FB2020_01, released Feb 12, 2020

Gene: Dmel\Ced-12

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General Information
Symbol
Dmel\Ced-12
Species
D. melanogaster
Name
Ced-12
Annotation Symbol
CG5336
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032409
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
Ced-12 (Ced-12) encodes a protein that functions with Dock family members (encoded by mbc or spg) to regulate GTPase activity. It contributes to myoblast fusion, apoptotic cell engulfment, cell migration, and embryonic cellularization. [Date last reviewed: 2018-11-15]
Other Summaries
Also Known As

ELMO, dCed-12, engulfment and cell motility

Key Links
Genomic Location
Cytogenetic map
33C4-33C4
Sequence location
2L:12,097,838..12,100,839 [+]
Recombination map

2-46

RefSeq locus
NT_033779 REGION:12097838..12100839
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Ced-12 or the JBrowse view of Dmel\Ced-12 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ced-12-RA
FBtr0080330
NM_135704
2586
724
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ced-12-PA
FBpp0079912
83.0
724
6.10
NP_609548
AAF53164
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ced-12 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Gene Ontology (13 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:msk; FB:FBgn0026252
(Liu et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (10 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
actin filament organization
inferred from mutant phenotype
(Zhou et al., 2001)
activation of GTPase activity
(Geisbrecht et al., 2008)
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:mbc; FB:FBgn0015513
(Geisbrecht et al., 2008)
border follicle cell migration
inferred from mutant phenotype
(Geisbrecht et al., 2008, Bianco et al., 2007)
cell migration
inferred from genetic interaction with WB:WBGene00000426
(Zhou et al., 2001)
central nervous system development
inferred from mutant phenotype
(Biersmith et al., 2011)
imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Ishimaru et al., 2004)
muscle attachment
inferred from mutant phenotype
(Liu et al., 2013)
inferred from genetic interaction with FLYBASE:mbc; FB:FBgn0015513
(Liu et al., 2013)
inferred from genetic interaction with FLYBASE:msk; FB:FBgn0026252
(Liu et al., 2013)
myoblast fusion
inferred from mutant phenotype
(Kim et al., 2015, Geisbrecht et al., 2008)
positive regulation of JNK cascade
inferred from direct assay
(Ishimaru et al., 2004)
vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Ishimaru et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Liu et al., 2013)
nucleus
inferred from direct assay
(Liu et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
somatic mesoderm
(Geisbrecht et al., 2008)
somatic muscle
(Geisbrecht et al., 2008)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
visceral mesoderm
(Geisbrecht et al., 2008)
embryonic/larval visceral muscle
(Geisbrecht et al., 2008)
embryonic stage 5
organism | ubiquitous
(Geisbrecht et al., 2008)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- pupal stage
(Geisbrecht et al., 2008)
adult stage | male
(Geisbrecht et al., 2008)
adult stage | female
(Geisbrecht et al., 2008)
ovary
(Geisbrecht et al., 2008)
Additional Descriptive Data

Ced-12 expression is ubiquitous in embryos in early stages. It is apparent in somatic and visceral mesoderm by stage 11. By stage 13, it is stronger in gut visceral mesoderm than somatic mesoderm. Expression is highest in the visceral mesoderm at stage 16

(Geisbrecht et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15 -- late third instar larval stage
muscle attachment site
(Liu et al., 2013)
larval stage
embryonic/larval hypodermal muscle
• Z disc
(Liu et al., 2013)
oogenesis stage S10
follicle cell
(Geisbrecht et al., 2008)
border follicle cell
(Geisbrecht et al., 2008)
oogenesis
female germline cell
(Geisbrecht et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Ced-12 protein is found in close proximity to msk protein at muscle attachment sites.

(Liu et al., 2013)

Broad Ced-12 expression is detected in the ovary throughout oogenesis. It is detected in the germline throughout oogenesis and is detected in follicle cells after stage 9, with prominent expression in the border cells at stage 10. A broad temporal and spatial pattern is seen at other stages of development.

(Geisbrecht et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Liu et al., 2013)
nucleus
inferred from direct assay
(Liu et al., 2013)
Expression Deduced from Reporters
Reporter: PBac{602.P.SVS-1}Ced-12CPTI000286
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ced-12 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ced-12
Transgenic constructs containing regulatory region of Ced-12
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Ced-128C6)
lethal (with Ced-129F4)
lethal (with Ced-1219F3)
lethal (with Ced-12c06760)
lethal - all die before end of embryonic stage | germline clone
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
endocytosis defective, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
neuroanatomy defective, with Scer\GAL4alrm.PD
neuroanatomy defective | embryonic stage
neuroanatomy defective | embryonic stage | germline clone
some die during embryonic stage | germline clone
Phenotype manifest in
Allele
border follicle cell, with Scer\GAL4slbo.2.6
border follicle cell | somatic clone
egg chamber, with Scer\GAL4GR1
embryonic myoblast
embryonic myoblast (with Df(2L)HO55)
embryonic myoblast | embryonic stage 16, with Scer\GAL4Mef2.PR
embryonic myoblast | germline clone (with Df(2L)Prl)
gamma Kenyon cell, with Scer\GAL4alrm.PD
glial cell, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
lateral longitudinal fascicle
muscle attachment site | embryonic stage
myoblast
nurse cell, with Scer\GAL4GR1
presumptive embryonic/larval muscle system
presumptive embryonic/larval muscle system (with Df(2L)HO55)
presumptive embryonic/larval muscle system | embryonic stage 16, with Scer\GAL4Mef2.PR
presumptive embryonic/larval muscle system | germline clone (with Df(2L)Prl)
reticular neuropil associated glial cell, with Scer\GAL4alrm.PD
tendon cell | embryonic stage
thorax, with Scer\GAL4pnr-MD237
vesicle, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
visceral muscle fiber | embryonic stage (with Ced-1219F3)
visceral muscle fiber | embryonic stage (with Ced-12KO)
visceral muscle fiber | embryonic stage | germline clone
visceral muscle fiber | third instar larval stage, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ELMO1
13 of 15
Yes
Yes
Hsap\ELMO2
11 of 15
No
Yes
Hsap\ELMO3
10 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Elmo1
13 of 15
Yes
Yes
Mmus\Elmo2
11 of 15
No
Yes
Mmus\Elmo3
10 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Elmo3
10 of 13
Yes
Yes
Rnor\Elmo1
9 of 13
No
Yes
Rnor\LOC102555457
6 of 13
No
Yes
Rnor\Elmo2
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\elmo1
7 of 12
Yes
Yes
Xtro\elmo3
3 of 12
No
Yes
Xtro\elmo2
2 of 12
No
Yes
Danio rerio (Zebrafish) (4)
Drer\elmo1
11 of 15
Yes
Yes
Drer\elmo3
10 of 15
No
Yes
Drer\elmo2
9 of 15
No
Yes
Drer\si:dkey-56f14.7
4 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ced-12
11 of 15
Yes
Yes
Cele\C56G7.3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\AT1G03620
3 of 9
Yes
No
Atha\AT3G03610
3 of 9
Yes
No
Atha\AT2G44770
2 of 9
No
No
Atha\AT3G60260
2 of 9
No
No
Atha\AT1G67400
1 of 9
No
No
Atha\AT3G43400
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190324 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Ced-12
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001994
Drosophila simulans
Dsim\GD23817
Drosophila sechellia
Dsec\GM26729
Drosophila erecta
Dere\GG23766
Drosophila yakuba
Dyak\GE18571
Drosophila ananassae
Dana\GF21563
Drosophila pseudoobscura pseudoobscura
Dpse\GA18811
Drosophila persimilis
Dper\GL19238
Drosophila willistoni
Dwil\GK21087
Drosophila virilis
Dvir\GJ17651
Drosophila mojavensis
Dmoj\GI17067
Drosophila grimshawi
Dgri\GH11577
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502MS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015123
Glossina morsitans
Tsetse fly
Gmor\GMOY001986
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05838
Mayetiola destructor
Hessian fly
Mdes\Mdes005001
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001223
Anopheles darlingi
American malaria mosquito
Adar\ADAC002044
Anopheles gambiae
Malaria mosquito
Agam\AGAP009236
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004175
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02E8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010524
Danaus plexippus
Monarch butterfly
Dple\DPOGS207663-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002674
Apis florea
Little honeybee
Aflo\2184453812
Apis mellifera
Western honey bee
Amel\Ced-12
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10564
Bombus terrestris
Buff-tailed bumblebee
Bter\15204765
Linepithema humile
Argentine ant
Lhum\LH23522
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0007d4
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010481
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07406
Tribolium castaneum
Red flour beetle
Tcas\TC002742
Pediculus humanus
Human body louse
Phum\PHUM347560
Rhodnius prolixus
Kissing bug
Rpro\RPRC011187
Cimex lectularius
Bed bug
Clec\CLEC006363
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002214
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07231
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02BW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR010272
Ixodes scapularis
Black-legged tick
Isca\ISCW009354
Ixodes scapularis
Black-legged tick
Isca\ISCW020886
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72867.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM72866.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g08770
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308856
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03JJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Elmo
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000597
Gallus gallus
Domestic chicken
Ggal\ELMO3
Gallus gallus
Domestic chicken
Ggal\ELMO1
Gallus gallus
Domestic chicken
Ggal\ELMO2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG10068
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ELMO1; engulfment and cell motility 1
    13 of 15
    606420
        ELMO2; engulfment and cell motility 2
        11 of 15
        606421
          ELMO3; engulfment and cell motility 3
          10 of 15
          606422
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Show neighbor-neighbor interactions:
              Select Layout:
              Legend:
              Protein
              RNA
              Selected Interactor(s)
              Interactions Browser
              View in Interactions Browser
              Please see the Physical Interaction reports below for full details
              RNA-RNA
              Physical Interaction
              Assay
              References
              Ced-12 - mir-8
              luminiscence technology
              (Hyun et al., 2009)
              protein-protein
              Physical Interaction
              Assay
              References
              Ced-12 - mbc
              anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, anti tag western blot, two hybrid
              (Geisbrecht et al., 2008, Ishimaru et al., 2004)
              Ced-12 - msk
              pull down, anti tag western blot, proximity ligation assay, tag visualisation, anti bait coimmunoprecipitation, western blot
              (Liu et al., 2013)
              Ced-12 - spg
              anti tag coimmunoprecipitation, western blot, multidimensional protein identification technology
              (Biersmith et al., 2011)
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Ced-12
              enhanceable
              Eato
              (Santoso et al., 2018)
              Ced-12
              enhanceable
              mbc
              (Geisbrecht et al., 2008)
              Ced-12
              enhanceable
              msk
              (Liu et al., 2013)
              Ced-12|mbc
              suppressible
              Rac1|Rac2
              (Liu et al., 2013, Geisbrecht et al., 2008)
              Ced-12
              enhanceable
              Rho1
              (Kim et al., 2015)
              Ced-12
              suppressible
              Sos
              (Lu et al., 2014)
              Ced-12
              enhanceable
              spg
              (Biersmith et al., 2011)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              drpr
              enhanceable
              Ced-12
              (Tasdemir-Yilmaz and Freeman, 2014)
              mbc
              enhanceable
              Ced-12
              (Geisbrecht et al., 2008)
              msk
              suppressible
              Ced-12
              (Liu et al., 2013)
              msk
              enhanceable
              Ced-12
              (Liu et al., 2013)
              msk
              suppressible
              Ced-12|mbc
              (Liu et al., 2013)
              Rac1
              suppressible
              Ced-12|mbc
              (Geisbrecht et al., 2008)
              spg
              enhanceable
              Ced-12
              (Biersmith et al., 2011)
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
              PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
              Metabolic Pathways
              External Data
              Linkouts
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2L
              Recombination map

              2-46

              Cytogenetic map
              33C4-33C4
              Sequence location
              2L:12,097,838..12,100,839 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              33C4-33C4
              Limits computationally determined from genome sequence between P{EP}JhI-21EP1187 and P{lacW}Aats-thrk04203
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              Experimentally Determined Recombination Data
              Location

              2-46

              (FlyBase, 2016)

              2-39.5

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (8)
              Genomic Clones (16)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (48)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequences
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Geisbrecht et al., 2008)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: Ced-12 CG5336

              (FlyBase, 1996-)
              Source for database merge of
              Additional comments

              Source for identity of Ced-12 CG5336 was sequence comparison ( date:020807 ).

              (FlyBase, 1996-)
              Other Comments

              Ced-12 is essential in early, posterior, border cell migration in developing egg chambers, but is not required for later, dorsal, border cell migration.

              (Bianco et al., 2007)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 37 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (14)
              Reported As
              Symbol Synonym
              CG5336
              (Kumar et al., 2016, Hosono et al., 2015, Walls et al., 2013, Abmayr and Pavlath, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Geisbrecht et al., 2008, Hughes et al., 2008, Stuart et al., 2007, Ishimaru et al., 2004, Zhou et al., 2001)
              Ced-12
              (Gene Disruption Project members, 2018-, Santoso et al., 2018, Tsai et al., 2018, Kutscher and Shaham, 2017, Winfree et al., 2017, Meehan et al., 2016, Nguyen et al., 2016, Maartens and Brown, 2015, Tasdemir-Yilmaz and Freeman, 2014, Toret et al., 2014, Japanese National Institute of Genetics, 2012.5.21, McPhee et al., 2010, Hyun et al., 2009, Bianco et al., 2007, Stuart et al., 2007)
              Ced12
              (Wood and Martin, 2017, Hyun et al., 2009)
              Dced-12
              (Reif and Cyster, 2002, Zhou et al., 2001)
              ELMO
              (Enomoto et al., 2018, Richardson and Portela, 2018, Schmidt and Grosshans, 2018, Schmidt et al., 2018, Winkler et al., 2015, Levayer and Moreno, 2013, Pastor-Pareja and Xu, 2013, Sopko and Perrimon, 2013, Tran et al., 2013, Miyamoto and Yamauchi, 2010, Meller et al., 2005, Ishimaru et al., 2004, Ishimaru et al., 2004)
              Elmo
              (Bothe and Baylies, 2016, Biersmith et al., 2015, Abmayr and Pavlath, 2012, McPhee et al., 2010)
              ced-12
              (Toret et al., 2018, Winkler et al., 2015, Geisbrecht et al., 2007, Zhou et al., 2001)
              ced12
              (Blanchard et al., 2014)
              dCed-12
              (Freeman, 2015, Lu et al., 2014, Ziegenfuss et al., 2012)
              dCed12
              (Pearce et al., 2015)
              dced-12
              (GOETHEM and FRANC, 2007)
              dced12
              (Nakano et al., 2019)
              elmo
              (Toret et al., 2018, Kim et al., 2015, Shiratsuchi et al., 2012, Biersmith et al., 2011, Ohsawa et al., 2011, Kuraishi et al., 2009, Geisbrecht et al., 2008, Huang et al., 2008, Bianco et al., 2007)
              Name Synonyms
              Ced-12
              (McPhee et al., 2010)
              Elmo
              (Amoyel and Bach, 2014)
              engulfment and cell motility
              (Levayer and Moreno, 2013, Bianco et al., 2007)
              Secondary FlyBase IDs
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (97)