• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\CG5045

General Information
Symbol	Dmel\CG5045	Species	D. melanogaster
Name		Annotation symbol	CG5045
Feature type	protein_coding_gene	FlyBase ID	FBgn0032229
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	31D10-31D10	Sequence location	2L:10,356,743..10,357,876 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5045 (FBgn0032229). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase activity. Based on sequence similarity, it is predicted to be involved in the biological process: proteolysis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S14, ClpP; Peptidase S14, ClpP, active site; Peptidase S14/S49. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633579_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5045. Gene sequence location is 2L:10356743..10357876.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
FB2012_01	Sequence features BKN20957 HFA02806
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 31D10-31D10   Limits computationally determined from genome sequence between P{lacW}RnrLk06709 and P{lacW}KdelRk00311
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5045 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5045-RA FBtr0080000  NM_135544   1025   253
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5045-PA   FBpp0079590   27.6   253   7.91     NP_609388   AAF52923
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S14, ClpP (IPR001907) Peptidase S14, ClpP, active site (IPR018215) Peptidase S14/S49 (IPR023562) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05045
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52923   AI113979   AI114139   AI238724   AI260057   AI297555   AI387320   AI402233   AI515460   AI517007   AI944875   AI945348   AI945878   AI946773   AI947195   AI947260   AY119497 AAM50151   BE975168   BF489211   BG640354   BI228124   BI563369   BI565542   BI593102   BI611022   BI632494   CO179074   CO181097   CO185458   CO187638   CO188145   CO189605   CO196082   CO261901   CO263743   CO264488   CO290184   CO291962   CO292289   CO294181   CO312729   CO320026   EC051627   EC051635   EC054111   EC054631   EC056401   EC064154   EC065033   EC072828   EC078584   EC091166   EC214334   EC223935   EC226184   EC229559   EC230293   EC235538   EC241098   EC248820
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VKY3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032229    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032229 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032229 expression level Developmental Stage   Expression Level embryo 00-02hr    4615 embryo 02-04hr    7696 embryo 04-06hr    7823 embryo 06-08hr    4208 embryo 08-10hr    3211 embryo 10-12hr    2597 embryo 12-14hr    1977 embryo 14-16hr    2555 embryo 16-18hr    2287 embryo 18-20hr    1786 embryo 20-22hr    2121 embryo 22-24hr    2086 larva L1    3622 larva L2    3890 larva L3 12hr old    3253 larva L3 puffstage 1-2    3413 larva L3 puffstage 3-6    3773 larva L3 puffstage 7-9    3613 white prepupae new    3485 white prepupae 12hr    4079 white prepupae 24hr    5560 pupae 2d postWPP    6412 pupae 3d postWPP    7144 pupae 4d postWPP    8354 adult male 01day    11680 adult male 05day    14548 adult male 30day    17009 adult female 01day    4714 adult female 05day    4082 adult female 30day    4254 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4615) embryo 02-04hr  (7696) embryo 04-06hr  (7823) embryo 06-08hr  (4208) embryo 08-10hr  (3211) embryo 10-12hr  (2597) embryo 12-14hr  (1977) embryo 14-16hr  (2555) embryo 16-18hr  (2287) embryo 18-20hr  (1786) embryo 20-22hr  (2121) embryo 22-24hr  (2086) larva L1  (3622) larva L2  (3890) larva L3 12hr old  (3253) larva L3 puffstage 1-2  (3413) larva L3 puffstage 3-6  (3773) larva L3 puffstage 7-9  (3613) white prepupae new  (3485) white prepupae 12hr  (4079) white prepupae 24hr  (5560) pupae 2d postWPP  (6412) pupae 3d postWPP  (7144) pupae 4d postWPP  (8354) adult male 01day  (11680) adult male 05day  (14548) adult male 30day  (17009) adult female 01day  (4714) adult female 05day  (4082) adult female 30day  (4254) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4615) embryo 02-04hr  (7696) embryo 04-06hr  (7823) embryo 06-08hr  (4208) embryo 08-10hr  (3211) embryo 10-12hr  (2597) embryo 12-14hr  (1977) embryo 14-16hr  (2555) embryo 16-18hr  (2287) embryo 18-20hr  (1786) embryo 20-22hr  (2121) embryo 22-24hr  (2086) larva L1  (3622) larva L2  (3890) larva L3 12hr old  (3253) larva L3 puffstage 1-2  (3413) larva L3 puffstage 3-6  (3773) larva L3 puffstage 7-9  (3613) white prepupae new  (3485) white prepupae 12hr  (4079) white prepupae 24hr  (5560) pupae 2d postWPP  (6412) pupae 3d postWPP  (7144) pupae 4d postWPP  (8354) adult male 01day  (11680) adult male 05day  (14548) adult male 30day  (17009) adult female 01day  (4714) adult female 05day  (4082) adult female 30day  (4254) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4615 embryo 02-04hr    7696 embryo 04-06hr    7823 embryo 06-08hr    4208 embryo 08-10hr    3211 embryo 10-12hr    2597 embryo 12-14hr    1977 embryo 14-16hr    2555 embryo 16-18hr    2287 embryo 18-20hr    1786 embryo 20-22hr    2121 embryo 22-24hr    2086 larva L1    3622 larva L2    3890 larva L3 12hr old    3253 larva L3 puffstage 1-2    3413 larva L3 puffstage 3-6    3773 larva L3 puffstage 7-9    3613 white prepupae new    3485 white prepupae 12hr    4079 white prepupae 24hr    5560 pupae 2d postWPP    6412 pupae 3d postWPP    7144 pupae 4d postWPP    8354 adult male 01day  (11680) adult male 05day  (14548) adult male 30day  (17009) adult female 01day    4714 adult female 05day    4082 adult female 30day    4254 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4615 embryo 02-04hr    7696 embryo 04-06hr    7823 embryo 06-08hr    4208 embryo 08-10hr    3211 embryo 10-12hr    2597 embryo 12-14hr    1977 embryo 14-16hr    2555 embryo 16-18hr    2287 embryo 18-20hr    1786 embryo 20-22hr    2121 embryo 22-24hr    2086 larva L1    3622 larva L2    3890 larva L3 12hr old    3253 larva L3 puffstage 1-2    3413 larva L3 puffstage 3-6    3773 larva L3 puffstage 7-9    3613 white prepupae new    3485 white prepupae 12hr    4079 white prepupae 24hr    5560 pupae 2d postWPP    6412 pupae 3d postWPP    7144 pupae 4d postWPP    8354 adult male 01day    11680 adult male 05day    14548 adult male 30day    17009 adult female 01day    4714 adult female 05day    4082 adult female 30day    4254 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032229 expression level Developmental Stage   Expression Level embryo 00-02hr    4615 embryo 02-04hr    7696 embryo 04-06hr    7823 embryo 06-08hr    4208 embryo 08-10hr    3211 embryo 10-12hr    2597 embryo 12-14hr    1977 embryo 14-16hr    2555 embryo 16-18hr    2287 embryo 18-20hr    1786 embryo 20-22hr    2121 embryo 22-24hr    2086 larva L1    3622 larva L2    3890 larva L3 12hr old    3253 larva L3 puffstage 1-2    3413 larva L3 puffstage 3-6    3773 larva L3 puffstage 7-9    3613 white prepupae new    3485 white prepupae 12hr    4079 white prepupae 24hr    5560 pupae 2d postWPP    6412 pupae 3d postWPP    7144 pupae 4d postWPP    8354 adult male 01day    11680 adult male 05day    14548 adult male 30day    17009 adult female 01day    4714 adult female 05day    4082 adult female 30day    4254 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4615) embryo 02-04hr  (7696) embryo 04-06hr  (7823) embryo 06-08hr  (4208) embryo 08-10hr  (3211) embryo 10-12hr  (2597) embryo 12-14hr  (1977) embryo 14-16hr  (2555) embryo 16-18hr  (2287) embryo 18-20hr  (1786) embryo 20-22hr  (2121) embryo 22-24hr  (2086) larva L1  (3622) larva L2  (3890) larva L3 12hr old  (3253) larva L3 puffstage 1-2  (3413) larva L3 puffstage 3-6  (3773) larva L3 puffstage 7-9  (3613) white prepupae new  (3485) white prepupae 12hr  (4079) white prepupae 24hr  (5560) pupae 2d postWPP  (6412) pupae 3d postWPP  (7144) pupae 4d postWPP  (8354) adult male 01day  (11680) adult male 05day  (14548) adult male 30day  (17009) adult female 01day  (4714) adult female 05day  (4082) adult female 30day  (4254) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4615) embryo 02-04hr  (7696) embryo 04-06hr  (7823) embryo 06-08hr  (4208) embryo 08-10hr  (3211) embryo 10-12hr  (2597) embryo 12-14hr  1977 embryo 14-16hr  (2555) embryo 16-18hr  2287 embryo 18-20hr  1786 embryo 20-22hr  2121 embryo 22-24hr  2086 larva L1  (3622) larva L2  (3890) larva L3 12hr old  (3253) larva L3 puffstage 1-2  (3413) larva L3 puffstage 3-6  (3773) larva L3 puffstage 7-9  (3613) white prepupae new  (3485) white prepupae 12hr  (4079) white prepupae 24hr  (5560) pupae 2d postWPP  (6412) pupae 3d postWPP  (7144) pupae 4d postWPP  (8354) adult male 01day  (11680) adult male 05day  (14548) adult male 30day  (17009) adult female 01day  (4714) adult female 05day  (4082) adult female 30day  (4254) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4615 embryo 02-04hr    7696 embryo 04-06hr    7823 embryo 06-08hr    4208 embryo 08-10hr    3211 embryo 10-12hr    2597 embryo 12-14hr    1977 embryo 14-16hr    2555 embryo 16-18hr    2287 embryo 18-20hr    1786 embryo 20-22hr    2121 embryo 22-24hr    2086 larva L1    3622 larva L2    3890 larva L3 12hr old    3253 larva L3 puffstage 1-2    3413 larva L3 puffstage 3-6    3773 larva L3 puffstage 7-9    3613 white prepupae new    3485 white prepupae 12hr    4079 white prepupae 24hr    5560 pupae 2d postWPP    6412 pupae 3d postWPP    7144 pupae 4d postWPP    8354 adult male 01day  11680 adult male 05day  14548 adult male 30day  17009 adult female 01day    4714 adult female 05day    4082 adult female 30day    4254 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4615 embryo 02-04hr    7696 embryo 04-06hr    7823 embryo 06-08hr    4208 embryo 08-10hr    3211 embryo 10-12hr    2597 embryo 12-14hr    1977 embryo 14-16hr    2555 embryo 16-18hr    2287 embryo 18-20hr    1786 embryo 20-22hr    2121 embryo 22-24hr    2086 larva L1    3622 larva L2    3890 larva L3 12hr old    3253 larva L3 puffstage 1-2    3413 larva L3 puffstage 3-6    3773 larva L3 puffstage 7-9    3613 white prepupae new    3485 white prepupae 12hr    4079 white prepupae 24hr    5560 pupae 2d postWPP    6412 pupae 3d postWPP    7144 pupae 4d postWPP    8354 adult male 01day    11680 adult male 05day    14548 adult male 30day    17009 adult female 01day    4714 adult female 05day    4082 adult female 30day    4254 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032229    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032229 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032229 expression level Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye    583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis    1549.7 Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye  (583.4) Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis  (1549.7) Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye    583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis  (1549.7) Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye    583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis    1549.7 Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032229 expression level Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye    583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis    1549.7 Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye  583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis  (1549.7) Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye    583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis  1549.7 Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    273.8 Larval Midgut    248 Larval Hindgut    329.7 Larval Malpighian Tubules    335.4 Larval Fat Body    413.3 Larval Salivary Gland    460.3 Larval Trachea    412.475 Larval Carcass    238 Adult Head    337.1 Adult Eye    583.4 Adult Brain    314.8 Adult Thoracic-Abdominal Ganglion    274.6 Adult Crop    368.3 Adult Midgut    395.9 Adult Hindgut    390.8 Adult Malpighian Tubules    376.1 Adult Fat Body    398.2 Adult Salivary Gland    452.9 Adult Heart    388.65 Adult VirginFemale Spermatheca    309 Adult InseminatedFemale Spermatheca    327.7 Adult Ovary    294.5 Adult Testis    1549.7 Adult Male Accessory Gland    345.1 Adult Carcass    338.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    337.1   NA  Eye    583.4   NA  Brain    314.8   273.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    274.6   NA  Crop    368.3   248  Midgut    395.9   329.7  Hindgut    390.8   335.4  Malpighian Tubules    376.1   413.3  Fat Body    398.2   460.3  Salivary Gland    452.9   NA  Heart    388.65   412.475  Trachea    NA   NA  VirginFemale Spermatheca    309   NA  InseminatedFemale Spermatheca    327.7   NA  Ovary    294.5   NA  Testis    1549.7   NA  Male Accessory Gland    345.1   238  Carcass    338.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5045-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5045GD11514 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of CG5045 Class Mutagen Stocks Known lesion CG5045100 P-element activity 0 Yes CG504516 P-element activity 0 Yes CG5045G2412 0 Yes
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5045 Class Mutagen Stocks Known lesion CG5045GD11514 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG5045KK100861 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Partially disrupted in	Df(2L)Cand116 (Kim et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11514} NA P{KK100861} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG5045G2412 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase activity inferred from sequence or structural similarity with EMBL:AJ005253 (FlyBase, 1992-)
Biological Process
CV term Evidence References
proteolysis inferred from sequence or structural similarity with UniProtKB:Q16740 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrion inferred from sequence or structural similarity with EMBL:AJ005253 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q16740 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5045 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60487 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032229 DroID - A comprehensive database of gene and protein interactions. • FBgn0032229 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34402
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15771 Dere\GG10114 Dgri\GH13604 Dmoj\GI20379 Dper\GL19149 Dpse\GA18618 Dsec\GM18225 Dsim\GD23683 Dvir\GJ13731 Dwil\GK15263 Dyak\GE18928
Curated drosophilid orthologs	Dpse\GA18618
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001797-PA Aedes aegypti (mosquito) AGAP009019-PA Anopheles gambiae (mosquito) XP_392540.2 Apis mellifera (honey bee) XP_001952413.1 Acyrthosiphon pisum (pea aphid) At5g23140.1 Arabidopsis thaliana (wall cress) 91564 Batrachochytrium dendrobatidis (chytrid fungus) 289482 Branchiostoma floridae (lancelet) 92198 Branchiostoma floridae (lancelet) XP_001900878.1 Brugia malayi (roundworm nematode) ENSBTAP00000019577 Bos taurus (bovine) CN12190 Caenorhabditis brenneri (small nematode) CBP30799 Caenorhabditis briggsae (nematode) CE02402 Caenorhabditis elegans (worm) ENSCAFP00000027588 Canis familiaris (dog) ENSCINP00000009302 Ciona intestinalis (sea squirt) CMQ045C Cyanidioschyzon merolae (red alga) cn14134 Cryptococcus neoformans (yeast-like fungus) CPIJ010938 Culex pipens (mosquito) ENSCPOP00000012572 Cavia porcellus (guinea pig) 120016 Chlamidomonas reinhardtii (green alga) RP34166 Caenorhabditis remanei (nematode) ENSCSAVP00000013661 Ciona savignyi (sedentary tunicate) 163852 Capitella spl (polychaete worm) 231060 Daphnia pulex (daphnia) ENSDARP00000013890 Danio rerio (zebra fish) ENSECAP00000020480 Equus caballus (horse) NP_414971.1 Escherichia coli K12 (bacteria) ENSGACP00000007293 Gymnopilus aculeatus (mushroom) 84094 Hypsipyla robusta (cedar shoot borer) ENSP00000245816 Homo sapiens (human) ISCW021455-PA Ixodes scapularis (deer tick) 162533 Lottia gigantea (owl limpet) 25007 Monocosta brevicollis (choanoflagellate) ENSMMUP00000031933 Macaca mulatta (rhesus monkey) ENSMUSP00000002735 Mus musculus (house mouse) 192713 Nematostella vectensis (starlet anemone) XP_001599209.1 Nasonia vitripennis (wasp) ENSOANP00000019340 Ornithorynchus anatinus (platypus) ENSORLP00000021659 Oryzias latipes (japanese killifish) LOC_Os04g44400.1 Oryza sativa (asian rice) 24901 Ostreococcus tauri (green alga) PF14_0348 Plasmodium falciparum (protozoal parasite) PHUM001001-PA Pediculus humanus (human body louse) PP20862 Pristionchus pacificus (nematode) 82283 Physcomitrella patens (moss) 94052 Phytophthora ramorum (sudden oak death pathogen) 156684 Phytophthora sojae (root rot pathogen) 562818 Populus trichocarpa (black cottonwood) 650895 Populus trichocarpa (black cottonwood) ENSPTRP00000017622 Pan troglodytes (chimpanzee) 133099 Sorghum bicolor (sorghum) XP_786892.2 Strongylocentrotus purpuratus (purple sea urchin) 64140 Trichoplax adhaerens (metazoa) TA16975 Theileria annulata (apicomplexan parasite) XP_971998.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017015 Tetraodon nigroviridis (green spotted pufferfish) TP04_0168 Theileria parva (parasitic protozoan) 18665 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031952 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000012276 Xenopus tropicalis (frog) YALI0F12353g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15725 NV18073 LH16644 ISCW021455 ISCW016708 FBgn0236301 FBgn0217268 FBgn0200952 FBgn0195060 FBgn0173132 JGI_V11_231060 FBgn0078619 FBgn0156748 FBgn0143115 FBgn0121080 FBgn0102426 FBgn0092795 CPIJ010938 BGIBMGA005089 ACYPI002586 GB10807 AGAP009019 AAEL001797 PHUM379750 GLEAN_04785 GLEAN_14333
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
VDRC	v103423 P{KK100861}VIE-260B v26688 w1118; P{GD11514}v26688 v26687 w1118; P{GD11514}v26687/CyO
Genomic Clones ( 2 )
	BACR30M19 BACR48K04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 58 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10833
Other clones	DPiM_GH10833
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT25145 GH10553 GH14824 GH17819 GH27627 LD47307 LP03734 LP11879 RE25567 RH11007 RH17101 RH33994 RH63330 SD11351 SD26288
Other clones	32525 69742 71389 78955 104747 119456 119528 125289 176721 bs06e02 bs11g06 bs17h06 bs30e07 bs36b10 bs36h09 bs39d05 CK01.36B.G11 CK01.44C.D12 CK01.74B.H9 CK01.117D.E1 EC13537 EC051627 EC051635 EC054111 EC054631 EC056401 EK000633 EK009608 EK031021 EK037748 EK044704 EK058331 EK073303 EK081507 EK089507 EK139404 EK198858 EK199728 EK206252 EK229761 EK281741
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34402
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135544 RefSeq (Proteins) • NP_609388 DDBJ / EMBL / GenBank • AAF52923 AAM50151 AI113979 AI114139 AI297555 AI402233 AI944875 AI945348 AI945878 AI946773 AI947195 AI947260 AY119497 Entrez Gene - A searchable database of RefSeq genes. • 34402 UniProtKB/TrEMBL • Q9VKY3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S14, ClpP (IPR001907) Peptidase S14, ClpP, active site (IPR018215) Peptidase S14/S49 (IPR023562) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME05045
Linkouts
	BioGRID - A database of protein and genetic interactions • 60487 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032229 DroID - A comprehensive database of gene and protein interactions. • FBgn0032229 DRSC - Results from RNAi screens. • FBgn0032229 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032229 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5045-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032229 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34402 InParanoid A subset of ortholog calls from InParanoid. • AAEL001797-PA Aedes aegypti (mosquito) AGAP009019-PA Anopheles gambiae (mosquito) XP_392540.2 Apis mellifera (honey bee) XP_001952413.1 Acyrthosiphon pisum (pea aphid) At5g23140.1 Arabidopsis thaliana (wall cress) 91564 Batrachochytrium dendrobatidis (chytrid fungus) 289482 Branchiostoma floridae (lancelet) 92198 Branchiostoma floridae (lancelet) XP_001900878.1 Brugia malayi (roundworm nematode) ENSBTAP00000019577 Bos taurus (bovine) CN12190 Caenorhabditis brenneri (small nematode) CBP30799 Caenorhabditis briggsae (nematode) CE02402 Caenorhabditis elegans (worm) ENSCAFP00000027588 Canis familiaris (dog) ENSCINP00000009302 Ciona intestinalis (sea squirt) CMQ045C Cyanidioschyzon merolae (red alga) cn14134 Cryptococcus neoformans (yeast-like fungus) CPIJ010938 Culex pipens (mosquito) ENSCPOP00000012572 Cavia porcellus (guinea pig) 120016 Chlamidomonas reinhardtii (green alga) RP34166 Caenorhabditis remanei (nematode) ENSCSAVP00000013661 Ciona savignyi (sedentary tunicate) 163852 Capitella spl (polychaete worm) 231060 Daphnia pulex (daphnia) ENSDARP00000013890 Danio rerio (zebra fish) ENSECAP00000020480 Equus caballus (horse) NP_414971.1 Escherichia coli K12 (bacteria) ENSGACP00000007293 Gymnopilus aculeatus (mushroom) 84094 Hypsipyla robusta (cedar shoot borer) ENSP00000245816 Homo sapiens (human) ISCW021455-PA Ixodes scapularis (deer tick) 162533 Lottia gigantea (owl limpet) 25007 Monocosta brevicollis (choanoflagellate) ENSMMUP00000031933 Macaca mulatta (rhesus monkey) ENSMUSP00000002735 Mus musculus (house mouse) 192713 Nematostella vectensis (starlet anemone) XP_001599209.1 Nasonia vitripennis (wasp) ENSOANP00000019340 Ornithorynchus anatinus (platypus) ENSORLP00000021659 Oryzias latipes (japanese killifish) LOC_Os04g44400.1 Oryza sativa (asian rice) 24901 Ostreococcus tauri (green alga) PF14_0348 Plasmodium falciparum (protozoal parasite) PHUM001001-PA Pediculus humanus (human body louse) PP20862 Pristionchus pacificus (nematode) 82283 Physcomitrella patens (moss) 94052 Phytophthora ramorum (sudden oak death pathogen) 156684 Phytophthora sojae (root rot pathogen) 562818 Populus trichocarpa (black cottonwood) 650895 Populus trichocarpa (black cottonwood) ENSPTRP00000017622 Pan troglodytes (chimpanzee) 133099 Sorghum bicolor (sorghum) XP_786892.2 Strongylocentrotus purpuratus (purple sea urchin) 64140 Trichoplax adhaerens (metazoa) TA16975 Theileria annulata (apicomplexan parasite) XP_971998.1 Tribolium castaneum (red flour beetle) ENSTNIP00000017015 Tetraodon nigroviridis (green spotted pufferfish) TP04_0168 Theileria parva (parasitic protozoan) 18665 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031952 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000012276 Xenopus tropicalis (frog) YALI0F12353g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34402 modMine - Data generated by the modENCODE project. • FBgn0032229 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15725 NV18073 LH16644 ISCW021455 ISCW016708 FBgn0236301 FBgn0217268 FBgn0200952 FBgn0195060 FBgn0173132 JGI_V11_231060 FBgn0078619 FBgn0156748 FBgn0143115 FBgn0121080 FBgn0102426 FBgn0092795 CPIJ010938 BGIBMGA005089 ACYPI002586 GB10807 AGAP009019 AAEL001797 PHUM379750 GLEAN_04785 GLEAN_14333
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG5045 (Keleman et al., 2009.8.5, Wasbrough et al., 2010, Kim et al., 2010)
Name Synonym
Secondary FlyBase IDs
References ( 13 )
Research paper	Kim et al., 2010, Dev. Biol. 346(2): 247--257 Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. [FBrf0211875]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Wasbrough et al., 2010, J. Proteomics 73(11): Supplemental Table 1. Mass spectrometry data. [FBrf0213252] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Coates, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126658]