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Gene Dmel\Dh31

General Information
Symbol	Dmel\Dh31	Species	D. melanogaster
Name	Diuretic hormone 31	Annotation symbol	CG13094
Feature type	protein_coding_gene	FlyBase ID	FBgn0032048
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Dh31
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	29D1-29D3	Sequence location	2L:8,491,868..8,506,845 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Diuretic hormone 31 is referred to in FlyBase by the symbol Dmel\Dh31 (CG13094, FBgn0032048). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: diuretic hormone activity. There is experimental evidence that it is involved in the biological process: body fluid secretion. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval/adult midgut. Comments on Affy2 ProbeSet: ProbeSet 1630467_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Dh31. Gene sequence location is 2L:8491868..8506845.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29D1-29D3
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dh31 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dh31-RA FBtr0079699  NM_078790   1292   116 Dh31-RC FBtr0079700  NM_164825   1295   117 Dh31-RD FBtr0300450  NM_001169442   609   72
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dh31-PA   FBpp0079307   12.6   116   8.05     NP_523514   AAF52685 Dh31-PC   FBpp0079308   12.9   117   8.48     NP_723401   AAN10672 Dh31-PD   FBpp0289678   7.9   72   4.37     NP_001162913   ACZ94204
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52685   AE014134 AAN10672   AE014134 ACZ94204   AF171803   AI541992   AX664471   BG639886   BG639912   BI236491   BI572579   BI572590   BI591062   BI626320   BI628573   BI631774   BI631856   BT012436   BT120329   BT125803   CL528244   CO273638   CO304271   CO314494   EC201478   EC213967   EC243854   EC253769   EL869850   EL873151   GH946378   GH947394   GH949770   GH960551   GH969868   GH972079   GH981943   GH982367
UniProtKB/Swiss-Prot	Q9VLK4
UniProtKB/TrEMBL	Q8IPF3 E1JHC0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, larval/adult midgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain    930 Adult Thoracic-Abdominal Ganglion    1383.2 Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain  (930) Adult Thoracic-Abdominal Ganglion  (1383.2) Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain    930 Adult Thoracic-Abdominal Ganglion  (1383.2) Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain    930 Adult Thoracic-Abdominal Ganglion    1383.2 Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain    930 Adult Thoracic-Abdominal Ganglion    1383.2 Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain  (930) Adult Thoracic-Abdominal Ganglion  (1383.2) Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain    930 Adult Thoracic-Abdominal Ganglion  1383.2 Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    372.225 Larval Midgut    232.2 Larval Hindgut    20.6 Larval Malpighian Tubules    1.9 Larval Fat Body    6.3 Larval Salivary Gland    2.5 Larval Trachea    1 Larval Carcass    3.75 Adult Head    242.3 Adult Eye    18.65 Adult Brain    930 Adult Thoracic-Abdominal Ganglion    1383.2 Adult Crop    1.6 Adult Midgut    113.6 Adult Hindgut    17 Adult Malpighian Tubules    3.3 Adult Fat Body    10 Adult Salivary Gland    15.5 Adult Heart    5.875 Adult VirginFemale Spermatheca    5.6 Adult InseminatedFemale Spermatheca    10.5 Adult Ovary    1.4 Adult Testis    1.6 Adult Male Accessory Gland    2.9 Adult Carcass    19.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    242.3   NA  Eye    18.65   NA  Brain    930   372.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1383.2   NA  Crop    1.6   232.2  Midgut    113.6   20.6  Hindgut    no informative data   1.9  Malpighian Tubules    3.3   6.3  Fat Body    no informative data   2.5  Salivary Gland    no informative data   NA  Heart    5.875   1  Trachea    NA   NA  VirginFemale Spermatheca    5.6   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1.4   NA  Testis    1.6   NA  Male Accessory Gland    2.9   3.75  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    37 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8  (29) head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male  (37) head, mated 20-day male  (60) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    37 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    37 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    37 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8  29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male  (37) head, mated 20-day male  (60) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    37 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    29 head, virgin 1-day female    14 head, virgin 4-day female    17 head, virgin 20-day female    23 head, mated 1-day female    11 head, mated 4-day female    17 head, mated 20-day female    16 head, mated 1-day male    25 head, mated 4-day male    37 head, mated 20-day male    60 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    7 digestive system, 4-day adult    4 digestive system, 20-day adult    5 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    3 carcass, 4-day adult    5 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    4 embryo 18-20hr    8 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    10 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    3 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    5 pupae 3d postWPP    7 pupae 4d postWPP    5 adult male 01day    6 adult male 05day    7 adult male 30day    9 adult female 01day    3 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    4 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    5 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • RH57020 RH67853 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13094-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Dh31KG09001 viable, with Scer\GAL4pnr-MD237 Dh31GD4601 Sterility Allele fertile Dh31KG09001 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Dh31 Class Mutagen Stocks Known lesion Dh31KG09001 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dh31 Class Mutagen Stocks Known lesion Dh31GD4601 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Dh31GD16889 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Dh31HMS02354 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7038 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4601} NA P{GD16889} NA P{TRiP.HMS02354} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Dh31KG09001 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
diuretic hormone activity inferred from direct assay (Coast et al., 2001)
Biological Process
CV term Evidence References
body fluid secretion inferred from direct assay (Coast et al., 2001)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
diuretic hormone activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) non-traceable author statement (Hewes and Taghert, 2001) neuropeptide hormone activity inferred from sequence or structural similarity (vanden Broeck, 2001)
Biological Process
CV term Evidence References
body fluid secretion inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) neuropeptide signaling pathway inferred from sequence or structural similarity (vanden Broeck, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Dh31 - tor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dh31 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0032048
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CC4N4 Dipteran inclusive ortholog search EOG62BXK5 Insect inclusive ortholog search EOG64F57F Arthropod inclusive ortholog search EOG6R22C5 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6CC4N4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dh31     Drosophila simulans   Dsim\GD22397 Y   Drosophila sechellia   Dsec\GM12880 Y   Drosophila erecta   Dere\GG24068 Y   Drosophila yakuba   Dyak\GE10938 Y   Drosophila ananassae   Dana\GF14370 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12042 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22214     Drosophila persimilis   Dper\GL25648 Y   Drosophila willistoni   Dwil\GK24837 Y   Drosophila virilis   Dvir\GJ18199 Y   Drosophila mojavensis   Dmoj\GI17634 Y   Drosophila grimshawi   Dgri\GH10771 Y
Orthologs in non-Drosophila Dipterans (EOG62BXK5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008070   Anopheles gambiae Malaria mosquito  Agam\DH31
Orthologs in non-Dipteran Insects (EOG64F57F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45734   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020280   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11343   Atta cephalotes Leafcutter ant  Acep\ACEP16069   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11645   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL10525   Linepithema humile Argentine ant  Lhum\LH12009   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17529   Solenopsis invicta Red fire ant  Sinv\SINV11067   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002403   Bombyx mori Silkmoth  Bmor\BGIBMGA011588   Tribolium castaneum Red flour beetle  Tcas\TC004987
Orthologs in non-Insect Arthropods (EOG6R22C5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_299999   Ixodes scapularis Deer tick  Isca\ISCW009341   Ixodes scapularis Deer tick  Isca\ISCW800158
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22397 Drosophila sechellia Dsec\GM12880 Drosophila erecta Dere\GG24068 Drosophila yakuba Dyak\GE10938 Drosophila ananassae Dana\GF14370 Drosophila pseudoobscura pseudoobscura Dpse\GA12042 Drosophila persimilis Dper\GL25648 Drosophila willistoni Dwil\GK24837 Drosophila virilis Dvir\GJ18199 Drosophila mojavensis Dmoj\GI17634 Drosophila grimshawi Dgri\GH10771
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	16474 y1; P{SUPor-P}Dh31KG09001 41957 y1 sc* v1; P{TRiP.HMS02354}attP2/TM3, Sb1
VDRC	v37763 w1118; P{GD4601}v37763 v37764 w1118; P{GD4601}v37764 v50295 w1118 P{GD16889}v50295 v43529 w1118; P{GD4601}v43529/TM3 v50296 w1118; P{GD16889}v50296/TM3
Genomic Clones ( 2 )
	BACR02I15 BACR23B08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 30 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE57395 RH57020 RH67853
Other clones	AF171803
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE32550 RH04762 RH08138 RH08153 RH61419 RH61519 RH67003
Other clones	11075 76973 106646 214217.8 EK111711 EK236706 EK244236 IP01971 IP04967 RP004180060 RP004208377 RP004220488 RP004223181 RP004227009 RP004402592 RP004434408 RP004544216 SD07992 SD08364
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34181
Antibody Information
	polyclonal (Park et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG13094 anon-EST:Posey114 (Bayraktaroglu, 2000.11.2) Source for merge of: Dh31 anon-WO02059370.45 (FlyBase, 1996-)
Additional comments	Source for merge of Dh31 anon-WO02059370.45 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Dh31 peptide stimulates fluid secretion by Malpighian tubules. (Coast et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078790 NM_164825 NM_001169442 RefSeq (Proteins) • NP_523514 NP_723401 NP_001162913 DDBJ / EMBL / GenBank • AAF52685 AAN10672 ACZ94204 AF171803 AX664471 BI628573 CL528244 Entrez Gene - A searchable database of RefSeq genes. • 34181 UniProtKB/Swiss-Prot • Q9VLK4 UniProtKB/TrEMBL • E1JHC0 Q8IPF3
Other Crossreferences
	BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH57020 RH67853
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0032048 DRSC - Results from RNAi screens. • FBgn0032048 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032048 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13094-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032048 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34181 modMine - Data generated by the modENCODE project. • FBgn0032048
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	anon-EST:Posey114   anon-WO02059370.45   CG13094 (Hewes and Taghert, 2001, Reiher et al., 2011, Wegener and Gorbashov, 2008, Ni et al., 2010.12.1) DH31 (Johnson et al., 2003, Shafer et al., 2008, Johnson et al., 2005, Veenstra, 2009, Choi et al., 2009, Veenstra et al., 2008, Duvall and Taghert, 2012) Dh31 (Lajeunesse et al., 2010, Reiher et al., 2011, Wegener and Gorbashov, 2008, Hazelett et al., 2009, Ruben et al., 2012) dh31 (Melcher and Pankratz, 2005) DH 31 (Park et al., 2008) Dh31 (Birse et al., 2006) DH31 (Hector et al., 2009) DH31 (Mertens et al., 2005) DH-II (Johnson et al., 2004) Drm-DH31 (vanden Broeck, 2001) drome-DH31 (O'Donnell et al., 2003) Drome-DH31 (Coast et al., 2001)
Name Synonym	diuretic hormone (Hewes and Taghert, 2001) diuretic hormone 31 (Johnson et al., 2004, Birse et al., 2006, Veenstra, 2009) Diuretic hormone 31 (Coast et al., 2001, Johnson et al., 2005, Veenstra et al., 2008) Diuretic Hormone 31 (Mertens et al., 2005, Lajeunesse et al., 2010) diuretic Hormone 31 (Hector et al., 2009)
Secondary FlyBase IDs
	FBgn0027765 FBgn0066015
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 3 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Patent  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 5 )
	Choi et al., 2012, Cell Rep. 2(2): 332--344 Autoreceptor Control of Peptide/Neurotransmitter Corelease from PDF Neurons Determines Allocation of Circadian Activity in Drosophila. [FBrf0219328] Duvall and Taghert, 2012, PLoS Biol. 10(6): e1001337 The Circadian Neuropeptide PDF Signals Preferentially through a Specific Adenylate Cyclase Isoform AC3 in M Pacemakers of Drosophila. [FBrf0218594] Fontana and Crews, 2012, Dev. Biol. 372(1): 131--142 Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation. [FBrf0219766] Ruben et al., 2012, J. Biol. Rhythms 27(5): 353--364 A mechanism for circadian control of pacemaker neuron excitability. [FBrf0219602] Reiher et al., 2011, J. Proteome Res. 10(4): 1881--1892 Peptidomics and Peptide hormone processing in the Drosophila midgut. [FBrf0214505] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...