FB2020_01, released Feb 12, 2020

Gene: Dmel\Pvr

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General Information
Symbol
Dmel\Pvr
Species
D. melanogaster
Name
PDGF- and VEGF-receptor related
Annotation Symbol
CG8222
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032006
Gene Model Status
Current
Stock Availability
30 publicly available
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Snapshot
PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. [Date last reviewed: 2019-09-12]
Other Summaries
Also Known As

PDGF/VEGF receptor, VEGFR, VEGF receptor, stai

Key Links
Genomic Location
Cytogenetic map
28F4-28F5
Sequence location
2L:8,220,980..8,239,878 [-]
Recombination map

2-30

RefSeq locus
NT_033779 REGION:8220980..8239878
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding
Predictions / Assertions
ATP binding; transmembrane receptor protein tyrosine kinase activity
Catalytic Activity (EC)
Experimental Evidence
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Pathway (FlyBase)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Gene Group (FlyBase)
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Summary (Interactive Fly)

Ig C-2 type domain receptor tyrosine kinase - required for border cell migration

Gene Model and Products
Number of Transcripts
13
Number of Unique Polypeptides
11

Please see the GBrowse view of Dmel\Pvr or the JBrowse view of Dmel\Pvr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pvr-RA
FBtr0079625
NM_078785
5276
1509
Pvr-RB
FBtr0079626
NM_164801
5276
1509
Pvr-RD
FBtr0079628
NM_205927
5893
1509
Pvr-RE
FBtr0079629
NM_205926
5311
1503
Pvr-RG
FBtr0301338
NM_175983
5153
1468
Pvr-RH
FBtr0301339
NM_001169438
5788
1474
Pvr-RI
FBtr0302147
NM_001169439
5480
1528
Pvr-RJ
FBtr0302148
NM_001169440
5627
1577
Pvr-RK
FBtr0303108
NM_001201791
5249
1500
Pvr-RL
FBtr0303109
NM_001201792
5149
1509
Pvr-RM
FBtr0332416
NM_001273305
5453
1568
Pvr-RN
FBtr0332417
NM_205925
5246
1499
Pvr-RO
FBtr0332418
NM_001273306
5246
1499
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pvr-PA
FBpp0079244
170.3
1509
5.86
NP_523509
AAF52626
Pvr-PB
FBpp0079245
170.1
1509
5.74
NP_723365
AAN11158
Pvr-PD
FBpp0089341
170.1
1509
5.74
NP_995649
AAS64656
Pvr-PE
FBpp0089342
169.5
1503
5.64
NP_995648
AAS64655
Pvr-PG
FBpp0290552
165.6
1468
5.46
NP_787997
AAO41166
Pvr-PH
FBpp0290553
166.2
1474
5.55
NP_001162909
ACZ94200
Pvr-PI
FBpp0291357
171.8
1528
6.28
NP_001162910
ACZ94201
Pvr-PJ
FBpp0291358
177.3
1577
5.75
NP_001162911
ACZ94202
Pvr-PK
FBpp0292227
169.0
1500
5.79
NP_001188720
ADV36970
Pvr-PL
FBpp0292228
170.1
1509
5.74
NP_001188721
ADV36971
Pvr-PM
FBpp0304689
176.2
1568
5.80
NP_001260234
AGB92770
Pvr-PN
FBpp0304690
168.9
1499
5.79
NP_995647
AAS64657
Pvr-PO
FBpp0304691
169.1
1499
5.91
NP_001260235
AGB92771
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1509 aa isoforms: Pvr-PB, Pvr-PD, Pvr-PL
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pvr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (38 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:Crk; FB:FBgn0024811
(Ishimaru et al., 2004)
transmembrane receptor protein tyrosine kinase activity
inferred from mutant phenotype
(Ishimaru et al., 2004)
inferred from direct assay
(Tran et al., 2013, Duchek et al., 2001)
vascular endothelial growth factor binding
inferred from physical interaction with FLYBASE:Pvf1; FB:FBgn0030964
(Duchek et al., 2001)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transmembrane receptor protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:3763
(Cho et al., 2002)
Biological Process (32 terms)
Terms Based on Experimental Evidence (29 terms)
CV Term
Evidence
References
anterior Malpighian tubule development
inferred from mutant phenotype
(Bunt et al., 2010)
border follicle cell migration
inferred from mutant phenotype
(Fernández-Espartero et al., 2013, Bianco et al., 2007)
cell projection assembly
inferred from mutant phenotype
(Fulga and Rorth, 2002)
dorsal closure
inferred from mutant phenotype
(Garlena et al., 2015, Macias et al., 2004)
glial cell migration
inferred from genetic interaction with FLYBASE:Tsp2A; FB:FBgn0024361
(Jeibmann et al., 2015)
inferred from mutant phenotype
(Learte et al., 2008)
hemocyte migration
inferred from mutant phenotype
(Bunt et al., 2010, Wood et al., 2006, Olofsson and Page, 2005, Cho et al., 2002)
hemopoiesis
inferred from expression pattern
(Heino et al., 2001)
imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Ishimaru et al., 2004)
imaginal disc-derived male genitalia morphogenesis
inferred from mutant phenotype
(Kuranaga et al., 2011)
innate immune response
inferred from mutant phenotype
(Bond and Foley, 2012)
intestinal stem cell homeostasis
inferred from mutant phenotype
(Bond and Foley, 2012)
larval lymph gland hemopoiesis
inferred from genetic interaction with FLYBASE:bip1; FB:FBgn0026263
(Mondal et al., 2014)
inferred from mutant phenotype
(Baril et al., 2017)
lymph gland development
inferred from mutant phenotype
(Ferguson and Martinez-Agosto, 2017)
Malpighian tubule morphogenesis
inferred from mutant phenotype
(Bunt et al., 2010)
negative regulation of apoptotic process
inferred from mutant phenotype
(Sopko et al., 2015, Tran et al., 2013)
negative regulation of humoral immune response
inferred from mutant phenotype
(Tsuzuki et al., 2014)
positive regulation of border follicle cell migration
inferred from mutant phenotype
(Mathieu et al., 2007, McDonald et al., 2006, Wang et al., 2006, Duchek et al., 2001)
inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731
(Jekely et al., 2005)
inferred from genetic interaction with FLYBASE:Cbl; FB:FBgn0020224
(Jekely et al., 2005)
positive regulation of cell migration
inferred from mutant phenotype
(Harris et al., 2007)
positive regulation of cell size
inferred from mutant phenotype
(Sims et al., 2009)
positive regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Sopko et al., 2015, Tran et al., 2013)
inferred from direct assay
(Ishimaru et al., 2004)
positive regulation of JNK cascade
inferred from direct assay
(Ishimaru et al., 2004)
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:Cdc42; FB:FBgn0010341
(Ishimaru et al., 2004)
positive regulation of phosphatidylinositol 3-kinase signaling
inferred from mutant phenotype
(Read, 2018)
positive regulation of protein kinase B signaling
inferred from mutant phenotype
(Sopko et al., 2015)
positive regulation of TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013)
response to tumor cell
inferred from mutant phenotype
(Parisi et al., 2014)
salivary gland morphogenesis
inferred from mutant phenotype
(Harris et al., 2007)
vascular endothelial growth factor receptor signaling pathway
inferred from direct assay
(Tsuzuki et al., 2014, Fernández-Espartero et al., 2013, Tran et al., 2013, Duchek et al., 2001)
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
(Read, 2018)
inferred from mutant phenotype
(Sopko et al., 2015, Ragab et al., 2011, Sims et al., 2009, Learte et al., 2008)
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Bruckner et al., 2004)
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:Cdc42; FB:FBgn0010341
(Ishimaru et al., 2004)
ventral cord development
inferred from mutant phenotype
(Olofsson and Page, 2005, Sears et al., 2003)
wound healing, spreading of epidermal cells
inferred from mutant phenotype
(Wu et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
multicellular organism development
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
vascular endothelial growth factor receptor signaling pathway
inferred from sequence or structural similarity with HGNC:3763
(Cho et al., 2002)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Wu et al., 2009, Harris et al., 2007, Jekely et al., 2005, Rosin et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ventral midline | restricted
(Cho et al., 2002)
embryonic stage 9 -- 17
embryonic hemocyte
(Cho et al., 2002)
embryonic stage 11 -- 13
tracheal branch primordium
(Cho et al., 2002)
larval stage
embryonic/larval hemocyte
(Cho et al., 2002)
embryonic stage 10
embryonic head
(Heino et al., 2001)
embryonic stage 10 -- 17
embryonic hemocyte
(Heino et al., 2001)
embryonic stage 11 -- 12
embryonic primordium of adult salivary gland
(Harris et al., 2007)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism

Comment: Expression is strongest in female adults and in early embryos.

(Heino et al., 2001)
Additional Descriptive Data

In addition to hemocytes, Pvr is expressed in the developing salivary gland. Salivary gland expression is strongest at embryonic stage 11 when salivary gland cells are circular placodes situated on the surface of the embryo. Transcript levels steadily decline during stage 12, when the placode cells invaginate and are nearly unetectable by stage 13.

(Harris et al., 2007)

Transcript is detected first at early stage 8 in two groups of bilaterally clustered cells of the mesoderm. These cells demonstrated to be developing blood cells undergo characteristic migragtion and end up distributed throughout the developing organism. Transcripts are also detected in larval hemocytes. Expression is also detected in some tracheal cells and a few cells in the ventral midline which may correspond to midline glia. The tracheal and midline cells are still present in srpneo45 mutants which lack all blood cells.

(Cho et al., 2002)

No Pvr transcript expression observed before embryonic stage 10.

(Heino et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
midline glial cell | subset
(Sears et al., 2003)
embryonic hemocyte
(Sears et al., 2003)
embryonic/larval hemocyte
(Zohar-Stoopel et al., 2014)
adult stage
follicle cell
(McDonald et al., 2003)
intestinal stem cell of posterior adult midgut epithelium
(Bond and Foley, 2012)
embryonic stage 14 -- 17
ectoderm
(Rosin et al., 2004)
midline glial cell
(Rosin et al., 2004)
hemocyte
(Rosin et al., 2004)
third instar larval stage -- pupal stage
wing disc
(Rosin et al., 2004)
third instar larval stage
eye disc
(Rosin et al., 2004)
prohemocyte
(Munier et al., 2002)
plasmatocyte
(Munier et al., 2002)
embryonic/larval lymph gland
(Munier et al., 2002)
embryonic stage 12
embryonic primordium of adult salivary gland
(Harris et al., 2007)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Pvr protein is localized to intestinal stem cells in the adult posterior midgut. Expression colocalizes with that of Dl and Pvf2 reporters. Expression is not observed in enteroblasts.

(Bond and Foley, 2012)

Pvr protein is detected in the developing salivary gland starting in embryonic stage 12 and is localized to the cell membrane.

(Harris et al., 2007)

Pvr protein is uniformly distributed along the apicobasal axis of the plasma membrane.

(Rosin et al., 2004)
Marker for
 
plasmatocyte
(Munier et al., 2002)
prohemocyte
(Munier et al., 2002)
Subcellular Localization
CV Term
Evidence
References
integral component of plasma membrane
inferred from direct assay
(Wu et al., 2009, Harris et al., 2007, Jekely et al., 2005, Rosin et al., 2004)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.un}PvrMI04181-TG4.un
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pvr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pvr
Transgenic constructs containing regulatory region of Pvr
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4srp.Hemo
lethal (with Df(2L)TE29Aa-11)
lethal (with Df(2L)TE29Aa-14)
lethal | recessive
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage, with Scer\GAL4da.G32
lethal - all die before end of embryonic stage, with Scer\GAL4e33C
lethal - all die before end of pupal stage, with Scer\GAL4unspecified
partially lethal, with Scer\GAL4NP5130
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4srp.Hemo
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
cell migration defective | larval stage, with Scer\GAL4repo
decreased cell number | larval stage, with Scer\GAL4He.PZ
decreased cell number | third instar larval stage, with Scer\GAL4Hml.Δ
decreased cell size | somatic clone
immune response defective, with Scer\GAL4NP5130
increased cell death | recessive
increased cell number | larval stage, with Scer\GAL4He.PZ
increased cell number | third instar larval stage, with Scer\GAL4Hml.Δ
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
neuroanatomy defective
neuroanatomy defective | larval stage, with Scer\GAL4repo
short lived | heat sensitive, with Scer\GAL4tin.CΔ4
size defective | third instar larval stage, with Scer\GAL4Hml.Δ
some die during embryonic stage
some die during embryonic stage, with Scer\GAL4da.G32
some die during embryonic stage, with Scer\GAL4e33C
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage, with Scer\GAL4unspecified
stress response defective | adult stage, with Scer\GAL4Hml.Δ
tumorigenic | larval stage, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4Hml.Δ
Phenotype manifest in
Allele
actin filament | ectopic, with Scer\GAL4Act5C.PP
actin filament | ectopic, with Scer\GAL4slbo.2.6
adult external abdomen | dorsal, with Scer\GAL4dpp.blk1
adult external abdomen | dorsal, with Scer\GAL4en-e16E
adult midgut, with Scer\GAL4NP5130
Bolwig nerve, with Scer\GAL4repo
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell & filopodium, with Scer\GAL4slbo.2.6
border follicle cell | somatic clone
centripetally migrating follicle cell, with Scer\GAL4slbo.2.6
centripetally migrating follicle cell & actin filament, with Scer\GAL4slbo.2.6
cortical actin cytoskeleton & oocyte associated follicle cell, with Scer\GAL4slbo.2.6
cortical zone of lymph gland primary lobe | third instar larval stage, with Scer\GAL4Hml.Δ
crystal cell | third instar larval stage, with Scer\GAL4Hml.Δ
dorsal mesothoracic disc & actin filament, with Scer\GAL4ptc-559.1
dorsal mesothoracic disc & actin filament & pupa | ectopic, with Scer\GAL4Bx-MS1096
dorsal mesothoracic disc & actin filament | ectopic, with Scer\GAL4dpp.blk1
embryo
embryonic/first instar larval cuticle, with Scer\GAL469B
embryonic/larval glial cell
embryonic/larval glial cell, with Scer\GAL4repo
embryonic/larval hemocyte
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval lymph gland | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic anterior Malpighian tubule
embryonic anterior Malpighian tubule, with Scer\GAL4gcm-rA87.P
embryonic hemocyte
embryonic hemocyte, with Scer\GAL4s.gcm
embryonic hemocyte, with Scer\GAL4srp.Hemo
enteroblast of posterior adult midgut epithelium | somatic clone
enterocyte, with Scer\GAL4NP5130
enteroendocrine cell | supernumerary, with Scer\GAL4NP5130
eye | adult stage, with Scer\GAL4Hml.Δ
follicle cell & actin filament | somatic clone, with Scer\GAL4Act5C.PI
follicle cell | somatic clone, with Scer\GAL4Act5C.PI
hemocyte
hemocyte, with Scer\GAL4gcm-rA87.P
hemocyte, with Scer\GAL4He.PZ
hemocyte | larval stage, with Scer\GAL4He.PZ
intestinal stem cell, with Scer\GAL4NP5130
intestinal stem cell | somatic clone
lamellocyte, with Scer\GAL4He.PZ
longitudinal connective
macrophage | embryonic stage
male genitalia, with Scer\GAL4en.PU
male terminalia, with Scer\GAL4dpp.blk1
male terminalia, with Scer\GAL4en-e16E
melanotic mass, with Scer\GAL4He.PZ
mesothoracic tergum, with Scer\GAL4pnr-MD237
microchaeta, with Scer\GAL4pnr-MD237
plasmatocyte | third instar larval stage, with Scer\GAL4Hml.Δ
posterior signalling center of lymph gland primary lobe | third instar larval stage, with Scer\GAL4Hml.Δ
presumptive embryonic/larval central nervous system
thorax, with Pvrc02195, Scer\GAL4pnr-MD237
thorax, with PvrdsRNA.UAS, Scer\GAL4pnr-MD237
thorax, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
ventral nerve cord | embryonic stage
ventral nerve cord | embryonic stage, with Scer\GAL4s.gcm
ventral nerve cord | embryonic stage, with Scer\GAL4sim.PS
wing, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4dpp.blk1
wing disc | larval stage, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FLT1
11 of 15
Yes
Yes
Hsap\FLT4
10 of 15
No
Yes
Hsap\KDR
10 of 15
No
Yes
 
Hsap\PDGFRA
7 of 15
No
Yes
Hsap\PDGFRB
7 of 15
No
Yes
 
Hsap\CSF1R
5 of 15
No
Yes
Hsap\FLT3
4 of 15
No
Yes
Hsap\KIT
4 of 15
No
Yes
Hsap\CD22
1 of 15
No
Yes
Hsap\CEACAM20
1 of 15
No
Yes
Hsap\FCRL2
1 of 15
No
Yes
Hsap\FGFR1
1 of 15
No
No
Hsap\FGFR2
1 of 15
No
No
Hsap\FGFR3
1 of 15
No
No
Hsap\FGFR4
1 of 15
No
No
 
Hsap\FGFRL1
1 of 15
No
No
Hsap\PDGFRL
1 of 15
No
Yes
Hsap\RET
1 of 15
No
No
 
Hsap\SIGLEC1
1 of 15
No
Yes
Hsap\STYK1
1 of 15
No
No
Hsap\TEK
1 of 15
No
No
Hsap\TIE1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Flt1
11 of 15
Yes
Yes
Mmus\Flt4
10 of 15
No
Yes
Mmus\Kdr
9 of 15
No
Yes
Mmus\Pdgfra
7 of 15
No
Yes
Mmus\Csf1r
5 of 15
No
Yes
Mmus\Pdgfrb
5 of 15
No
Yes
Mmus\Flt3
4 of 15
No
Yes
Mmus\Kit
3 of 15
No
Yes
Mmus\Ceacam20
1 of 15
No
Yes
Mmus\Dscam
1 of 15
No
No
 
Mmus\Fgfr1
1 of 15
No
No
Mmus\Fgfr2
1 of 15
No
No
Mmus\Fgfr3
1 of 15
No
No
Mmus\Fgfr4
1 of 15
No
No
Mmus\Fgfrl1
1 of 15
No
No
Mmus\Pdgfrl
1 of 15
No
Yes
Mmus\Ret
1 of 15
No
No
Mmus\Styk1
1 of 15
No
No
Mmus\Tek
1 of 15
No
No
Mmus\Tie1
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
Rnor\Flt1
10 of 13
Yes
Yes
Rnor\Flt4
9 of 13
No
Yes
Rnor\Kdr
7 of 13
No
Yes
Rnor\Pdgfra
6 of 13
No
Yes
Rnor\Pdgfrb
5 of 13
No
Yes
Rnor\Csf1r
4 of 13
No
Yes
Rnor\Kit
4 of 13
No
Yes
Rnor\Flt3
2 of 13
No
Yes
Rnor\Cd22
1 of 13
No
Yes
Rnor\Ceacam20
1 of 13
No
Yes
Rnor\Dscam
1 of 13
No
No
Rnor\Fgfr1
1 of 13
No
No
Rnor\Fgfr2
1 of 13
No
No
Rnor\Fgfr3
1 of 13
No
No
Rnor\Fgfr4
1 of 13
No
No
Rnor\Fgfrl1
1 of 13
No
No
Rnor\Pdgfrl
1 of 13
No
Yes
Rnor\Ret
1 of 13
No
No
Rnor\Styk1
1 of 13
No
No
Rnor\Tek
1 of 13
No
No
Rnor\Tie1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\flt1
4 of 12
Yes
Yes
Xtro\pdgfra
4 of 12
Yes
Yes
Xtro\csf1r
3 of 12
No
Yes
Xtro\flt4
3 of 12
No
Yes
Xtro\kdr
3 of 12
No
Yes
Xtro\fgfr1
1 of 12
No
No
Xtro\fgfr2
1 of 12
No
No
Xtro\fgfr3
1 of 12
No
No
Xtro\fgfr4
1 of 12
No
No
Xtro\fgfrl1
1 of 12
No
No
Xtro\kdrl
1 of 12
No
Yes
Xtro\pdgfrb
1 of 12
No
Yes
Xtro\pdgfrl.2
1 of 12
No
Yes
Xtro\pdgfrl
1 of 12
No
Yes
Xtro\ret
1 of 12
No
No
Xtro\styk1
1 of 12
No
No
Xtro\tek
1 of 12
No
No
Xtro\tie1
1 of 12
No
No
Danio rerio (Zebrafish) (27)
Drer\flt1
11 of 15
Yes
Yes
Drer\flt4
10 of 15
No
Yes
Drer\kdr
10 of 15
No
Yes
Drer\kdrl
10 of 15
No
Yes
Drer\csf1ra
4 of 15
No
Yes
Drer\flt3
4 of 15
No
Yes
Drer\kita
4 of 15
No
Yes
Drer\kitb
4 of 15
No
Yes
Drer\pdgfra
4 of 15
No
Yes
Drer\pdgfrb
4 of 15
No
Yes
Drer\csf1rb
2 of 15
No
Yes
Drer\fgfr1a
1 of 15
No
No
Drer\fgfr2
1 of 15
No
No
Drer\fgfr3
1 of 15
No
No
Drer\fgfr4
1 of 15
No
No
Drer\fgfrl1a
1 of 15
No
No
Drer\fgfrl1b
1 of 15
No
No
Drer\LOC569566
1 of 15
No
No
Drer\pdgfrl
1 of 15
No
Yes
Drer\ret
1 of 15
No
No
Drer\si:ch73-206d17.1
1 of 15
No
No
Drer\si:ch211-167j9.5
1 of 15
No
Yes
Drer\si:dkey-14o18.6
1 of 15
No
No
Drer\si:zfos-1069f5.1
1 of 15
No
Yes
Drer\styk1
1 of 15
No
No
Drer\tek
1 of 15
No
No
Drer\tie1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (28)
Cele\ver-1
6 of 15
Yes
Yes
Cele\ver-4
6 of 15
Yes
Yes
Cele\ver-3
5 of 15
No
Yes
Cele\kin-15
3 of 15
No
Yes
Cele\kin-23
3 of 15
No
Yes
Cele\kin-30
3 of 15
No
Yes
Cele\old-1
3 of 15
No
Yes
Cele\old-2
3 of 15
No
Yes
Cele\R09D1.12
3 of 15
No
Yes
Cele\B0252.1
2 of 15
No
Yes
Cele\kin-9
2 of 15
No
No
Cele\kin-16
2 of 15
No
Yes
Cele\R09D1.13
2 of 15
No
Yes
Cele\W04G5.10
2 of 15
No
Yes
Cele\Y50D4B.6
2 of 15
No
No
Cele\C24G6.2
1 of 15
No
No
Cele\egl-15
1 of 15
No
No
Cele\F09A5.2
1 of 15
No
No
Cele\F09G2.1
1 of 15
No
No
Cele\F40G9.8
1 of 15
No
Yes
Cele\F59F5.3
1 of 15
No
No
Cele\igcm-4
1 of 15
No
No
Cele\R151.1
1 of 15
No
No
Cele\T01G5.1
1 of 15
No
No
Cele\T17A3.10
1 of 15
No
Yes
Cele\T22B11.4
1 of 15
No
Yes
Cele\W03A5.1
1 of 15
No
Yes
Cele\Y38H6C.20
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT1G66830
1 of 9
Yes
Yes
Atha\AT5G38260
1 of 9
Yes
Yes
Atha\MRLK
1 of 9
Yes
Yes
Atha\RLK
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SKM1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900FT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Pvr
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000395
Drosophila simulans
Dsim\GD22428
Drosophila sechellia
Dsec\GM13122
Drosophila erecta
Dere\GG23464
Drosophila yakuba
Dyak\GE11101
Drosophila ananassae
Dana\GF15270
Drosophila pseudoobscura pseudoobscura
Dpse\GA20908
Drosophila persimilis
Dper\GL19392
Drosophila willistoni
Dwil\GK23859
Drosophila virilis
Dvir\GJ20603
Drosophila mojavensis
Dmoj\GI14251
Drosophila grimshawi
Dgri\GH10187
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500EG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018697
Musca domestica
House fly
Mdoa\17022563
Glossina morsitans
Tsetse fly
Gmor\GMOY011032
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11454
Mayetiola destructor
Hessian fly
Mdes\Mdes009659
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003928
Anopheles darlingi
American malaria mosquito
Adar\ADAC000753
Anopheles darlingi
American malaria mosquito
Adar\ADAC007273
Anopheles darlingi
American malaria mosquito
Adar\ADAC001503
Anopheles darlingi
American malaria mosquito
Adar\ADAC000752
Anopheles darlingi
American malaria mosquito
Adar\ADAC004627
Anopheles darlingi
American malaria mosquito
Adar\ADAC004292
Anopheles darlingi
American malaria mosquito
Adar\ADAC004291
Anopheles gambiae
Malaria mosquito
Agam\AGAP008813
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019108
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012088
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012087
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W018A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001183
Danaus plexippus
Monarch butterfly
Dple\DPOGS215992-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016676
Apis florea
Little honeybee
Aflo\2616276724
Apis mellifera
Western honey bee
Amel\GB54852
Apis mellifera
Western honey bee
Amel\GB54853
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10013
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10014
Bombus terrestris
Buff-tailed bumblebee
Bter\15204647
Linepithema humile
Argentine ant
Lhum\LH12809
Linepithema humile
Argentine ant
Lhum\LH21975
Linepithema humile
Argentine ant
Lhum\LH21972
Linepithema humile
Argentine ant
Lhum\LH12808
Linepithema humile
Argentine ant
Lhum\LH21974
Linepithema humile
Argentine ant
Lhum\LH10487
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0030a0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008697
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010703
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07584
Pediculus humanus
Human body louse
Phum\PHUM006460
Rhodnius prolixus
Kissing bug
Rpro\RPRC005427
Rhodnius prolixus
Kissing bug
Rpro\RPRC001637
Cimex lectularius
Bed bug
Clec\CLEC011579
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002447
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06719
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01127
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X016C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001587
Strigamia maritima
European centipede
Smar\SMAR008344
Ixodes scapularis
Black-legged tick
Isca\ISCW005359
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78276.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76603.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g03790
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g03900
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g01390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g03980
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g04060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur297g00030
Tetranychus urticae
Two-spotted spider mite
Turt\tetur615g00010
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_108386
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_58385
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43719
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_119760
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_215703
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_64428
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_7210
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305264
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_58353
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308030
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_325477
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_43619
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_130537
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_253800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308023
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_110024
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_130102
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_110251
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44144
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48616
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_114299
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_331276
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_53509
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302459
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_61463
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302458
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_130278
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_4284
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48631
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01TL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pdgfr/vegfrL_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_004848gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pdgfr/vegfrL
Ciona intestinalis
Vase tunicate
Cint\LOC778954
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005725
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013925
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000017093
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000021313
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013907
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005802
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000007646
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013929
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000017091
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
btl
3 of 10
Cad96Ca
3 of 10
htl
3 of 10
Ret
3 of 10
CG3277
2 of 10
Tie
2 of 10
tor
2 of 10
Alk
1 of 10
CG10702
1 of 10
Ddr
1 of 10
dnt
1 of 10
Drl-2
1 of 10
drl
1 of 10
drpr
1 of 10
Egfr
1 of 10
Eph
1 of 10
InR
1 of 10
Nrk
1 of 10
Ror
1 of 10
sev
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 13 )
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
FLT1; fms related receptor tyrosine kinase 1
11 of 15
165070
      FLT4; fms related receptor tyrosine kinase 4
      10 of 15
      136352
      KDR; kinase insert domain receptor
      10 of 15
      191306
         
        PDGFRA; platelet derived growth factor receptor alpha
        7 of 15
        173490
          PDGFRB; platelet derived growth factor receptor beta
          7 of 15
          173410
           
          CSF1R; colony stimulating factor 1 receptor
          5 of 15
          164770
          FLT3; fms related receptor tyrosine kinase 3
          4 of 15
          136351
          KIT; KIT proto-oncogene, receptor tyrosine kinase
          4 of 15
          164920
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Pvr - Abl
          two hybrid
          (Bianco et al., 2007)
          Pvr - Btk29A
          two hybrid
          (Bianco et al., 2007)
          Pvr - CG10916
          anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
          (Friedman et al., 2011, Friedman et al., 2011)
          Pvr - CG12004
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CG14767
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CG14879
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CG3164
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CG5447
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CG7668
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CG8034
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - CanA-14F
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Pvr - Cbl
          two hybrid
          (Jekely et al., 2005)
          Pvr - Crk
          anti tag coimmunoprecipitation, anti tag western blot
          (Ishimaru et al., 2004)
          Pvr - DnaJ-1
          two hybrid
          (Cobreros et al., 2008)
          Pvr - Frl
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - HDAC3
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Pvr - PVRAP
          anti bait coimmunoprecipitation, anti tag western blot
          (Tran et al., 2013)
          Pvr - Pi3K21B
          two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry, anti tag western blot
          (Breitkopf et al., 2016, Vinayagam et al., 2016, Glatter et al., 2011, Bianco et al., 2007, Jekely et al., 2005, Ishimaru et al., 2004)
          Pvr - Pi3K92E
          anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry
          (Breitkopf et al., 2016, Vinayagam et al., 2016)
          Pvr - Pp2B-14D
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Friedman et al., 2011)
          Pvr - Ptpmeg
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Li et al., 2015)
          Pvr - Pvf1
          affinity technology, inferred by author
          (Duchek et al., 2001)
          Pvr - Shc
          two hybrid, experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot
          (Guruharsha et al., 2011, Bianco et al., 2007, Ishimaru et al., 2004)
          Pvr - Spt6
          two hybrid
          (Bianco et al., 2007)
          Pvr - Src42A
          anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid
          (Friedman et al., 2011, Bianco et al., 2007)
          Pvr - Syb
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - Syx7
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - Vav
          anti bait coimmunoprecipitation, western blot, two hybrid
          (Fernández-Espartero et al., 2013, Bianco et al., 2007)
          Pvr - by
          two hybrid
          (Bianco et al., 2007)
          Pvr - csw
          two hybrid
          (Bianco et al., 2007)
          Pvr - dock
          two hybrid
          (Bianco et al., 2007)
          Pvr - drk
          two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
          (Friedman et al., 2011, Bianco et al., 2007, Ishimaru et al., 2004)
          Pvr - sax
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - sl
          anti tag coimmunoprecipitation, anti tag western blot
          (Ishimaru et al., 2004)
          Pvr - spri
          two hybrid
          (Bianco et al., 2007, Jekely et al., 2005)
          Pvr - sty
          experimental knowledge based
          (Guruharsha et al., 2011)
          Pvr - vap
          two hybrid, anti tag coimmunoprecipitation, anti tag western blot
          (Rowshanravan et al., 2014, Bianco et al., 2007)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Pvr
          enhanceable
          ago
          (Zhu et al., 2005)
          Pvr
          enhanceable
          Amun
          (Zhu et al., 2005)
          Pvr
          suppressible
          Arf79F
          (Khadilkar et al., 2014)
          Pvr
          suppressible
          ball
          (Zhu et al., 2005)
          Pvr
          enhanceable
          bol
          (Zhu et al., 2005)
          Pvr
          enhanceable
          bsk
          (Mathieu et al., 2007, Ishimaru et al., 2004)
          Pvr
          enhanceable
          Cdc42
          (Ishimaru et al., 2004)
          Pvr
          enhanceable
          CG1090
          (Zhu et al., 2005)
          Pvr
          enhanceable
          CG3542
          (Zhu et al., 2005)
          Pvr
          suppressible
          CG4266
          (Zhu et al., 2005)
          Pvr
          enhanceable
          CG7231
          (Zhu et al., 2005)
          Pvr
          suppressible
          CG10082
          (Zhu et al., 2005)
          Pvr
          suppressible
          CG10321
          (Zhu et al., 2005)
          Pvr
          suppressible
          CG10433
          (Zhu et al., 2005)
          Pvr
          suppressible
          CHES-1-like
          (Zhu et al., 2005)
          Pvr
          suppressible
          Cortactin
          (Somogyi and Rorth, 2004)
          Pvr
          enhanceable
          Crk
          (Ishimaru et al., 2004)
          Pvr
          suppressible
          dco
          (Zhu et al., 2005)
          Pvr|hep
          suppressible
          Diap1
          (Mathieu et al., 2007)
          Pvr
          suppressible
          Diap1
          (Geisbrecht and Montell, 2004)
          Pvr
          enhanceable
          Dlc90F
          (Zhu et al., 2005)
          Pvr
          enhanceable
          Egfr
          (Poukkula et al., 2011, McDonald et al., 2006, Fulga and Rorth, 2002, Duchek et al., 2001)
          Pvr
          enhanceable
          EP595b
          (Zhu et al., 2005)
          Pvr
          suppressible
          EP712
          (Zhu et al., 2005)
          Pvr
          suppressible
          EP1207
          (Zhu et al., 2005)
          Pvr
          suppressible
          EP1340
          (Zhu et al., 2005)
          Pvr
          suppressible
          EP2204
          (Zhu et al., 2005)
          Pvr
          enhanceable
          EP2444
          (Zhu et al., 2005)
          Pvr
          suppressible
          hep
          (Bond and Foley, 2012)
          Pvr
          enhanceable
          hep
          (Mathieu et al., 2007, Ishimaru et al., 2004)
          Pvr
          enhanceable
          HmgD
          (Zhu et al., 2005)
          Pvr|hep
          suppressible
          kay
          (Mathieu et al., 2007)
          Pvr
          enhanceable
          lilli
          (Zhu et al., 2005)
          Pvr
          suppressible
          Manf
          (Neves et al., 2016)
          Pvr
          suppressible
          mbc
          (Duchek et al., 2001)
          Pvr
          enhanceable
          mbc
          (Ishimaru et al., 2004)
          Pvr
          suppressible
          MESR4
          (Zhu et al., 2005)
          Pvr
          enhanceable
          Mtl|Rac1|Rac2
          (Ishimaru et al., 2004)
          Pvr
          suppressible
          NFAT
          (Zhu et al., 2005)
          Pvr
          suppressible
          Pi3K92E
          (Bruckner et al., 2004)
          Pvr
          suppressible
          puc
          (Ishimaru et al., 2004)
          Pvr
          enhanceable
          puc
          (Mathieu et al., 2007)
          Pvr
          enhanceable
          Pvf1
          (Rosin et al., 2004, Fulga and Rorth, 2002)
          Pvr
          suppressible
          Ras85D
          (Bond and Foley, 2012, Bruckner et al., 2004)
          Pvr
          suppressible
          robo2
          (Zhu et al., 2005)
          Pvr
          suppressible
          skd
          (Zhu et al., 2005)
          Pvr
          enhanceable
          slpr
          (Ishimaru et al., 2004)
          Pvr
          suppressible
          Smg5
          (Zhu et al., 2005)
          Pvr
          suppressible
          Tao
          (Zhu et al., 2005)
          Pvr|Egfr
          enhanceable
          Tie
          (Wang et al., 2006)
          Pvr
          enhanceable
          Tie
          (Wang et al., 2006)
          Pvr
          suppressible
          Tlk
          (Zhu et al., 2005)
          Pvr
          suppressible
          tou
          (Zhu et al., 2005)
          Pvr
          enhanceable
          vn
          (Duchek et al., 2001)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Arf79F
          suppressible
          Pvr
          (Khadilkar et al., 2014)
          bip1
          suppressible
          Pvr
          (Mondal et al., 2014)
          Cbl
          enhanceable
          Pvr
          (Jekely et al., 2005)
          dlg1
          suppressible
          Pvr
          (Parisi et al., 2014)
          dlg1
          enhanceable
          Pvr
          (Parisi et al., 2014)
          Egfr
          enhanceable
          Pvr
          (Poukkula et al., 2011, Fulga and Rorth, 2002, Duchek et al., 2001)
          grk
          suppressible
          Pvr
          (Poukkula et al., 2011)
          Pvf1
          enhanceable
          Pvr
          (Fulga and Rorth, 2002, Duchek et al., 2001)
          vn
          suppressible
          Pvr
          (Duchek et al., 2001)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
          PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
          Metabolic Pathways
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map

          2-30

          Cytogenetic map
          28F4-28F5
          Sequence location
          2L:8,220,980..8,239,878 [-]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          28F4-28F5
          Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          28F4-28F5
          (Heino et al., 2001)
          29A2-29B1
          (Roos, 1999.11.18)
          Experimentally Determined Recombination Data
          Location

          2-30

          (FlyBase, 2016)

          2-27.3

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (30)
          Genomic Clones (29)
          cDNA Clones (87)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Tran et al., 2013, McDonald et al., 2003)

          monoclonal

          (Janssens et al., 2010, Munier et al., 2002)

          polyclonal antibody, amino acids 1291-1509 (Pvr-PA)

          (Rosin et al., 2004)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: Pvr Vgr1

          (Rorth and Roos, 2001.8.16)

          Source for identity of: Vgr1 CG8222

          (FlyBase, 1996-)
          Source for database merge of
          Additional comments

          Source for identity of Vgr1 CG8222 was sequence comparison ( date:010525 ).

          (FlyBase, 1996-)
          Other Comments

          Hyperactive Pvr signals disrupt midgut homeostasis and promote intestinal dysplasia.

          (Bond and Foley, 2012)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

          (Goshima et al., 2007)

          dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.

          (Guertin et al., 2006)

          dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.

          (Zhang et al., 2006)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

          (Kleino et al., 2005)

          When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the proportion of S phase cells, an increase in the proportion of G2/M phase cells, a decrease in mitotic index and a decrease in cytokinetic index are seen.

          (Bettencourt-Dias et al., 2004)

          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

          (Boutros et al., 2004)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.

          (Kiger et al., 2003)

          Pvr has a role in controlling the embryonic migration of blood cells.

          (Cho et al., 2002)

          Pvr acts in border cells to guide them to the oocyte. This guidance is largely redundant with that of Egfr.

          (Duchek et al., 2001)

          Pvr appears to have a role in haematopoeitic cells.

          (Heino et al., 2001)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 116 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (31)
          Reported As
          Symbol Synonym
          8222
          (Ravi et al., 2009)
          CG8222
          (Kolkhof et al., 2017, Neuert et al., 2017, Hosono et al., 2015, Schertel et al., 2013, Vogel et al., 2013, Christis and Munro, 2012, Castillo et al., 2011, Glatter et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Schiess et al., 2009, Begun et al., 2007, Goshima et al., 2007, Altenhein et al., 2006, Boutros et al., 2004, Wang et al., 2004, Wheeler et al., 2004, Cho et al., 2002, Morrison et al., 2000)
          CT24332
          (Hynes and Zhao, 2000)
          DmVEGFR
          (Heino et al., 2001)
          PVR
          (Enomoto et al., 2018, Richardson and Portela, 2018, Swevers et al., 2018, Baker, 2017, Willoughby et al., 2017, Yoon et al., 2017, Zheng et al., 2017, Cai et al., 2016, Ratheesh et al., 2015, Sansone et al., 2015, Abnave et al., 2014, Kim et al., 2014, Park et al., 2014, Rowshanravan et al., 2014, Valanne, 2014, Zhang et al., 2014, Ferrandon, 2013, Fukuyama et al., 2013, Law et al., 2013, Levayer and Moreno, 2013, Pastor-Pareja and Xu, 2013, Wong et al., 2013, Inaki et al., 2012, Friedman et al., 2011, Friedman et al., 2011, Hidalgo et al., 2011, Lee et al., 2011, Ohsawa et al., 2011, Poukkula et al., 2011, Ragab et al., 2011, Wang et al., 2010, Wang et al., 2010, Jang et al., 2009, Nagaraj and Banerjee, 2009, Park et al., 2009, Choi et al., 2008, Cobreros et al., 2008, Melani et al., 2008, Bianco et al., 2007, Bianco et al., 2007, Bunt et al., 2007, Gonda and Stronach, 2007, Lindner et al., 2007, Mathieu et al., 2007, Prasad and Montell, 2007, Igaki et al., 2006, Igaki et al., 2006, McDonald et al., 2006, Wang et al., 2006, Haesemeyer et al., 2005, Lu and Bilder, 2005, Zhu et al., 2005, Geisbrecht and Montell, 2004, Wheeler et al., 2004, Bruckner et al., 2003, Jekely and Rorth, 2003, Bruckner and Perrimon, 2002, Duchek and Rorth, 2002, Rorth, 2002, Rosin et al., 2002)
          PvR
          (Neves et al., 2016)
          Pvr
          (Banerjee et al., 2019, Chen and Read, 2019, Mele and Johnson, 2019, Moreno et al., 2019, Ohsawa, 2019, Schumacher, 2019, Sinha et al., 2019, Tudrej et al., 2019, Zhang et al., 2019, Read, 2018, Tsai et al., 2018, Baril et al., 2017, Das and Cagan, 2017, Ferguson and Martinez-Agosto, 2017, Khadilkar et al., 2017, Kolkhof et al., 2017, Liu and Jin, 2017, Liu et al., 2017, Neuert et al., 2017, Breitkopf et al., 2016, Gene Disruption Project members, 2016-, Parsons and Foley, 2016, Sarov et al., 2016, Vinayagam et al., 2016, Yadav et al., 2016, Di Cara et al., 2015, Doggett et al., 2015, Felix et al., 2015, Gene Disruption Project members, 2015-, Guan et al., 2015, Jeibmann et al., 2015, Li et al., 2015, Morán et al., 2015, Pasco et al., 2015, Sopko et al., 2015, Amoyel and Bach, 2014, Ashwal-Fluss et al., 2014, Cai et al., 2014, Khadilkar et al., 2014, Lee et al., 2014, Mondal et al., 2014, Parisi et al., 2014, Salazar-Jaramillo et al., 2014, Tsuzuki et al., 2014, Wang et al., 2014, Carter, 2013, Chintapalli et al., 2013, Fernández-Espartero et al., 2013, Morin-Poulard et al., 2013, Ozkan et al., 2013, Schertel et al., 2013, Shim et al., 2013, Sopko and Perrimon, 2013, Wan et al., 2013, Yin et al., 2013, Zhang et al., 2013, Amoyel and Bach, 2012, Bond and Foley, 2012, Brock et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jeon et al., 2012, Rodriguez et al., 2012, van der Harst et al., 2012, Fauvarque and Williams, 2011, Friedman et al., 2011, Glatter et al., 2011, Juarez et al., 2011, Kulkarni et al., 2011, Kuranaga et al., 2011, Lindquist et al., 2011, Marcu et al., 2011, Michaut et al., 2011, Poukkula et al., 2011, Zhang et al., 2011, Guenin et al., 2010, Janssens et al., 2010, Moreira et al., 2010, Siekhaus et al., 2010, Wasbrough et al., 2010, Bond and Foley, 2009, Hilger et al., 2009, Leatherbarrow and Halfon, 2009, Liu et al., 2009, Obbard et al., 2009, Sims et al., 2009, Wu et al., 2009, Elwell et al., 2008, Begun et al., 2007, Bianco et al., 2007, Goshima et al., 2007, Harris et al., 2007, Kronhamn et al., 2007, Nallamothu et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Choksi et al., 2006, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Friedman and Perrimon, 2006, Jekely et al., 2005, Bruckner et al., 2004, Bruckner et al., 2004, Paladi and Tepass, 2004, Rosin et al., 2004, Wang et al., 2004, Wheeler et al., 2004, Munier et al., 2002)
          VEGFR
          (Zhu et al., 2019, Siekhaus et al., 2006, Haesemeyer et al., 2005, Evans et al., 2003)
          VEGFR-A
          (Ebens, 2002.2.19)
          VGR1
          (Roos, 1999.11.18)
          Vegf
          (Wu and Sato, 2008)
          Vegfr
          (Learte et al., 2008, Cho et al., 2002)
          Vegfr-b
          (Ebens, 2002.2.19)
          Vegfr-c
          (Ebens, 2002.2.19)
          Vgr1
          pvr
          (Tsarouhas et al., 2019, Hirabayashi, 2016, Levinson and Cagan, 2016, Zheng et al., 2016, Álvarez-Fernández et al., 2015, Ghosh et al., 2015, Luo et al., 2015, Tran et al., 2013, Vlachos and Harden, 2011, Bunt et al., 2010, Witte et al., 2009, Learte et al., 2008, Mattila et al., 2008, Nallamothu et al., 2008, Montell, 2006, Wood et al., 2006, Zhang et al., 2006, Cabernard and Affolter, 2005, DasGupta et al., 2005, Starz-Gaiano and Montell, 2004)
          stai
          (Guertin et al., 2006, Cho et al., 2002)
          vgr1
          (Roos, 1999.11.18)
          Name Synonyms
          PDGF receptor
          (Kim et al., 2014)
          PDGF- and VEGF Receptor related
          (Marcu et al., 2011)
          PDGF- and VEGF- receptor related
          (Lee et al., 2014)
          PDGF- and VEGF-Receptor Related
          (Lindner et al., 2007)
          PDGF- and VEGF-receptor related
          (Mele and Johnson, 2019, Álvarez-Fernández et al., 2015, Felix et al., 2015, Amoyel and Bach, 2014, Fukuyama et al., 2013, Chang et al., 2008, Zeitouni et al., 2007, Rorth and Roos, 2001.8.16)
          PDGF- and VEGF-related receptor
          (Bianco et al., 2007)
          PDGF/VEGF receptor
          (Lee et al., 2014, Jaspers et al., 2012, Moreira et al., 2010, Harris et al., 2007, Wood et al., 2006, Meller et al., 2005, Jekely and Rorth, 2003, Munier et al., 2002)
          PVF receptor
          (Montell, 2006)
          VEGF receptor
          (Dormann and Weijer, 2003, Li and White, 2003, Heino et al., 2001)
          Vascular endothelial growth factor receptor
          (Banyai and Patthy, 2004)
          Vascular endothelial growth factor receptor-1 like
          platelet-derived growth factor/vascular endothelial growth factor receptor
          (Meller et al., 2005)
          stasis
          (Cho et al., 2002)
          Secondary FlyBase IDs
            Datasets (1)
            Study focus (1)
            Experimental Role
            Project
            Project Type
            Title
            • bait_protein
            RTK-Ras-ERK_interaction_map
            Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
            References (321)