FlyBase Gene Report: Dmel\CycY

General Information

Symbol

Dmel\CycY

Species

D. melanogaster

Name

Cyclin Y

Annotation Symbol

CG14939

Feature Type

protein_coding_gene

FlyBase ID

FBgn0032378

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

cyclin that interacts with the cyclin dependent kinase Eip63E - has essential functions during embryogenesis, larval development, and metamorphosis - regulates wnt signaling (Interactive Fly, CycY )

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

33A2-33A2

Sequence location

2L:11,810,092..11,813,780 [-]

Recombination map

2-45

RefSeq locus

NT_033779 REGION:11810092..11813780

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cyclin-dependent protein serine/threonine kinase activator activity

inferred from mutant phenotype

(Davidson et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein kinase binding

inferred from electronic annotation with InterPro:IPR012399

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in developmental growth

inferred from mutant phenotype

(Liu and Finley, 2010)

involved_in positive regulation of canonical Wnt signaling pathway

inferred from mutant phenotype

(Davidson et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of canonical Wnt signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001285301

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000420501

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Pathway (FlyBase)

Positive Regulators of Wnt-TCF Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Pathway (FlyBase)

Positive Regulators of Wnt-TCF Signaling Pathway -: Positive regulators of Wnt-TCF (canonical Wnt) signaling up-regulate the pathway, resulting in the enhancement of transcriptional regulation mediated by β-catenin (arm).

Summary (Interactive Fly)

cyclin that interacts with the cyclin dependent kinase Eip63E - has essential functions during embryogenesis, larval development, and metamorphosis - regulates wnt signaling

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CycY for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VKF0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CycY-RA

FBtr0080259

NM_135675

2148

406

CycY-RB

FBtr0333425

NM_001273465

2553

406

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CycY-PA

FBpp0079843

45.1

406

6.69

FBpp0305616

45.1

406

6.69

Q9VKF0

NP_001260394

AGB92929

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

406 aa isoforms: CycY-PA, CycY-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VKF0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CycY using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.36

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CycY in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CycY

View exonic expression by tissue for Dmel\CycY

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032378

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34593/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032378

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032378

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032378

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14939

Flygut - An atlas of the Drosophila adult midgut

FBgn0032378

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CycY

Transgenic constructs containing regulatory region of CycY

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)CycY^E8

(Liu and Finley, 2010)

Df(2L)Exel6030

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Scer\GAL4^Mef2.PR

CycY^GD8494

viable, with Scer\GAL4^pnr-MD237

CycY^GD8494

viable, with Scer\GAL4^tin.CΔ4

CycY^GD8494

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (10)

Hsap\CCNY

14 of 14

Yes

Hsap\CCNYL1

11 of 14

Yes

Hsap\CCNYL2

5 of 14

Yes

Hsap\CCNYL3

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Ccny

14 of 14

Yes

Rnor\Ccnyl1

10 of 14

Yes

Rnor\Cnppd1

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\Ccny

14 of 14

Yes

Mmus\Ccnyl1

10 of 14

Yes

Mmus\Cnppd1

1 of 14

Xenopus tropicalis (Western clawed frog) (3)

Xtro\ccny

11 of 13

Yes

Xtro\ccnyl1

9 of 13

Yes

Xtro\LOC100492075

1 of 13

Yes

Danio rerio (Zebrafish) (3)

Drer\ccny

14 of 14

Yes

Drer\ccnyl1

10 of 14

Yes

Drer\cnppd1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\cyy-1

13 of 14

Yes

Cele\F09G2.2

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP008969

12 of 12

Yes

Agam\AgaP_AGAP009020

1 of 12

Arabidopsis thaliana (thale-cress) (8)

Atha\CYCP1;1

3 of 13

Yes

Atha\AT3G05327

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\CYCP4;2

2 of 13

Yes

Atha\CYCP4;3

2 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (11)

Scer\LAM1

2 of 13

Yes

Scer\SIP3

2 of 13

Yes

Scer\PCL1

1 of 13

Scer\PCL2

1 of 13

Scer\PCL5

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\psl1

1 of 12

Yes

Spom\SPAC19A8.02

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CycY. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

CG40191

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CCNY; cyclin Y

14 of 14

612786

CCNYL1; cyclin Y like 1

11 of 14

620559

CCNYL2; cyclin Y like 2 (pseudogene)

5 of 14

CCNYL3; cyclin Y like 3 (pseudogene)

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CycY - Eip63E

anti tag coimmunoprecipitation, anti tag western blot, two hybrid

(Liu and Finley, 2010)

CycY - stumps

two hybrid

(Battersby et al., 2003)

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60646

DroID - A comprehensive database of gene and protein interactions.

FBgn0032378

MIST (protein-protein) - An integrated Molecular Interaction Database

34593

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Wnt-TCF Signaling Pathway

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VKF0

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-45

Cytogenetic map

33A2-33A2

Sequence location

2L:11,810,092..11,813,780 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33A2-33A2

Limits computationally determined from genome sequence between P{PZ}crol⁰⁴⁴¹⁸&P{EP}crol^EP1183 and P{EP}MESK1^EP980

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-45

(FlyBase, 2016)

2-38.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

34175

y¹ w^*; Mi{MIC}CycY^MI01297

26950

y¹ w^*; P{EP}CycY^G18966/CyO, P{lArB}A208.1M2

34009

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00974}attP2

NIG-Fly

M2L-0373

y¹ w¹¹¹⁸; CycY^SK2 P{neoFRT}40A/CyO-Tb

M2L-0374

y¹ w¹¹¹⁸; CycY^SK5 P{neoFRT}40A/CyO-Tb

2LG-0303

y² VhaAC39-1^cho-1 v¹; P{U6-CycY.NIG.sgRNA}attP40/CyO

HMS00974

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00974}attP2/TM3, Sb¹

VDRC

v107010

P{KK101577}VIE-260B

v32334

w¹¹¹⁸; P{GD8494}v32334

v342103

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01574}attP40/CyO-GFP

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (90)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD31675

Other clones

DPiM_LD31675

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0032378

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0032378

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Area matching Drosophila ESTS AA979442 and AA392418 (inverted).

(Davies, 2001.3.15)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG14939 anon-WO0118547.165

(FlyBase, 1996-)

Additional comments

Source for merge of CG14939 anon-WO0118547.165 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: CycY CG14939

(Liu and Finley, 2010)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG14939

(National Institute of Genetics Fly Stocks, 2022-, Christis and Munro, 2012, Liu and Finley, 2010, Ni et al., 2010.12.1, Davidson et al., 2009, Keleman et al., 2009.8.5, Liu and Finley, 2008, Liu and Finley, 2007, Stanyon et al., 2004)

CycY

(Goins et al., 2024, Szlanka et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Liu and Finley, 2010)

Dcyclin Y

(Davidson et al., 2009)

anon-WO0118547.165

i182

(Battersby et al., 2003)

Name Synonyms

Cyclin Y

(Liu and Finley, 2010)

Drosophila cyclin Y

(Davidson et al., 2009)

Secondary FlyBase IDs

FBgn0062199

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34593

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VKF0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VKF0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VKF0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032378

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34593/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032378

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032378

FlyMine - An integrated database for Drosophila genomics

FBgn0032378

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG14939

MARRVEL_MODEL - MARRVEL (model organism gene)

34593

Linkouts

BioGRID - A database of protein and genetic interactions.

60646

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0032378

DroID - A comprehensive database of gene and protein interactions.

FBgn0032378

DRSC - Results frm RNAi screens

FBgn0032378

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032378

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0032378

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14939

Flygut - An atlas of the Drosophila adult midgut

FBgn0032378

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013890

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

34593

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VKF0

References (35)

The following external sites may use different assemblies or annotations than FlyBase.

-0.36

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