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Gene Dmel\Toll-4

General Information
Symbol	Dmel\Toll-4	Species	D. melanogaster
Name	Toll-4	Annotation symbol	CG18241
Feature type	protein_coding_gene	FlyBase ID	FBgn0032095
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	30A1-30A1	Sequence location	2L:9,084,107..9,089,440 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Toll-4 is referred to in FlyBase by the symbol Dmel\Toll-4 (CG18241, FBgn0032095). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: transmembrane signaling receptor activity. There is experimental evidence that it is involved in the biological process: cytokinesis. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cysteine-rich flanking region, C-terminal; Leucine-rich repeat; Leucine-rich repeat-containing N-terminal; Toll/interleukin-1 receptor homology (TIR) domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1631398_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Toll-4. Gene sequence location is 2L:9084107..9089440.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30A1-30A1   Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
Experimentally Determined Cytological Location
Cytogenetic map Notes References 30A1-30A2     (Tauszig, 2000.3.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Toll-4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51 5' exons and translation start based on gene model prediction data only.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Toll-4-RA FBtr0079768  NM_078795   3378   1125
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Toll-4-PA   FBpp0079369   130.9   1125   6.43     NP_523519   AAF52747
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat-containing N-terminal (IPR000372) Leucine-rich repeat (IPR001611) Cysteine-rich flanking region, C-terminal (IPR000483)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52747   AF247768 AAF86228   BT125710   BT126055
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VLE6 Q9NBK7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	Toll-4 transcripts could not be detected by northern blot but were detected by RT-PCR indicating that they are expressed at low levels. (Tauszig et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    14.1 Larval Midgut    2 Larval Hindgut    3.3 Larval Malpighian Tubules    1.4 Larval Fat Body    4.2 Larval Salivary Gland    6.2 Larval Trachea    6.225 Larval Carcass    5.675 Adult Head    1.4 Adult Eye    4.275 Adult Brain    1.7 Adult Thoracic-Abdominal Ganglion    5.4 Adult Crop    8.8 Adult Midgut    3.4 Adult Hindgut    3.8 Adult Malpighian Tubules    5.3 Adult Fat Body    16.9 Adult Salivary Gland    16.9 Adult Heart    5.85 Adult VirginFemale Spermatheca    12.8 Adult InseminatedFemale Spermatheca    15.2 Adult Ovary    1.2 Adult Testis    10.5 Adult Male Accessory Gland    8.8 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1.4   NA  Eye    4.275   NA  Brain    1.7   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    5.4   NA  Crop    8.8   2  Midgut    3.4   3.3  Hindgut    3.8   1.4  Malpighian Tubules    5.3   4.2  Fat Body    no informative data   6.2  Salivary Gland    no informative data   NA  Heart    5.85   6.225  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1.2   NA  Testis    no informative data   NA  Male Accessory Gland    8.8   5.675  Carcass    2.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032095 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18241-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Toll-4 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Toll-4 Class Mutagen Stocks Known lesion Toll-4GD1029 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Toll-4HM05029 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-4KK103537 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Toll-4Scer\UAS.cYa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6021 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1029} NA P{KK103537} NA P{TRiP.HM05029} NA P{UAS-Toll-4.Y} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Kiger et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
transmembrane signaling receptor activity inferred from sequence or structural similarity (Lemaitre, 2000.12.20) non-traceable author statement (Tauszig, 2000.3.23)
Biological Process
CV term Evidence References
defense response non-traceable author statement (Lemaitre, 2000.12.20) signal transduction inferred from electronic annotation with InterPro:IPR000157, InterPro:IPR004075 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lemaitre, 2000.12.20)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Lemaitre, 2000.12.20) plasma membrane non-traceable author statement (Tauszig, 2000.3.23)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Toll-4 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0032095 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34235
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6DNFPR Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG65F8HQ, EOG6RVFJ2
Orthologs in Drosophila Species (EOG6DNFPR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Toll-4     Drosophila melanogaster fruit fly  Dmel\MstProx     Drosophila simulans   Dsim\GD23585 Y Y Drosophila simulans   Dsim\GD19483   Y Drosophila sechellia   Dsec\GM17391 Y Y Drosophila erecta   Dere\GG25330   Y Drosophila erecta   Dere\GG16698   Y Drosophila yakuba   Dyak\GE10610 Y Y Drosophila yakuba   Dyak\GE18824   Y Drosophila yakuba   Dyak\GE12336   Y Drosophila yakuba   Dyak\GE10850   Y Drosophila ananassae   Dana\GF20151   Y Drosophila ananassae   Dana\GF22704 Y Y Drosophila ananassae   Dana\GF17820   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA25220 Y Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28062   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA25434   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA24352   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA28051   Y Drosophila persimilis   Dper\GL17072   Y Drosophila persimilis   Dper\GL25764 Y Y Drosophila persimilis   Dper\GL25762   Y Drosophila persimilis   Dper\GL26183   Y Drosophila persimilis   Dper\GL25612   Y Drosophila persimilis   Dper\GL25987   Y Drosophila persimilis   Dper\GL25763   Y Drosophila willistoni   Dwil\GK18128   Y Drosophila willistoni   Dwil\GK18261   Y Drosophila willistoni   Dwil\GK18129   Y Drosophila willistoni   Dwil\GK18130   Y Drosophila willistoni   Dwil\GK15289   Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (6) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23585 Drosophila sechellia Dsec\GM17391 Drosophila yakuba Dyak\GE10610 Drosophila ananassae Dana\GF22704 Drosophila pseudoobscura pseudoobscura Dpse\GA25220 Drosophila persimilis Dper\GL25764
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28543 y1 v1; P{TRiP.HM05029}attP2
VDRC	v102642 P{KK103537}VIE-260B v47966 w1118; P{GD1029}v47966 v47967 w1118; P{GD1029}v47967
Genomic Clones ( 2 )
	BACR14M08 BACR48E15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	RT10087 RT11128
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032095 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34235
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Toll-4 CG18241 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Toll-4 CG18241 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078795 RefSeq (Proteins) • NP_523519 DDBJ / EMBL / GenBank • AAF52747 AAF86228 AF247768 Entrez Gene - A searchable database of RefSeq genes. • 34235 UniProtKB/TrEMBL • Q9NBK7 Q9VLE6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Toll/interleukin-1 receptor homology (TIR) domain (IPR000157) Leucine-rich repeat-containing N-terminal (IPR000372) Leucine-rich repeat (IPR001611) Cysteine-rich flanking region, C-terminal (IPR000483)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0032095 DRSC - Results from RNAi screens. • FBgn0032095 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032095 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18241-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032095 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34235 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34235 modMine - Data generated by the modENCODE project. • FBgn0032095
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG18241 (Wasserman, 2000, Keleman et al., 2009.8.5, Perkins et al., 2009) CT29238 (Hynes and Zhao, 2000) dTLR4 (Silverman and Maniatis, 2001) dToll4 (Singh et al., 2003) TL4 (Lemaitre, 2000.12.20) Tl-4 (Khush and Lemaitre, 2000) toll (Janssens and Beyaert, 2002) Toll-4 (Lazzaro et al., 2006, Izutsu et al., 2012, Nakamoto et al., 2012, Lazzaro et al., 2004, Yagi et al., 2010, Inomata et al., 2008, Ooi et al., 2002, Wasbrough et al., 2010)
Name Synonym	Toll-4 (Tauszig, 2000.3.23, Christophides et al., 2002) Toll-like (Hynes and Zhao, 2000) toll receptor (Haesemeyer M et al., 2007)
Secondary FlyBase IDs
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 4 ) Review  ( 8 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Izutsu et al., 2012, PLoS ONE 7(3): e33288 Genome features of "dark-fly", a Drosophila line reared long-term in a dark environment. [FBrf0217825] Nakamoto et al., 2012, Immunity 36(4): 658--667 Virus recognition by toll-7 activates antiviral autophagy in Drosophila. [FBrf0218107] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...