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Gene Dmel\Scgα

General Information
Symbol	Dmel\Scgα	Species	D. melanogaster
Name	Sarcoglycan α	Annotation symbol	CG7851
Feature type	protein_coding_gene	FlyBase ID	FBgn0032013
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	29A3-29A3	Sequence location	2L:8,303,433..8,305,376 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sarcoglycan α is referred to in FlyBase by the symbol Dmel\Scgα (CG7851, FBgn0032013). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of muscle. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cadherin-like; Dystroglycan-type cadherin-like; Immunoglobulin-like fold; Sarcoglycan alphaepsilon. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1630045_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Scgalpha. Gene sequence location is 2L:8303433..8305376.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA03076 BKN21800 BKN46473
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29A3-29A3   Limits computationally determined from genome sequence between P{lacW}Btk29Ak00206&P{EP}Btk29AEP715 and P{EP}EP646EP646&P{lacW}RpS13k09614
Experimentally Determined Cytological Location
Cytogenetic map Notes References 29A1-29C1     (Greener, 2000.6.14)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Scgα for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Scgalpha-RA FBtr0079597  NM_078786   1653   443
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Scgalpha-PA   FBpp0079217   50.7   443   6.67     NP_523510   AAF52634
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cadherin-like (IPR015919) Dystroglycan-type cadherin-like (IPR006644) Sarcoglycan alphaepsilon (IPR008908) Immunoglobulin-like fold (IPR013783)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698806   AE014134 AAF52634   AF277391 AAG17400   AY071690 AAL49312   BI238609   BI565436   BI566654   BI593363   BI608186   BI609766   EC088306   GH752598   GH757352   GH773833   GH779886   GH779887   GH782159   GH787712   GH788760   GH796455   GH797279   GH803728   GH805706   GH806138   GH817285   GH819729   GH820162   GH822178   GH825033   GH830552   GH831804   GH833952   GH863160   GH864454   GH864604   GH874812   GH880605   GH881479   GH891533   GH902299   GH911199   GH923162   GH926048   GH929002   GH931801   GH938212   GH939147   GH942480
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9GT66 Q9VLQ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032013    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032013 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032013 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP    1843 pupae 3d postWPP    1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr  (157) embryo 06-08hr  (130) embryo 08-10hr  (173) embryo 10-12hr  (319) embryo 12-14hr  (541) embryo 14-16hr  (825) embryo 16-18hr  (1220) embryo 18-20hr  (1178) embryo 20-22hr  (841) embryo 22-24hr  (1204) larva L1  (917) larva L2  (460) larva L3 12hr old  (189) larva L3 puffstage 1-2  (117) larva L3 puffstage 3-6    99 larva L3 puffstage 7-9  (149) white prepupae new  (134) white prepupae 12hr  (762) white prepupae 24hr  (1015) pupae 2d postWPP  (1843) pupae 3d postWPP  (1474) pupae 4d postWPP  (437) adult male 01day  (341) adult male 05day  (295) adult male 30day  (215) adult female 01day  (145) adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP  (1843) pupae 3d postWPP  1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP    1843 pupae 3d postWPP    1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP    1843 pupae 3d postWPP    1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032013 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP    1843 pupae 3d postWPP    1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr  (157) embryo 06-08hr  130 embryo 08-10hr  (173) embryo 10-12hr  (319) embryo 12-14hr  (541) embryo 14-16hr  (825) embryo 16-18hr  (1220) embryo 18-20hr  (1178) embryo 20-22hr  (841) embryo 22-24hr  (1204) larva L1  (917) larva L2  (460) larva L3 12hr old  (189) larva L3 puffstage 1-2  117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9  (149) white prepupae new  134 white prepupae 12hr  (762) white prepupae 24hr  (1015) pupae 2d postWPP  (1843) pupae 3d postWPP  (1474) pupae 4d postWPP  (437) adult male 01day  (341) adult male 05day  (295) adult male 30day  (215) adult female 01day  (145) adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP  1843 pupae 3d postWPP  1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP    1843 pupae 3d postWPP    1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    72 embryo 04-06hr    157 embryo 06-08hr    130 embryo 08-10hr    173 embryo 10-12hr    319 embryo 12-14hr    541 embryo 14-16hr    825 embryo 16-18hr    1220 embryo 18-20hr    1178 embryo 20-22hr    841 embryo 22-24hr    1204 larva L1    917 larva L2    460 larva L3 12hr old    189 larva L3 puffstage 1-2    117 larva L3 puffstage 3-6    99 larva L3 puffstage 7-9    149 white prepupae new    134 white prepupae 12hr    762 white prepupae 24hr    1015 pupae 2d postWPP    1843 pupae 3d postWPP    1474 pupae 4d postWPP    437 adult male 01day    341 adult male 05day    295 adult male 30day    215 adult female 01day    145 adult female 05day    48 adult female 30day    42 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032013    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032013 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032013 expression level Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032013 expression level Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    59.775 Larval Midgut    9.5 Larval Hindgut    17.2 Larval Malpighian Tubules    7.3 Larval Fat Body    4.9 Larval Salivary Gland    9.1 Larval Trachea    4.8 Larval Carcass    33.975 Adult Head    59.6 Adult Eye    86.25 Adult Brain    195.6 Adult Thoracic-Abdominal Ganglion    147.9 Adult Crop    67.2 Adult Midgut no informative data Adult Hindgut    22.4 Adult Malpighian Tubules    3.1 Adult Fat Body    5.1 Adult Salivary Gland    8.8 Adult Heart    16.675 Adult VirginFemale Spermatheca    2.7 Adult InseminatedFemale Spermatheca    3.1 Adult Ovary    3.8 Adult Testis    9.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    59.6   NA  Eye    86.25   NA  Brain    195.6   59.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    147.9   NA  Crop    67.2   9.5  Midgut    no informative data   17.2  Hindgut    22.4   7.3  Malpighian Tubules    3.1   4.9  Fat Body    5.1   9.1  Salivary Gland    8.8   NA  Heart    16.675   4.8  Trachea    NA   NA  VirginFemale Spermatheca    2.7   NA  InseminatedFemale Spermatheca    3.1   NA  Ovary    3.8   NA  Testis    9.9   NA  Male Accessory Gland    no informative data   33.975  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032013 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7851-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Scgα Stages(s) 9-10 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 ScgαGD996 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Scgα Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Scgα Class Mutagen Stocks Known lesion ScgαGD996 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ScgαHMS00997 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ScgαKK101749 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH1923SH1923 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR006644, InterPro:IPR015919 (FlyBase Curators et al., 2004-) structural constituent of muscle inferred from sequence or structural similarity with human SGCA AND inferred from sequence or structural similarity with human SGCE (Greener and Roberts, 2000)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
sarcoglycan complex inferred from sequence or structural similarity with human SGCA AND inferred from sequence or structural similarity with human SGCE (Greener and Roberts, 2000) non-traceable author statement (Greener, 2000.6.14)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Scgα allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60261 DroID - A comprehensive database of gene and protein interactions. • FBgn0032013 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34135
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14630 Dere\GG10529 Dgri\GH11586 Dmoj\GI17155 Dper\GL18733 Dpse\GA20633 Dsec\GM16870 Dsim\GD23519 Dvir\GJ17659 Dwil\GK15542 Dyak\GE18749
Curated drosophilid orthologs	Dpse\GA20633
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006601-PA Aedes aegypti (mosquito) AGAP007686-PA Anopheles gambiae (mosquito) XP_001120044.1 Apis mellifera (honey bee) XP_001947886.1 Acyrthosiphon pisum (pea aphid) BGIBMGA000030-PA Bombyx mori (silk worm) ENSBTAP00000028355 Bos taurus (bovine) CBP17031 Caenorhabditis briggsae (nematode) CE37119 Caenorhabditis elegans (worm) ENSCAFP00000003088 Canis familiaris (dog) CPIJ004329 Culex pipens (mosquito) ENSCPOP00000009578 Cavia porcellus (guinea pig) RP37335 Caenorhabditis remanei (nematode) 113963 Daphnia pulex (daphnia) ENSDARP00000026836 Danio rerio (zebra fish) ENSECAP00000017868 Equus caballus (horse) ENSGACP00000008801 Gymnopilus aculeatus (mushroom) ENSGALP00000015724 Gallus gallus (chicken) ENSP00000369219 Homo sapiens (human) ENSMODP00000027345 Monodelphis domestica (gray opossum) ENSMMUP00000021528 Macaca mulatta (rhesus monkey) ENSMUSP00000111240 Mus musculus (house mouse) 237734 Nematostella vectensis (starlet anemone) XP_001602796.1 Nasonia vitripennis (wasp) ENSOANP00000006767 Ornithorynchus anatinus (platypus) ENSORLP00000005506 Oryzias latipes (japanese killifish) PHUM003237-PA Pediculus humanus (human body louse) ENSPPYP00000019959 Pongo pygmaeus (orangutan) ENSPTRP00000047842 Pan troglodytes (chimpanzee) ENSRNOP00000005381 Rattus norvegicus (norway rat) XP_794953.2 Strongylocentrotus purpuratus (purple sea urchin) XP_001811825.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017460 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000040618 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000007318 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17784 LH18271 ISCW007524 FBgn0236141 FBgn0217547 FBgn0204828 FBgn0194897 FBgn0171783 JGI_V11_113963 FBgn0080627 FBgn0156334 FBgn0139899 FBgn0119066 FBgn0102837 FBgn0091657 CPIJ004329 BGIBMGA000030 ACYPI003766 GB11262 AGAP007686 AAEL006601 PB25382 PHUM456280 GLEAN_12123
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	34027 y1 sc* v1; P{TRiP.HMS00997}attP2
VDRC	v108612 P{KK101749}VIE-260B v33157 w1118; P{GD996}v33157/TM3 v33158 w1118; P{GD996}v33158/TM3
Genomic Clones ( 1 )
	BACR15P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH11377
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL05727 RE35112 RH12366 RH14592 RH36360 RH63211
Other clones	117320 RP003012190 RP003030530 RP003046737 RP003119809 RP003137021 RP003144705 RP003151067 RP003176230 RP003177719 RP003180750 RP003187857 RP003190203 RP003221980 RP003230718 RP003250029 RP003270352 RP003284681 RP003317078 RP003332684 RP003336674 RP003357111 RP003368740 RP003382539 RP003387819 RP003418457 RP003424326 RP003430162 RP003432968 RP003434230 RP003462114 RP003474020 RP003576078 RP003580529 RP003585597 RP003587744 RP003588914 RP003682335
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032013 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34135
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Scgα CG7851 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Scgα CG7851 was sequence comparison (date:001003). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078786 RefSeq (Proteins) • NP_523510 DDBJ / EMBL / GenBank • AAF52634 AAG17400 AAL49312 AF277391 AY071690 BI593363 Entrez Gene - A searchable database of RefSeq genes. • 34135 UniProtKB/TrEMBL • Q9GT66 Q9VLQ0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cadherin-like (IPR015919) Dystroglycan-type cadherin-like (IPR006644) Sarcoglycan alphaepsilon (IPR008908) Immunoglobulin-like fold (IPR013783)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60261 DroID - A comprehensive database of gene and protein interactions. • FBgn0032013 DRSC - Results from RNAi screens. • FBgn0032013 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032013 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7851-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032013 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34135 InParanoid A subset of ortholog calls from InParanoid. • AAEL006601-PA Aedes aegypti (mosquito) AGAP007686-PA Anopheles gambiae (mosquito) XP_001120044.1 Apis mellifera (honey bee) XP_001947886.1 Acyrthosiphon pisum (pea aphid) BGIBMGA000030-PA Bombyx mori (silk worm) ENSBTAP00000028355 Bos taurus (bovine) CBP17031 Caenorhabditis briggsae (nematode) CE37119 Caenorhabditis elegans (worm) ENSCAFP00000003088 Canis familiaris (dog) CPIJ004329 Culex pipens (mosquito) ENSCPOP00000009578 Cavia porcellus (guinea pig) RP37335 Caenorhabditis remanei (nematode) 113963 Daphnia pulex (daphnia) ENSDARP00000026836 Danio rerio (zebra fish) ENSECAP00000017868 Equus caballus (horse) ENSGACP00000008801 Gymnopilus aculeatus (mushroom) ENSGALP00000015724 Gallus gallus (chicken) ENSP00000369219 Homo sapiens (human) ENSMODP00000027345 Monodelphis domestica (gray opossum) ENSMMUP00000021528 Macaca mulatta (rhesus monkey) ENSMUSP00000111240 Mus musculus (house mouse) 237734 Nematostella vectensis (starlet anemone) XP_001602796.1 Nasonia vitripennis (wasp) ENSOANP00000006767 Ornithorynchus anatinus (platypus) ENSORLP00000005506 Oryzias latipes (japanese killifish) PHUM003237-PA Pediculus humanus (human body louse) ENSPPYP00000019959 Pongo pygmaeus (orangutan) ENSPTRP00000047842 Pan troglodytes (chimpanzee) ENSRNOP00000005381 Rattus norvegicus (norway rat) XP_794953.2 Strongylocentrotus purpuratus (purple sea urchin) XP_001811825.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017460 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000040618 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000007318 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34135 modMine - Data generated by the modENCODE project. • FBgn0032013 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV17784 LH18271 ISCW007524 FBgn0236141 FBgn0217547 FBgn0204828 FBgn0194897 FBgn0171783 JGI_V11_113963 FBgn0080627 FBgn0156334 FBgn0139899 FBgn0119066 FBgn0102837 FBgn0091657 CPIJ004329 BGIBMGA000030 ACYPI003766 GB11262 AGAP007686 AAEL006601 PB25382 PHUM456280 GLEAN_12123
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG7851 (Dekkers et al., 2004, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) DmSCG-αε (Greener and Roberts, 2000) Scga (Haussmann et al., 2008) Scgalpha (Giot et al., 2003) Scgα (Haussmann et al., 2008, Haussmann and Soller, 2010)
Name Synonym	Sarcoglycan α (Greener, 2000.6.14)
Secondary FlyBase IDs
References ( 16 )
Research paper	Haussmann and Soller, 2010, Dev. Biol. 348(2): 224--230 Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation. [FBrf0212261] Haussmann et al., 2008, Genome Biol. 9(4): R73 Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. [FBrf0209726] Dekkers et al., 2004, Gene Expression Patterns 4(2): 153--159 Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. [FBrf0174640]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Review	Pilgram et al., 2010, Molec. Neurobiol. 41(1): 1--21 The roles of the dystrophin-associated glycoprotein complex at the synapse. [FBrf0212855] Greener and Roberts, 2000, FEBS Lett. 482(1-2): 13--18 Conservation of components of the dystrophin complex in Drosophila. [FBrf0129834]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]
DNA/RNA sequence record	Greener, 2000.6.14, GenBank/EMBL/DDBJ: AF277391 Drosophila melanogaster alpha/epsilon-sarcoglycan-like protein SCG-ALPHA/EPSILON mRNA, partial cds. [FBrf0130693]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]