FB2020_06, released Dec 22, 2020

Gene: Dmel\Toll-4

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General Information
Symbol
Dmel\Toll-4
Species
D. melanogaster
Name
Toll-4
Annotation Symbol
CG18241
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032095
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Toll-4 (Toll-4) encodes a putative transmembrane protein related to Toll by virtue of containing intracellular TIR domain and extracellular Leucine-rich repeats. It is expressed in the apical part of the embryonic lymph gland precursors. [Date last reviewed: 2018-11-15]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
30A1-30A1
Sequence location
2L:9,084,107..9,089,440 [+]
Recombination map

2-35

RefSeq locus
NT_033779 REGION:9084107..9089440
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables signaling receptor activity
inferred from biological aspect of ancestor with PANTHER:PTN002808045
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in signal transduction
inferred from mutant phenotype
(Chowdhury et al., 2019)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in toll-like receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000687652
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002808045
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TOLL RECEPTORS -
The Toll/Toll-like receptor (TLR) family members are type-I single-pass transmembrane receptors with an intracellular Toll IL-1R homology (TIR) domain and extracellular Leucine-rich repeats. The archetypal family member, Tl, was first characterized for its role in embryonic dorsal/ventral patterning. In larval and adult stages, Tl is involved with innate immune response. Tl is activated by binding an endogenous spatzle ligand and activation of NF-κB is the target of canonical Toll/Toll-like receptor signaling. Non-canonical signaling pathways are less well characterized. (Adapted from FBrf0130108, FBrf0212564 and FBrf0239503).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Toll-4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

5' exons and translation start based on gene model prediction data only.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Toll-4-RA
FBtr0079768
NM_078795
3378
1125
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Toll-4-PA
FBpp0079369
130.9
1125
6.43
NP_523519
AAF52747
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Toll-4 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
embryonic/larval lymph gland
(Kambris et al., 2002)
Additional Descriptive Data

Toll-4 is expressed in only a few cells in the embryo. Double staining with anit-kn shows that they located in the apical portion of the lymph gland precursors.

(Kambris et al., 2002)

Toll-4 transcripts could not be detected by northern blot but were detected by RT-PCR indicating that they are expressed at low levels.

(Tauszig et al., 2000)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Toll-4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Toll-4
Transgenic constructs containing regulatory region of Toll-4
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TLR10
5 of 15
Yes
No
Hsap\TLR1
4 of 15
No
No
1  
Hsap\TLR2
4 of 15
No
No
1  
Hsap\TLR4
4 of 15
No
Yes
Hsap\TLR5
4 of 15
No
Yes
Hsap\TLR6
4 of 15
No
No
Hsap\CD180
3 of 15
No
Yes
Hsap\TLR3
3 of 15
No
No
1  
Hsap\TLR7
3 of 15
No
Yes
Hsap\TLR8
3 of 15
No
Yes
1  
Hsap\TLR9
3 of 15
No
Yes
Hsap\FGFR1
1 of 15
No
No
Hsap\IL1R1
1 of 15
No
Yes
Hsap\IL1R2
1 of 15
No
Yes
Hsap\IL1RAP
1 of 15
No
Yes
Hsap\IL1RAPL1
1 of 15
No
Yes
Hsap\IL1RAPL2
1 of 15
No
Yes
1  
Hsap\IL1RL1
1 of 15
No
Yes
Hsap\IL1RL2
1 of 15
No
Yes
Hsap\IL18R1
1 of 15
No
Yes
Hsap\IL18RAP
1 of 15
No
Yes
1  
Hsap\SIGIRR
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (24)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tlr6
5 of 15
Yes
No
Mmus\Tlr1
4 of 15
No
No
Mmus\Tlr2
4 of 15
No
No
Mmus\Tlr3
4 of 15
No
Yes
Mmus\Tlr4
4 of 15
No
Yes
Mmus\Tlr13
4 of 15
No
No
Mmus\Tlr5
3 of 15
No
Yes
Mmus\Tlr7
3 of 15
No
Yes
Mmus\Tlr8
3 of 15
No
Yes
Mmus\Tlr9
3 of 15
No
Yes
Mmus\Tlr11
3 of 15
No
Yes
Mmus\Tlr12
3 of 15
No
Yes
Mmus\Cd180
2 of 15
No
Yes
Mmus\Fgfr1
1 of 15
No
No
Mmus\Il1r1
1 of 15
No
Yes
Mmus\Il1r2
1 of 15
No
Yes
Mmus\Il1rapl1
1 of 15
No
Yes
Mmus\Il1rapl2
1 of 15
No
Yes
Mmus\Il1rap
1 of 15
No
Yes
Mmus\Il1rl1
1 of 15
No
Yes
Mmus\Il1rl2
1 of 15
No
Yes
Mmus\Il18r1
1 of 15
No
Yes
Mmus\Il18rap
1 of 15
No
Yes
Mmus\Sigirr
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (22)
Rnor\Tlr2
4 of 13
Yes
No
Rnor\Tlr4
4 of 13
Yes
Yes
Rnor\Tlr5
4 of 13
Yes
Yes
Rnor\Tlr6
4 of 13
Yes
Yes
Rnor\Tlr3
3 of 13
No
No
Rnor\Tlr7
3 of 13
No
Yes
Rnor\Tlr8
3 of 13
No
Yes
Rnor\Tlr10
3 of 13
No
No
Rnor\Tlr11
3 of 13
No
Yes
Rnor\Tlr12
3 of 13
No
Yes
Rnor\Cd180
2 of 13
No
Yes
Rnor\Tlr9
2 of 13
No
Yes
Rnor\Il1r1
1 of 13
No
Yes
Rnor\Il1r2
1 of 13
No
Yes
Rnor\Il1rapl1
1 of 13
No
Yes
Rnor\Il1rap
1 of 13
No
Yes
Rnor\Il1rl1
1 of 13
No
Yes
Rnor\Il1rl2
1 of 13
No
Yes
Rnor\Il18r1
1 of 13
No
Yes
Rnor\Sigirr
1 of 13
No
Yes
Rnor\Tlr1
1 of 13
No
No
Rnor\Tlr13
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (22)
Xtro\LOC100485164
3 of 12
Yes
No
Xtro\LOC100485706
3 of 12
Yes
Yes
Xtro\tlr5
3 of 12
Yes
Yes
Xtro\tlr9
3 of 12
Yes
Yes
Xtro\LOC100485201
2 of 12
No
No
Xtro\LOC100485512
2 of 12
No
No
Xtro\LOC100495326
2 of 12
No
No
Xtro\tlr2
2 of 12
No
No
Xtro\tlr3
2 of 12
No
No
Xtro\tlr6
2 of 12
No
No
Xtro\tlr7
2 of 12
No
No
Xtro\cd180
1 of 12
No
Yes
Xtro\fgfr1
1 of 12
No
No
Xtro\fgfr3
1 of 12
No
No
Xtro\il1r2
1 of 12
No
Yes
Xtro\LOC100485927
1 of 12
No
Yes
Xtro\LOC100489423
1 of 12
No
No
Xtro\LOC100497009
1 of 12
No
Yes
Xtro\LOC100498493
1 of 12
No
No
Xtro\LOC101734746
1 of 12
No
Yes
Xtro\tlr1
1 of 12
No
No
Xtro\tlr8
1 of 12
No
Yes
Danio rerio (Zebrafish) (29)
Drer\tlr1
4 of 15
Yes
No
Drer\tlr2
4 of 15
Yes
Yes
Drer\tlr3
4 of 15
Yes
Yes
Drer\tlr4bb
4 of 15
Yes
No
Drer\tlr5b
4 of 15
Yes
Yes
Drer\LOC572462
3 of 15
No
Yes
Drer\LOC100332583
3 of 15
No
Yes
Drer\tlr4ba
3 of 15
No
No
Drer\tlr5a
3 of 15
No
Yes
Drer\tlr9
3 of 15
No
Yes
Drer\tlr18
3 of 15
No
Yes
Drer\tlr19
3 of 15
No
Yes
Drer\tlr20.2
3 of 15
No
No
Drer\tlr20.4
3 of 15
No
No
Drer\tlr21
3 of 15
No
No
Drer\cd180
2 of 15
No
Yes
Drer\tlr7
2 of 15
No
No
Drer\tlr8b
2 of 15
No
No
Drer\tlr22
2 of 15
No
No
Drer\fgfr2
1 of 15
No
No
Drer\il1rapl1a
1 of 15
No
Yes
Drer\il1rapl1b
1 of 15
No
Yes
Drer\il1rapl2
1 of 15
No
Yes
Drer\LOC799279
1 of 15
No
Yes
Drer\LOC103911657
1 of 15
No
No
Drer\ncam1a
1 of 15
No
No
Drer\tlr4al
1 of 15
No
Yes
Drer\tlr8a
1 of 15
No
Yes
Drer\tlr20f
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\tol-1
4 of 15
Yes
No
Cele\egg-6
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (5)
Atha\AT2G25790
1 of 9
Yes
Yes
Atha\AT2G33170
1 of 9
Yes
No
Atha\AT4G28650
1 of 9
Yes
No
Atha\RLP35
1 of 9
Yes
No
Atha\RLP40
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901EQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010936
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001554
Drosophila simulans
Dsim\GD23585
Drosophila simulans
Dsim\GD19483
Drosophila sechellia
Dsec\GM17391
Drosophila erecta
Dere\GG25330
Drosophila yakuba
Dyak\GE10610
Drosophila yakuba
Dyak\GE12336
Drosophila yakuba
Dyak\GE10850
Drosophila ananassae
Dana\GF20151
Drosophila ananassae
Dana\GF17820
Drosophila pseudoobscura pseudoobscura
Dpse\GA25220
Drosophila pseudoobscura pseudoobscura
Dpse\GA28062
Drosophila pseudoobscura pseudoobscura
Dpse\GA32237
Drosophila pseudoobscura pseudoobscura
Dpse\GA32586
Drosophila pseudoobscura pseudoobscura
Dpse\GA25434
Drosophila pseudoobscura pseudoobscura
Dpse\GA31479
Drosophila pseudoobscura pseudoobscura
Dpse\GA28051
Drosophila persimilis
Dper\GL17072
Drosophila persimilis
Dper\GL25764
Drosophila persimilis
Dper\GL25762
Drosophila persimilis
Dper\GL26183
Drosophila persimilis
Dper\GL25612
Drosophila persimilis
Dper\GL25987
Drosophila persimilis
Dper\GL25763
Drosophila willistoni
Dwil\GK27286
Drosophila willistoni
Dwil\GK18128
Drosophila willistoni
Dwil\GK18129
Drosophila willistoni
Dwil\GK18130
Drosophila willistoni
Dwil\GK15296
Drosophila willistoni
Dwil\GK27547
Drosophila willistoni
Dwil\GK28130
Drosophila willistoni
Dwil\GK15289
Drosophila willistoni
Dwil\GK26900
Drosophila willistoni
Dwil\GK28254
Drosophila willistoni
Dwil\GK28112
Drosophila virilis
Dvir\GJ13648
Drosophila virilis
Dvir\GJ26678
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00LO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001267
Strigamia maritima
European centipede
Smar\SMAR001264
Strigamia maritima
European centipede
Smar\SMAR009088
Strigamia maritima
European centipede
Smar\SMAR002313
Strigamia maritima
European centipede
Smar\SMAR001265
Strigamia maritima
European centipede
Smar\SMAR001268
Strigamia maritima
European centipede
Smar\SMAR013561
Strigamia maritima
European centipede
Smar\SMAR007905
Strigamia maritima
European centipede
Smar\SMAR014573
Strigamia maritima
European centipede
Smar\SMAR010074
Strigamia maritima
European centipede
Smar\SMAR012279
Strigamia maritima
European centipede
Smar\SMAR012127
Strigamia maritima
European centipede
Smar\SMAR015400
Strigamia maritima
European centipede
Smar\SMAR010912
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00ZN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ci-tlr2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (29)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Tl
5 of 10
18w
4 of 10
MstProx
4 of 10
Tehao
4 of 10
Toll-7
4 of 10
Tollo
4 of 10
Toll-6
3 of 10
Toll-9
3 of 10
rdo
2 of 10
2mit
1 of 10
caps
1 of 10
cDIP
1 of 10
CG4168
1 of 10
CG4950
1 of 10
CG5810
1 of 10
CG6749
1 of 10
CG7800
1 of 10
CG7896
1 of 10
CG16974
1 of 10
CG18249
1 of 10
CG18480
1 of 10
CG32055
1 of 10
CG42346
1 of 10
CG42709
1 of 10
chp
1 of 10
kek5
1 of 10
kek6
1 of 10
ltl
1 of 10
trn
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TLR10; toll like receptor 10
    5 of 15
    606270
        TLR1; toll like receptor 1
        4 of 15
        601194
           
          TLR2; toll like receptor 2
          4 of 15
          603028
           
          TLR4; toll like receptor 4
          4 of 15
          603030
              TLR5; toll like receptor 5
              4 of 15
              603031
                TLR6; toll like receptor 6
                4 of 15
                605403
                    CD180; CD180 molecule
                    3 of 15
                    602226
                        TLR3; toll like receptor 3
                        3 of 15
                        603029
                           
                          TLR7; toll like receptor 7
                          3 of 15
                          300365
                            TLR8; toll like receptor 8
                            3 of 15
                            300366
                                 
                                TLR9; toll like receptor 9
                                3 of 15
                                605474
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    esyN Network Diagram
                                    Interactions Browser
                                    Summary of Genetic Interactions
                                    esyN Network Diagram
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    External Data
                                    Linkouts
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    2L
                                    Recombination map

                                    2-35

                                    Cytogenetic map
                                    30A1-30A1
                                    Sequence location
                                    2L:9,084,107..9,089,440 [+]
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    30A1-30A1
                                    Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    30A1-30A2
                                    (Tauszig, 2000.3.23)
                                    Experimentally Determined Recombination Data
                                    Location

                                    2-35

                                    (FlyBase, 2016)

                                    2-29.7

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (5)
                                    Genomic Clones (25)
                                    cDNA Clones (2)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                      Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                        Other clones
                                          RNAi and Array Information
                                          Linkouts
                                          DRSC - Results frm RNAi screens
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          Antibody Information
                                          Laboratory Generated Antibodies
                                           
                                          Commercially Available Antibodies
                                           
                                          Other Information
                                          Relationship to Other Genes
                                          Source for database identify of

                                          Source for identity of: Toll-4 CG18241

                                          (FlyBase, 1996-)
                                          Source for database merge of
                                          Additional comments

                                          Source for identity of Toll-4 CG18241 was sequence comparison ( date:000721 ).

                                          (FlyBase, 1996-)
                                          Other Comments

                                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                                          (Kiger et al., 2003)

                                          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells.

                                          (Kiger et al., 2003)
                                          Origin and Etymology
                                          Discoverer
                                          Etymology
                                          Identification
                                          External Crossreferences and Linkouts ( 26 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          Flygut - An atlas of the Drosophila adult midgut
                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          modMine - A data warehouse for the modENCODE project
                                          Linkouts
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          FlyMine - An integrated database for Drosophila genomics
                                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                          Synonyms and Secondary IDs (12)
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
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                                          References (62)