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Gene Dmel\borr

General Information
Symbol	Dmel\borr	Species	D. melanogaster
Name	borealin-related	Annotation symbol	CG4454
Feature type	protein_coding_gene	FlyBase ID	FBgn0032105
Gene Model Status	Current	Stock availability	1 publicly available
Also Known As	Bor
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	30A6-30A6	Sequence location	2L:9,251,472..9,253,116 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene borealin-related is referred to in FlyBase by the symbol Dmel\borr (CG4454, FBgn0032105). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: protein localization; mitotic cell cycle, embryonic; sensory organ development; mitosis; mitotic spindle organization; cytokinesis; histone phosphorylation; mitotic prometaphase. 6 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum; chromatin. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cell division protein borealin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1634359_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of borr. Gene sequence location is 2L:9251472..9253116.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA02749 BKN25784
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30A6-30A6   Limits computationally determined from genome sequence between P{PZ}tai01351 and P{PZ}scat1&P{PZ}numb03235
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\borr for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) borr-RA FBtr0079817  NM_135435   1281   315 borr-RB FBtr0079818  NM_164850   1296   319
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein borr-PA   FBpp0079416   34.7   315   10.80     NP_609279   AAF52757 borr-PB   FBpp0079417   35.1   319   10.75     NP_723450   AAN10690
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cell division protein borealin (IPR018867)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201359   AA246994   AA392223   AA392565   AA438331   AA440908   AA441143   AA816577   AA817071   AA817614   AA817621   AA820564   AA820847   AA941949   AA978986   AA979173   AA979691   AE014134 AAF52757   AE014134 AAN10690   AI295409   AI388715   AI455426   AI455965   AI456241   AI456818   AI511862   AI512668   AI513435   AI514701   AI515201   AI515429   AI515694   AI515877   AI516095   AI516171   AI516712   AI518402   AI519213   AI520057   AI520114   AI543977   AW943323   AY061432 AAL28980   BE977797   BE978447   BG637340   BG641438   BI169338   BI172423   BI212153   BI214531   BI234380   BI234873   BI235854   BI236535   BI237573   BI239370   BI239974   BI241628   BI243669   BI367471   BI369033   BI371937   BI483992   BI484075   BI484094   BI485083   BI640061   BQ102697   BT001609 AAN71364   CO186381   CO273106   CO277159   CO282442   CO287463   CO295489   CO301777   CO303289   CO308436   CO312727   CO328660   EC068006   EC080137   EC083645   EC086919   EC087805   EC090108   EC209300   EC214438   EC215048   EC220248   EC221117   EC223001   EC227475   EC237003   EC243626   EC259577   EL876324   EL876325   EL878118   EL878235   EV598813
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VLD6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032105    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032105 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032105 expression level Developmental Stage   Expression Level embryo 00-02hr    15818 embryo 02-04hr    24944 embryo 04-06hr    23181 embryo 06-08hr    16902 embryo 08-10hr    11049 embryo 10-12hr    5608 embryo 12-14hr    3081 embryo 14-16hr    3613 embryo 16-18hr    2734 embryo 18-20hr    1597 embryo 20-22hr    7656 embryo 22-24hr    4849 larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9    1660 white prepupae new    1541 white prepupae 12hr    2108 white prepupae 24hr    1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day    2159 adult female 05day    5169 adult female 30day    5601 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (15818) embryo 02-04hr  (24944) embryo 04-06hr  (23181) embryo 06-08hr  (16902) embryo 08-10hr  (11049) embryo 10-12hr  (5608) embryo 12-14hr  (3081) embryo 14-16hr  (3613) embryo 16-18hr  (2734) embryo 18-20hr  (1597) embryo 20-22hr  (7656) embryo 22-24hr  (4849) larva L1    96 larva L2  (209) larva L3 12hr old  (292) larva L3 puffstage 1-2  (831) larva L3 puffstage 3-6  (1388) larva L3 puffstage 7-9  (1660) white prepupae new  (1541) white prepupae 12hr  (2108) white prepupae 24hr  (1859) pupae 2d postWPP  (630) pupae 3d postWPP  (294) pupae 4d postWPP  (378) adult male 01day  (363) adult male 05day  (649) adult male 30day  (475) adult female 01day  (2159) adult female 05day  (5169) adult female 30day  (5601) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (15818) embryo 02-04hr  (24944) embryo 04-06hr  (23181) embryo 06-08hr  (16902) embryo 08-10hr  (11049) embryo 10-12hr  (5608) embryo 12-14hr  (3081) embryo 14-16hr  (3613) embryo 16-18hr  (2734) embryo 18-20hr  (1597) embryo 20-22hr  (7656) embryo 22-24hr  (4849) larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9  (1660) white prepupae new  (1541) white prepupae 12hr  (2108) white prepupae 24hr  (1859) pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day  (2159) adult female 05day  (5169) adult female 30day  (5601) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (15818) embryo 02-04hr  (24944) embryo 04-06hr  (23181) embryo 06-08hr  (16902) embryo 08-10hr  (11049) embryo 10-12hr    5608 embryo 12-14hr    3081 embryo 14-16hr    3613 embryo 16-18hr    2734 embryo 18-20hr    1597 embryo 20-22hr    7656 embryo 22-24hr    4849 larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9    1660 white prepupae new    1541 white prepupae 12hr    2108 white prepupae 24hr    1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day    2159 adult female 05day    5169 adult female 30day    5601 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15818 embryo 02-04hr    24944 embryo 04-06hr    23181 embryo 06-08hr    16902 embryo 08-10hr    11049 embryo 10-12hr    5608 embryo 12-14hr    3081 embryo 14-16hr    3613 embryo 16-18hr    2734 embryo 18-20hr    1597 embryo 20-22hr    7656 embryo 22-24hr    4849 larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9    1660 white prepupae new    1541 white prepupae 12hr    2108 white prepupae 24hr    1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day    2159 adult female 05day    5169 adult female 30day    5601 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032105 expression level Developmental Stage   Expression Level embryo 00-02hr    15818 embryo 02-04hr    24944 embryo 04-06hr    23181 embryo 06-08hr    16902 embryo 08-10hr    11049 embryo 10-12hr    5608 embryo 12-14hr    3081 embryo 14-16hr    3613 embryo 16-18hr    2734 embryo 18-20hr    1597 embryo 20-22hr    7656 embryo 22-24hr    4849 larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9    1660 white prepupae new    1541 white prepupae 12hr    2108 white prepupae 24hr    1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day    2159 adult female 05day    5169 adult female 30day    5601 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (15818) embryo 02-04hr  (24944) embryo 04-06hr  (23181) embryo 06-08hr  (16902) embryo 08-10hr  (11049) embryo 10-12hr  (5608) embryo 12-14hr  (3081) embryo 14-16hr  (3613) embryo 16-18hr  (2734) embryo 18-20hr  (1597) embryo 20-22hr  (7656) embryo 22-24hr  (4849) larva L1    96 larva L2  (209) larva L3 12hr old  (292) larva L3 puffstage 1-2  (831) larva L3 puffstage 3-6  (1388) larva L3 puffstage 7-9  (1660) white prepupae new  (1541) white prepupae 12hr  (2108) white prepupae 24hr  (1859) pupae 2d postWPP  (630) pupae 3d postWPP  (294) pupae 4d postWPP  (378) adult male 01day  (363) adult male 05day  (649) adult male 30day  (475) adult female 01day  (2159) adult female 05day  (5169) adult female 30day  (5601) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (15818) embryo 02-04hr  (24944) embryo 04-06hr  (23181) embryo 06-08hr  (16902) embryo 08-10hr  (11049) embryo 10-12hr  (5608) embryo 12-14hr  (3081) embryo 14-16hr  (3613) embryo 16-18hr  (2734) embryo 18-20hr  1597 embryo 20-22hr  (7656) embryo 22-24hr  (4849) larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9  1660 white prepupae new  1541 white prepupae 12hr  2108 white prepupae 24hr  1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day  2159 adult female 05day  (5169) adult female 30day  (5601) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  15818 embryo 02-04hr  (24944) embryo 04-06hr  (23181) embryo 06-08hr  16902 embryo 08-10hr  11049 embryo 10-12hr    5608 embryo 12-14hr    3081 embryo 14-16hr    3613 embryo 16-18hr    2734 embryo 18-20hr    1597 embryo 20-22hr    7656 embryo 22-24hr    4849 larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9    1660 white prepupae new    1541 white prepupae 12hr    2108 white prepupae 24hr    1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day    2159 adult female 05day    5169 adult female 30day    5601 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    15818 embryo 02-04hr    24944 embryo 04-06hr    23181 embryo 06-08hr    16902 embryo 08-10hr    11049 embryo 10-12hr    5608 embryo 12-14hr    3081 embryo 14-16hr    3613 embryo 16-18hr    2734 embryo 18-20hr    1597 embryo 20-22hr    7656 embryo 22-24hr    4849 larva L1    96 larva L2    209 larva L3 12hr old    292 larva L3 puffstage 1-2    831 larva L3 puffstage 3-6    1388 larva L3 puffstage 7-9    1660 white prepupae new    1541 white prepupae 12hr    2108 white prepupae 24hr    1859 pupae 2d postWPP    630 pupae 3d postWPP    294 pupae 4d postWPP    378 adult male 01day    363 adult male 05day    649 adult male 30day    475 adult female 01day    2159 adult female 05day    5169 adult female 30day    5601 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032105    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032105 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032105 expression level Tissue   Expression Level Larval Central Nervous System    590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1282.3 Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (590.325) Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (1282.3) Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (1282.3) Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1282.3 Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032105 expression level Tissue   Expression Level Larval Central Nervous System    590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1282.3 Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (1282.3) Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary  1282.3 Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    590.325 Larval Midgut    35.4 Larval Hindgut    56 Larval Malpighian Tubules no informative data Larval Fat Body    91.1 Larval Salivary Gland    4.8 Larval Trachea    156.9 Larval Carcass    74.15 Adult Head    2.6 Adult Eye    2.5 Adult Brain    2.7 Adult Thoracic-Abdominal Ganglion    3.3 Adult Crop    8.9 Adult Midgut no informative data Adult Hindgut    8.5 Adult Malpighian Tubules no informative data Adult Fat Body    36.6 Adult Salivary Gland no informative data Adult Heart    31.425 Adult VirginFemale Spermatheca    22.1 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1282.3 Adult Testis    236.3 Adult Male Accessory Gland    2.5 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.6   NA  Eye    2.5   NA  Brain    2.7   590.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3.3   NA  Crop    8.9   35.4  Midgut    no informative data   56  Hindgut    8.5   no informative data  Malpighian Tubules    no informative data   91.1  Fat Body    36.6   4.8  Salivary Gland    no informative data   NA  Heart    31.425   156.9  Trachea    NA   NA  VirginFemale Spermatheca    22.1   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1282.3   NA  Testis    236.3   NA  Male Accessory Gland    2.5   74.15  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4454-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for borr Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage borrE133 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 borrGD11322 viable | somatic clone | third instar larval stage borrE133 Other Phenotypes Allele cell size defective | larval stage | somatic clone borrE133 increased cell death | larval stage | somatic clone borrE133 Minute | pupal stage borrE133 mitotic cell cycle defective borrunspecified mitotic cell cycle defective | larval stage | somatic clone borrE133 visible, with Scer\GAL4pnr-MD237 borrGD11322 Phenotype manifest in Allele brain & nucleus borrE133 chromatin borrunspecified eye | somatic clone borrE133 leg | somatic clone borrE133 mesothoracic tergum, with Scer\GAL4pnr-MD237 borrGD11322 nucleus | somatic clone borrE133 spindle | somatic clone borrE133 trichogen cell, with Scer\GAL4pnr-MD237 borrGD11322 ventral nerve cord & nucleus borrE133 wing | somatic clone borrE133 wing hair | ectopic | somatic clone borrE133 wing margin bristle | somatic clone borrE133
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of borr Class Mutagen Stocks Known lesion borrE133 loss of function allele ethyl methanesulfonate 0 Yes borrunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of borr Class Mutagen Stocks Known lesion borrGD11322 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes borrAct5C.C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion 0 Yes borrAct5C.N.T:Avic\GFP-EGFP in vitro construct - regulatory fusion 0 Yes borrN.T:Avic\GFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)2892 (Chang et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
	There is no information supporting a molecular function term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Eggert et al., 2004) histone phosphorylation inferred from mutant phenotype (assigned by UniProtKB) (Hanson et al., 2005) mitosis inferred from mutant phenotype (Hanson and Bienz, 2005, Hanson et al., 2005) mitotic cell cycle, embryonic inferred from mutant phenotype (assigned by UniProtKB) (Hanson et al., 2005) mitotic prometaphase inferred from mutant phenotype (Hanson et al., 2005) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) protein localization inferred from mutant phenotype (assigned by UniProtKB) (Hanson et al., 2005) sensory organ development inferred from mutant phenotype (Hanson et al., 2005)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (assigned by UniProtKB) (Hanson et al., 2005) chromatin inferred from direct assay (assigned by UniProtKB) (Hanson et al., 2005) chromosome passenger complex inferred from direct assay (Gao et al., 2008) spindle midzone inferred from direct assay (assigned by UniProtKB) (Hanson et al., 2005)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions borr allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60352 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032105 DroID - A comprehensive database of gene and protein interactions. • FBgn0032105 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34245
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22038 Dere\GG24035 Dgri\GH13640 Dmoj\GI11901 Dper\GL25535 Dpse\GA18196 Dsec\GM12517 Dsim\GD22362 Dvir\GJ14013 Dwil\GK15062 Dyak\GE10577
Curated drosophilid orthologs	Dana\borr (Gao et al., 2008) Dere\borr (Gao et al., 2008) Dgri\borr (Gao et al., 2008) Dmoj\borr (Gao et al., 2008) Dper\borr (Gao et al., 2008) Dpse\GA18196 (Gao et al., 2008) Dsec\borr (Gao et al., 2008) Dsim\borr (Gao et al., 2008) Dvir\borr (Gao et al., 2008) Dyak\borr (Gao et al., 2008)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011330-PA Aedes aegypti (mosquito) AGAP011220-PA Anopheles gambiae (mosquito) XP_001120534.1 Apis mellifera (honey bee) BGIBMGA009153-PA Bombyx mori (silk worm) CPIJ008059 Culex pipens (mosquito) CPIJ019850 Culex pipens (mosquito) XP_001604532.1 Nasonia vitripennis (wasp) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12456 LH19335 FBgn0228432 FBgn0217067 FBgn0201231 FBgn0193768 FBgn0167454 FBgn0078203 FBgn0163119 FBgn0134659 FBgn0121116 FBgn0120748 FBgn0116174 FBgn0099037 CPIJ019850 CPIJ008059 BGIBMGA009153 ACYPI002449 GB14288 AGAP011220 AAEL011330 PB20901 GLEAN_08996
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
VDRC	v34848 w1118; P{GD11322}v34848/TM3
Genomic Clones ( 1 )
	BACR20B09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 97 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD36125 RE31802
Other clones	DPiM_LD36125 DPiM_RE31802
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH19702 LD02120 LD04333 LD06091 LD11022 LD11476 LD12283 LD12709 LD16037 LD22091 LD23484 LD24104 LD24359 LD24758 LD27309 LD33216 LD33462 LD35716 LD36958 LD37901 LD38727 LD39993 LD40090 LD41193 LD41339 LD41572 LD41850 LD41945 LD42693 LD43407 LD44603 LD45685 LD45705 LD46927 LD47258 LP09027 RE10479 RE14906 RE17177 RE20366 RE30071 RE30642 RE32606 RE33822 RE35843 RE36613 RE38744 RE41376 RE53243 RE55114 RE58969 RE66990 RE67128 RE67169 RE68356 SD12778 SD15276 SD22833
Other clones	1795 9955 16787 28057 55562 77012 103258 104811 120847 154530 175986 181917 283221 bs69c03 bs79h07 CK01.20D.F10 CK01.133C.G2 Dmel_neb_012020_0941_1632 EC259577 EK019155 EK065922 EK109541 EK123212 EK160508 EK182139 EK210146 EK229758 EK240761 EK258147 EK291108 IP06224 IP08021 IP08121 LD24113 UUGC0078
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032105 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34245
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Borr CG4454 (Hanson, 2005.3.2) Source for identity of: Borr CG4454 (Eggert et al., 2004)
Source for database merge of
Additional comments
Other Comments
	The borr protein is a chromosomal passenger protein in all mitotic tissues studied, but is specifically replaced by aust protein for the two male meiotic divisions. (Gao et al., 2008) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape and monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) GFP-tagged Borr co-localizes with endogenous ial and Incenp in transfected DmD8 cells. (Hanson and Bienz, 2005) RNAi-depletion of Borr in Kc167 cells results in multinucleate and polyploid cells. Loss of zygotic Borr function in the embryo results in large, polyploid cells in the ventral nerve cord and brain. The mitotic population of these VNC cells is mainly blocked in a prometaphase state, and shows markedly reduced levels of S10-phosphorylated histone H3. Unexpectedly, Borr mutant clones induced late can survive larval development; these cells display cell-autonomous mutant phenotypes reflective of their large size and mitotic defects, but can still contribute significantly to adult structures. In contrast, in Borr mutant clones induced early in larval development, the mutant cells become polyploid, as expected, but undergo apoptosis. Intriguingly, this resulted in non-autonomous perturbation of the expression patterns of developmental regulators such as ct and wg, and subsequent non-autonomous defects in adult flies, such as wing nicks and leg truncations. (Hanson and Bienz, 2005) May be the Drosophila homolog of Borealin/Dastra. dsRNA made from templates generated with primers directed against Borr is used to study the effect of Borr on mitosis and morphology in the embryo and Kc167 cells. (Hanson et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells. (Eggert et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135435 NM_164850 RefSeq (Proteins) • NP_609279 NP_723450 DDBJ / EMBL / GenBank • AAF52757 AAL28980 AAN10690 AAN71364 AI456241 AW943323 AY061432 BI235854 BT001609 Entrez Gene - A searchable database of RefSeq genes. • 34245 UniProtKB/TrEMBL • Q9VLD6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cell division protein borealin (IPR018867)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60352 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032105 DroID - A comprehensive database of gene and protein interactions. • FBgn0032105 DRSC - Results from RNAi screens. • FBgn0032105 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032105 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4454-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032105 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34245 InParanoid A subset of ortholog calls from InParanoid. • AAEL011330-PA Aedes aegypti (mosquito) AGAP011220-PA Anopheles gambiae (mosquito) XP_001120534.1 Apis mellifera (honey bee) BGIBMGA009153-PA Bombyx mori (silk worm) CPIJ008059 Culex pipens (mosquito) CPIJ019850 Culex pipens (mosquito) XP_001604532.1 Nasonia vitripennis (wasp) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/borealin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34245 modMine - Data generated by the modENCODE project. • FBgn0032105 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12456 LH19335 FBgn0228432 FBgn0217067 FBgn0201231 FBgn0193768 FBgn0167454 FBgn0078203 FBgn0163119 FBgn0134659 FBgn0121116 FBgn0120748 FBgn0116174 FBgn0099037 CPIJ019850 CPIJ008059 BGIBMGA009153 ACYPI002449 GB14288 AGAP011220 AAEL011330 PB20901 GLEAN_08996
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	Bor (Hanson, 2005.3.2, Gruenewald et al., 2009) borr (Hanson et al., 2005, Gan et al., 2010, Gao et al., 2008) Borr   CG4454 (Eggert et al., 2004, Goshima et al., 2007, Gao et al., 2008) dBor (Hanson and Bienz, 2005)
Name Synonym	Borealin (Hanson and Bienz, 2005, Goshima et al., 2007, Gao et al., 2008, Somma et al., 2008) borealin (Chang et al., 2006) Borealin-related   borealin-related
Secondary FlyBase IDs
References ( 17 )
Research paper	Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Gruenewald et al., 2009, Free Radical Biol. Med. 46(12): 1668--1676 Hyperoxia-induced neurodegeneration as a tool to identify neuroprotective genes in Drosophila melanogaster. [FBrf0208024] Gao et al., 2008, J. Cell Biol. 180(3): 521--535 Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. [FBrf0202888] Somma et al., 2008, PLoS Genet. 4(7): e1000126 Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. [FBrf0206064] Chang et al., 2006, J. Cell Sci. 119(6): 1144--1153 Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system. [FBrf0190952] Hanson et al., 2005, Development 132(21): 4777--4787 Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. [FBrf0190293] Eggert et al., 2004, PLoS Biol. 2(12): 2135--2143 Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets. [FBrf0180476]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Goshima et al., 2007, Science 316(5823): Supporting online material for Genes required for mitotic spindle assembly in Drosophila S2 cells. [FBrf0200397] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Review	Anonymous, 2005, PLoS Biol. 2(12): 2005 Chemical and Genetic Screens Hit the Target in Cytokinesis. [FBrf0188406]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Hanson, 2005.3.2, Helping FlyBase: ADRC-50471. Helping FlyBase: ADRC-50471. [FBrf0182897]
Abstract	Hanson and Bienz, 2005, A. Dros. Res. Conf. 46: 83 Loss of Borealin function causes cell autonomous mitotic defects and has non-autonomous effects on tissue development. [FBrf0182898]
FlyBase analysis	FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]