General Information Symbol Dmel\ RfC3Species D. melanogaster Name Replication factor C subunit 3 Annotation symbol CG5313 Feature type protein_coding_gene FlyBase ID FBgn0032244 Gene Model Status Current Stock availability 3 publicly
available Genomic Location Chromosome (arm) 2L Recombination map Cytogenetic map 31E1-31E1 Sequence location 2L:10,419,190..10,420,612 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
Replication factor C subunit 3 is referred to in FlyBase by the symbol
Dmel\RfC3 (CG5313, FBgn0032244). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : DNA binding. There is experimental evidence that it is involved in the
biological process : lateral inhibition; neurogenesis.
3 alleles are reported . The
phenotypes of these alleles are annotated with: trichogen cell; chaeta. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: AAA+ ATPase domain; ATPase, AAA-type, core; DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal; Replication factor C, C-terminal domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1637166_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RfC3. Gene sequence location is
2L:10419190..10420612 .
User Contributed Data
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.45
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
High
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
178.525
Larval Midgut
23
Larval Hindgut
19.1
Larval Malpighian Tubules
17.4
Larval Fat Body
23.8
Larval Salivary Gland
68.1
Larval Trachea
75.675
Larval Carcass
44.325
Adult Head
20.4
Adult Eye
23.9
Adult Brain
30.5
Adult Thoracic-Abdominal Ganglion
40.5
Adult Crop
21.9
Adult Midgut
23.5
Adult Hindgut
18.1
Adult Malpighian Tubules
16.8
Adult Fat Body
11.2
Adult Salivary Gland
15.9
Adult Heart
16.55
Adult VirginFemale Spermatheca
18.9
Adult InseminatedFemale Spermatheca
21.9
Adult Ovary
291.8
Adult Testis
71.3
Adult Male Accessory Gland
100.2
Adult Carcass
16.1
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
20.4
NA
Eye
23.9
NA
Brain
30.5
178.525
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
40.5
NA
Crop
21.9
23
Midgut
no informative data
no informative data
Hindgut
no informative data
no informative data
Malpighian Tubules
no informative data
no informative data
Fat Body
no informative data
68.1
Salivary Gland
no informative data
NA
Heart
16.55
75.675
Trachea
NA
NA
VirginFemale Spermatheca
no informative data
NA
InseminatedFemale Spermatheca
21.9
NA
Ovary
291.8
NA
Testis
71.3
NA
Male Accessory Gland
100.2
44.325
Carcass
no informative data
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
33
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
(33)
ovary, mated 4-day female
(27)
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
33
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
33
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
33
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
(33)
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
33
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
9
central nervous system, larvae L3
8
central nervous system, pupae P8
2
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
1
head, mated 1-day female
1
head, mated 4-day female
1
head, mated 20-day female
1
head, mated 1-day male
1
head, mated 4-day male
2
head, mated 20-day male
2
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
2
digestive system, 1-day adult
2
digestive system, 4-day adult
2
digestive system, 20-day adult
3
fat body, larvae L3 wandering
0
fat body, white prepupae
2
fat body, pupae P8
1
carcass, larvae L3 wandering
6
carcass, 1-day adult
1
carcass, 4-day adult
2
carcass, 20-day adult
1
ovary, virgin 4-day female
33
ovary, mated 4-day female
27
testis, mated 4-day male
6
accessory gland, mated 4-day male
1
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
42
embryo 02-04hr
19
embryo 04-06hr
50
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(42)
embryo 02-04hr
19
embryo 04-06hr
(50)
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
(27)
adult female 30day
(29)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
42
embryo 02-04hr
19
embryo 04-06hr
50
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
42
embryo 02-04hr
19
embryo 04-06hr
50
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
42
embryo 02-04hr
19
embryo 04-06hr
50
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(42)
embryo 02-04hr
19
embryo 04-06hr
(50)
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
42
embryo 02-04hr
19
embryo 04-06hr
50
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
42
embryo 02-04hr
19
embryo 04-06hr
50
embryo 06-08hr
25
embryo 08-10hr
14
embryo 10-12hr
8
embryo 12-14hr
5
embryo 14-16hr
4
embryo 16-18hr
3
embryo 18-20hr
2
embryo 20-22hr
2
embryo 22-24hr
2
larva L1
8
larva L2
6
larva L3 12hr old
6
larva L3 puffstage 1-2
6
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
9
white prepupae new
7
white prepupae 12hr
14
white prepupae 24hr
10
pupae 2d postWPP
5
pupae 3d postWPP
4
pupae 4d postWPP
3
adult male 01day
4
adult male 05day
5
adult male 30day
5
adult female 01day
12
adult female 05day
27
adult female 30day
29
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
38
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
36
leg disc CME L1
14
wing disc CME-W2
35
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(38)
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
(36)
leg disc CME L1
14
wing disc CME-W2
(35)
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
(32)
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
(32)
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
(30)
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
38
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
36
leg disc CME L1
14
wing disc CME-W2
35
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
38
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
36
leg disc CME L1
14
wing disc CME-W2
35
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
38
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
36
leg disc CME L1
14
wing disc CME-W2
35
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(38)
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
(36)
leg disc CME L1
14
wing disc CME-W2
(35)
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
38
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
36
leg disc CME L1
14
wing disc CME-W2
35
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
38
Schneider line 2 Sg4
20
embryonic 1182-4H
15
embryonic GM2
16
embryonic Kc167
13
embryonic S1
23
embryonic S3
36
leg disc CME L1
14
wing disc CME-W2
35
wing disc ML-DmD8
16
wing disc ML-DmD9
19
wing disc ML-DmD16-c3
11
wing disc ML-DmD21
32
wing disc ML-DmD32
13
haltere disc ML-DmD17-c3
21
eye-antennal disc ML-DmD11
18
antennal disc ML-DmD20-c5
32
mixed discs ML-DmD4-c1
21
CNS ML-DmBG1-c1
13
CNS ML-DmBG2-c2
30
tumorous blood cells mbn2
21
ovary fGS/OSS
8
ovary OSC
9
ovary OSS
5
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
5
cold shock, 4-day adult
3
heat shock, 4-day adult
9
Cadmium 50 mM 6 hrs, larvae L3
5
Cadmium 50 mM 12 hrs, larvae L3
6
Cadmium 50 mM 48 hrs, 4-day adult
7
Cadmium 100 mM 48 hrs, 4-day adult
17
Copper 0.5 mM 12 hrs, larvae L3
0
Copper 15 mM 48 hrs, 4-day adult
9
Zinc 5 mM 12 hrs, larvae L3
0
Zinc 4.5 mM 48 hrs, 4-day adult
2
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
5
Ethanol 10% 3 hrs, larvae L3
4
Caffeine 1.5 mg/ml 4 hrs, larvae L3
4
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
5
Paraquat 5 mM 48 hrs, 4-day adult
14
Paraquat 10 mM 48 hrs, 4-day adult
10
Rotenone 2 μg 12 hrs, larvae L3
6
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 0 ) For All Classical Alleles Show Allele of
RfC3 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs
( 3 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Transgenic Constructs & Insertions
Transgenic Constructs Insertions Gene Ontology: Function, Process
& Cellular Component ( 8 unique terms ) Terms Based on
Experimental Evidence ( 3 terms ) Molecular Function ( 0 terms) Biological Process inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component inferred from direct assay
Terms Based on Predictions or
Assertions ( 5 terms ) Molecular Function inferred from sequence or structural similarity
Biological Process inferred from sequence or structural similarity
Cellular Component inferred from sequence or structural similarity
Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (44)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG615H0G )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG66WZJ3 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects
(EOG63TXR6 )
Apis mellifera
Western honey bee
Amel\LOC410266
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020126
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH14608
Atta cephalotes
Leafcutter ant
Acep\ACEP19095
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO20188
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL13375
Linepithema humile
Argentine ant
Lhum\LH16623
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB15266
Solenopsis invicta
Red fire ant
Sinv\SINV25753
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Orthologs in non-Insect Arthropods
(EOG6STQM8 )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG679T1Q )
Caenorhabditis elegans
Nematode
Y
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (2)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 3 )VDRC Genomic Clones ( 2 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 11 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for identity of: RfC3 CG5313
Source for database merge of Additional comments Source for identity of RfC3 CG5313 was sequence comparison (date:000414).
Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 7 )Reported As Symbol Synonym Name Synonym Drosophila replication factor C
Replication factor C subunit 3
Secondary FlyBase
IDs References ( 29 )Generate a list of List References by type
Recent research papers ( 2 )
Érdi et al., 2012, Autophagy 8(7): 1124--1135Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. [FBrf0219844] Davis et al., 2011, BMC Dev. Biol. 11: 66Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830]