Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hand using the Feature Mapper tool.
Hand is expressed in visceral mesoderm founder cells in embryos at stage 11.
Hand is expressed in the developing heart starting at stage 12. Colocalization experiments show that Hand is expressed in all cardioblasts and in all pericardial cells in each hemisegment. Expression is also observed in the lymph glands and garland cells. Hand is detected in the trunk mesoderm and circular visceral muscle progenitors starting at embryonic stage 11. From stage 12-16 Hand expression is observed in circular muscle. At the end of embryogenesis, hand expression in the visceral mesoderm becomes most prominent in myofibers located at the midgut constrictions.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hand in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hand CG18144
Hand is required for the survival of cardioblasts, pericardial cells and lymph gland hematopoietic progenitors.