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Gene Dmel\Ced-12

General Information
Symbol	Dmel\Ced-12	Species	D. melanogaster
Name	Ced-12	Annotation symbol	CG5336
Feature type	protein_coding_gene	FlyBase ID	FBgn0032409
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	ELMO, Dced-12
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33C4-33C4	Sequence location	2L:12,097,843..12,100,839 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ced-12 is referred to in FlyBase by the symbol Dmel\Ced-12 (CG5336, FBgn0032409). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding. There is experimental evidence that it is involved in the biological process: border follicle cell migration; cell migration; actin filament organization. 13 alleles are reported. The phenotype of these alleles is annotated with: thorax. It has one annotated transcript and one annotated polypeptide. Protein features are: Armadillo-like helical; Engulfment/cell motility, ELMO; Pleckstrin homology-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1626390_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ced-12. Gene sequence location is 2L:12097843..12100839.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features HFA02840 BKN22884
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33C4-33C4   Limits computationally determined from genome sequence between P{EP}JhI-21EP1187 and P{lacW}Aats-thrk04203
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ced-12 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ced-12-RA FBtr0080330  NM_135704   2581   724
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ced-12-PA   FBpp0079912   83.0   724   6.10     NP_609548   AAF53164
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Engulfment/cell motility, ELMO (IPR006816) Pleckstrin homology-type (IPR011993) Armadillo-like helical (IPR011989)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA203097   AA392782   AA440804   AA540979   AA978454   AE014134 AAF53164   AF417860 AAL38511   AY119153 AAM51013   BG637505   BI172058   BI216135   BI231622   BI362430   BI367455   BI373295   BI374644   BI481800   BI486634   BI576922   BI593295   BI605084   BI620415   BI624509   BI636219   BT100121   CO153026   CO266031   CO268688   CO268752   CO291738   CO304516   CO309622   CO320475   CO339038   CO342177   CZ470980   EC064512   EC072981   EC078666   EC197273   EC212356   EC244251   EC257209   EC257802   EC260820   GH773348   GH776803   GH818607   GH820114   GH849524   GH855920   GH916640
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MS15 Q9VKB2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0032409    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0032409 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0032409 expression level Developmental Stage   Expression Level embryo 00-02hr    2920 embryo 02-04hr    4232 embryo 04-06hr    4341 embryo 06-08hr    3520 embryo 08-10hr    3387 embryo 10-12hr    2783 embryo 12-14hr    2548 embryo 14-16hr    2094 embryo 16-18hr    1675 embryo 18-20hr    1156 embryo 20-22hr    1901 embryo 22-24hr    1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new    1735 white prepupae 12hr    1485 white prepupae 24hr    1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day    1584 adult female 30day    1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2920) embryo 02-04hr  (4232) embryo 04-06hr  (4341) embryo 06-08hr  (3520) embryo 08-10hr  (3387) embryo 10-12hr  (2783) embryo 12-14hr  (2548) embryo 14-16hr  (2094) embryo 16-18hr  (1675) embryo 18-20hr  (1156) embryo 20-22hr  (1901) embryo 22-24hr  (1806) larva L1  (624) larva L2  (521) larva L3 12hr old  (387) larva L3 puffstage 1-2  (510) larva L3 puffstage 3-6  (849) larva L3 puffstage 7-9  (1367) white prepupae new  (1735) white prepupae 12hr  (1485) white prepupae 24hr  (1420) pupae 2d postWPP  (1072) pupae 3d postWPP  (636) pupae 4d postWPP  (431) adult male 01day  (507) adult male 05day  (419) adult male 30day  (462) adult female 01day  (991) adult female 05day  (1584) adult female 30day  (1535) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2920) embryo 02-04hr  (4232) embryo 04-06hr  (4341) embryo 06-08hr  (3520) embryo 08-10hr  (3387) embryo 10-12hr  (2783) embryo 12-14hr  (2548) embryo 14-16hr  (2094) embryo 16-18hr  (1675) embryo 18-20hr    1156 embryo 20-22hr  (1901) embryo 22-24hr  (1806) larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new  (1735) white prepupae 12hr  1485 white prepupae 24hr  1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day  (1584) adult female 30day  (1535) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2920 embryo 02-04hr    4232 embryo 04-06hr    4341 embryo 06-08hr    3520 embryo 08-10hr    3387 embryo 10-12hr    2783 embryo 12-14hr    2548 embryo 14-16hr    2094 embryo 16-18hr    1675 embryo 18-20hr    1156 embryo 20-22hr    1901 embryo 22-24hr    1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new    1735 white prepupae 12hr    1485 white prepupae 24hr    1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day    1584 adult female 30day    1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2920 embryo 02-04hr    4232 embryo 04-06hr    4341 embryo 06-08hr    3520 embryo 08-10hr    3387 embryo 10-12hr    2783 embryo 12-14hr    2548 embryo 14-16hr    2094 embryo 16-18hr    1675 embryo 18-20hr    1156 embryo 20-22hr    1901 embryo 22-24hr    1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new    1735 white prepupae 12hr    1485 white prepupae 24hr    1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day    1584 adult female 30day    1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0032409 expression level Developmental Stage   Expression Level embryo 00-02hr    2920 embryo 02-04hr    4232 embryo 04-06hr    4341 embryo 06-08hr    3520 embryo 08-10hr    3387 embryo 10-12hr    2783 embryo 12-14hr    2548 embryo 14-16hr    2094 embryo 16-18hr    1675 embryo 18-20hr    1156 embryo 20-22hr    1901 embryo 22-24hr    1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new    1735 white prepupae 12hr    1485 white prepupae 24hr    1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day    1584 adult female 30day    1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2920) embryo 02-04hr  (4232) embryo 04-06hr  (4341) embryo 06-08hr  (3520) embryo 08-10hr  (3387) embryo 10-12hr  (2783) embryo 12-14hr  (2548) embryo 14-16hr  (2094) embryo 16-18hr  (1675) embryo 18-20hr  (1156) embryo 20-22hr  (1901) embryo 22-24hr  (1806) larva L1  (624) larva L2  (521) larva L3 12hr old  (387) larva L3 puffstage 1-2  (510) larva L3 puffstage 3-6  (849) larva L3 puffstage 7-9  (1367) white prepupae new  (1735) white prepupae 12hr  (1485) white prepupae 24hr  (1420) pupae 2d postWPP  (1072) pupae 3d postWPP  (636) pupae 4d postWPP  (431) adult male 01day  (507) adult male 05day  (419) adult male 30day  (462) adult female 01day  (991) adult female 05day  (1584) adult female 30day  (1535) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2920) embryo 02-04hr  (4232) embryo 04-06hr  (4341) embryo 06-08hr  (3520) embryo 08-10hr  (3387) embryo 10-12hr  (2783) embryo 12-14hr  (2548) embryo 14-16hr  2094 embryo 16-18hr  1675 embryo 18-20hr    1156 embryo 20-22hr  1901 embryo 22-24hr  1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new  1735 white prepupae 12hr  1485 white prepupae 24hr  1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day  1584 adult female 30day  1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2920 embryo 02-04hr    4232 embryo 04-06hr    4341 embryo 06-08hr    3520 embryo 08-10hr    3387 embryo 10-12hr    2783 embryo 12-14hr    2548 embryo 14-16hr    2094 embryo 16-18hr    1675 embryo 18-20hr    1156 embryo 20-22hr    1901 embryo 22-24hr    1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new    1735 white prepupae 12hr    1485 white prepupae 24hr    1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day    1584 adult female 30day    1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2920 embryo 02-04hr    4232 embryo 04-06hr    4341 embryo 06-08hr    3520 embryo 08-10hr    3387 embryo 10-12hr    2783 embryo 12-14hr    2548 embryo 14-16hr    2094 embryo 16-18hr    1675 embryo 18-20hr    1156 embryo 20-22hr    1901 embryo 22-24hr    1806 larva L1    624 larva L2    521 larva L3 12hr old    387 larva L3 puffstage 1-2    510 larva L3 puffstage 3-6    849 larva L3 puffstage 7-9    1367 white prepupae new    1735 white prepupae 12hr    1485 white prepupae 24hr    1420 pupae 2d postWPP    1072 pupae 3d postWPP    636 pupae 4d postWPP    431 adult male 01day    507 adult male 05day    419 adult male 30day    462 adult female 01day    991 adult female 05day    1584 adult female 30day    1535 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0032409    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0032409 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0032409 expression level Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0032409 expression level Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.275 Larval Midgut    99.4 Larval Hindgut    99.1 Larval Malpighian Tubules    107.8 Larval Fat Body    83 Larval Salivary Gland    32.4 Larval Trachea    97.325 Larval Carcass    60.4 Adult Head    91 Adult Eye    72.3 Adult Brain    145.2 Adult Thoracic-Abdominal Ganglion    146.5 Adult Crop    75 Adult Midgut    91.8 Adult Hindgut    65.1 Adult Malpighian Tubules    66.4 Adult Fat Body    43.1 Adult Salivary Gland no informative data Adult Heart    57.475 Adult VirginFemale Spermatheca    34.5 Adult InseminatedFemale Spermatheca    34.1 Adult Ovary    216.5 Adult Testis    37.2 Adult Male Accessory Gland    39.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    91   NA  Eye    72.3   NA  Brain    145.2   155.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    146.5   NA  Crop    75   99.4  Midgut    91.8   99.1  Hindgut    65.1   107.8  Malpighian Tubules    66.4   83  Fat Body    43.1   32.4  Salivary Gland    no informative data   NA  Heart    57.475   97.325  Trachea    NA   NA  VirginFemale Spermatheca    34.5   NA  InseminatedFemale Spermatheca    34.1   NA  Ovary    216.5   NA  Testis    37.2   NA  Male Accessory Gland    39.6   60.4  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032409 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5336-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Ced-12GD4186 Phenotype manifest in Allele border follicle cell | somatic clone Ced-12KO thorax, with Scer\GAL4pnr-MD237 Ced-12dsRNA.Scer\UAS
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ced-12 Class Mutagen Stocks Known lesion Ced-12c06760 piggyBac transposase 2 -- Ced-12CPTI000286 piggyBac transposase 0 Yes Ced-12KO loss of function allele recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ced-12 Class Mutagen Stocks Known lesion Ced-12GD4186 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12GL00516 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12HM05042 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12KK102788 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ced-12dsRNA.cIa in vitro construct - RNAi 0 Yes Ced-12dsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Ced-12MtnA.T:Hsap\MYC,T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes Ced-12Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes Ced-12Scer\UAS.T:Hsap\MYC,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ced-12ΔPRM.MtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6032 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4186} NA P{KK102788} NA P{TRiP.GL00516} NA P{TRiP.HM05042} NA P{UAS-elmo.B} NA P{UAS-ELMO.IR} NA P{UAS-ELMO.MYC} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{602.P.SVS-1}Ced-12CPTI000286 NA PBac{PB}Ced-12c06760 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Zhou et al., 2001) border follicle cell migration inferred from mutant phenotype (Bianco et al., 2007) cell migration inferred from genetic interaction with worm ced-12 (Zhou et al., 2001)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011989 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
phagocytosis inferred from electronic annotation with InterPro:IPR006816 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ced-12 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60684 DroID - A comprehensive database of gene and protein interactions. • FBgn0032409 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34633
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21563 Dere\GG23766 Dgri\GH11577 Dmoj\GI17067 Dper\GL19238 Dpse\GA18811 Dsec\GM26729 Dsim\GD23817 Dvir\GJ17651 Dwil\GK21087 Dyak\GE18571
Curated drosophilid orthologs	Dpse\GA18811
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001223-PA Aedes aegypti (mosquito) AGAP009236-PA Anopheles gambiae (mosquito) XP_395913.2 Apis mellifera (honey bee) XP_001945196.1 Acyrthosiphon pisum (pea aphid) 221852 Branchiostoma floridae (lancelet) BGIBMGA010524-PA Bombyx mori (silk worm) ENSBTAP00000004747 Bos taurus (bovine) CBP36880 Caenorhabditis briggsae (nematode) CE27228 Caenorhabditis elegans (worm) ENSCAFP00000015214 Canis familiaris (dog) ENSCINP00000001093 Ciona intestinalis (sea squirt) cn06428 Cryptococcus neoformans (yeast-like fungus) CPIJ004175 Culex pipens (mosquito) ENSCPOP00000005175 Cavia porcellus (guinea pig) RP26966 Caenorhabditis remanei (nematode) 228466 Capitella spl (polychaete worm) DDB0233912 Dictyostelium discoideum (amoeba) 308856 Daphnia pulex (daphnia) ENSDARP00000061737 Danio rerio (zebra fish) ENSECAP00000017068 Equus caballus (horse) ENSGACP00000007730 Gymnopilus aculeatus (mushroom) ENSGALP00000038288 Gallus gallus (chicken) 185222 Hypsipyla robusta (cedar shoot borer) ENSP00000312185 Homo sapiens (human) ISCW020886-PA Ixodes scapularis (deer tick) 222972 Lottia gigantea (owl limpet) ENSMODP00000017404 Monodelphis domestica (gray opossum) ENSMMUP00000030417 Macaca mulatta (rhesus monkey) ENSMUSP00000072334 Mus musculus (house mouse) 171873 Nematostella vectensis (starlet anemone) XP_001603757.1 Nasonia vitripennis (wasp) ENSOANP00000023931 Ornithorynchus anatinus (platypus) ENSORLP00000004190 Oryzias latipes (japanese killifish) PHUM003221-PA Pediculus humanus (human body louse) PP22442 Pristionchus pacificus (nematode) ENSPPYP00000019761 Pongo pygmaeus (orangutan) ENSPTRP00000032609 Pan troglodytes (chimpanzee) ENSRNOP00000025516 Rattus norvegicus (norway rat) XP_001180132.1 Strongylocentrotus purpuratus (purple sea urchin) 55703 Trichoplax adhaerens (metazoa) XP_969248.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020118 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029809 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000016036 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14873 LH23522 ISCW020886 FBgn0235979 FBgn0223079 FBgn0204820 FBgn0195187 FBgn0181582 JGI_V11_308856 FBgn0078811 FBgn0156837 FBgn0139812 FBgn0119057 FBgn0115905 FBgn0098563 CPIJ004175 BGIBMGA010524 ACYPI002214 GB12569 AGAP009236 AAEL001223 PB24263 PHUM347560 GLEAN_02742
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28556 y1 v1; P{TRiP.HM05042}attP2 17781 w1118; PBac{PB}Ced-12c06760/CyO 36097 y1 sc* v1; P{TRiP.GL00516}attP40
Harvard	- PBac{PB}Ced-12c06760
VDRC	v107590 P{KK102788}VIE-260B v10455 w1118; P{GD4186}v10455
Genomic Clones ( 1 )
	BACR02B06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE62284
Other clones	FI01538
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD03601 LD11904 LD15684 LD20195 LD30626 RE13984 RE22916 RE23060 RE46980 RE53225 RE60553 RE64405 RE70084 RH11295 RH33596 RH51559 RH64075 RH70606 SD15541 SD17833
Other clones	29903 34666 70447 84031 179192 286579 CK01.126B.H3 EC257209 EC257802 EK092408 EK092609 EK144739 EK198059 EK218628 EK245002 EK285631 EN01124 EP00653 EP14115 RP003079936 RP003106686 RP003199552 RP003204286 RP003223789 RP003247422 RP003665766
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0032409 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34633
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ced-12 CG5336 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Ced-12 CG5336 was sequence comparison (date:020807). (FlyBase, 1996-)
Other Comments
	Ced-12 is essential in early, posterior, border cell migration in developing egg chambers, but is not required for later, dorsal, border cell migration. (Bianco et al., 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135704 RefSeq (Proteins) • NP_609548 DDBJ / EMBL / GenBank • AAF53164 AAL38511 AAM51013 AF417860 AY119153 BI374644 CZ470980 Entrez Gene - A searchable database of RefSeq genes. • 34633 UniProtKB/TrEMBL • Q8MS15 Q9VKB2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Engulfment/cell motility, ELMO (IPR006816) Pleckstrin homology-type (IPR011993) Armadillo-like helical (IPR011989)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60684 DroID - A comprehensive database of gene and protein interactions. • FBgn0032409 DRSC - Results from RNAi screens. • FBgn0032409 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0032409 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5336-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0032409 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34633 InParanoid A subset of ortholog calls from InParanoid. • AAEL001223-PA Aedes aegypti (mosquito) AGAP009236-PA Anopheles gambiae (mosquito) XP_395913.2 Apis mellifera (honey bee) XP_001945196.1 Acyrthosiphon pisum (pea aphid) 221852 Branchiostoma floridae (lancelet) BGIBMGA010524-PA Bombyx mori (silk worm) ENSBTAP00000004747 Bos taurus (bovine) CBP36880 Caenorhabditis briggsae (nematode) CE27228 Caenorhabditis elegans (worm) ENSCAFP00000015214 Canis familiaris (dog) ENSCINP00000001093 Ciona intestinalis (sea squirt) cn06428 Cryptococcus neoformans (yeast-like fungus) CPIJ004175 Culex pipens (mosquito) ENSCPOP00000005175 Cavia porcellus (guinea pig) RP26966 Caenorhabditis remanei (nematode) 228466 Capitella spl (polychaete worm) DDB0233912 Dictyostelium discoideum (amoeba) 308856 Daphnia pulex (daphnia) ENSDARP00000061737 Danio rerio (zebra fish) ENSECAP00000017068 Equus caballus (horse) ENSGACP00000007730 Gymnopilus aculeatus (mushroom) ENSGALP00000038288 Gallus gallus (chicken) 185222 Hypsipyla robusta (cedar shoot borer) ENSP00000312185 Homo sapiens (human) ISCW020886-PA Ixodes scapularis (deer tick) 222972 Lottia gigantea (owl limpet) ENSMODP00000017404 Monodelphis domestica (gray opossum) ENSMMUP00000030417 Macaca mulatta (rhesus monkey) ENSMUSP00000072334 Mus musculus (house mouse) 171873 Nematostella vectensis (starlet anemone) XP_001603757.1 Nasonia vitripennis (wasp) ENSOANP00000023931 Ornithorynchus anatinus (platypus) ENSORLP00000004190 Oryzias latipes (japanese killifish) PHUM003221-PA Pediculus humanus (human body louse) PP22442 Pristionchus pacificus (nematode) ENSPPYP00000019761 Pongo pygmaeus (orangutan) ENSPTRP00000032609 Pan troglodytes (chimpanzee) ENSRNOP00000025516 Rattus norvegicus (norway rat) XP_001180132.1 Strongylocentrotus purpuratus (purple sea urchin) 55703 Trichoplax adhaerens (metazoa) XP_969248.1 Tribolium castaneum (red flour beetle) ENSTNIP00000020118 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000029809 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000016036 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/ced-12_elmo.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34633 modMine - Data generated by the modENCODE project. • FBgn0032409 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14873 LH23522 ISCW020886 FBgn0235979 FBgn0223079 FBgn0204820 FBgn0195187 FBgn0181582 JGI_V11_308856 FBgn0078811 FBgn0156837 FBgn0139812 FBgn0119057 FBgn0115905 FBgn0098563 CPIJ004175 BGIBMGA010524 ACYPI002214 GB12569 AGAP009236 AAEL001223 PB24263 PHUM347560 GLEAN_02742
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Ced-12 (Stuart et al., 2007, Bianco et al., 2007, Geisbrecht et al., 2008, Hyun et al., 2009, McPhee et al., 2010) ced-12 (Geisbrecht et al., 2007, Zhou et al., 2001) Ced12 (Hyun et al., 2009) CG5336 (Ishimaru et al., 2004, Stuart et al., 2007, Zhou et al., 2001, Geisbrecht et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009, Hughes et al., 2008, Ni et al., 2011.7.19) Dced-12 (Reif and Cyster, 2002, Zhou et al., 2001) dced-12 (GOETHEM and FRANC, 2007) ELMO (Ishimaru et al., 2004, Ishimaru et al., 2004, Meller et al., 2005, Geisbrecht et al., 2008) elmo (Bianco et al., 2007, Huang et al., 2008, Ohsawa et al., 2011, Kuraishi et al., 2009) Elmo (McPhee et al., 2010)
Name Synonym	Ced-12 (McPhee et al., 2010) engulfment and cell motility (Bianco et al., 2007)
Secondary FlyBase IDs
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Computer file  ( 3 )
Recent research papers ( 3 )
	Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Lesch et al., 2010, Genetics 186(3): 943--957 A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. [FBrf0212282] McPhee et al., 2010, Nature 465(7301): 1093--1096 Activation of autophagy during cell death requires the engulfment receptor Draper. [FBrf0211145] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...