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General Information
Symbol
Dmel\Pvr
Species
D. melanogaster
Name
PDGF- and VEGF-receptor related
Annotation Symbol
CG8222
Feature Type
FlyBase ID
FBgn0032006
Gene Model Status
Stock Availability
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Snapshot
PDGF- and VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (encoded by Pvf1, Pvf2 or Pvf3). It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. [Date last reviewed: 2019-09-12]
Also Known As

PDGF/VEGF receptor, VEGFR, VEGF receptor, stai

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:8,220,980..8,239,878 [-]
Recombination map

2-30

RefSeq locus
NT_033779 REGION:8220980..8239878
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Catalytic Activity (EC)
Experimental Evidence
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Pathway (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Gene Group (FlyBase)
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Summary (Interactive Fly)

Ig C-2 type domain receptor tyrosine kinase - required for border cell migration

Gene Model and Products
Number of Transcripts
13
Number of Unique Polypeptides
11

Please see the GBrowse view of Dmel\Pvr or the JBrowse view of Dmel\Pvr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0079625
5276
1509
FBtr0079626
5276
1509
FBtr0079628
5893
1509
FBtr0079629
5311
1503
FBtr0301338
5153
1468
FBtr0301339
5788
1474
FBtr0302147
5480
1528
FBtr0302148
5627
1577
FBtr0303108
5249
1500
FBtr0303109
5149
1509
FBtr0332416
5453
1568
FBtr0332417
5246
1499
FBtr0332418
5246
1499
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0079244
170.3
1509
5.86
FBpp0079245
170.1
1509
5.74
FBpp0089341
170.1
1509
5.74
FBpp0089342
169.5
1503
5.64
FBpp0290552
165.6
1468
5.46
FBpp0290553
166.2
1474
5.55
FBpp0291357
171.8
1528
6.28
FBpp0291358
177.3
1577
5.75
FBpp0292227
169.0
1500
5.79
FBpp0292228
170.1
1509
5.74
FBpp0304689
176.2
1568
5.80
FBpp0304690
168.9
1499
5.79
FBpp0304691
169.1
1499
5.91
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1509 aa isoforms: Pvr-PB, Pvr-PD, Pvr-PL
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pvr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (38 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:3763
Biological Process (32 terms)
Terms Based on Experimental Evidence (29 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Tsp2A; FB:FBgn0024361
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:bip1; FB:FBgn0026263
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: Expression is strongest in female adults and in early embryos.

Additional Descriptive Data

In addition to hemocytes, Pvr is expressed in the developing salivary gland. Salivary gland expression is strongest at embryonic stage 11 when salivary gland cells are circular placodes situated on the surface of the embryo. Transcript levels steadily decline during stage 12, when the placode cells invaginate and are nearly unetectable by stage 13.

Transcript is detected first at early stage 8 in two groups of bilaterally clustered cells of the mesoderm. These cells demonstrated to be developing blood cells undergo characteristic migragtion and end up distributed throughout the developing organism. Transcripts are also detected in larval hemocytes. Expression is also detected in some tracheal cells and a few cells in the ventral midline which may correspond to midline glia. The tracheal and midline cells are still present in srpneo45 mutants which lack all blood cells.

No Pvr transcript expression observed before embryonic stage 10.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Pvr protein is localized to intestinal stem cells in the adult posterior midgut. Expression colocalizes with that of Dl and Pvf2 reporters. Expression is not observed in enteroblasts.

Pvr protein is detected in the developing salivary gland starting in embryonic stage 12 and is localized to the cell membrane.

Pvr protein is uniformly distributed along the apicobasal axis of the plasma membrane.

Marker for
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pvr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pvr
Transgenic constructs containing regulatory region of Pvr
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
border follicle cell & filopodium, with Scer\GAL4slbo.2.6
centripetally migrating follicle cell & actin filament, with Scer\GAL4slbo.2.6
cortical actin cytoskeleton & oocyte associated follicle cell, with Scer\GAL4slbo.2.6
dorsal mesothoracic disc & actin filament, with Scer\GAL4ptc-559.1
dorsal mesothoracic disc & actin filament & pupa | ectopic, with Scer\GAL4Bx-MS1096
dorsal mesothoracic disc & actin filament | ectopic, with Scer\GAL4dpp.blk1
follicle cell & actin filament | somatic clone, with Scer\GAL4Act5C.PI
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
10 of 15
Yes
Yes
10 of 15
Yes
Yes
 
6 of 15
No
Yes
6 of 15
No
Yes
 
5 of 15
No
Yes
5 of 15
No
Yes
3 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
 
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
10 of 15
Yes
Yes
9 of 15
No
Yes
6 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
3 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (22)
9 of 13
Yes
Yes
8 of 13
No
Yes
7 of 13
No
Yes
5 of 13
No
Yes
4 of 13
No
Yes
4 of 13
No
Yes
3 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (20)
4 of 12
Yes
Yes
3 of 12
No
Yes
3 of 12
No
Yes
3 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (25)
10 of 15
Yes
Yes
10 of 15
Yes
Yes
10 of 15
Yes
Yes
9 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
Yes
4 of 15
No
Yes
4 of 15
No
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (30)
5 of 15
Yes
Yes
5 of 15
Yes
Yes
4 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (4)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900FT )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500EG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W018A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X016C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G01TL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (21)
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 13 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Metabolic Pathways
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map

2-30

Cytogenetic map
Sequence location
2L:8,220,980..8,239,878 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
28F4-28F5
Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
29A2-29B1
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (30)
Genomic Clones (29)
cDNA Clones (87)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 

polyclonal antibody, amino acids 1291-1509 (Pvr-PA)

Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: Pvr Vgr1

Source for identity of: Vgr1 CG8222

Source for database merge of
Additional comments

Source for identity of Vgr1 CG8222 was sequence comparison ( date:010525 ).

Other Comments

Hyperactive Pvr signals disrupt midgut homeostasis and promote intestinal dysplasia.

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation.

dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the proportion of S phase cells, an increase in the proportion of G2/M phase cells, a decrease in mitotic index and a decrease in cytokinetic index are seen.

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells.

Pvr has a role in controlling the embryonic migration of blood cells.

Pvr acts in border cells to guide them to the oocyte. This guidance is largely redundant with that of Egfr.

Pvr appears to have a role in haematopoeitic cells.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 116 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (31)
Reported As
Symbol Synonym
Pvr
(Banerjee et al., 2019, Chen and Read, 2019, Mele and Johnson, 2019, Moreno et al., 2019, Ohsawa, 2019, Schumacher, 2019, Sinha et al., 2019, Tudrej et al., 2019, Zhang et al., 2019, Read, 2018, Tsai et al., 2018, Baril et al., 2017, Das and Cagan, 2017, Ferguson and Martinez-Agosto, 2017, Khadilkar et al., 2017, Kolkhof et al., 2017, Liu and Jin, 2017, Liu et al., 2017, Neuert et al., 2017, Breitkopf et al., 2016, Gene Disruption Project members, 2016-, Parsons and Foley, 2016, Sarov et al., 2016, Vinayagam et al., 2016, Yadav et al., 2016, Di Cara et al., 2015, Doggett et al., 2015, Felix et al., 2015, Gene Disruption Project members, 2015-, Guan et al., 2015, Jeibmann et al., 2015, Li et al., 2015, Morán et al., 2015, Pasco et al., 2015, Sopko et al., 2015, Amoyel and Bach, 2014, Ashwal-Fluss et al., 2014, Cai et al., 2014, Khadilkar et al., 2014, Lee et al., 2014, Mondal et al., 2014, Parisi et al., 2014, Salazar-Jaramillo et al., 2014, Tsuzuki et al., 2014, Wang et al., 2014, Carter, 2013, Chintapalli et al., 2013, Fernández-Espartero et al., 2013, Morin-Poulard et al., 2013, Ozkan et al., 2013, Schertel et al., 2013, Shim et al., 2013, Sopko and Perrimon, 2013, Wan et al., 2013, Yin et al., 2013, Zhang et al., 2013, Amoyel and Bach, 2012, Bond and Foley, 2012, Brock et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jeon et al., 2012, Rodriguez et al., 2012, van der Harst et al., 2012, Fauvarque and Williams, 2011, Friedman et al., 2011, Glatter et al., 2011, Juarez et al., 2011, Kulkarni et al., 2011, Kuranaga et al., 2011, Lindquist et al., 2011, Marcu et al., 2011, Michaut et al., 2011, Poukkula et al., 2011, Zhang et al., 2011, Guenin et al., 2010, Janssens et al., 2010, Moreira et al., 2010, Siekhaus et al., 2010, Wasbrough et al., 2010, Bond and Foley, 2009, Hilger et al., 2009, Leatherbarrow and Halfon, 2009, Liu et al., 2009, Obbard et al., 2009, Sims et al., 2009, Wu et al., 2009, Elwell et al., 2008, Begun et al., 2007, Bianco et al., 2007, Goshima et al., 2007, Harris et al., 2007, Kronhamn et al., 2007, Nallamothu et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Choksi et al., 2006, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.12.5, Friedman and Perrimon, 2006, Jekely et al., 2005, Bruckner et al., 2004, Bruckner et al., 2004, Paladi and Tepass, 2004, Rosin et al., 2004, Wang et al., 2004, Wheeler et al., 2004, Munier et al., 2002)
Vgr1
Name Synonyms
PDGF receptor
PDGF- and VEGF Receptor related
PDGF- and VEGF- receptor related
PDGF- and VEGF-Receptor Related
PDGF- and VEGF-related receptor
PVF receptor
Vascular endothelial growth factor receptor
Vascular endothelial growth factor receptor-1 like
platelet-derived growth factor/vascular endothelial growth factor receptor
Secondary FlyBase IDs
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (323)