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Gene Dmel\Apoltp

General Information
Symbol	Dmel\Apoltp	Species	D. melanogaster
Name	Apolipoprotein lipid transfer particle	Annotation symbol	CG15828
Feature type	protein_coding_gene	FlyBase ID	FBgn0032136
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	30C2-30C2	Sequence location	2L:9,634,179..9,656,026 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Apolipoprotein lipid transfer particle is referred to in FlyBase by the symbol Dmel\Apoltp (CG15828, FBgn0032136). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: lipid transporter activity. There is experimental evidence that it is involved in the biological process: acylglycerol transport; sterol transport. 10 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Lipid transport protein, N-terminal; Lipid transport protein, beta-sheet shell; Lipid transport, open beta-sheet; Vitellinogen, beta-sheet N-terminal; Vitellinogen, open beta-sheet; Vitellinogen, open beta-sheet, subdomain 1; Vitellinogen, open beta-sheet, subdomain 2; Vitellinogen, superhelical; von Willebrand factor, type D domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult hindgut, larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1628049_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG15828. Gene sequence location is 2L:9634179..9656026.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30C2-30C2   Limits computationally determined from genome sequence between P{EP}EP361&P{EP}peloEP2160 and P{lacW}zf30Ck02506&P{EP}undEP424
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Apoltp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 DGC clone LD15094 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Apoltp-RC FBtr0303874  NM_205948   13330   4333
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Apoltp-PC   FBpp0292877   494.3   4333   6.28     NP_995670   AAS64667
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Lipid transport protein, N-terminal (IPR001747) von Willebrand factor, type D domain (IPR001846) Lipid transport, open beta-sheet (IPR009454) Vitellinogen, superhelical (IPR011030) Vitellinogen, beta-sheet N-terminal (IPR015816) Vitellinogen, open beta-sheet, subdomain 1 (IPR015817) Lipid transport protein, beta-sheet shell (IPR015819) Vitellinogen, open beta-sheet (IPR015255) Vitellinogen, open beta-sheet, subdomain 2 (IPR015818)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140964   AA440024   AE014134 AAS64667   AI260281   AI944515   AW942336   AY119586 AAM50240   BT088906   CO155780   CO275893   CO276117   CO300300   CO305428   CO306852   CO330605   CO337900   EC208847   EC214711   EC243365   EC264344   EC267532   EL875169   EL875170   EL875302   EL875303   EL884034   EL887295   EL887328   EV589824   FL502466   FL502518   FL502711   FL502903   GH291296   GH944803   GH948046   GH949907   GH979653
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KTG2 Q9VLA0 Q8MRJ0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   fat body/gonad primordium   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   amnioserosa   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
basal part of cell inferred from direct assay (Palm et al., 2012) extracellular space inferred from direct assay (Palm et al., 2012) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult heart, adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult hindgut, larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head    875.3 Adult Eye    543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body    2684.5 Adult Salivary Gland    18.8 Adult Heart    1384.575 Adult VirginFemale Spermatheca    2079.4 Adult InseminatedFemale Spermatheca    2395.8 Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass    1359.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head  (875.3) Adult Eye  (543.125) Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body  (2684.5) Adult Salivary Gland    18.8 Adult Heart  (1384.575) Adult VirginFemale Spermatheca  (2079.4) Adult InseminatedFemale Spermatheca  (2395.8) Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass  (1359.9) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head    875.3 Adult Eye    543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body  (2684.5) Adult Salivary Gland    18.8 Adult Heart  (1384.575) Adult VirginFemale Spermatheca  (2079.4) Adult InseminatedFemale Spermatheca  (2395.8) Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass  (1359.9) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head    875.3 Adult Eye    543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body    2684.5 Adult Salivary Gland    18.8 Adult Heart    1384.575 Adult VirginFemale Spermatheca    2079.4 Adult InseminatedFemale Spermatheca    2395.8 Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass    1359.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head    875.3 Adult Eye    543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body    2684.5 Adult Salivary Gland    18.8 Adult Heart    1384.575 Adult VirginFemale Spermatheca    2079.4 Adult InseminatedFemale Spermatheca    2395.8 Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass    1359.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head  (875.3) Adult Eye  543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body  (2684.5) Adult Salivary Gland    18.8 Adult Heart  (1384.575) Adult VirginFemale Spermatheca  (2079.4) Adult InseminatedFemale Spermatheca  (2395.8) Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass  (1359.9) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head    875.3 Adult Eye    543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body  (2684.5) Adult Salivary Gland    18.8 Adult Heart  1384.575 Adult VirginFemale Spermatheca  (2079.4) Adult InseminatedFemale Spermatheca  (2395.8) Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass  1359.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    50.55 Larval Midgut    10.7 Larval Hindgut    56.9 Larval Malpighian Tubules    8 Larval Fat Body    430.3 Larval Salivary Gland    62.9 Larval Trachea    27.1 Larval Carcass    20.175 Adult Head    875.3 Adult Eye    543.125 Adult Brain    140.7 Adult Thoracic-Abdominal Ganglion    129.5 Adult Crop    44.6 Adult Midgut    7.6 Adult Hindgut    105.8 Adult Malpighian Tubules    34.8 Adult Fat Body    2684.5 Adult Salivary Gland    18.8 Adult Heart    1384.575 Adult VirginFemale Spermatheca    2079.4 Adult InseminatedFemale Spermatheca    2395.8 Adult Ovary    2.6 Adult Testis    10.1 Adult Male Accessory Gland    12.2 Adult Carcass    1359.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    875.3   NA  Eye    543.125   NA  Brain    140.7   50.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    129.5   NA  Crop    44.6   no informative data  Midgut    7.6   56.9  Hindgut    105.8   8  Malpighian Tubules    no informative data   430.3  Fat Body    2684.5   62.9  Salivary Gland    no informative data   NA  Heart    1384.575   27.1  Trachea    NA   NA  VirginFemale Spermatheca    2079.4   NA  InseminatedFemale Spermatheca    2395.8   NA  Ovary    2.6   NA  Testis    no informative data   NA  Male Accessory Gland    no informative data   20.175  Carcass    1359.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female    34 head, virgin 4-day female    30 head, virgin 20-day female    77 head, mated 1-day female    26 head, mated 4-day female    54 head, mated 20-day female    73 head, mated 1-day male    17 head, mated 4-day male    27 head, mated 20-day male    43 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult    34 carcass, 4-day adult    46 carcass, 20-day adult    44 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female  (34) head, virgin 4-day female  (30) head, virgin 20-day female  (77) head, mated 1-day female  26 head, mated 4-day female  (54) head, mated 20-day female  (73) head, mated 1-day male    17 head, mated 4-day male  (27) head, mated 20-day male  (43) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult  (34) carcass, 4-day adult  (46) carcass, 20-day adult  (44) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female    34 head, virgin 4-day female    30 head, virgin 20-day female    77 head, mated 1-day female    26 head, mated 4-day female    54 head, mated 20-day female    73 head, mated 1-day male    17 head, mated 4-day male    27 head, mated 20-day male    43 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult    34 carcass, 4-day adult    46 carcass, 20-day adult    44 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female    34 head, virgin 4-day female    30 head, virgin 20-day female    77 head, mated 1-day female    26 head, mated 4-day female    54 head, mated 20-day female    73 head, mated 1-day male    17 head, mated 4-day male    27 head, mated 20-day male    43 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult    34 carcass, 4-day adult    46 carcass, 20-day adult    44 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female    34 head, virgin 4-day female    30 head, virgin 20-day female    77 head, mated 1-day female    26 head, mated 4-day female    54 head, mated 20-day female    73 head, mated 1-day male    17 head, mated 4-day male    27 head, mated 20-day male    43 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult    34 carcass, 4-day adult    46 carcass, 20-day adult    44 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female  (34) head, virgin 4-day female  30 head, virgin 20-day female  (77) head, mated 1-day female  26 head, mated 4-day female  (54) head, mated 20-day female  (73) head, mated 1-day male    17 head, mated 4-day male  27 head, mated 20-day male  (43) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult  (34) carcass, 4-day adult  (46) carcass, 20-day adult  (44) ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female    34 head, virgin 4-day female    30 head, virgin 20-day female    77 head, mated 1-day female    26 head, mated 4-day female    54 head, mated 20-day female    73 head, mated 1-day male    17 head, mated 4-day male    27 head, mated 20-day male    43 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult    34 carcass, 4-day adult    46 carcass, 20-day adult    44 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    15 head, virgin 1-day female    34 head, virgin 4-day female    30 head, virgin 20-day female    77 head, mated 1-day female    26 head, mated 4-day female    54 head, mated 20-day female    73 head, mated 1-day male    17 head, mated 4-day male    27 head, mated 20-day male    43 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    13 carcass, larvae L3 wandering    1 carcass, 1-day adult    34 carcass, 4-day adult    46 carcass, 20-day adult    44 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr    41 embryo 14-16hr    32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1    38 larva L2    42 larva L3 12hr old    41 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr  (41) embryo 14-16hr  (32) embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1  (38) larva L2  (42) larva L3 12hr old  (41) larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr    41 embryo 14-16hr    32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1    38 larva L2    42 larva L3 12hr old    41 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr    41 embryo 14-16hr    32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1    38 larva L2    42 larva L3 12hr old    41 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr    41 embryo 14-16hr    32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1    38 larva L2    42 larva L3 12hr old    41 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr  (41) embryo 14-16hr  32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1  (38) larva L2  (42) larva L3 12hr old  (41) larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr    41 embryo 14-16hr    32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1    38 larva L2    42 larva L3 12hr old    41 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    6 embryo 06-08hr    19 embryo 08-10hr    24 embryo 10-12hr    17 embryo 12-14hr    41 embryo 14-16hr    32 embryo 16-18hr    24 embryo 18-20hr    17 embryo 20-22hr    20 embryo 22-24hr    24 larva L1    38 larva L2    42 larva L3 12hr old    41 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    4 white prepupae 12hr    5 white prepupae 24hr    10 pupae 2d postWPP    10 pupae 3d postWPP    6 pupae 4d postWPP    4 adult male 01day    12 adult male 05day    11 adult male 30day    11 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    34 embryonic 1182-4H    79 embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3    84 leg disc CME L1    63 wing disc CME-W2    140 wing disc ML-DmD8    14 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    170 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4  (34) embryonic 1182-4H  (79) embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3  (84) leg disc CME L1  (63) wing disc CME-W2  (140) wing disc ML-DmD8    14 wing disc ML-DmD9  (40) wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32  (37) haltere disc ML-DmD17-c3  (170) eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    34 embryonic 1182-4H    79 embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3    84 leg disc CME L1    63 wing disc CME-W2  (140) wing disc ML-DmD8    14 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3  (170) eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    34 embryonic 1182-4H    79 embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3    84 leg disc CME L1    63 wing disc CME-W2    140 wing disc ML-DmD8    14 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    170 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    34 embryonic 1182-4H    79 embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3    84 leg disc CME L1    63 wing disc CME-W2    140 wing disc ML-DmD8    14 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    170 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4  (34) embryonic 1182-4H  (79) embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3  (84) leg disc CME L1  (63) wing disc CME-W2  (140) wing disc ML-DmD8    14 wing disc ML-DmD9  (40) wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32  (37) haltere disc ML-DmD17-c3  (170) eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    34 embryonic 1182-4H    79 embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3    84 leg disc CME L1    63 wing disc CME-W2  140 wing disc ML-DmD8    14 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3  (170) eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    14 Schneider line 2 Sg4    34 embryonic 1182-4H    79 embryonic GM2    1 embryonic Kc167    1 embryonic S1    1 embryonic S3    84 leg disc CME L1    63 wing disc CME-W2    140 wing disc ML-DmD8    14 wing disc ML-DmD9    40 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    11 wing disc ML-DmD32    37 haltere disc ML-DmD17-c3    170 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    2 mixed discs ML-DmD4-c1    25 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    19 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    9 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LD15094 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032136 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15828-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Apoltp Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele embryonic/larval brain | third instar larval stage, with Scer\GAL4Adh.PF ApoltpdsRNA.Scer\UAS.II embryonic/larval fat body | third instar larval stage, with Scer\GAL4Adh.PF ApoltpdsRNA.Scer\UAS.II embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4Rfabg.PB ApoltpdsRNA.Scer\UAS.II embryonic/larval midgut | third instar larval stage, with Scer\GAL4Adh.PF ApoltpdsRNA.Scer\UAS.I ApoltpdsRNA.Scer\UAS.II wing disc | third instar larval stage, with Scer\GAL4Adh.PF ApoltpdsRNA.Scer\UAS.II
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Apoltp Class Mutagen Stocks Known lesion ApoltpMI05227 1 -- ApoltpMI05275 1 -- ApoltpMI06766 1 -- ApoltpDex1C P-element activity 0 Yes ApoltpΔex1A P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Apoltp Class Mutagen Stocks Known lesion ApoltpdsRNA.Scer\FRT.Scer\UAS.I in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ApoltpdsRNA.Scer\FRT.Scer\UAS.II in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ApoltpdsRNA.Scer\UAS.I FLPase 0 Yes ApoltpdsRNA.Scer\UAS.II FLPase 0 Yes ApoltpGD1216 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6024 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS(FRT.Hcri\RFP)Apoltp.dsRNA.1} NA P{UAS(FRT.Hcri\RFP)Apoltp.dsRNA.II} NA P{UAS(-FRT)Apoltp.dsRNA.1} NA P{UAS(-FRT)Apoltp.dsRNA.II} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}ApoltpMI05227 NA Mi{MIC}ApoltpMI05275 NA Mi{MIC}ApoltpMI06766 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
lipid transporter activity inferred from mutant phenotype (Palm et al., 2012)
Biological Process
CV term Evidence References
acylglycerol transport inferred from mutant phenotype (Palm et al., 2012) sterol transport inferred from mutant phenotype (Palm et al., 2012)
Cellular Component
CV term Evidence References
basal part of cell inferred from direct assay (Palm et al., 2012) extracellular space inferred from direct assay (Palm et al., 2012) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
lipid binding inferred from sequence or structural similarity with UniProtKB:Q25490 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
extracellular space inferred from sequence or structural similarity with UniProtKB:Q25490 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Apoltp - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Apoltp - CG13430 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Apoltp allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0032136
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61C7FG Dipteran inclusive ortholog search EOG61RQ2V Insect inclusive ortholog search EOG6K9970 Arthropod inclusive ortholog search EOG641NS6 Metazoa inclusive ortholog search EOG6G4VH0
Orthologs in Drosophila Species (EOG61C7FG)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Apoltp     Drosophila simulans   Dsim\GD23620 Y   Drosophila sechellia   Dsec\GM17602     Drosophila sechellia   Dsec\GM17625     Drosophila erecta   Dere\GG10045 Y   Drosophila yakuba   Dyak\GE18859 Y   Drosophila ananassae   Dana\GF22784 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13976 Y   Drosophila persimilis   Dper\GL18924     Drosophila persimilis   Dper\GL18925     Drosophila willistoni   Dwil\GK14654 Y   Drosophila virilis   Dvir\GJ18317 Y   Drosophila mojavensis   Dmoj\GI11106 Y   Drosophila grimshawi   Dgri\GH10678 Y
Orthologs in non-Drosophila Dipterans (EOG61RQ2V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004969   Anopheles gambiae Malaria mosquito  Agam\AGAP008807   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009271
Orthologs in non-Dipteran Insects (EOG6K9970)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55490   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008331   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20354   Atta cephalotes Leafcutter ant  Acep\ACEP18730   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18090   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13748   Linepithema humile Argentine ant  Lhum\LH11956   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15108   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19236   Solenopsis invicta Red fire ant  Sinv\SINV18945   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006628   Bombyx mori Silkmoth  Bmor\BGIBMGA013893   Bombyx mori Silkmoth  Bmor\BGIBMGA013894   Pediculus humanus Human body louse  Phum\PHUM009400   Tribolium castaneum Red flour beetle  Tcas\TC004643
Orthologs in non-Insect Arthropods (EOG641NS6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_332702   Daphnia pulex Water flea  Dpux\Olfr319   Daphnia pulex Water flea  Dpux\Traf2   Daphnia pulex Water flea  Dpux\JGI_V11_332703   Ixodes scapularis Deer tick  Isca\ISCW009032
Orthologs in non-Arthropod Metazoa (EOG6G4VH0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016052gn   Danio rerio Zebrafish  Drer\si:dkeyp-88f5.1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23620 Drosophila erecta Dere\GG10045 Drosophila yakuba Dyak\GE18859 Drosophila ananassae Dana\GF22784 Drosophila pseudoobscura pseudoobscura Dpse\GA13976 Drosophila willistoni Dwil\GK14654 Drosophila virilis Dvir\GJ18317 Drosophila mojavensis Dmoj\GI11106 Drosophila grimshawi Dgri\GH10678
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	41413 y1 w*; Mi{MIC}ApoltpMI05227 40780 y1 w*; Mi{MIC}ApoltpMI05275/SM6a 40821 y1 w*; Mi{MIC}ApoltpMI06766/SM6a
Genomic Clones ( 2 )
	BACR02I05 BACR24A22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15094
Other clones	IP15506
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP04022
Other clones	145814 292434 298980 bs03d09 CK01.142B.F12 CK01.145D.F11 CK01043 Dmel_neb_012805_0376_2537 DMG4-chr2L.17.012.pred.a DMG5-chr2L.18.005.pred.a EK119054 EK119724 EK177902 EK248560 EK252604 EK295708 EN06731 EN15538 IP15206 IP15306 IP15406 IP18446 RP004180215 RP004202632 RP004237662 RP004248580
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032136 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34283
Antibody Information
	polyclonal (Palm et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_205948 RefSeq (Proteins) • NP_995670 DDBJ / EMBL / GenBank • AA440024 AAF52796 AAM50240 AAS64667 AI944515 AW942336 AY119586 Entrez Gene - A searchable database of RefSeq genes. • 34283 UniProtKB/TrEMBL • Q7KTG2 Q8MRJ0 Q9VLA0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Lipid transport protein, N-terminal (IPR001747) von Willebrand factor, type D domain (IPR001846) Lipid transport, open beta-sheet (IPR009454) Vitellinogen, superhelical (IPR011030) Vitellinogen, beta-sheet N-terminal (IPR015816) Vitellinogen, open beta-sheet, subdomain 1 (IPR015817) Lipid transport protein, beta-sheet shell (IPR015819) Vitellinogen, open beta-sheet (IPR015255) Vitellinogen, open beta-sheet, subdomain 2 (IPR015818) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15094
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0032136 DRSC - Results from RNAi screens. • FBgn0032136 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032136 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15828-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032136 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34283 modMine - Data generated by the modENCODE project. • FBgn0032136
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	Apoltp   apoLTP (Palm et al., 2012) apoltp (Palm et al., 2012) CG15828 (Hughes et al., 2008, Johansson et al., 2005, Mosallanejad et al., 2010, Scherzer et al., 2003, Wasbrough et al., 2010, Fisher et al., 2008) CT39214 (Hynes and Zhao, 2000) LTP (Palm et al., 2012)
Name Synonym	Apolipoprotein lipid transfer particle
Secondary FlyBase IDs
References ( 24 )
Generate a list of	All references relating to this gene ( 24 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Palm et al., 2012, PLoS Genet. 8(7): e1002828 Lipoproteins in Drosophila melanogaster-Assembly, Function, and Influence on Tissue Lipid Composition. [FBrf0219024] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...