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Gene Dmel\CG6712

General Information
Symbol	Dmel\CG6712	Species	D. melanogaster
Name		Annotation symbol	CG6712
Feature type	protein_coding_gene	FlyBase ID	FBgn0032408
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33C4-33C4	Sequence location	2L:12,095,176..12,096,511 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6712 (FBgn0032408). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: RNA binding. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Anticodon-binding; Brix domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval hindgut, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1638350_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6712. Gene sequence location is 2L:12095176..12096510.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33C4-33C4   Limits computationally determined from genome sequence between P{EP}JhI-21EP1187 and P{lacW}Aats-thrk04203
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6712 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6712-RA FBtr0080364  NM_058131   1336   394
Additional Transcript Data & Comments
Reported size (kB)	1.4 (northern blot) (Lyko et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6712-PA   FBpp0079946   46.0   394   6.67     NP_477479   AAF53162
Additional Polypeptide Data & Comments
Reported size (kDa)	394 (aa) (Lyko et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Brix domain (IPR007109) Anticodon-binding (IPR004154)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202831   AA390378   AA940987   AA942425   AE014134 AAF53162   AC011066   AI514749   AI515323   AW942675   AY051683 AAK93107   BI162447   BI214686   BI229580   BI351688   BI352719   BI354528   BI356327   BI366211   BI367087   BI368667   BI370037   BI374787   BI636861   BI636950   BI640386   BI641614   CK660647   CO281195   CO325011   EC073214   EC257642   EV582607   EV593796   EV595269   GH755665   GH757163   GH771745   GH775262   GH778168   GH780088   GH781949   GH782946   GH784001   GH786686   GH789625   GH790193   GH790803   GH816498   GH823856   GH824371   GH836036   GH837937   GH838198   GH838757   GH840480   GH841726   GH842101   GH844667   GH845611   GH849359   GH851385   GH851771   GH856845   GH858578   GH861017   GH864003   GH866822   GH868605   GH872501   GH884285   GH890040   GH893268   GH897686   GH901519   GH905414   GH910084   GH911007   GH911978   GH912666   GH916039   GH917125   GH917320   GH919504   GH922536   GH927282   GH928149   GH928830   GH930845   GH932187   GH933730   GH938514   GH940611   GH940689
UniProtKB/Swiss-Prot	Q9VKB4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Lyko et al., 2000) presumptive embryonic/larval digestive system   (Lyko et al., 2000) neuroblast   (Lyko et al., 2000) embryonic stage | early   organism | ubiquitous   (Lyko et al., 2000) adult stage | female     (Lyko et al., 2000) ovary   (Lyko et al., 2000) adult stage & oogenesis stage S10   nurse cell   (Lyko et al., 2000)
Additional Descriptive Data
	CG6712 transcripts are observed in embryos and adult females. The female transcripts are retricted to the ovaries. In situ hybridization reveals that ovarian transcripts are localized primarily in the nurse cells in stage 10 egg chambers. Transcripts are ubiquitously distributed in blastoderm embryos and are restricted to neuroblasts and the gut at later embryonic stages. (Lyko et al., 2000)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval hindgut, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    309.9 Larval Midgut    76.2 Larval Hindgut    122.4 Larval Malpighian Tubules    43.7 Larval Fat Body    50.1 Larval Salivary Gland    167.2 Larval Trachea    247.4 Larval Carcass    148.075 Adult Head    81.4 Adult Eye    75.6 Adult Brain    64 Adult Thoracic-Abdominal Ganglion    84.8 Adult Crop    96.8 Adult Midgut    102.1 Adult Hindgut    70.5 Adult Malpighian Tubules    82.4 Adult Fat Body    114.6 Adult Salivary Gland    91.9 Adult Heart    87.525 Adult VirginFemale Spermatheca    102.5 Adult InseminatedFemale Spermatheca    153.4 Adult Ovary    392.8 Adult Testis    32.8 Adult Male Accessory Gland    218.3 Adult Carcass    79.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    81.4   NA  Eye    75.6   NA  Brain    64   309.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    84.8   NA  Crop    96.8   76.2  Midgut    102.1   122.4  Hindgut    70.5   43.7  Malpighian Tubules    82.4   50.1  Fat Body    114.6   167.2  Salivary Gland    91.9   NA  Heart    87.525   247.4  Trachea    NA   NA  VirginFemale Spermatheca    102.5   NA  InseminatedFemale Spermatheca    153.4   NA  Ovary    392.8   NA  Testis    32.8   NA  Male Accessory Gland    218.3   148.075  Carcass    79.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    40 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female    58 ovary, mated 4-day female    106 testis, mated 4-day male    26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (28) central nervous system, larvae L3  (40) central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult  (28) digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering  (36) carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (106) testis, mated 4-day male  26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    40 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female    58 ovary, mated 4-day female  106 testis, mated 4-day male    26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    40 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female    58 ovary, mated 4-day female    106 testis, mated 4-day male    26 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    40 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female    58 ovary, mated 4-day female    106 testis, mated 4-day male    26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  28 central nervous system, larvae L3  (40) central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult  28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering  (36) carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (106) testis, mated 4-day male  26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    40 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female    58 ovary, mated 4-day female  106 testis, mated 4-day male    26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    40 central nervous system, pupae P8    13 head, virgin 1-day female    12 head, virgin 4-day female    16 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    24 head, mated 20-day female    10 head, mated 1-day male    10 head, mated 4-day male    16 head, mated 20-day male    10 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    12 digestive system, 4-day adult    28 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    9 fat body, pupae P8    14 carcass, larvae L3 wandering    36 carcass, 1-day adult    11 carcass, 4-day adult    25 carcass, 20-day adult    13 ovary, virgin 4-day female    58 ovary, mated 4-day female    106 testis, mated 4-day male    26 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    72 embryo 04-06hr    68 embryo 06-08hr    75 embryo 08-10hr    71 embryo 10-12hr    65 embryo 12-14hr    40 embryo 14-16hr    29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    34 embryo 22-24hr    30 larva L1    60 larva L2    29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    27 adult female 05day    40 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (72) embryo 04-06hr  (68) embryo 06-08hr  (75) embryo 08-10hr  (71) embryo 10-12hr  (65) embryo 12-14hr  (40) embryo 14-16hr  (29) embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr  (34) embryo 22-24hr  (30) larva L1  (60) larva L2  (29) larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day  (27) adult female 05day  (40) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    72 embryo 04-06hr    68 embryo 06-08hr    75 embryo 08-10hr    71 embryo 10-12hr    65 embryo 12-14hr    40 embryo 14-16hr    29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    34 embryo 22-24hr    30 larva L1    60 larva L2    29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    27 adult female 05day    40 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    72 embryo 04-06hr    68 embryo 06-08hr    75 embryo 08-10hr    71 embryo 10-12hr    65 embryo 12-14hr    40 embryo 14-16hr    29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    34 embryo 22-24hr    30 larva L1    60 larva L2    29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    27 adult female 05day    40 adult female 30day    42 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    72 embryo 04-06hr    68 embryo 06-08hr    75 embryo 08-10hr    71 embryo 10-12hr    65 embryo 12-14hr    40 embryo 14-16hr    29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    34 embryo 22-24hr    30 larva L1    60 larva L2    29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    27 adult female 05day    40 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (51) embryo 02-04hr  (72) embryo 04-06hr  (68) embryo 06-08hr  (75) embryo 08-10hr  (71) embryo 10-12hr  (65) embryo 12-14hr  (40) embryo 14-16hr  29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr  (34) embryo 22-24hr  30 larva L1  (60) larva L2  29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day  27 adult female 05day  (40) adult female 30day  (42) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    72 embryo 04-06hr    68 embryo 06-08hr    75 embryo 08-10hr    71 embryo 10-12hr    65 embryo 12-14hr    40 embryo 14-16hr    29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    34 embryo 22-24hr    30 larva L1    60 larva L2    29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    27 adult female 05day    40 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    51 embryo 02-04hr    72 embryo 04-06hr    68 embryo 06-08hr    75 embryo 08-10hr    71 embryo 10-12hr    65 embryo 12-14hr    40 embryo 14-16hr    29 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    34 embryo 22-24hr    30 larva L1    60 larva L2    29 larva L3 12hr old    16 larva L3 puffstage 1-2    9 larva L3 puffstage 3-6    10 larva L3 puffstage 7-9    12 white prepupae new    11 white prepupae 12hr    11 white prepupae 24hr    10 pupae 2d postWPP    9 pupae 3d postWPP    5 pupae 4d postWPP    6 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    27 adult female 05day    40 adult female 30day    42 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    64 embryonic 1182-4H    49 embryonic GM2    26 embryonic Kc167    28 embryonic S1    56 embryonic S3    50 leg disc CME L1    79 wing disc CME-W2    52 wing disc ML-DmD8    43 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    109 wing disc ML-DmD21    100 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    72 antennal disc ML-DmD20-c5    72 mixed discs ML-DmD4-c1    144 CNS ML-DmBG1-c1    105 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    83 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (91) Schneider line 2 Sg4  (64) embryonic 1182-4H  (49) embryonic GM2  26 embryonic Kc167  (28) embryonic S1  (56) embryonic S3  (50) leg disc CME L1  (79) wing disc CME-W2  (52) wing disc ML-DmD8  (43) wing disc ML-DmD9  (56) wing disc ML-DmD16-c3  (109) wing disc ML-DmD21  (100) wing disc ML-DmD32  (73) haltere disc ML-DmD17-c3  (62) eye-antennal disc ML-DmD11  (72) antennal disc ML-DmD20-c5  (72) mixed discs ML-DmD4-c1  (144) CNS ML-DmBG1-c1  (105) CNS ML-DmBG2-c2  (96) tumorous blood cells mbn2  (41) ovary fGS/OSS  (78) ovary OSC  (83) ovary OSS  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    64 embryonic 1182-4H    49 embryonic GM2    26 embryonic Kc167    28 embryonic S1    56 embryonic S3    50 leg disc CME L1    79 wing disc CME-W2    52 wing disc ML-DmD8    43 wing disc ML-DmD9    56 wing disc ML-DmD16-c3  (109) wing disc ML-DmD21    100 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    72 antennal disc ML-DmD20-c5    72 mixed discs ML-DmD4-c1  (144) CNS ML-DmBG1-c1  105 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    83 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    64 embryonic 1182-4H    49 embryonic GM2    26 embryonic Kc167    28 embryonic S1    56 embryonic S3    50 leg disc CME L1    79 wing disc CME-W2    52 wing disc ML-DmD8    43 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    109 wing disc ML-DmD21    100 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    72 antennal disc ML-DmD20-c5    72 mixed discs ML-DmD4-c1    144 CNS ML-DmBG1-c1    105 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    83 ovary OSS    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    64 embryonic 1182-4H    49 embryonic GM2    26 embryonic Kc167    28 embryonic S1    56 embryonic S3    50 leg disc CME L1    79 wing disc CME-W2    52 wing disc ML-DmD8    43 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    109 wing disc ML-DmD21    100 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    72 antennal disc ML-DmD20-c5    72 mixed discs ML-DmD4-c1    144 CNS ML-DmBG1-c1    105 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    83 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (91) Schneider line 2 Sg4  (64) embryonic 1182-4H  (49) embryonic GM2  26 embryonic Kc167  28 embryonic S1  (56) embryonic S3  (50) leg disc CME L1  (79) wing disc CME-W2  (52) wing disc ML-DmD8  (43) wing disc ML-DmD9  (56) wing disc ML-DmD16-c3  (109) wing disc ML-DmD21  (100) wing disc ML-DmD32  (73) haltere disc ML-DmD17-c3  (62) eye-antennal disc ML-DmD11  (72) antennal disc ML-DmD20-c5  (72) mixed discs ML-DmD4-c1  (144) CNS ML-DmBG1-c1  (105) CNS ML-DmBG2-c2  (96) tumorous blood cells mbn2  (41) ovary fGS/OSS  (78) ovary OSC  (83) ovary OSS  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    64 embryonic 1182-4H    49 embryonic GM2    26 embryonic Kc167    28 embryonic S1    56 embryonic S3    50 leg disc CME L1    79 wing disc CME-W2    52 wing disc ML-DmD8    43 wing disc ML-DmD9    56 wing disc ML-DmD16-c3  109 wing disc ML-DmD21    100 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    72 antennal disc ML-DmD20-c5    72 mixed discs ML-DmD4-c1  (144) CNS ML-DmBG1-c1  105 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    83 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    91 Schneider line 2 Sg4    64 embryonic 1182-4H    49 embryonic GM2    26 embryonic Kc167    28 embryonic S1    56 embryonic S3    50 leg disc CME L1    79 wing disc CME-W2    52 wing disc ML-DmD8    43 wing disc ML-DmD9    56 wing disc ML-DmD16-c3    109 wing disc ML-DmD21    100 wing disc ML-DmD32    73 haltere disc ML-DmD17-c3    62 eye-antennal disc ML-DmD11    72 antennal disc ML-DmD20-c5    72 mixed discs ML-DmD4-c1    144 CNS ML-DmBG1-c1    105 CNS ML-DmBG2-c2    96 tumorous blood cells mbn2    41 ovary fGS/OSS    78 ovary OSC    83 ovary OSS    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  (27) heat shock, 4-day adult  (27) Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult  (32) Cadmium 100 mM 48 hrs, 4-day adult  (58) Copper 0.5 mM 12 hrs, larvae L3  (55) Copper 15 mM 48 hrs, 4-day adult  (53) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (61) Caffeine 25 mg/ml 48 hrs, 4-day adult  (40) Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (50) cold shock, 4-day adult  27 heat shock, 4-day adult  27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult  32 Cadmium 100 mM 48 hrs, 4-day adult  (58) Copper 0.5 mM 12 hrs, larvae L3  (55) Copper 15 mM 48 hrs, 4-day adult  (53) Zinc 5 mM 12 hrs, larvae L3  (37) Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3  (35) Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (61) Caffeine 25 mg/ml 48 hrs, 4-day adult  (40) Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (33) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    50 cold shock, 4-day adult    27 heat shock, 4-day adult    27 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    32 Cadmium 100 mM 48 hrs, 4-day adult    58 Copper 0.5 mM 12 hrs, larvae L3    55 Copper 15 mM 48 hrs, 4-day adult    53 Zinc 5 mM 12 hrs, larvae L3    37 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    35 Ethanol 5% 3 hrs, larvae L3    8 Ethanol 10% 3 hrs, larvae L3    17 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    40 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    33 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD23405 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032408 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6712-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 CG6712GD12012 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG6712GD12012 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CG6712GD12012
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG6712 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6712 Class Mutagen Stocks Known lesion CG6712GD12012 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6712KK101236 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6712NIG.6712R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6032 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12012} NA P{KK101236} NA P{NIG.6712R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from sequence or structural similarity with UniProtKB:Q9H9Y2 (assigned by UniProtKB) (UniProtKB Project Members, 2005.7.19)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleolus inferred from sequence or structural similarity with UniProtKB:Q9H9Y2 (assigned by UniProtKB) (UniProtKB Project Members, 2005.7.19)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG6712 - Aats-glupro anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Atg4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG10425 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG10566 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6712 - CG10688 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG1129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG12264 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG12301 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG1444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG14718 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG1532 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG15784 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG2182 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG5033 experimental knowledge based (Guruharsha et al., 2011) CG6712 - CG5043 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG7845 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6712 - CG8005 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG8801 experimental knowledge based (Guruharsha et al., 2011) CG6712 - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CG8939 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6712 - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - CkIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Cyp6d4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Eap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Fmo-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Hmgs anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6712 - Ice anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Lst8 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6712 - MRP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Nf-YB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Nnp-1 experimental knowledge based (Guruharsha et al., 2011) CG6712 - PH4αEFB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - PSR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Pop2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Pp1-87B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Rbm13 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6712 - RpL24-like experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) CG6712 - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) CG6712 - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - Vha55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - bcn92 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - l(1)G0469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - l(2)gl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - l(2)k12914 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - msn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - mtacp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - pit anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - slmb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6712 - tmod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6712 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032408 DroID - A comprehensive database of gene and protein interactions. • FBgn0032408 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34631
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BK5PV Dipteran inclusive ortholog search EOG6BG94S Insect inclusive ortholog search EOG6M3858 Arthropod inclusive ortholog search EOG65HQDR Metazoa inclusive ortholog search EOG6PCPN2
Orthologs in Drosophila Species (EOG6BK5PV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6712     Drosophila simulans   Dsim\GD22130 Y   Drosophila sechellia   Dsec\GM26329 Y   Drosophila erecta   Dere\GG10274 Y   Drosophila yakuba   Dyak\GE12424 Y   Drosophila ananassae   Dana\GF23434 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19804 Y   Drosophila persimilis   Dper\GL14129 Y   Drosophila willistoni   Dwil\GK21080 Y   Drosophila virilis   Dvir\GJ20668 Y   Drosophila mojavensis   Dmoj\GI14801 Y   Drosophila grimshawi   Dgri\GH10194 Y
Orthologs in non-Drosophila Dipterans (EOG6BG94S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004997   Anopheles gambiae Malaria mosquito  Agam\AGAP009968   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009285
Orthologs in non-Dipteran Insects (EOG6M3858)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410875   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005192   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17835   Atta cephalotes Leafcutter ant  Acep\ACEP21603   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18250   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17936   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22016   Linepithema humile Argentine ant  Lhum\LH17327   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14585   Solenopsis invicta Red fire ant  Sinv\SINV16791   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008315   Bombyx mori Silkmoth  Bmor\BGIBMGA007955   Pediculus humanus Human body louse  Phum\PHUM216950   Tribolium castaneum Red flour beetle  Tcas\TC003427
Orthologs in non-Insect Arthropods (EOG65HQDR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\COI   Ixodes scapularis Deer tick  Isca\ISCW018100
Orthologs in non-Arthropod Metazoa (EOG6PCPN2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F44G4.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001164gn   Danio rerio Zebrafish  Drer\rpf1   Xenopus tropicalis Western clawed frog  Xtro\rpf1   Gallus gallus Domestic chicken  Ggal\RPF1   Mus musculus House mouse  Mmus\Rpf1   Rattus norvegicus Norway rat  Rnor\Rpf1   Homo sapiens Human  Hsap\ENSG00000117133
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000117133
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22130 Drosophila sechellia Dsec\GM26329 Drosophila erecta Dere\GG10274 Drosophila yakuba Dyak\GE12424 Drosophila ananassae Dana\GF23434 Drosophila pseudoobscura pseudoobscura Dpse\GA19804 Drosophila persimilis Dper\GL14129 Drosophila willistoni Dwil\GK21080 Drosophila virilis Dvir\GJ20668 Drosophila mojavensis Dmoj\GI14801 Drosophila grimshawi Dgri\GH10194
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v103907 P{KK101236}VIE-260B v39012 w1118; P{GD12012}v39012
Genomic Clones ( 1 )
	BACR02B06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 90 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23405
Other clones	DPiM_LD23405
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM15706 GM20505 GM27193 LD03155 LD09132 LD26635 LD46427 LD47085 LP19388 RE01761 RE20684 RE27390 RE42443 RE51706 RE52761 RE54674 RE56406 RE62461 SD18694 SD18802 SD23225 SD25041
Other clones	38899 Dmel_dig_010730_0672_2093 Dmel_neb_004723_0582_1357 Dmel_neb_008344_0631_2279 EC257642 EK156155 EK195404 RP003048794 RP003065444 RP003083369 RP003100326 RP003114915 RP003135134 RP003152444 RP003161517 RP003175256 RP003179137 RP003182315 RP003188613 RP003197271 RP003216184 RP003230515 RP003239027 RP003240813 RP003243308 RP003255353 RP003259548 RP003269717 RP003270059 RP003279242 RP003282185 RP003284127 RP003289663 RP003293358 RP003314654 RP003327906 RP003332358 RP003352631 RP003409920 RP003415883 RP003433918 RP003454547 RP003465077 RP003469553 RP003473932 RP003479943 RP003483026 RP003483472 RP003484874 RP003492269 RP003495609 RP003510801 RP003516200 RP003529795 RP003550462 RP003551346 RP003570814 RP003578008 RP003589401 RP003610698 RP003611275 RP003623557 RP003638685 RP003653146 RP003655130 RP003670610
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032408 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34631
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene in combination with dsRNA against gig results in suppression of the final average cell size, with it being closer to the control average cell size, rather than the average cell size resulting from knockdown of the candidate gene alone. (Guertin et al., 2006) Several aspects of the organisation of the divergently transcribed, coordinately expressed Dnmt2 and CG6712 open reading frames suggest that they are components of a transposon-like element (although each of the two open reading frames appears to be encoded by a single copy locus in the genome at 33C--33D). Dnmt2 and CG6712 are tightly linked and neither open reading frame is interrupted by introns. There is a 12bp inverted repeat close to the 3' ends of both the open reading frames. Sequences homologous to Dnmt2 are present in a limited distribution of Drosophila species. Overall orientation not stated: Dnmt2- CG6712+ (Lyko et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058131 RefSeq (Proteins) • NP_477479 DDBJ / EMBL / GenBank • AA202831 AA390378 AA940987 AA942425 AAF53162 AAK93107 AC011066 AI514749 AI515323 AW942675 AY051683 Entrez Gene - A searchable database of RefSeq genes. • 34631 UniProtKB/Swiss-Prot • Q9VKB4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Brix domain (IPR007109) Anticodon-binding (IPR004154) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD23405
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0032408 DroID - A comprehensive database of gene and protein interactions. • FBgn0032408 DRSC - Results from RNAi screens. • FBgn0032408 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032408 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6712-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032408 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34631 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34631 modMine - Data generated by the modENCODE project. • FBgn0032408
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG6712 (UniProtKB Project Members, 2005.7.19, Guertin et al., 2006, Furrer et al., 2010, Yi et al., 2007, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21) ORF2 (Lyko et al., 2000)
Name Synonym
Secondary FlyBase IDs
References ( 20 )
Research paper	Furrer et al., 2010, J. Biol. Chem. 285(51): 39623--39636 Drosophila Myc Interacts with Host Cell Factor (dHCF) to Activate Transcription and Control Growth. [FBrf0212501] Yi et al., 2007, J. Cell Biol. 179(4): 619--626 A genome-wide RNAi screen reveals multiple regulators of caspase activation. [FBrf0200901] Guertin et al., 2006, Curr. Biol. 16(10): 958--970 Functional genomics identifies TOR-regulated genes that control growth and division. [FBrf0192539] Tang et al., 2003, J. Biol. Chem. 278(36): 33613--33616 The eukaryotic DNMT2 genes encode a new class of cytosine-5 DNA methyltransferases. [FBrf0173168] Lyko et al., 2000, Mech. Dev. 95(1-2): 215--217 The putative Drosophila methyltransferase gene dDnmt2 is contained in a transposon-like element and is expressed specifically in ovaries. [FBrf0129952]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Review	Mayer et al., 2001, Trends Biochem. Sci. 26(3): 143--144 The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component. [FBrf0183186]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Protein sequence record	UniProtKB Project Members, 2005.7.19, UniProtKB: Q9VKB4 Probable ribosome production factor 1 (Ribosome biogenesis protein RPF1). [FBrf0198851]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]