ELMO, dCed-12, engulfment and cell motility
Please see the JBrowse view of Dmel\Ced-12 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ced-12 using the Feature Mapper tool.
Comment: maternally deposited
Ced-12 expression is ubiquitous in embryos in early stages. It is apparent in somatic and visceral mesoderm by stage 11. By stage 13, it is stronger in gut visceral mesoderm than somatic mesoderm. Expression is highest in the visceral mesoderm at stage 16
Broad Ced-12 expression is detected in the ovary throughout oogenesis. It is detected in the germline throughout oogenesis and is detected in follicle cells after stage 9, with prominent expression in the border cells at stage 10. A broad temporal and spatial pattern is seen at other stages of development.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ced-12 in GBrowse 22-46
2-39.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: Ced-12 CG5336
Source for identity of Ced-12 CG5336 was sequence comparison ( date:020807 ).
Ced-12 is essential in early, posterior, border cell migration in developing egg chambers, but is not required for later, dorsal, border cell migration.