Gene Dmel\CG6750

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General Information

Symbol

Dmel\CG6750

Species

D. melanogaster

Name

Annotation symbol

CG6750

Feature type

protein_coding_gene

FlyBase ID

FBgn0032292

Gene Model Status

Current

Stock availability

6 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

32A5-32A5

Sequence location

2L:10,731,400..10,732,423 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG6750 (FBgn0032292). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: wound healing. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein of unknown function DUF106, transmembrane; Uncharacterised conserved protein UCP010045, transmembrane eukaryotic. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult heart, adult fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634883_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6750. Gene sequence location is 2L:10731400..10732423.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

32A5-32A5

Limits computationally determined from genome sequence between P{PZ}dbf¹ and P{lacW}SCAR^k03107

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG6750 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG6750-RA

FBtr0080122

NM_135600

964

247

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG6750-PA

FBpp0079711

27.7

247

8.77

NP_609444

AAF53000

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Uncharacterised conserved protein UCP010045, transmembrane eukaryotic (IPR008568)

Protein of unknown function DUF106, transmembrane (IPR002809)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VKR0

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult heart, adult fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		(631.525)
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		232.25
Larval Midgut		203.3
Larval Hindgut		261.2
Larval Malpighian Tubules		236.6
Larval Fat Body		230.4
Larval Salivary Gland		350.2
Larval Trachea		230.825
Larval Carcass		221.625
Adult Head		237.7
Adult Eye		331.35
Adult Brain		228.4
Adult Thoracic-Abdominal Ganglion		240.7
Adult Crop		374.1
Adult Midgut		261.6
Adult Hindgut		279.6
Adult Malpighian Tubules		157.2
Adult Fat Body		516.5
Adult Salivary Gland		378.9
Adult Heart		631.525
Adult VirginFemale Spermatheca		162.9
Adult InseminatedFemale Spermatheca		178.4
Adult Ovary		406
Adult Testis		419.2
Adult Male Accessory Gland		384.4
Adult Carcass		441.8
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	237.7
NA	Eye	331.35
NA	Brain	228.4
232.25	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	240.7
NA	Crop	374.1
203.3	Midgut	261.6
261.2	Hindgut	279.6
236.6	Malpighian Tubules	157.2
230.4	Fat Body	516.5
350.2	Salivary Gland	378.9
NA	Heart	631.525
230.825	Trachea	NA
NA	VirginFemale Spermatheca	162.9
NA	InseminatedFemale Spermatheca	178.4
NA	Ovary	406
NA	Testis	419.2
NA	Male Accessory Gland	384.4
221.625	Carcass	441.8

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		37
central nervous system, pupae P8		35
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		42
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		36
head, mated 4-day male		31
head, mated 20-day male		42
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		33
carcass, 4-day adult		36
carcass, 20-day adult		47
ovary, virgin 4-day female		80
ovary, mated 4-day female		48
testis, mated 4-day male		199
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(105)
central nervous system, larvae L3		(37)
central nervous system, pupae P8		(35)
head, virgin 1-day female		(30)
head, virgin 4-day female		(32)
head, virgin 20-day female		(42)
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		(27)
head, mated 1-day male		(36)
head, mated 4-day male		(31)
head, mated 20-day male		(42)
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		(34)
digestive system, 1-day adult		(31)
digestive system, 4-day adult		26
digestive system, 20-day adult		(30)
fat body, larvae L3 wandering		12
fat body, white prepupae		(28)
fat body, pupae P8		(32)
carcass, larvae L3 wandering		(32)
carcass, 1-day adult		(33)
carcass, 4-day adult		(36)
carcass, 20-day adult		(47)
ovary, virgin 4-day female		(80)
ovary, mated 4-day female		(48)
testis, mated 4-day male		(199)
accessory gland, mated 4-day male		(49)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		37
central nervous system, pupae P8		35
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		42
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		36
head, mated 4-day male		31
head, mated 20-day male		42
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		33
carcass, 4-day adult		36
carcass, 20-day adult		47
ovary, virgin 4-day female		80
ovary, mated 4-day female		48
testis, mated 4-day male		(199)
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		37
central nervous system, pupae P8		35
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		42
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		36
head, mated 4-day male		31
head, mated 20-day male		42
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		33
carcass, 4-day adult		36
carcass, 20-day adult		47
ovary, virgin 4-day female		80
ovary, mated 4-day female		48
testis, mated 4-day male		199
accessory gland, mated 4-day male		49
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		37
central nervous system, pupae P8		35
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		42
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		36
head, mated 4-day male		31
head, mated 20-day male		42
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		33
carcass, 4-day adult		36
carcass, 20-day adult		47
ovary, virgin 4-day female		80
ovary, mated 4-day female		48
testis, mated 4-day male		199
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(105)
central nervous system, larvae L3		(37)
central nervous system, pupae P8		(35)
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		(42)
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		(36)
head, mated 4-day male		31
head, mated 20-day male		(42)
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		(34)
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		(33)
carcass, 4-day adult		(36)
carcass, 20-day adult		(47)
ovary, virgin 4-day female		(80)
ovary, mated 4-day female		(48)
testis, mated 4-day male		(199)
accessory gland, mated 4-day male		(49)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		37
central nervous system, pupae P8		35
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		42
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		36
head, mated 4-day male		31
head, mated 20-day male		42
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		33
carcass, 4-day adult		36
carcass, 20-day adult		47
ovary, virgin 4-day female		80
ovary, mated 4-day female		48
testis, mated 4-day male		(199)
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		105
central nervous system, larvae L3		37
central nervous system, pupae P8		35
head, virgin 1-day female		30
head, virgin 4-day female		32
head, virgin 20-day female		42
head, mated 1-day female		18
head, mated 4-day female		20
head, mated 20-day female		27
head, mated 1-day male		36
head, mated 4-day male		31
head, mated 20-day male		42
salivary gland, larvae L3 wandering		10
salivary gland, white prepupae		10
digestive system, larvae L3 wandering		34
digestive system, 1-day adult		31
digestive system, 4-day adult		26
digestive system, 20-day adult		30
fat body, larvae L3 wandering		12
fat body, white prepupae		28
fat body, pupae P8		32
carcass, larvae L3 wandering		32
carcass, 1-day adult		33
carcass, 4-day adult		36
carcass, 20-day adult		47
ovary, virgin 4-day female		80
ovary, mated 4-day female		48
testis, mated 4-day male		199
accessory gland, mated 4-day male		49
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		107
embryo 02-04hr		86
embryo 04-06hr		58
embryo 06-08hr		68
embryo 08-10hr		75
embryo 10-12hr		90
embryo 12-14hr		67
embryo 14-16hr		61
embryo 16-18hr		48
embryo 18-20hr		41
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		49
larva L2		76
larva L3 12hr old		52
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		43
larva L3 puffstage 7-9		47
white prepupae new		48
white prepupae 12hr		36
white prepupae 24hr		47
pupae 2d postWPP		63
pupae 3d postWPP		55
pupae 4d postWPP		39
adult male 01day		56
adult male 05day		76
adult male 30day		68
adult female 01day		46
adult female 05day		55
adult female 30day		62
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(107)
embryo 02-04hr		(86)
embryo 04-06hr		(58)
embryo 06-08hr		(68)
embryo 08-10hr		(75)
embryo 10-12hr		(90)
embryo 12-14hr		(67)
embryo 14-16hr		(61)
embryo 16-18hr		(48)
embryo 18-20hr		(41)
embryo 20-22hr		(29)
embryo 22-24hr		26
larva L1		(49)
larva L2		(76)
larva L3 12hr old		(52)
larva L3 puffstage 1-2		(31)
larva L3 puffstage 3-6		(43)
larva L3 puffstage 7-9		(47)
white prepupae new		(48)
white prepupae 12hr		(36)
white prepupae 24hr		(47)
pupae 2d postWPP		(63)
pupae 3d postWPP		(55)
pupae 4d postWPP		(39)
adult male 01day		(56)
adult male 05day		(76)
adult male 30day		(68)
adult female 01day		(46)
adult female 05day		(55)
adult female 30day		(62)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		107
embryo 02-04hr		86
embryo 04-06hr		58
embryo 06-08hr		68
embryo 08-10hr		75
embryo 10-12hr		90
embryo 12-14hr		67
embryo 14-16hr		61
embryo 16-18hr		48
embryo 18-20hr		41
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		49
larva L2		76
larva L3 12hr old		52
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		43
larva L3 puffstage 7-9		47
white prepupae new		48
white prepupae 12hr		36
white prepupae 24hr		47
pupae 2d postWPP		63
pupae 3d postWPP		55
pupae 4d postWPP		39
adult male 01day		56
adult male 05day		76
adult male 30day		68
adult female 01day		46
adult female 05day		55
adult female 30day		62
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		107
embryo 02-04hr		86
embryo 04-06hr		58
embryo 06-08hr		68
embryo 08-10hr		75
embryo 10-12hr		90
embryo 12-14hr		67
embryo 14-16hr		61
embryo 16-18hr		48
embryo 18-20hr		41
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		49
larva L2		76
larva L3 12hr old		52
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		43
larva L3 puffstage 7-9		47
white prepupae new		48
white prepupae 12hr		36
white prepupae 24hr		47
pupae 2d postWPP		63
pupae 3d postWPP		55
pupae 4d postWPP		39
adult male 01day		56
adult male 05day		76
adult male 30day		68
adult female 01day		46
adult female 05day		55
adult female 30day		62
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		107
embryo 02-04hr		86
embryo 04-06hr		58
embryo 06-08hr		68
embryo 08-10hr		75
embryo 10-12hr		90
embryo 12-14hr		67
embryo 14-16hr		61
embryo 16-18hr		48
embryo 18-20hr		41
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		49
larva L2		76
larva L3 12hr old		52
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		43
larva L3 puffstage 7-9		47
white prepupae new		48
white prepupae 12hr		36
white prepupae 24hr		47
pupae 2d postWPP		63
pupae 3d postWPP		55
pupae 4d postWPP		39
adult male 01day		56
adult male 05day		76
adult male 30day		68
adult female 01day		46
adult female 05day		55
adult female 30day		62
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(107)
embryo 02-04hr		(86)
embryo 04-06hr		(58)
embryo 06-08hr		(68)
embryo 08-10hr		(75)
embryo 10-12hr		(90)
embryo 12-14hr		(67)
embryo 14-16hr		(61)
embryo 16-18hr		(48)
embryo 18-20hr		(41)
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		(49)
larva L2		(76)
larva L3 12hr old		(52)
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		(43)
larva L3 puffstage 7-9		(47)
white prepupae new		(48)
white prepupae 12hr		(36)
white prepupae 24hr		(47)
pupae 2d postWPP		(63)
pupae 3d postWPP		(55)
pupae 4d postWPP		(39)
adult male 01day		(56)
adult male 05day		(76)
adult male 30day		(68)
adult female 01day		(46)
adult female 05day		(55)
adult female 30day		(62)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		107
embryo 02-04hr		86
embryo 04-06hr		58
embryo 06-08hr		68
embryo 08-10hr		75
embryo 10-12hr		90
embryo 12-14hr		67
embryo 14-16hr		61
embryo 16-18hr		48
embryo 18-20hr		41
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		49
larva L2		76
larva L3 12hr old		52
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		43
larva L3 puffstage 7-9		47
white prepupae new		48
white prepupae 12hr		36
white prepupae 24hr		47
pupae 2d postWPP		63
pupae 3d postWPP		55
pupae 4d postWPP		39
adult male 01day		56
adult male 05day		76
adult male 30day		68
adult female 01day		46
adult female 05day		55
adult female 30day		62
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		107
embryo 02-04hr		86
embryo 04-06hr		58
embryo 06-08hr		68
embryo 08-10hr		75
embryo 10-12hr		90
embryo 12-14hr		67
embryo 14-16hr		61
embryo 16-18hr		48
embryo 18-20hr		41
embryo 20-22hr		29
embryo 22-24hr		26
larva L1		49
larva L2		76
larva L3 12hr old		52
larva L3 puffstage 1-2		31
larva L3 puffstage 3-6		43
larva L3 puffstage 7-9		47
white prepupae new		48
white prepupae 12hr		36
white prepupae 24hr		47
pupae 2d postWPP		63
pupae 3d postWPP		55
pupae 4d postWPP		39
adult male 01day		56
adult male 05day		76
adult male 30day		68
adult female 01day		46
adult female 05day		55
adult female 30day		62
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		54
embryonic 1182-4H		53
embryonic GM2		76
embryonic Kc167		44
embryonic S1		129
embryonic S3		89
leg disc CME L1		60
wing disc CME-W2		49
wing disc ML-DmD8		25
wing disc ML-DmD9		50
wing disc ML-DmD16-c3		47
wing disc ML-DmD21		82
wing disc ML-DmD32		48
haltere disc ML-DmD17-c3		47
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		58
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		77
tumorous blood cells mbn2		59
ovary fGS/OSS		28
ovary OSC		45
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(88)
Schneider line 2 Sg4		(54)
embryonic 1182-4H		(53)
embryonic GM2		(76)
embryonic Kc167		(44)
embryonic S1		(129)
embryonic S3		(89)
leg disc CME L1		(60)
wing disc CME-W2		(49)
wing disc ML-DmD8		25
wing disc ML-DmD9		(50)
wing disc ML-DmD16-c3		(47)
wing disc ML-DmD21		(82)
wing disc ML-DmD32		(48)
haltere disc ML-DmD17-c3		(47)
eye-antennal disc ML-DmD11		(58)
antennal disc ML-DmD20-c5		(58)
mixed discs ML-DmD4-c1		(43)
CNS ML-DmBG1-c1		(58)
CNS ML-DmBG2-c2		(77)
tumorous blood cells mbn2		(59)
ovary fGS/OSS		(28)
ovary OSC		(45)
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		54
embryonic 1182-4H		53
embryonic GM2		76
embryonic Kc167		44
embryonic S1		(129)
embryonic S3		89
leg disc CME L1		60
wing disc CME-W2		49
wing disc ML-DmD8		25
wing disc ML-DmD9		50
wing disc ML-DmD16-c3		47
wing disc ML-DmD21		82
wing disc ML-DmD32		48
haltere disc ML-DmD17-c3		47
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		58
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		77
tumorous blood cells mbn2		59
ovary fGS/OSS		28
ovary OSC		45
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		54
embryonic 1182-4H		53
embryonic GM2		76
embryonic Kc167		44
embryonic S1		129
embryonic S3		89
leg disc CME L1		60
wing disc CME-W2		49
wing disc ML-DmD8		25
wing disc ML-DmD9		50
wing disc ML-DmD16-c3		47
wing disc ML-DmD21		82
wing disc ML-DmD32		48
haltere disc ML-DmD17-c3		47
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		58
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		77
tumorous blood cells mbn2		59
ovary fGS/OSS		28
ovary OSC		45
ovary OSS		16
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		54
embryonic 1182-4H		53
embryonic GM2		76
embryonic Kc167		44
embryonic S1		129
embryonic S3		89
leg disc CME L1		60
wing disc CME-W2		49
wing disc ML-DmD8		25
wing disc ML-DmD9		50
wing disc ML-DmD16-c3		47
wing disc ML-DmD21		82
wing disc ML-DmD32		48
haltere disc ML-DmD17-c3		47
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		58
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		77
tumorous blood cells mbn2		59
ovary fGS/OSS		28
ovary OSC		45
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(88)
Schneider line 2 Sg4		(54)
embryonic 1182-4H		(53)
embryonic GM2		(76)
embryonic Kc167		(44)
embryonic S1		(129)
embryonic S3		(89)
leg disc CME L1		(60)
wing disc CME-W2		(49)
wing disc ML-DmD8		25
wing disc ML-DmD9		(50)
wing disc ML-DmD16-c3		(47)
wing disc ML-DmD21		(82)
wing disc ML-DmD32		(48)
haltere disc ML-DmD17-c3		(47)
eye-antennal disc ML-DmD11		(58)
antennal disc ML-DmD20-c5		(58)
mixed discs ML-DmD4-c1		(43)
CNS ML-DmBG1-c1		(58)
CNS ML-DmBG2-c2		(77)
tumorous blood cells mbn2		(59)
ovary fGS/OSS		28
ovary OSC		(45)
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		54
embryonic 1182-4H		53
embryonic GM2		76
embryonic Kc167		44
embryonic S1		129
embryonic S3		89
leg disc CME L1		60
wing disc CME-W2		49
wing disc ML-DmD8		25
wing disc ML-DmD9		50
wing disc ML-DmD16-c3		47
wing disc ML-DmD21		82
wing disc ML-DmD32		48
haltere disc ML-DmD17-c3		47
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		58
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		77
tumorous blood cells mbn2		59
ovary fGS/OSS		28
ovary OSC		45
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		88
Schneider line 2 Sg4		54
embryonic 1182-4H		53
embryonic GM2		76
embryonic Kc167		44
embryonic S1		129
embryonic S3		89
leg disc CME L1		60
wing disc CME-W2		49
wing disc ML-DmD8		25
wing disc ML-DmD9		50
wing disc ML-DmD16-c3		47
wing disc ML-DmD21		82
wing disc ML-DmD32		48
haltere disc ML-DmD17-c3		47
eye-antennal disc ML-DmD11		58
antennal disc ML-DmD20-c5		58
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		58
CNS ML-DmBG2-c2		77
tumorous blood cells mbn2		59
ovary fGS/OSS		28
ovary OSC		45
ovary OSS		16
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		36
Cadmium 50 mM 48 hrs, 4-day adult		38
Cadmium 100 mM 48 hrs, 4-day adult		46
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		49
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		45
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		48
Paraquat 10 mM 48 hrs, 4-day adult		48
Rotenone 2 μg 12 hrs, larvae L3		44
Rotenone 8 μg 12 hrs, larvae L3		47
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		(28)
Cadmium 50 mM 6 hrs, larvae L3		(29)
Cadmium 50 mM 12 hrs, larvae L3		(36)
Cadmium 50 mM 48 hrs, 4-day adult		(38)
Cadmium 100 mM 48 hrs, 4-day adult		(46)
Copper 0.5 mM 12 hrs, larvae L3		(27)
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		(49)
Ethanol 5% 3 hrs, larvae L3		(30)
Ethanol 10% 3 hrs, larvae L3		(29)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		(28)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(45)
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		(48)
Paraquat 10 mM 48 hrs, 4-day adult		(48)
Rotenone 2 μg 12 hrs, larvae L3		(44)
Rotenone 8 μg 12 hrs, larvae L3		(47)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		36
Cadmium 50 mM 48 hrs, 4-day adult		38
Cadmium 100 mM 48 hrs, 4-day adult		46
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		49
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		45
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		48
Paraquat 10 mM 48 hrs, 4-day adult		48
Rotenone 2 μg 12 hrs, larvae L3		44
Rotenone 8 μg 12 hrs, larvae L3		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		36
Cadmium 50 mM 48 hrs, 4-day adult		38
Cadmium 100 mM 48 hrs, 4-day adult		46
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		49
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		45
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		48
Paraquat 10 mM 48 hrs, 4-day adult		48
Rotenone 2 μg 12 hrs, larvae L3		44
Rotenone 8 μg 12 hrs, larvae L3		47
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		36
Cadmium 50 mM 48 hrs, 4-day adult		38
Cadmium 100 mM 48 hrs, 4-day adult		46
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		49
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		45
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		48
Paraquat 10 mM 48 hrs, 4-day adult		48
Rotenone 2 μg 12 hrs, larvae L3		44
Rotenone 8 μg 12 hrs, larvae L3		47
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		(36)
Cadmium 50 mM 48 hrs, 4-day adult		(38)
Cadmium 100 mM 48 hrs, 4-day adult		(46)
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		(49)
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(45)
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		(48)
Paraquat 10 mM 48 hrs, 4-day adult		(48)
Rotenone 2 μg 12 hrs, larvae L3		(44)
Rotenone 8 μg 12 hrs, larvae L3		(47)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		36
Cadmium 50 mM 48 hrs, 4-day adult		38
Cadmium 100 mM 48 hrs, 4-day adult		46
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		49
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		45
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		48
Paraquat 10 mM 48 hrs, 4-day adult		48
Rotenone 2 μg 12 hrs, larvae L3		44
Rotenone 8 μg 12 hrs, larvae L3		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		23
cold shock, 4-day adult		19
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		36
Cadmium 50 mM 48 hrs, 4-day adult		38
Cadmium 100 mM 48 hrs, 4-day adult		46
Copper 0.5 mM 12 hrs, larvae L3		27
Copper 15 mM 48 hrs, 4-day adult		16
Zinc 5 mM 12 hrs, larvae L3		25
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		49
Ethanol 5% 3 hrs, larvae L3		30
Ethanol 10% 3 hrs, larvae L3		29
Caffeine 1.5 mg/ml 4 hrs, larvae L3		28
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		45
Caffeine 25 mg/ml 48 hrs, 4-day adult		19
Paraquat 5 mM 48 hrs, 4-day adult		48
Paraquat 10 mM 48 hrs, 4-day adult		48
Rotenone 2 μg 12 hrs, larvae L3		44
Rotenone 8 μg 12 hrs, larvae L3		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

LD37839

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0032292

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG6750-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | pupal stage, with Scer\GAL4^pnr-MD237

CG6750^GD1074

Phenotype manifest in

Allele

Classical Alleles ( 1 )

For All Classical Alleles Show

Allele of CG6750	Class	Mutagen	Stocks	Known lesion
CG6750^e02662		piggyBac transposase	3	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG6750	Mutagen	Stocks	Known lesion
CG6750^GD1074	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG6750^HMS02242	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG6750^KK101192	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)Exel8026

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD1074}

P{KK101192}

P{TRiP.HMS02242}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{RB}CG6750^e02662

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

There is no information supporting a molecular function term for this gene.

(Based on a review of available data on: 2010-03-25)

Terms Based on Experimental Evidence ( 1 term )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

wound healing

inferred from mutant phenotype

(Campos et al., 2010)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 1 term )

Molecular Function ( 0 terms)

Biological Process ( 0 terms)

Cellular Component

CV term

Evidence

References

membrane

inferred from electronic annotation with InterPro:IPR002809, InterPro:IPR008568

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

CG6750 - CG11137

experimental knowledge based

(Guruharsha et al., 2011)

CG6750 - CG2943

experimental knowledge based

(Guruharsha et al., 2011)

CG6750 - CG3501

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)

CG6750 - CG3678

experimental knowledge based

(Guruharsha et al., 2011)

CG6750 - Snap

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG6750 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0032292

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

34479

Orthologs

OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6QZ868

Dipteran inclusive ortholog search

EOG61JZN8

Insect inclusive ortholog search

EOG67H4M4

Arthropod inclusive ortholog search

EOG62NGGG

Metazoa inclusive ortholog search

EOG66DZX1

Orthologs in Drosophila Species (EOG6QZ868)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19832

Drosophila persimilis

Dper\GL26390

Drosophila willistoni

Dwil\GK15452

Drosophila virilis

Dvir\GJ17648

Drosophila mojavensis

Dmoj\GI17819

Drosophila grimshawi

Dgri\GH17887

Orthologs in non-Drosophila Dipterans (EOG61JZN8)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006611

Anopheles gambiae

Malaria mosquito

Agam\AGAP007885

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ802181

Orthologs in non-Dipteran Insects (EOG67H4M4)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC551505

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007272

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH21044

Atta cephalotes

Leafcutter ant

Acep\ACEP21833

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO21924

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL23167

Linepithema humile

Argentine ant

Lhum\LH13551

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB25155

Solenopsis invicta

Red fire ant

Sinv\SINV22529

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI084297

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI070418

Bombyx mori

Silkmoth

Bmor\BGIBMGA006981

Pediculus humanus

Human body louse

Phum\PHUM080340

Tribolium castaneum

Red flour beetle

Tcas\TC000094

Orthologs in non-Insect Arthropods (EOG62NGGG)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\JGI_V11_231825

Ixodes scapularis

Deer tick

Isca\ISCW022478

Orthologs in non-Arthropod Metazoa (EOG66DZX1)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\Y62E10A.10

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_002817gn

Danio rerio

Zebrafish

Drer\DKEY-181C21.1

Danio rerio

Zebrafish

Drer\tmem111

Xenopus tropicalis

Western clawed frog

Xtro\tmem111.2

Xenopus tropicalis

Western clawed frog

Xtro\tmem111

Gallus gallus

Domestic chicken

Ggal\TMEM111

Mus musculus

House mouse

Mmus\Tmem111

Rattus norvegicus

Norway rat

Rnor\Tmem111

Homo sapiens

Human

Hsap\TMEM111

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\TMEM111

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19832

Drosophila persimilis

Dper\GL26390

Drosophila willistoni

Dwil\GK15452

Drosophila virilis

Dvir\GJ17648

Drosophila mojavensis

Dmoj\GI17819

Drosophila grimshawi

Dgri\GH17887

Stocks & Reagents

Stocks Listed in FlyBase ( 6 )

Bloomington

41678

y¹ v¹; P{TRiP.HMS02242}attP2

18072

w¹¹¹⁸; PBac{RB}CG6750^e02662/CyO

Harvard

PBac{RB}CG6750^e02662

Kyoto

114504

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; PBac{RB}CG6750^e02662 P{neoFRT}40A/CyO y⁺

VDRC

v105637

P{KK101192}VIE-260B

v9408

w¹¹¹⁸ P{GD1074}v9408

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 19 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD37839

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0032292

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

34479

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_135600

RefSeq (Proteins)

•

NP_609444

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

34479

UniProtKB/TrEMBL

•

Q9VKR0

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Uncharacterised conserved protein UCP010045, transmembrane eukaryotic (IPR008568)

Protein of unknown function DUF106, transmembrane (IPR002809)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

LD37839

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0032292

DRSC - Results from RNAi screens.

•

FBgn0032292

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0032292

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG6750-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0032292

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

34479

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

34479

modMine - Data generated by the modENCODE project.

•

FBgn0032292

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG6750

(Vardanyan et al., 2008, Keleman et al., 2009.8.5, Campos et al., 2010, Cammarato et al., 2011, Yano et al., 2012, Ni et al., 2010.12.1)

Name Synonym

Secondary FlyBase IDs

References ( 21 )

Generate a list of

All references relating to this gene ( 21 )

List References by type

Research paper ( 4 )
Supplementary material ( 5 )
Personal communication to FlyBase ( 10 )
FlyBase analysis ( 1 )

Recent research papers ( 1 )

Yano et al., 2012, J. Neurogenet. 26(1): 53--63: Identification of proteasome components required for apical localization of chaoptin using functional genomics. [FBrf0217843]

Show all research papers ...