-20hr  (2718) embryo 20-22hr  (2769) embryo 22-24hr  (3067) larva L1  (1780) larva L2  (2237) larva L3 12hr old  (1948) larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6  (1527) larva L3 puffstage 7-9  1483 white prepupae new  (1541) white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP  (1584) pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day  (2003) adult male 05day  (1909) adult male 30day  (1761) adult female 01day  1418 adult female 05day  (2079) adult female 30day  (1958) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2032 embryo 02-04hr    4229 embryo 04-06hr    1830 embryo 06-08hr    1274 embryo 08-10hr    1499 embryo 10-12hr    1159 embryo 12-14hr    2503 embryo 14-16hr    2587 embryo 16-18hr    3038 embryo 18-20hr    2718 embryo 20-22hr    2769 embryo 22-24hr    3067 larva L1    1780 larva L2    2237 larva L3 12hr old    1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6    1527 larva L3 puffstage 7-9    1483 white prepupae new    1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP    1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day    2003 adult male 05day    1909 adult male 30day    1761 adult female 01day    1418 adult female 05day    2079 adult female 30day    1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2032 embryo 02-04hr    4229 embryo 04-06hr    1830 embryo 06-08hr    1274 embryo 08-10hr    1499 embryo 10-12hr    1159 embryo 12-14hr    2503 embryo 14-16hr    2587 embryo 16-18hr    3038 embryo 18-20hr    2718 embryo 20-22hr    2769 embryo 22-24hr    3067 larva L1    1780 larva L2    2237 larva L3 12hr old    1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6    1527 larva L3 puffstage 7-9    1483 white prepupae new    1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP    1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day    2003 adult male 05day    1909 adult male 30day    1761 adult female 01day    1418 adult female 05day    2079 adult female 30day    1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0031990 expression level Developmental Stage   Expression Level embryo 00-02hr    2032 embryo 02-04hr    4229 embryo 04-06hr    1830 embryo 06-08hr    1274 embryo 08-10hr    1499 embryo 10-12hr    1159 embryo 12-14hr    2503 embryo 14-16hr    2587 embryo 16-18hr    3038 embryo 18-20hr    2718 embryo 20-22hr    2769 embryo 22-24hr    3067 larva L1    1780 larva L2    2237 larva L3 12hr old    1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6    1527 larva L3 puffstage 7-9    1483 white prepupae new    1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP    1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day    2003 adult male 05day    1909 adult male 30day    1761 adult female 01day    1418 adult female 05day    2079 adult female 30day    1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2032) embryo 02-04hr  (4229) embryo 04-06hr  (1830) embryo 06-08hr  (1274) embryo 08-10hr  (1499) embryo 10-12hr  (1159) embryo 12-14hr  (2503) embryo 14-16hr  (2587) embryo 16-18hr  (3038) embryo 18-20hr  (2718) embryo 20-22hr  (2769) embryo 22-24hr  (3067) larva L1  (1780) larva L2  (2237) larva L3 12hr old  (1948) larva L3 puffstage 1-2  (1143) larva L3 puffstage 3-6  (1527) larva L3 puffstage 7-9  (1483) white prepupae new  (1541) white prepupae 12hr  (939) white prepupae 24hr  (1223) pupae 2d postWPP  (1584) pupae 3d postWPP  (1300) pupae 4d postWPP  (1109) adult male 01day  (2003) adult male 05day  (1909) adult male 30day  (1761) adult female 01day  (1418) adult female 05day  (2079) adult female 30day  (1958) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2032 embryo 02-04hr  (4229) embryo 04-06hr  1830 embryo 06-08hr    1274 embryo 08-10hr  1499 embryo 10-12hr    1159 embryo 12-14hr  (2503) embryo 14-16hr  (2587) embryo 16-18hr  (3038) embryo 18-20hr  (2718) embryo 20-22hr  (2769) embryo 22-24hr  (3067) larva L1  1780 larva L2  2237 larva L3 12hr old  1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6  1527 larva L3 puffstage 7-9  1483 white prepupae new  1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP  1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day  2003 adult male 05day  1909 adult male 30day  1761 adult female 01day  1418 adult female 05day  2079 adult female 30day  1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2032 embryo 02-04hr    4229 embryo 04-06hr    1830 embryo 06-08hr    1274 embryo 08-10hr    1499 embryo 10-12hr    1159 embryo 12-14hr    2503 embryo 14-16hr    2587 embryo 16-18hr    3038 embryo 18-20hr    2718 embryo 20-22hr    2769 embryo 22-24hr    3067 larva L1    1780 larva L2    2237 larva L3 12hr old    1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6    1527 larva L3 puffstage 7-9    1483 white prepupae new    1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP    1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day    2003 adult male 05day    1909 adult male 30day    1761 adult female 01day    1418 adult female 05day    2079 adult female 30day    1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2032 embryo 02-04hr    4229 embryo 04-06hr    1830 embryo 06-08hr    1274 embryo 08-10hr    1499 embryo 10-12hr    1159 embryo 12-14hr    2503 embryo 14-16hr    2587 embryo 16-18hr    3038 embryo 18-20hr    2718 embryo 20-22hr    2769 embryo 22-24hr    3067 larva L1    1780 larva L2    2237 larva L3 12hr old    1948 larva L3 puffstage 1-2    1143 larva L3 puffstage 3-6    1527 larva L3 puffstage 7-9    1483 white prepupae new    1541 white prepupae 12hr    939 white prepupae 24hr    1223 pupae 2d postWPP    1584 pupae 3d postWPP    1300 pupae 4d postWPP    1109 adult male 01day    2003 adult male 05day    1909 adult male 30day    1761 adult female 01day    1418 adult female 05day    2079 adult female 30day    1958 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0031990    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0031990 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0031990 expression level Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland    961.5 Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland    731 Adult Heart    240.675 Adult VirginFemale Spermatheca    502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland  (961.5) Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland  (731) Adult Heart    240.675 Adult VirginFemale Spermatheca  502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland    961.5 Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland    731 Adult Heart    240.675 Adult VirginFemale Spermatheca    502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland    961.5 Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland    731 Adult Heart    240.675 Adult VirginFemale Spermatheca    502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0031990 expression level Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland    961.5 Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland    731 Adult Heart    240.675 Adult VirginFemale Spermatheca    502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland  (961.5) Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland  731 Adult Heart    240.675 Adult VirginFemale Spermatheca  502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland    961.5 Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland    731 Adult Heart    240.675 Adult VirginFemale Spermatheca    502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    183.3 Larval Midgut    335.1 Larval Hindgut    199 Larval Malpighian Tubules    249.7 Larval Fat Body    278.4 Larval Salivary Gland    961.5 Larval Trachea    153.25 Larval Carcass    166.8 Adult Head    326.3 Adult Eye    192.2 Adult Brain    391.4 Adult Thoracic-Abdominal Ganglion    321.9 Adult Crop    268.2 Adult Midgut    317.8 Adult Hindgut    288.4 Adult Malpighian Tubules    205.5 Adult Fat Body    378.4 Adult Salivary Gland    731 Adult Heart    240.675 Adult VirginFemale Spermatheca    502.1 Adult InseminatedFemale Spermatheca    414.9 Adult Ovary    251.5 Adult Testis    315 Adult Male Accessory Gland    429.5 Adult Carcass    316.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    326.3   NA  Eye    192.2   NA  Brain    391.4   183.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    321.9   NA  Crop    268.2   335.1  Midgut    317.8   199  Hindgut    288.4   249.7  Malpighian Tubules    205.5   278.4  Fat Body    378.4   961.5  Salivary Gland    731   NA  Heart    240.675   153.25  Trachea    NA   NA  VirginFemale Spermatheca    502.1   NA  InseminatedFemale Spermatheca    414.9   NA  Ovary    251.5   NA  Testis    315   NA  Male Accessory Gland    429.5   166.8  Carcass    316.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031990 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8552-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG8552 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG8552EY03635 CG8552f04269 viable, with Scer\GAL4pnr-MD237 CG8552GD13962 Sterility Allele fertile CG8552EY03635 CG8552f04269 Phenotype manifest in Allele
Classical Alleles ( 15 )
For All Classical Alleles Show
Allele of CG8552 Class Mutagen Stocks Known lesion CG8552c03991 piggyBac transposase 2 -- CG8552f04269 piggyBac transposase 2 -- CG8552KG03914 P-element activity 2 -- CG8552c01080 piggyBac transposase 1 -- CG8552e00047 piggyBac transposase 1 -- CG8552e02633 piggyBac transposase 1 -- CG8552EY03635 P-element activity 1 -- CG8552f07514 piggyBac transposase 1 -- CG8552MB02562 1 -- CG8552MB03243 1 -- CG8552CPTI001111 piggyBac transposase 0 Yes CG8552CPTI001288 piggyBac transposase 0 Yes CG8552CPTI001450 piggyBac transposase 0 Yes CG8552CPTI100044 piggyBac transposase 0 Yes CG8552f04257 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8552 Class Mutagen Stocks Known lesion CG8552GD13962 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG8552KK100753 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7034 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13962} NA P{KK100753} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}GE11609 NA P{EPgy2}CG8552EY03635 NA miscellaneous insertions P{PTT-GA}CA07352 NA P{SUPor-P}CG8552KG03914 NA PBac{544.SVS-1}CG8552CPTI100044 NA PBac{602.P.SVS-1}CG8552CPTI001111 NA PBac{681.P.FSVS-1}CG8552CPTI001288 NA PBac{681.P.FSVS-1}CG8552CPTI001450 NA PBac{PB}CG8552c01080 NA PBac{PB}CG8552c03991 NA PBac{RB}CG8552e00047 NA PBac{RB}CG8552e02633 NA PBac{RB}CG43394e00174 NA PBac{RB}CG43394e02200 NA PBac{RB}CG43394e04150 NA PBac{WH}CG8552f04257 NA PBac{WH}CG8552f04269 NA PBac{WH}CG8552f07514 NA PBac{y+-attP-3B}VK00002 NA insertion of enhancer trap binary system Mi{ET1}CG8552MB02562 No Mi{ET1}CG8552MB03243 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
metal ion binding inferred from electronic annotation with InterPro:IPR004177 (FlyBase Curators et al., 2004-) phosphatidylcholine 1-acylhydrolase activity inferred from sequence or structural similarity with EMBL:AF045022 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8552 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60238 DroID - A comprehensive database of gene and protein interactions. • FBgn0031990 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34109
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14409 Dere\GG23474 Dgri\GH13095 Dmoj\GI14167 Dper\GL19322 Dpse\GA21159 Dsec\GM13161 Dvir\GJ17502 Dwil\GK23744 Dyak\GE11176
Curated drosophilid orthologs	Dpse\GA21159   Dsim\CG8552 (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009930-PA Aedes aegypti (mosquito) AAEL014360-PA Aedes aegypti (mosquito) AGAP002379-PA Anopheles gambiae (mosquito) XP_392149.3 Apis mellifera (honey bee) 34604 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA001646-PA Bombyx mori (silk worm) CN06204 Caenorhabditis brenneri (small nematode) CBP03293 Caenorhabditis briggsae (nematode) ENSCAFP00000018116 Canis familiaris (dog) ENSCINP00000014302 Ciona intestinalis (sea squirt) JA16825 Caenorhabditis japonica (nematode) CPIJ002701 Culex pipens (mosquito) RP37060 Caenorhabditis remanei (nematode) 169179 Capitella spl (polychaete worm) ENSGACP00000004358 Gymnopilus aculeatus (mushroom) ENSGALP00000020284 Gallus gallus (chicken) 193825 Hypsipyla robusta (cedar shoot borer) 232837 Lottia gigantea (owl limpet) ENSMMUP00000012499 Macaca mulatta (rhesus monkey) ENSMUSP00000035610 Mus musculus (house mouse) XP_001602740.1 Nasonia vitripennis (wasp) ENSOANP00000002443 Ornithorynchus anatinus (platypus) ENSORLP00000017437 Oryzias latipes (japanese killifish) PHUM005207-PA Pediculus humanus (human body louse) ENSPPYP00000003161 Pongo pygmaeus (orangutan) 5058279 Sorghum bicolor (sorghum) Smp_140970 Schistosoma mansoni (trematode parasite) XP_783634.2 Strongylocentrotus purpuratus (purple sea urchin) ENSXETP00000033235 Xenopus tropicalis (frog) YALI0E34815g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16266 NV12652 LH22696 ISCW018654 FBgn0228998 FBgn0225706 FBgn0204672 FBgn0193841 JGI_V11_54700 JGI_V11_321889 FBgn0081147 FBgn0156921 FBgn0136920 FBgn0120572 FBgn0115621 FBgn0091436 CPIJ002701 BGIBMGA001646 ACYPI006464 GB18106 AGAP002379 AAEL014360 AAEL009930 PHUM513230 GLEAN_01611
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	18752 w1118; PBac{WH}CG8552f04269 23480 w1118; Mi{ET1}CG8552MB02562 23525 w1118; Mi{ET1}CG8552MB03243
Harvard	- PBac{PB}CG8552c01080 - PBac{PB}CG8552c03991 - PBac{RB}CG8552e00047 - PBac{RB}CG8552e02633 - PBac{WH}CG8552f04269 - PBac{WH}CG8552f07514
VDRC	v108121 P{KK100753}VIE-260B v35956 w1118; P{GD13962}v35956 v35957 w1118; P{GD13962}v35957
	More stocks available...
Genomic Clones ( 1 )
	BACR14I17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 73 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21041 LD21067
Other clones	MIP14830
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08693 AT20320 AT31879 LD45239 LP14951 LP23368 SD11820 SD14194
Other clones	10742 29011 31201 51232 52986 58622 64113 64180 70173 71250 75434 106524 108806 144907 173304 173459 274360 281081 293072 542535 bs23b03 CK01.1B.B10 CK01.54C.B2 CK01.77C.G5 CK01.125A.D11 CK01.143A.F4 Dmel_dig_010418_0634_0682 Dmel_neb_003048_0670_0397 Dmel_neb_012345_0187_2530 EC258710 EC260092 EC260650 EK006240 EK044237 EK060527 EK095416 EK116154 EK137021 EK174434 EK177329 EK181133 EK189632 EK189921 EK197633 EK200114 EK207310 EK213207 EK234932 EK251026 EK277542 EK277713 EK291728 EK301743 EK306340 EN10263 EN10819 EP03651 EP18026 GH08959 GH27701 LD23770 RP004170455
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0031990 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34109
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG8552 CG14278 (FlyBase, 1996-)
Additional comments	FlyBase curator comment: Correspondence with author Muller revealed that 'Sec23-IP' = 'CG8552'. (Muller et al., 2008) Source for merge of CG8552 CG14278 was sequence comparison (date:001216). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. (Pilot et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135341 NM_001201785 NM_001201786 RefSeq (Proteins) • NP_609185 NP_001188714 NP_001188715 DDBJ / EMBL / GenBank • AA541202 AAF52607 AAM75037 ADV36964 ADV36965 AI109703 AW942587 AY128444 AY394340 AY394341 AY394342 AY394343 AY394344 AY394345 AY394346 AY394347 AY394348 AY394349 AY394350 AY394351 AY394352 AY394353 AY394354 AY394355 AY394356 AY394357 AY394358 AY394359 AY394360 AY394363 AY394364 AY394365 AY394366 AY394367 AY394368 AY394369 AY394370 AY394371 AY394372 AY394373 AY394374 AY394375 AY394376 AY394377 AY394378 AY394379 AY394380 AY394381 AY394382 AY394383 BE662098 BH809456 CZ466867 CZ466868 CZ477957 CZ477958 CZ480412 CZ486791 CZ486803 CZ486804 CZ490254 Entrez Gene - A searchable database of RefSeq genes. • 34109 UniProtKB/TrEMBL • Q8MQQ8 Q9VLS7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WWE domain (IPR004170) DDHD (IPR004177)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60238 DroID - A comprehensive database of gene and protein interactions. • FBgn0031990 DRSC - Results from RNAi screens. • FBgn0031990 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0031990 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8552-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0031990 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34109 InParanoid A subset of ortholog calls from InParanoid. • AAEL009930-PA Aedes aegypti (mosquito) AAEL014360-PA Aedes aegypti (mosquito) AGAP002379-PA Anopheles gambiae (mosquito) XP_392149.3 Apis mellifera (honey bee) 34604 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA001646-PA Bombyx mori (silk worm) CN06204 Caenorhabditis brenneri (small nematode) CBP03293 Caenorhabditis briggsae (nematode) ENSCAFP00000018116 Canis familiaris (dog) ENSCINP00000014302 Ciona intestinalis (sea squirt) JA16825 Caenorhabditis japonica (nematode) CPIJ002701 Culex pipens (mosquito) RP37060 Caenorhabditis remanei (nematode) 169179 Capitella spl (polychaete worm) ENSGACP00000004358 Gymnopilus aculeatus (mushroom) ENSGALP00000020284 Gallus gallus (chicken) 193825 Hypsipyla robusta (cedar shoot borer) 232837 Lottia gigantea (owl limpet) ENSMMUP00000012499 Macaca mulatta (rhesus monkey) ENSMUSP00000035610 Mus musculus (house mouse) XP_001602740.1 Nasonia vitripennis (wasp) ENSOANP00000002443 Ornithorynchus anatinus (platypus) ENSORLP00000017437 Oryzias latipes (japanese killifish) PHUM005207-PA Pediculus humanus (human body louse) ENSPPYP00000003161 Pongo pygmaeus (orangutan) 5058279 Sorghum bicolor (sorghum) Smp_140970 Schistosoma mansoni (trematode parasite) XP_783634.2 Strongylocentrotus purpuratus (purple sea urchin) ENSXETP00000033235 Xenopus tropicalis (frog) YALI0E34815g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34109 modMine - Data generated by the modENCODE project. • FBgn0031990 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16266 NV12652 LH22696 ISCW018654 FBgn0228998 FBgn0225706 FBgn0204672 FBgn0193841 JGI_V11_54700 JGI_V11_321889 FBgn0081147 FBgn0156921 FBgn0136920 FBgn0120572 FBgn0115621 FBgn0091436 CPIJ002701 BGIBMGA001646 ACYPI006464 GB18106 AGAP002379 AAEL014360 AAEL009930 PHUM513230 GLEAN_01611
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG8552 (Pilot et al., 2006, Buszczak et al., 2007, Liebl et al., 2006, Lecuyer et al., 2007, Kohn et al., 2004, Keleman et al., 2009.8.5, Mottola et al., 2010, Wasbrough et al., 2010) CG14278   Sec23-IP (Muller et al., 2008)
Name Synonym	Sec23-interacting protein (Muller et al., 2008)
Secondary FlyBase IDs
	FBgn0031989
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 7 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Mottola et al., 2010, Development 137(14): 2353--2364 A novel function for the Rab5 effector Rabenosyn-5 in planar cell polarity. [FBrf0211104] Show all research papers ...