FB2021_01, released Feb 18, 2021

Gene: Dmel\Schip1

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General Information
Symbol
Dmel\Schip1
Species
D. melanogaster
Name
Schwannomin interacting protein 1
Annotation Symbol
CG5375
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032221
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Snapshot
Schwannomin interacting protein 1 (Schip1) encodes a protein that is involved in negative regulation of organ growth by promoting the Hippo signaling pathway. It binds to the products of ex and Tao, activating the phosphorylation of the kinase encoded by hpo. [Date last reviewed: 2018-11-15]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
31D8-31D9
Sequence location
2L:10,328,200..10,331,116 [-]
Recombination map

2-41

RefSeq locus
NT_033779 REGION:10328200..10331116
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:Q0KHQ5
(assigned by UniProt )
(Chung et al., 2016)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in negative regulation of growth
inferred from mutant phenotype
(Chung et al., 2016)
involved_in positive regulation of hippo signaling
inferred from mutant phenotype
(Chung et al., 2016)
involved_in positive regulation of protein serine/threonine kinase activity
inferred from mutant phenotype
(assigned by UniProt )
(Chung et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in positive regulation of hippo signaling
inferred from biological aspect of ancestor with PANTHER:PTN002294880
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in adherens junction
inferred from direct assay
(assigned by UniProt )
(Chung et al., 2016)
located_in apical plasma membrane
inferred from direct assay
(assigned by UniProt )
(Chung et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in cell junction
inferred from biological aspect of ancestor with PANTHER:PTN002294880
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002294880
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the SCHIP1 family. (A8DYY6)
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
Positive Regulators of Hippo Signaling Pathway -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Protein Function (UniProtKB)
Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein. Schip1 promotes kinase activity of Tao and enhances phosphorylation of hpo by Tao.
(UniProt, A8DYY6)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Schip1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 6.13

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Schip1-RB
FBtr0113033
NM_001103669
2063
616
Schip1-RC
FBtr0452145
NM_001347808
2063
621
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Schip1-PB
FBpp0111946
70.5
616
5.04
NP_001097139
ABV53662
Schip1-PC
FBpp0402895
71.1
621
5.10
NP_001334735
API64985
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with ex; the interaction results in recruitment of Schip1 to the apical cell membrane. Interacts with Tao; the interaction enhances Tao kinase activity. Interacts with Mer.

(UniProt, A8DYY6)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Schip1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
wing disc | ubiquitous
(Chung et al., 2016)
eye disc | ubiquitous
(Chung et al., 2016)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in adherens junction
inferred from direct assay
(assigned by UniProt )
(Chung et al., 2016)
located_in apical plasma membrane
inferred from direct assay
(assigned by UniProt )
(Chung et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Schip1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Schip1
Transgenic constructs containing regulatory region of Schip1
Aberrations (Deficiencies and Duplications) ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\IQCJ-SCHIP1
9 of 15
Yes
Yes
Hsap\SCHIP1
7 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Schip1
7 of 15
Yes
Yes
Mmus\Iqschfp
6 of 15
No
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Schip1
8 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\schip1
6 of 12
Yes
Yes
Danio rerio (Zebrafish) (4)
Drer\zgc:153615
6 of 15
Yes
Yes
Drer\schip1
5 of 15
No
Yes
Drer\im:7136398
1 of 15
No
Yes
Drer\si:dkey-6n21.12
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\F35H12.1
7 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904G8 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD22271
Drosophila sechellia
Dsec\GM11746
Drosophila erecta
Dere\GG23944
Drosophila yakuba
Dyak\GE26075
Drosophila ananassae
Dana\GF14110
Drosophila pseudoobscura pseudoobscura
Dpse\GA30758
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502IG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019453
Glossina morsitans
Tsetse fly
Gmor\GMOY004787
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05175
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09931
Mayetiola destructor
Hessian fly
Mdes\Mdes009883
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008571
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0J27 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_383
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IQCJ-SCHIP1; IQCJ-SCHIP1 readthrough
    9 of 15
        SCHIP1; schwannomin interacting protein 1
        7 of 15
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Schip1 - Mer
            anti bait coimmunoprecipitation, anti tag western blot, pull down, western blot
            (Chung et al., 2016)
            Schip1 - ex
            pull down, anti tag western blot, anti bait coimmunoprecipitation
            (Chung et al., 2016)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Schip1
            suppressible
            Tao
            (Chung et al., 2016)
            Schip1
            suppressible
            wts
            (Chung et al., 2016)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            crb
            suppressible
            Schip1
            (Chung et al., 2016)
            ex
            suppressible
            Schip1
            (Chung et al., 2016)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with ex; the interaction results in recruitment of Schip1 to the apical cell membrane. Interacts with Tao; the interaction enhances Tao kinase activity. Interacts with Mer.
            (UniProt, A8DYY6 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Positive Regulators of Hippo Signaling Pathway -
            The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map

            2-41

            Cytogenetic map
            31D8-31D9
            Sequence location
            2L:10,328,200..10,331,116 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            31D8-31D9
            Limits computationally determined from genome sequence between P{lacW}RnrLk06709 and P{lacW}KdelRk00311
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-41

            (FlyBase, 2016)

            2-35.2

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (3)
            Genomic Clones (15)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (12)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (Chung et al., 2016)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: Schip1 CG5375

                    (Chung et al., 2016)
                    Source for database merge of
                    Additional comments
                    Other Comments
                    Origin and Etymology
                    Discoverer
                    Etymology

                    Named 'Schip1' after its human homolog.

                    (FlyBase, 2009-)
                    Identification
                    External Crossreferences and Linkouts ( 27 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Synonyms and Secondary IDs (4)
                    Reported As
                    Symbol Synonym
                    CG5375
                    (Chung et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Zhang et al., 2010, Keleman et al., 2009.8.5)
                    Schip1
                    (Chung and Choi, 2016.6.24, Chung et al., 2016)
                    Name Synonyms
                    Schip1 ortholog
                    Schwannomin interacting protein 1
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (19)