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Gene Dmel\escl

General Information
Symbol	Dmel\escl	Species	D. melanogaster
Name	escl	Annotation symbol	CG5202
Feature type	protein_coding_gene	FlyBase ID	FBgn0032391
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33B5-33B5	Sequence location	2L:11,990,927..11,992,848 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene escl is referred to in FlyBase by the symbol Dmel\escl (CG5202, FBgn0032391). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: histone methyltransferase activity. There is experimental evidence that it is involved in the biological process: histone H3-K27 methylation. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626638_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of escl. Gene sequence location is 2L:11990927..11992848.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Clones RE75220
FB2012_01	Sequence features HFA02828 BKN22487
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33B5-33B5   Limits computationally determined from genome sequence between P{EP}MESK1EP980 and P{PZ}l(2)0181001810&P{EP}CG6785EP340
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\escl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Atypical cDNA: retained intron (GH14744). DGC clone SD02661 appears problematic: unspliced intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) escl-RA FBtr0080286  NM_164979   1809   462
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein escl-PA   FBpp0079870   52.4   462   6.03     NP_723702   AAF53141
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, subgroup (IPR019781) WD40 repeat, conserved site (IPR019775) WD40 repeat 2 (IPR019782)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801933   AE014134 AAF53141   AI514817   AI531567   AW944258   AY060456 AAL25495   BT015954 AAV36839   BT128791   CO306979   CO324753   CZ472282   EC077460   EC235290   EV595233
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95SW6 Q9VKD5 Q2PDU4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032391    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032391 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032391 expression level Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (898) embryo 02-04hr  (161) embryo 04-06hr  (148) embryo 06-08hr  (143) embryo 08-10hr  (139) embryo 10-12hr  (163) embryo 12-14hr  (166) embryo 14-16hr  (150) embryo 16-18hr  (133) embryo 18-20hr    77 embryo 20-22hr  104 embryo 22-24hr    79 larva L1  (134) larva L2  (113) larva L3 12hr old    94 larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6  (241) larva L3 puffstage 7-9  (396) white prepupae new  (311) white prepupae 12hr  (472) white prepupae 24hr  (514) pupae 2d postWPP  (289) pupae 3d postWPP  (110) pupae 4d postWPP    80 adult male 01day  106 adult male 05day  (122) adult male 30day  107 adult female 01day  (266) adult female 05day  (572) adult female 30day  (585) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032391 expression level Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (898) embryo 02-04hr  (161) embryo 04-06hr  (148) embryo 06-08hr  143 embryo 08-10hr  139 embryo 10-12hr  (163) embryo 12-14hr  (166) embryo 14-16hr  (150) embryo 16-18hr  133 embryo 18-20hr    77 embryo 20-22hr  104 embryo 22-24hr    79 larva L1  134 larva L2  113 larva L3 12hr old    94 larva L3 puffstage 1-2  (167) larva L3 puffstage 3-6  (241) larva L3 puffstage 7-9  (396) white prepupae new  (311) white prepupae 12hr  (472) white prepupae 24hr  (514) pupae 2d postWPP  (289) pupae 3d postWPP  110 pupae 4d postWPP    80 adult male 01day  106 adult male 05day  122 adult male 30day  107 adult female 01day  (266) adult female 05day  (572) adult female 30day  (585) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    898 embryo 02-04hr    161 embryo 04-06hr    148 embryo 06-08hr    143 embryo 08-10hr    139 embryo 10-12hr    163 embryo 12-14hr    166 embryo 14-16hr    150 embryo 16-18hr    133 embryo 18-20hr    77 embryo 20-22hr    104 embryo 22-24hr    79 larva L1    134 larva L2    113 larva L3 12hr old    94 larva L3 puffstage 1-2    167 larva L3 puffstage 3-6    241 larva L3 puffstage 7-9    396 white prepupae new    311 white prepupae 12hr    472 white prepupae 24hr    514 pupae 2d postWPP    289 pupae 3d postWPP    110 pupae 4d postWPP    80 adult male 01day    106 adult male 05day    122 adult male 30day    107 adult female 01day    266 adult female 05day    572 adult female 30day    585 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032391    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032391 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032391 expression level Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032391 expression level Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    103.6 Larval Midgut    39 Larval Hindgut    34.8 Larval Malpighian Tubules    35.8 Larval Fat Body    21.8 Larval Salivary Gland no informative data Larval Trachea    12.325 Larval Carcass    23.025 Adult Head    28.5 Adult Eye    7.35 Adult Brain    75.8 Adult Thoracic-Abdominal Ganglion    52.1 Adult Crop    24.3 Adult Midgut    21.7 Adult Hindgut    17.4 Adult Malpighian Tubules    24.1 Adult Fat Body    17.9 Adult Salivary Gland no informative data Adult Heart    7.225 Adult VirginFemale Spermatheca    21.4 Adult InseminatedFemale Spermatheca    17.4 Adult Ovary    129.6 Adult Testis    12.9 Adult Male Accessory Gland    16.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    28.5   NA  Eye    7.35   NA  Brain    75.8   103.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    52.1   NA  Crop    24.3   39  Midgut    21.7   34.8  Hindgut    17.4   35.8  Malpighian Tubules    24.1   21.8  Fat Body    17.9   no informative data  Salivary Gland    no informative data   NA  Heart    7.225   12.325  Trachea    NA   NA  VirginFemale Spermatheca    21.4   NA  InseminatedFemale Spermatheca    17.4   NA  Ovary    129.6   NA  Testis    12.9   NA  Male Accessory Gland    16.8   23.025  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5202-RA;CG5202-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable escld01514 viable, with Scer\GAL4pnr-MD237 esclGD11575 esclGD16892 Sterility Allele fertile escld01514 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of escl Class Mutagen Stocks Known lesion escld01514 P-element activity 2 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of escl Class Mutagen Stocks Known lesion esclGD11575 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes esclGD16892 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes esclKK102406 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes escldsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes esclinc.Act.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes esclinc.esc.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes esclsp.esc.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes esclsp.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6031 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11575} NA P{GD16892} NA P{KK102406} NA P{UAS-escl.IR} NA characterization construct P{Act-Flag-escl.inc} NA P{esc-Flag-escl.inc} NA P{esc-Flag-escl.sp} NA P{escl-Flag-escl.sp} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{XP}escld01514 NA miscellaneous insertions P{wHy}CG6746DG09208 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function
CV term Evidence References
contributes_to histone methyltransferase activity inferred from direct assay (Ohno et al., 2008)
Biological Process
CV term Evidence References
histone H3-K27 methylation inferred from genetic interaction with esc (Ohno et al., 2008)
Cellular Component
CV term Evidence References
ESC/E(Z) complex inferred from direct assay (Ohno et al., 2008)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions escl allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0032391 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34611
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15137 Dere\GG23752 Dgri\GH13063 Dmoj\GI17683 Dper\GL18539 Dpse\GA18733 Dsec\GM26690 Dsim\GD23804 Dvir\GJ17469 Dwil\GK15174 Dyak\GE18559
Curated drosophilid orthologs	Dpse\GA18733
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014536-PA Aedes aegypti (mosquito) AGAP008550-PA Anopheles gambiae (mosquito) XP_623808.1 Apis mellifera (honey bee) XP_001949768.1 Acyrthosiphon pisum (pea aphid) 122984 Branchiostoma floridae (lancelet) 287986 Branchiostoma floridae (lancelet) BGIBMGA006325-PA Bombyx mori (silk worm) ENSBTAP00000010324 Bos taurus (bovine) CE24796 Caenorhabditis elegans (worm) ENSCAFP00000006672 Canis familiaris (dog) ENSCINP00000014284 Ciona intestinalis (sea squirt) CMK173C Cyanidioschyzon merolae (red alga) CPIJ000419 Culex pipens (mosquito) ENSCPOP00000001643 Cavia porcellus (guinea pig) 106725 Chlamidomonas reinhardtii (green alga) RP24772 Caenorhabditis remanei (nematode) RP31594 Caenorhabditis remanei (nematode) ENSCSAVP00000008464 Ciona savignyi (sedentary tunicate) 1436 Capitella spl (polychaete worm) 307962 Daphnia pulex (daphnia) ENSDARP00000059344 Danio rerio (zebra fish) ENSECAP00000014113 Equus caballus (horse) ENSGACP00000019715 Gymnopilus aculeatus (mushroom) ENSGALP00000001822 Gallus gallus (chicken) 105574 Hypsipyla robusta (cedar shoot borer) ENSP00000338186 Homo sapiens (human) ISCW022648-PA Ixodes scapularis (deer tick) 229029 Lottia gigantea (owl limpet) ENSMODP00000005243 Monodelphis domestica (gray opossum) ENSMMUP00000025774 Macaca mulatta (rhesus monkey) ENSMUSP00000032850 Mus musculus (house mouse) 102199 Nematostella vectensis (starlet anemone) XP_001607271.1 Nasonia vitripennis (wasp) ENSOANP00000014144 Ornithorynchus anatinus (platypus) LOC_Os08g04270.1 Oryza sativa (asian rice) PHUM004005-PA Pediculus humanus (human body louse) 61985 Physcomitrella patens (moss) ENSPPYP00000004284 Pongo pygmaeus (orangutan) ENSPTRP00000007124 Pan troglodytes (chimpanzee) ENSRNOP00000024082 Rattus norvegicus (norway rat) 4838275 Sorghum bicolor (sorghum) Smp_165220 Schistosoma mansoni (trematode parasite) XP_786345.2 Strongylocentrotus purpuratus (purple sea urchin) 31681 Trichoplax adhaerens (metazoa) XP_973780.1 Tribolium castaneum (red flour beetle) ENSTNIP00000004051 Tetraodon nigroviridis (green spotted pufferfish) 270065 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034091 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022912 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13162 NV11774 LH25107 ISCW022648 FBgn0235968 FBgn0217179 FBgn0204641 FBgn0195174 FBgn0181543 JGI_V11_307962 FBgn0078733 FBgn0156140 FBgn0140424 FBgn0120540 FBgn0115891 FBgn0092162 CPIJ000419 BGIBMGA006325 ACYPI008596 GB15930 AGAP008550 AAEL014536 PHUM331420 GLEAN_01356
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	19163 w1118; P{XP}escld01514
Harvard	- P{XP}escld01514
VDRC	v103747 P{KK102406}VIE-260B v27373 w1118; P{GD11575}v27373 v49982 w1118; P{GD16892}v49982 v27374 w1118; P{GD11575}v27374/TM3
Genomic Clones ( 1 )
	BACR37P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD02661 SD11903
Other clones	RE75220
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03605 LD46516
Other clones	66679 147527 Dmel_neb_012864_0695_3589 EK194733 EK252940
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34611
Antibody Information
	polyclonal (Wang et al., 2006, Tie et al., 2007, Kurzhals et al., 2008, Ohno et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: escl CG5202 (Harte, 2004.2.24)
Source for database merge of
Additional comments	"CG31864" is a putative chimeric gene derived from the "CG12264" and "escl" genes (where coding sequences of the two parental genes contribute to the coding sequence of the chimeric gene). (Rogers et al., 2009)
Other Comments
	escl may be required later in development, after esc protein disappears. (Kurzhals and Harte, 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_164979 RefSeq (Proteins) • NP_723702 DDBJ / EMBL / GenBank • AAF53141 AAF53141.1 AAL25495 AAN10792 AAV36839 AI531567 AW944258 AY060456 BT015954 CZ472282 Entrez Gene - A searchable database of RefSeq genes. • 34611 UniProtKB/TrEMBL • Q2PDU4 Q9VKD5 Q95SW6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40-repeat-containing domain (IPR017986) WD40/YVTN repeat-like-containing domain (IPR015943) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) WD40 repeat, subgroup (IPR019781) WD40 repeat, conserved site (IPR019775) WD40 repeat 2 (IPR019782)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0032391 DRSC - Results from RNAi screens. • FBgn0032391 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5202-RA;CG5202-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34611 InParanoid A subset of ortholog calls from InParanoid. • AAEL014536-PA Aedes aegypti (mosquito) AGAP008550-PA Anopheles gambiae (mosquito) XP_623808.1 Apis mellifera (honey bee) XP_001949768.1 Acyrthosiphon pisum (pea aphid) 122984 Branchiostoma floridae (lancelet) 287986 Branchiostoma floridae (lancelet) BGIBMGA006325-PA Bombyx mori (silk worm) ENSBTAP00000010324 Bos taurus (bovine) CE24796 Caenorhabditis elegans (worm) ENSCAFP00000006672 Canis familiaris (dog) ENSCINP00000014284 Ciona intestinalis (sea squirt) CMK173C Cyanidioschyzon merolae (red alga) CPIJ000419 Culex pipens (mosquito) ENSCPOP00000001643 Cavia porcellus (guinea pig) 106725 Chlamidomonas reinhardtii (green alga) RP24772 Caenorhabditis remanei (nematode) RP31594 Caenorhabditis remanei (nematode) ENSCSAVP00000008464 Ciona savignyi (sedentary tunicate) 1436 Capitella spl (polychaete worm) 307962 Daphnia pulex (daphnia) ENSDARP00000059344 Danio rerio (zebra fish) ENSECAP00000014113 Equus caballus (horse) ENSGACP00000019715 Gymnopilus aculeatus (mushroom) ENSGALP00000001822 Gallus gallus (chicken) 105574 Hypsipyla robusta (cedar shoot borer) ENSP00000338186 Homo sapiens (human) ISCW022648-PA Ixodes scapularis (deer tick) 229029 Lottia gigantea (owl limpet) ENSMODP00000005243 Monodelphis domestica (gray opossum) ENSMMUP00000025774 Macaca mulatta (rhesus monkey) ENSMUSP00000032850 Mus musculus (house mouse) 102199 Nematostella vectensis (starlet anemone) XP_001607271.1 Nasonia vitripennis (wasp) ENSOANP00000014144 Ornithorynchus anatinus (platypus) LOC_Os08g04270.1 Oryza sativa (asian rice) PHUM004005-PA Pediculus humanus (human body louse) 61985 Physcomitrella patens (moss) ENSPPYP00000004284 Pongo pygmaeus (orangutan) ENSPTRP00000007124 Pan troglodytes (chimpanzee) ENSRNOP00000024082 Rattus norvegicus (norway rat) 4838275 Sorghum bicolor (sorghum) Smp_165220 Schistosoma mansoni (trematode parasite) XP_786345.2 Strongylocentrotus purpuratus (purple sea urchin) 31681 Trichoplax adhaerens (metazoa) XP_973780.1 Tribolium castaneum (red flour beetle) ENSTNIP00000004051 Tetraodon nigroviridis (green spotted pufferfish) 270065 Thalassiosira pseudonana (marine diatom) ENSTRUP00000034091 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000022912 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34611 modMine - Data generated by the modENCODE project. • FBgn0032391 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13162 NV11774 LH25107 ISCW022648 FBgn0235968 FBgn0217179 FBgn0204641 FBgn0195174 FBgn0181543 JGI_V11_307962 FBgn0078733 FBgn0156140 FBgn0140424 FBgn0120540 FBgn0115891 FBgn0092162 CPIJ000419 BGIBMGA006325 ACYPI008596 GB15930 AGAP008550 AAEL014536 PHUM331420 GLEAN_01356
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG5202 (Huen, 2002.9.22, Gruenewald et al., 2009, Brodsky et al., 2004, Higa et al., 2006, Keleman et al., 2009.8.5, Zhan et al., 2011) CG5202-PA (Rogers et al., 2009) ESC (Higa et al., 2006) ESC1 (Higa et al., 2006) escl (Tie et al., 2007, Akdemir et al., 2007, Wang et al., 2006, Tie et al., 2007, Kurzhals et al., 2008, Rogers et al., 2010, Rogers et al., 2009, Ohno et al., 2008, Margueron et al., 2009) ESCL (Schwartz and Pirrotta, 2007, Tie et al., 2007, Tie et al., 2009) ESC-LIKE (Wang et al., 2005)
Name Synonym	escl   esc-like (Kurzhals and Harte, 2004, Kurzhals et al., 2008)
Secondary FlyBase IDs
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 2 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Zhan et al., 2011, Gene 470(1-2): 1--6 Evolution of alternative splicing in newly evolved genes of Drosophila. [FBrf0212278] Rogers et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(24): 10943--10948 Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. [FBrf0211052] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...