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Gene Dmel\CG4901

General Information
Symbol	Dmel\CG4901	Species	D. melanogaster
Name		Annotation symbol	CG4901
Feature type	protein_coding_gene	FlyBase ID	FBgn0032194
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31B1-31B1	Sequence location	2L:10,211,183..10,213,721 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4901 (FBgn0032194). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: helicase activity; ATP-dependent RNA helicase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: DEAD-like helicase; DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Domain of unknown function DUF1605; Helicase, C-terminal; Helicase-associated domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1624141_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG4901. Gene sequence location is 2L:10211183..10213721.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA02788 BKN45034 BKN23289
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31B1-31B1   Limits computationally determined from genome sequence between P{lacW}l(2)k06324k06324 and P{lacW}me31Bk06607
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4901 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4901-RA FBtr0079947  NM_135512   2233   694
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4901-PA   FBpp0079537   78.3   694   9.14     NP_609356   AAF52873
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (IPR002464) Helicase-associated domain (IPR007502) Domain of unknown function DUF1605 (IPR011709) DEAD-like helicase (IPR014001) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52873   AI295854   AI297430   AY113491 AAM29496   BG640023   BI363455   BI636824   BI637559   BP546703   BP546846   CO190275   CO283267   CO344328   EC051595   EC052582   EC052583   EC054542   EC055130   EC055575   EC080845   EC199512   EC209986   EC255087   EV578768   EV582359
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VL25
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032194    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032194 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032194 expression level Developmental Stage   Expression Level embryo 00-02hr    2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1    1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day    2014 adult female 05day    3091 adult female 30day    3051 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2445) embryo 02-04hr  (414) embryo 04-06hr  (642) embryo 06-08hr  (955) embryo 08-10hr  (1202) embryo 10-12hr  (1295) embryo 12-14hr  (1275) embryo 14-16hr  (905) embryo 16-18hr  (797) embryo 18-20hr  (719) embryo 20-22hr  (1173) embryo 22-24hr  (1272) larva L1  (1826) larva L2  (1069) larva L3 12hr old  (722) larva L3 puffstage 1-2  (601) larva L3 puffstage 3-6  (773) larva L3 puffstage 7-9  (936) white prepupae new  (823) white prepupae 12hr  (1086) white prepupae 24hr  (1089) pupae 2d postWPP  (880) pupae 3d postWPP  (569) pupae 4d postWPP  (430) adult male 01day  (490) adult male 05day  (492) adult male 30day  (536) adult female 01day  (2014) adult female 05day  (3091) adult female 30day  (3051) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2445) embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1  (1826) larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day  (2014) adult female 05day  (3091) adult female 30day  (3051) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1    1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day    2014 adult female 05day    3091 adult female 30day    3051 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1    1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day    2014 adult female 05day    3091 adult female 30day    3051 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032194 expression level Developmental Stage   Expression Level embryo 00-02hr    2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1    1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day    2014 adult female 05day    3091 adult female 30day    3051 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2445) embryo 02-04hr  (414) embryo 04-06hr  (642) embryo 06-08hr  (955) embryo 08-10hr  (1202) embryo 10-12hr  (1295) embryo 12-14hr  (1275) embryo 14-16hr  (905) embryo 16-18hr  (797) embryo 18-20hr  (719) embryo 20-22hr  (1173) embryo 22-24hr  (1272) larva L1  (1826) larva L2  (1069) larva L3 12hr old  (722) larva L3 puffstage 1-2  (601) larva L3 puffstage 3-6  (773) larva L3 puffstage 7-9  (936) white prepupae new  (823) white prepupae 12hr  (1086) white prepupae 24hr  (1089) pupae 2d postWPP  (880) pupae 3d postWPP  (569) pupae 4d postWPP  (430) adult male 01day  (490) adult male 05day  (492) adult male 30day  (536) adult female 01day  (2014) adult female 05day  (3091) adult female 30day  (3051) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1  1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day  2014 adult female 05day  (3091) adult female 30day  (3051) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1    1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day    2014 adult female 05day    3091 adult female 30day    3051 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2445 embryo 02-04hr    414 embryo 04-06hr    642 embryo 06-08hr    955 embryo 08-10hr    1202 embryo 10-12hr    1295 embryo 12-14hr    1275 embryo 14-16hr    905 embryo 16-18hr    797 embryo 18-20hr    719 embryo 20-22hr    1173 embryo 22-24hr    1272 larva L1    1826 larva L2    1069 larva L3 12hr old    722 larva L3 puffstage 1-2    601 larva L3 puffstage 3-6    773 larva L3 puffstage 7-9    936 white prepupae new    823 white prepupae 12hr    1086 white prepupae 24hr    1089 pupae 2d postWPP    880 pupae 3d postWPP    569 pupae 4d postWPP    430 adult male 01day    490 adult male 05day    492 adult male 30day    536 adult female 01day    2014 adult female 05day    3091 adult female 30day    3051 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032194    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032194 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032194 expression level Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032194 expression level Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    156.25 Larval Midgut    54 Larval Hindgut    105.4 Larval Malpighian Tubules    128.2 Larval Fat Body    60.2 Larval Salivary Gland    136.9 Larval Trachea    134.275 Larval Carcass    110.15 Adult Head    64.9 Adult Eye    47.9 Adult Brain    61.5 Adult Thoracic-Abdominal Ganglion    67.3 Adult Crop    114.4 Adult Midgut    74.6 Adult Hindgut    89.6 Adult Malpighian Tubules    104 Adult Fat Body    77.1 Adult Salivary Gland    147.3 Adult Heart    61.275 Adult VirginFemale Spermatheca    150.2 Adult InseminatedFemale Spermatheca    150.9 Adult Ovary    328.3 Adult Testis    38.5 Adult Male Accessory Gland    166.2 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    64.9   NA  Eye    47.9   NA  Brain    61.5   156.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    67.3   NA  Crop    114.4   54  Midgut    74.6   105.4  Hindgut    89.6   128.2  Malpighian Tubules    104   60.2  Fat Body    77.1   136.9  Salivary Gland    147.3   NA  Heart    61.275   134.275  Trachea    NA   NA  VirginFemale Spermatheca    150.2   NA  InseminatedFemale Spermatheca    150.9   NA  Ovary    328.3   NA  Testis    38.5   NA  Male Accessory Gland    166.2   110.15  Carcass    74.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032194 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4901-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG4901 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CG4901GD11464 viable, with Scer\GAL4pnr-MD237 CG4901GD11464 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 CG4901GD11464 visible, with Scer\GAL4pnr-MD237 CG4901GD11464 Phenotype manifest in Allele ganglion mother cell | larval stage, with Scer\GAL41407 CG4901GD11464 mesothoracic tergum, with Scer\GAL4pnr-MD237 CG4901GD11464 trichogen cell, with Scer\GAL4pnr-MD237 CG4901GD11464
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG4901 Class Mutagen Stocks Known lesion CG4901G2578 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4901 Class Mutagen Stocks Known lesion CG4901GD11464 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG4901KK103097 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6026 (Ryder, 2004.4.26) Df(2L)Exel8024 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11464} NA P{KK103097} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG4901G2578 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR002464, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent RNA helicase activity inferred from sequence or structural similarity with Saccharomyces PRP22 (FlyBase, 1992-) helicase activity inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR002464, InterPro:IPR011545 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
spliceosome disassembly inferred from sequence or structural similarity with Saccharomyces PRP22 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
spliceosomal complex inferred from sequence or structural similarity with Saccharomyces PRP22 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4901 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60448 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032194 DroID - A comprehensive database of gene and protein interactions. • FBgn0032194 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34357
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15750 Dere\GG10090 Dgri\GH13648 Dmoj\GI13606 Dper\GL19155 Dpse\GA25550 Dsec\GM17994 Dsim\GD23663 Dvir\GJ18332 Dwil\GK14866 Dyak\GE18905
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014106-PA Aedes aegypti (mosquito) AAEL014256-PA Aedes aegypti (mosquito) AGAP006138-PA Anopheles gambiae (mosquito) XP_001122093.1 Apis mellifera (honey bee) XP_001946906.1 Acyrthosiphon pisum (pea aphid) ENSCAFP00000022848 Canis familiaris (dog) CPIJ004458 Culex pipens (mosquito) ENSCPOP00000003321 Cavia porcellus (guinea pig) 197070 Capitella spl (polychaete worm) 302589 Daphnia pulex (daphnia) ENSDARP00000008078 Danio rerio (zebra fish) ENSECAP00000008364 Equus caballus (horse) ENSGACP00000026728 Gymnopilus aculeatus (mushroom) GL50803_15930 Giardia lamblia (flagellated protozoan) ENSP00000225296 Homo sapiens (human) ENSMMUP00000008672 Macaca mulatta (rhesus monkey) ENSMUSP00000038018 Mus musculus (house mouse) XP_001600447.1 Nasonia vitripennis (wasp) ENSORLP00000014807 Oryzias latipes (japanese killifish) PHUM004679-PA Pediculus humanus (human body louse) ENSPPYP00000008860 Pongo pygmaeus (orangutan) ENSPTRP00000014730 Pan troglodytes (chimpanzee) ENSRNOP00000009468 Rattus norvegicus (norway rat) ENSTNIP00000011386 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007955 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000020150 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10589 LH13166 ISCW014008 FBgn0236282 FBgn0216871 FBgn0205491 FBgn0195040 FBgn0172901 JGI_V11_302589 FBgn0246928 FBgn0156754 FBgn0136361 FBgn0121124 FBgn0102402 FBgn0092774 CPIJ004458 CPIJ020095 ACYPI007280 GB11427 AGAP006138 AAEL014256 AAEL014106 PB23942 PHUM078070 GLEAN_13109
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	27095 y1 w*; P{EP}CG4901G2578
VDRC	v34904 w1118; P{GD11464}v34904 v34905 w1118; P{GD11464}v34905/TM3
Genomic Clones ( 2 )
	BACR07H08 BACR29P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 24 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE48269
Other clones	DPiM_RE48269
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP09613 LP11728 SD10502 SD18649 SD19610
Other clones	17232 43416 CK01.58D.E12 Dmel_dig_010607_0660_1345 Dmel_dig_020781_0635_0630 EC051595 EC052582 EC052583 EC054542 EC055130 EC055575 EC255087 EK047652 EK162734 EP19052 FGH109C01 FGH110G02
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032194 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34357
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135512 RefSeq (Proteins) • NP_609356 DDBJ / EMBL / GenBank • AAF52873 AAM29496 AY113491 BI363455 Entrez Gene - A searchable database of RefSeq genes. • 34357 UniProtKB/TrEMBL • Q9VL25
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (IPR002464) Helicase-associated domain (IPR007502) Domain of unknown function DUF1605 (IPR011709) DEAD-like helicase (IPR014001) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60448 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032194 DroID - A comprehensive database of gene and protein interactions. • FBgn0032194 DRSC - Results from RNAi screens. • FBgn0032194 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032194 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4901-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032194 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34357 InParanoid A subset of ortholog calls from InParanoid. • AAEL014106-PA Aedes aegypti (mosquito) AAEL014256-PA Aedes aegypti (mosquito) AGAP006138-PA Anopheles gambiae (mosquito) XP_001122093.1 Apis mellifera (honey bee) XP_001946906.1 Acyrthosiphon pisum (pea aphid) ENSCAFP00000022848 Canis familiaris (dog) CPIJ004458 Culex pipens (mosquito) ENSCPOP00000003321 Cavia porcellus (guinea pig) 197070 Capitella spl (polychaete worm) 302589 Daphnia pulex (daphnia) ENSDARP00000008078 Danio rerio (zebra fish) ENSECAP00000008364 Equus caballus (horse) ENSGACP00000026728 Gymnopilus aculeatus (mushroom) GL50803_15930 Giardia lamblia (flagellated protozoan) ENSP00000225296 Homo sapiens (human) ENSMMUP00000008672 Macaca mulatta (rhesus monkey) ENSMUSP00000038018 Mus musculus (house mouse) XP_001600447.1 Nasonia vitripennis (wasp) ENSORLP00000014807 Oryzias latipes (japanese killifish) PHUM004679-PA Pediculus humanus (human body louse) ENSPPYP00000008860 Pongo pygmaeus (orangutan) ENSPTRP00000014730 Pan troglodytes (chimpanzee) ENSRNOP00000009468 Rattus norvegicus (norway rat) ENSTNIP00000011386 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007955 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000020150 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34357 modMine - Data generated by the modENCODE project. • FBgn0032194 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10589 LH13166 ISCW014008 FBgn0236282 FBgn0216871 FBgn0205491 FBgn0195040 FBgn0172901 JGI_V11_302589 FBgn0246928 FBgn0156754 FBgn0136361 FBgn0121124 FBgn0102402 FBgn0092774 CPIJ004458 CPIJ020095 ACYPI007280 GB11427 AGAP006138 AAEL014256 AAEL014106 PB23942 PHUM078070 GLEAN_13109
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cg4901 (Lasko, 2000) CG4901 (Akdemir et al., 2007, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
References ( 17 )
Research paper	Akdemir et al., 2007, Oncogene 26(36): 5184--5193 p53 directs focused genomic responses in Drosophila. [FBrf0202061] Sanjuan and Marin, 2001, Molec. Biol. Evol. 18(3): 330--343 Tracing the origin of the Compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. [FBrf0134757] Lasko, 2000, J. Cell Biol. 150(2): F51--F56 The Drosophila melanogaster genome: translation factors and RNA binding proteins. [FBrf0129923]
Supplementary material	Neumüller et al., 2011, Cell Stem Cell 8(5): Supplemental Table S1. [FBrf0214431] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2009.4.8, BDGP_2009_0408.GenExel.xml BDGP_2009_0408.GenExel.xml [FBrf0207636] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]