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Gene Dmel\Ced-12

General Information
Symbol	Dmel\Ced-12	Species	D. melanogaster
Name	Ced-12	Annotation symbol	CG5336
Feature type	protein_coding_gene	FlyBase ID	FBgn0032409
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	ELMO, Dced-12
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33C4-33C4	Sequence location	2L:12,097,838..12,100,839 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ced-12 is referred to in FlyBase by the symbol Dmel\Ced-12 (CG5336, FBgn0032409). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: myoblast fusion; central nervous system development; border follicle cell migration; activation of Rac GTPase activity; cell migration; actin filament organization. 19 alleles are reported. The phenotypes of these alleles are annotated with: lateral longitudinal fascicle; presumptive embryonic/larval muscle system; embryonic myoblast; border follicle cell; thorax. It has one annotated transcript and one annotated polypeptide. Protein features are: Domain of unknown function DUF3361; Engulfment/cell motility, ELMO; Pleckstrin homology-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626390_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ced-12. Gene sequence location is 2L:12097843..12100839.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33C4-33C4   Limits computationally determined from genome sequence between P{EP}JhI-21EP1187 and P{lacW}Aats-thrk04203
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ced-12 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ced-12-RA FBtr0080330  NM_135704   2586   724
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ced-12-PA   FBpp0079912   83.0   724   6.10     NP_609548   AAF53164
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF3361 (IPR024574) Engulfment/cell motility, ELMO (IPR006816) Pleckstrin homology-like domain (IPR011993)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA203097   AA392782   AA440804   AA540979   AA978454   AE014134 AAF53164   AF417860 AAL38511   AY119153 AAM51013   BG637505   BI172058   BI216135   BI231622   BI362430   BI367455   BI373295   BI374644   BI481800   BI486634   BI576922   BI593295   BI605084   BI620415   BI624509   BI636219   BT100121   CO153026   CO266031   CO268688   CO268752   CO291738   CO304516   CO309622   CO320475   CO339038   CO342177   CZ470980   EC064512   EC072981   EC078666   EC197273   EC212356   EC244251   EC257209   EC257802   EC260820   GH773348   GH776803   GH818607   GH820114   GH849524   GH855920   GH916640
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VKB2 Q8MS15
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland    52.7 Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass    51.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    91   NA  Eye    72.3   NA  Brain    145.2   155.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    146.5   NA  Crop    75   99.4  Midgut    91.8   99.1  Hindgut    65.1   107.8  Malpighian Tubules    66.4   83  Fat Body    43.1   32.4  Salivary Gland    no informative data   NA  Heart    57.475   97.325  Trachea    NA   NA  VirginFemale Spermatheca    34.5   NA  InseminatedFemale Spermatheca    34.1   NA  Ovary    216.5   NA  Testis    37.2   NA  Male Accessory Gland    39.6   60.4  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    47 central nervous system, pupae P8    48 head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8    44 carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3  (47) central nervous system, pupae P8  (48) head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male  (30) salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering  (32) digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8  (44) carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (55) testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    47 central nervous system, pupae P8    48 head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8    44 carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    47 central nervous system, pupae P8    48 head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8    44 carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    47 central nervous system, pupae P8    48 head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8    44 carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3  (47) central nervous system, pupae P8  (48) head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male  30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering  32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8  (44) carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (55) testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    47 central nervous system, pupae P8    48 head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8    44 carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    20 central nervous system, larvae L3    47 central nervous system, pupae P8    48 head, virgin 1-day female    18 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    14 head, mated 20-day female    12 head, mated 1-day male    21 head, mated 4-day male    24 head, mated 20-day male    30 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    20 digestive system, larvae L3 wandering    32 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    16 fat body, larvae L3 wandering    4 fat body, white prepupae    22 fat body, pupae P8    44 carcass, larvae L3 wandering    25 carcass, 1-day adult    8 carcass, 4-day adult    10 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    55 testis, mated 4-day male    7 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    46 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr  (56) embryo 04-06hr  (57) embryo 06-08hr  (46) embryo 08-10hr  (44) embryo 10-12hr  (37) embryo 12-14hr  (33) embryo 14-16hr  (28) embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    46 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    46 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    46 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (38) embryo 02-04hr  (56) embryo 04-06hr  (57) embryo 06-08hr  (46) embryo 08-10hr  (44) embryo 10-12hr  (37) embryo 12-14hr  (33) embryo 14-16hr  28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    46 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    38 embryo 02-04hr    56 embryo 04-06hr    57 embryo 06-08hr    46 embryo 08-10hr    44 embryo 10-12hr    37 embryo 12-14hr    33 embryo 14-16hr    28 embryo 16-18hr    22 embryo 18-20hr    15 embryo 20-22hr    25 embryo 22-24hr    24 larva L1    8 larva L2    7 larva L3 12hr old    5 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    18 white prepupae new    23 white prepupae 12hr    20 white prepupae 24hr    19 pupae 2d postWPP    14 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    7 adult male 05day    6 adult male 30day    6 adult female 01day    13 adult female 05day    21 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    70 Schneider line 2 Sg4    64 embryonic 1182-4H    120 embryonic GM2    84 embryonic Kc167    66 embryonic S1    82 embryonic S3    41 leg disc CME L1    81 wing disc CME-W2    70 wing disc ML-DmD8    63 wing disc ML-DmD9    113 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    49 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    61 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (70) Schneider line 2 Sg4  (64) embryonic 1182-4H  (120) embryonic GM2  (84) embryonic Kc167  (66) embryonic S1  (82) embryonic S3  (41) leg disc CME L1  (81) wing disc CME-W2  (70) wing disc ML-DmD8  (63) wing disc ML-DmD9  (113) wing disc ML-DmD16-c3  (74) wing disc ML-DmD21  (49) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (60) antennal disc ML-DmD20-c5  (76) mixed discs ML-DmD4-c1  (62) CNS ML-DmBG1-c1  (63) CNS ML-DmBG2-c2  (99) tumorous blood cells mbn2  (61) ovary fGS/OSS    25 ovary OSC  (27) ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    70 Schneider line 2 Sg4    64 embryonic 1182-4H  (120) embryonic GM2    84 embryonic Kc167    66 embryonic S1    82 embryonic S3    41 leg disc CME L1    81 wing disc CME-W2    70 wing disc ML-DmD8    63 wing disc ML-DmD9  (113) wing disc ML-DmD16-c3    74 wing disc ML-DmD21    49 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    61 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    70 Schneider line 2 Sg4    64 embryonic 1182-4H    120 embryonic GM2    84 embryonic Kc167    66 embryonic S1    82 embryonic S3    41 leg disc CME L1    81 wing disc CME-W2    70 wing disc ML-DmD8    63 wing disc ML-DmD9    113 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    49 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    61 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    70 Schneider line 2 Sg4    64 embryonic 1182-4H    120 embryonic GM2    84 embryonic Kc167    66 embryonic S1    82 embryonic S3    41 leg disc CME L1    81 wing disc CME-W2    70 wing disc ML-DmD8    63 wing disc ML-DmD9    113 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    49 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    61 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (70) Schneider line 2 Sg4  (64) embryonic 1182-4H  (120) embryonic GM2  (84) embryonic Kc167  (66) embryonic S1  (82) embryonic S3  (41) leg disc CME L1  (81) wing disc CME-W2  (70) wing disc ML-DmD8  (63) wing disc ML-DmD9  (113) wing disc ML-DmD16-c3  (74) wing disc ML-DmD21  (49) wing disc ML-DmD32  (81) haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (60) antennal disc ML-DmD20-c5  (76) mixed discs ML-DmD4-c1  (62) CNS ML-DmBG1-c1  (63) CNS ML-DmBG2-c2  (99) tumorous blood cells mbn2  (61) ovary fGS/OSS    25 ovary OSC  27 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    70 Schneider line 2 Sg4    64 embryonic 1182-4H  120 embryonic GM2    84 embryonic Kc167    66 embryonic S1    82 embryonic S3    41 leg disc CME L1    81 wing disc CME-W2    70 wing disc ML-DmD8    63 wing disc ML-DmD9  113 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    49 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    61 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    70 Schneider line 2 Sg4    64 embryonic 1182-4H    120 embryonic GM2    84 embryonic Kc167    66 embryonic S1    82 embryonic S3    41 leg disc CME L1    81 wing disc CME-W2    70 wing disc ML-DmD8    63 wing disc ML-DmD9    113 wing disc ML-DmD16-c3    74 wing disc ML-DmD21    49 wing disc ML-DmD32    81 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    62 CNS ML-DmBG1-c1    63 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    61 ovary fGS/OSS    25 ovary OSC    27 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  (29) Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (34) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  (31) Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (38) Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult  29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3  (34) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult  31 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    11 heat shock, 4-day adult    20 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    19 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    38 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    29 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    19 Ethanol 2.5% 3 hrs, larvae L3    34 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    17 Paraquat 5 mM 48 hrs, 4-day adult    31 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE62284 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032409 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5336-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Ced-12c06760 lethal (with Ced-128C6) Ced-12c06760 lethal (with Ced-129F4) Ced-12c06760 lethal (with Ced-1219F3) Ced-12c06760 lethal (with Ced-12c06760) Ced-128C6 Ced-129F4 Ced-1219F3 lethal | embryonic stage | germline clone Ced-1219F3 Ced-12KO viable, with Scer\GAL4pnr-MD237 Ced-12GD4186 Other Phenotypes Allele neuroanatomy defective | embryonic stage Ced-1219F3 neuroanatomy defective | embryonic stage | germline clone Ced-12c06760 Phenotype manifest in Allele border follicle cell, with Scer\GAL4slbo.2.6 Ced-12dsRNA.Scer\UAS border follicle cell | somatic clone Ced-12KO Ced-1219F3 embryonic myoblast Ced-12c06760 Ced-128C6 embryonic myoblast (with Df(2L)HO55) Ced-12c06760 Ced-1219F3 Ced-128C6 Ced-129F4 embryonic myoblast | embryonic stage 16, with Scer\GAL4Mef2.PR Ced-12dsRNA.Scer\UAS embryonic myoblast | germline clone (with Df(2L)Prl) Ced-12c06760 Ced-128C6 lateral longitudinal fascicle Ced-12c06760 presumptive embryonic/larval muscle system Ced-12c06760 Ced-128C6 presumptive embryonic/larval muscle system (with Df(2L)HO55) Ced-12c06760 Ced-1219F3 Ced-128C6 Ced-129F4 presumptive embryonic/larval muscle system | embryonic stage 16, with Scer\GAL4Mef2.PR Ced-12dsRNA.Scer\UAS presumptive embryonic/larval muscle system | germline clone (with Df(2L)Prl) Ced-12c06760 Ced-128C6 thorax, with Scer\GAL4pnr-MD237 Ced-12dsRNA.Scer\UAS
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Ced-12 Class Mutagen Stocks Known lesion Ced-12c06760 hypomorphic allele - molecular evidence piggyBac transposase 2 Yes Ced-1219F3 ethyl methanesulfonate 0 Yes Ced-128C6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Ced-129F4 ethyl methanesulfonate 0 Yes Ced-12CPTI000286 piggyBac transposase 0 Yes Ced-12KO loss of function allele recombination gene targeting by homologous recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ced-12 Class Mutagen Stocks Known lesion Ced-12GD4186 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12GL00516 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12HM05042 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12KK102788 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12dsRNA.cIa in vitro construct - RNAi 0 Yes Ced-12dsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ced-12MtnA.T:Hsap\MYC,T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Ced-12NIG.5336R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ced-12Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes Ced-12Scer\UAS.cGa in vitro construct - regulatory fusion 0 Yes Ced-12Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ced-12Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes Ced-12ΔPRM.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6032 (Ryder, 2004.4.26) Df(2L)HO55 (Geisbrecht et al., 2008, Geisbrecht et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4186} NA P{KK102788} NA P{NIG.5336R} NA P{TRiP.GL00516} NA P{TRiP.HM05042} NA P{UAS-Ced-12.G} NA P{UAS-Ced-12.HA} NA P{UAS-elmo.B} NA P{UAS-ELMO.IR} NA P{UAS-ELMO.MYC} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{602.P.SVS-1}Ced-12CPTI000286 NA PBac{PB}Ced-12c06760 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Zhou et al., 2001) activation of Rac GTPase activity inferred from genetic interaction with Rac1, mbc (Geisbrecht et al., 2008) inferred from genetic interaction with Rac1, mbc, Rac2 (Geisbrecht et al., 2008) border follicle cell migration inferred from mutant phenotype (Bianco et al., 2007, Geisbrecht et al., 2008) cell migration inferred from genetic interaction with worm ced-12 (Zhou et al., 2001) central nervous system development inferred from mutant phenotype (Biersmith et al., 2011) myoblast fusion inferred from mutant phenotype (Geisbrecht et al., 2008)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
phagocytosis inferred from electronic annotation with InterPro:IPR006816 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ced-12 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60684 DroID - A comprehensive database of gene and protein interactions. • FBgn0032409 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34633
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6NZVCR Dipteran inclusive ortholog search EOG68D13G Insect inclusive ortholog search EOG6B8H84 Arthropod inclusive ortholog search EOG6QRFK3 Metazoa inclusive ortholog search EOG6H1PNK
Orthologs in Drosophila Species (EOG6NZVCR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ced-12     Drosophila simulans   Dsim\GD23817 Y   Drosophila sechellia   Dsec\GM26729 Y   Drosophila erecta   Dere\GG23766 Y   Drosophila yakuba   Dyak\GE18571 Y   Drosophila ananassae   Dana\GF21563 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18811 Y   Drosophila persimilis   Dper\GL19238 Y   Drosophila willistoni   Dwil\GK21087 Y   Drosophila virilis   Dvir\GJ17651 Y   Drosophila mojavensis   Dmoj\GI17067 Y   Drosophila grimshawi   Dgri\GH11577 Y
Orthologs in non-Drosophila Dipterans (EOG68D13G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001223   Anopheles gambiae Malaria mosquito  Agam\AGAP009236   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004175
Orthologs in non-Dipteran Insects (EOG6B8H84)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ced-12   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010481   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15899   Atta cephalotes Leafcutter ant  Acep\ACEP10952   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18039   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15940   Linepithema humile Argentine ant  Lhum\LH23522   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24263   Solenopsis invicta Red fire ant  Sinv\SINV14863   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002214   Bombyx mori Silkmoth  Bmor\BGIBMGA010524   Pediculus humanus Human body louse  Phum\PHUM347560   Tribolium castaneum Red flour beetle  Tcas\TC002742
Orthologs in non-Insect Arthropods (EOG6QRFK3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_308856   Ixodes scapularis Deer tick  Isca\ISCW020886
Orthologs in non-Arthropod Metazoa (EOG6H1PNK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ced-12   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024948gn   Danio rerio Zebrafish  Drer\ENSDARG00000063527   Danio rerio Zebrafish  Drer\im:7143453   Danio rerio Zebrafish  Drer\ENSDARG00000055400   Danio rerio Zebrafish  Drer\elmo1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031168   Xenopus tropicalis Western clawed frog  Xtro\elmo3   Xenopus tropicalis Western clawed frog  Xtro\elmo1   Gallus gallus Domestic chicken  Ggal\ELMO3   Gallus gallus Domestic chicken  Ggal\ELMO1   Gallus gallus Domestic chicken  Ggal\ELMO2   Mus musculus House mouse  Mmus\Elmo3   Mus musculus House mouse  Mmus\Elmo1   Mus musculus House mouse  Mmus\ENSMUSG00000017670   Rattus norvegicus Norway rat  Rnor\Elmo3   Rattus norvegicus Norway rat  Rnor\Elmo1   Rattus norvegicus Norway rat  Rnor\Elmo2   Homo sapiens Human  Hsap\ELMO3   Homo sapiens Human  Hsap\ELMO2   Homo sapiens Human  Hsap\ELMO1
Human Orthologs (3)
Gene OMIM HGNC Hsap\ELMO3     Hsap\ELMO2     Hsap\ELMO1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23817 Drosophila sechellia Dsec\GM26729 Drosophila erecta Dere\GG23766 Drosophila yakuba Dyak\GE18571 Drosophila ananassae Dana\GF21563 Drosophila pseudoobscura pseudoobscura Dpse\GA18811 Drosophila persimilis Dper\GL19238 Drosophila willistoni Dwil\GK21087 Drosophila virilis Dvir\GJ17651 Drosophila mojavensis Dmoj\GI17067 Drosophila grimshawi Dgri\GH11577
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28556 y1 v1; P{TRiP.HM05042}attP2 17781 w1118; PBac{PB}Ced-12c06760/CyO 36097 y1 sc* v1; P{TRiP.GL00516}attP40
Harvard	- PBac{PB}Ced-12c06760
VDRC	v107590 P{KK102788}VIE-260B v10455 w1118; P{GD4186}v10455
Genomic Clones ( 1 )
	BACR02B06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE62284
Other clones	FI01538
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03601 LD11904 LD15684 LD20195 LD30626 RE13984 RE22916 RE23060 RE46980 RE53225 RE60553 RE64405 RE70084 RH11295 RH33596 RH51559 RH64075 RH70606 SD15541 SD17833
Other clones	29903 34666 70447 84031 179192 286579 CK01.126B.H3 EC257209 EC257802 EK092408 EK092609 EK144739 EK198059 EK218628 EK245002 EK285631 EN01124 EP00653 EP14115 RP003079936 RP003106686 RP003199552 RP003204286 RP003223789 RP003247422 RP003665766
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032409 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34633
Antibody Information
	polyclonal (Geisbrecht et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ced-12 CG5336 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Ced-12 CG5336 was sequence comparison (date:020807). (FlyBase, 1996-)
Other Comments
	Ced-12 is essential in early, posterior, border cell migration in developing egg chambers, but is not required for later, dorsal, border cell migration. (Bianco et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135704 RefSeq (Proteins) • NP_609548 DDBJ / EMBL / GenBank • AAF53164 AAL38511 AAM51013 AF417860 AY119153 BI374644 CZ470980 Entrez Gene - A searchable database of RefSeq genes. • 34633 UniProtKB/TrEMBL • Q8MS15 Q9VKB2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Domain of unknown function DUF3361 (IPR024574) Engulfment/cell motility, ELMO (IPR006816) Pleckstrin homology-like domain (IPR011993) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE62284
Linkouts
	BioGRID - A database of protein and genetic interactions • 60684 DroID - A comprehensive database of gene and protein interactions. • FBgn0032409 DRSC - Results from RNAi screens. • FBgn0032409 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032409 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5336-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032409 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34633 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/ced-12_elmo.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34633 modMine - Data generated by the modENCODE project. • FBgn0032409
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Ced-12 (Stuart et al., 2007, Bianco et al., 2007, Hyun et al., 2009, McPhee et al., 2010, Japanese National Institute of Genetics, 2012.5.21) ced-12 (Geisbrecht et al., 2007, Zhou et al., 2001) Ced12 (Hyun et al., 2009) CG5336 (Ishimaru et al., 2004, Stuart et al., 2007, Zhou et al., 2001, Keleman et al., 2009.8.5, Perkins et al., 2009, Geisbrecht et al., 2008, Hughes et al., 2008, Ni et al., 2011.7.19) Dced-12 (Reif and Cyster, 2002, Zhou et al., 2001) dced-12 (GOETHEM and FRANC, 2007) dCed-12 (Ziegenfuss et al., 2012) ELMO (Ishimaru et al., 2004, Ishimaru et al., 2004, Meller et al., 2005) elmo (Bianco et al., 2007, Biersmith et al., 2011, Huang et al., 2008, Ohsawa et al., 2011, Geisbrecht et al., 2008, Kuraishi et al., 2009, Shiratsuchi et al., 2012) Elmo (McPhee et al., 2010)
Name Synonym	Ced-12 (McPhee et al., 2010) engulfment and cell motility (Bianco et al., 2007)
Secondary FlyBase IDs
References ( 40 )
Generate a list of	All references relating to this gene ( 40 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 5 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers ( 5 )
	Shiratsuchi et al., 2012, J. Biol. Chem. 287(26): 21663--21672 Independent Recognition of Staphylococcus aureus by Two Receptors for Phagocytosis in Drosophila. [FBrf0218644] Van Goethem et al., 2012, PLoS ONE 7(2): e31488 The Drosophila TRPP Cation Channel, PKD2 and Dmel/Ced-12 Act in Genetically Distinct Pathways during Apoptotic Cell Clearance. [FBrf0217505] Ziegenfuss et al., 2012, Nat. Neurosci. 15(7): 979--987 Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. [FBrf0218752] Biersmith et al., 2011, PLoS ONE 6(1): e16120 The DOCK Protein Sponge Binds to ELMO and Functions in Drosophila Embryonic CNS Development. [FBrf0212890] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...